DK0618899T3 - Aromatiske estere af phenylendialkanoater som inhibitorer af human neutrofil elastase - Google Patents
Aromatiske estere af phenylendialkanoater som inhibitorer af human neutrofil elastaseInfo
- Publication number
- DK0618899T3 DK0618899T3 DK92925470.4T DK92925470T DK0618899T3 DK 0618899 T3 DK0618899 T3 DK 0618899T3 DK 92925470 T DK92925470 T DK 92925470T DK 0618899 T3 DK0618899 T3 DK 0618899T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- carbons
- neutrophil elastase
- human neutrophil
- dialkanoates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/809,378 US5216022A (en) | 1991-12-19 | 1991-12-19 | Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0618899T3 true DK0618899T3 (da) | 1996-04-01 |
Family
ID=25201206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92925470.4T DK0618899T3 (da) | 1991-12-19 | 1992-12-01 | Aromatiske estere af phenylendialkanoater som inhibitorer af human neutrofil elastase |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5216022A (da) |
| EP (1) | EP0618899B1 (da) |
| JP (1) | JP3127436B2 (da) |
| KR (1) | KR100250099B1 (da) |
| AT (1) | ATE135344T1 (da) |
| AU (1) | AU662379B2 (da) |
| CA (1) | CA2126195C (da) |
| DE (1) | DE69209092T2 (da) |
| DK (1) | DK0618899T3 (da) |
| ES (1) | ES2087568T3 (da) |
| FI (1) | FI942928L (da) |
| GR (1) | GR3019438T3 (da) |
| HU (1) | HUT71518A (da) |
| IL (1) | IL104122A (da) |
| MX (1) | MX9207428A (da) |
| NO (1) | NO302518B1 (da) |
| NZ (1) | NZ246115A (da) |
| TW (1) | TW211562B (da) |
| WO (1) | WO1993011760A1 (da) |
| ZA (1) | ZA929697B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100266467B1 (ko) * | 1995-09-27 | 2000-10-02 | 우에노 도시오 | 설폰아미드 유도체 |
| EP0994104A4 (en) * | 1996-06-27 | 2001-09-12 | Ono Pharmaceutical Co | ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT |
| US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
| AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| AU3864000A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| DK2520654T3 (da) * | 2003-08-26 | 2017-05-01 | Univ Colorado Regents | Inhibitorer for serinproteaseaktivitet og disses anvendelse i fremgangsmåder og sammensætninger til behandling af bakterielle infektioner |
| EP3628327A1 (en) | 2011-06-24 | 2020-04-01 | The Regents of the University of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| KR20140137347A (ko) | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| AU2020349353A1 (en) | 2019-09-17 | 2022-04-14 | Duke University | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| HUE064089T2 (hu) | 2020-04-16 | 2024-02-28 | Mereo Biopharma 4 Ltd | Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére |
| AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683241A (en) * | 1984-05-21 | 1987-07-28 | G. D. Searle & Co. | Phenolic ester derivatives as elastase inhibitors |
| US5214191A (en) * | 1990-05-22 | 1993-05-25 | Cortech, Inc. | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase |
-
1991
- 1991-12-19 US US07/809,378 patent/US5216022A/en not_active Expired - Lifetime
-
1992
- 1992-12-01 CA CA002126195A patent/CA2126195C/en not_active Expired - Fee Related
- 1992-12-01 EP EP92925470A patent/EP0618899B1/en not_active Expired - Lifetime
- 1992-12-01 DE DE69209092T patent/DE69209092T2/de not_active Expired - Fee Related
- 1992-12-01 FI FI942928A patent/FI942928L/fi unknown
- 1992-12-01 HU HU9401842A patent/HUT71518A/hu unknown
- 1992-12-01 JP JP05510954A patent/JP3127436B2/ja not_active Expired - Fee Related
- 1992-12-01 WO PCT/US1992/010358 patent/WO1993011760A1/en not_active Ceased
- 1992-12-01 NZ NZ246115A patent/NZ246115A/en unknown
- 1992-12-01 KR KR1019940702129A patent/KR100250099B1/ko not_active Expired - Fee Related
- 1992-12-01 AT AT92925470T patent/ATE135344T1/de not_active IP Right Cessation
- 1992-12-01 AU AU31510/93A patent/AU662379B2/en not_active Ceased
- 1992-12-01 DK DK92925470.4T patent/DK0618899T3/da active
- 1992-12-01 ES ES92925470T patent/ES2087568T3/es not_active Expired - Lifetime
- 1992-12-14 ZA ZA929697A patent/ZA929697B/xx unknown
- 1992-12-15 TW TW081110045A patent/TW211562B/zh active
- 1992-12-17 IL IL104122A patent/IL104122A/en not_active IP Right Cessation
- 1992-12-18 MX MX9207428A patent/MX9207428A/es not_active IP Right Cessation
-
1994
- 1994-06-17 NO NO942308A patent/NO302518B1/no not_active IP Right Cessation
-
1996
- 1996-03-27 GR GR960400824T patent/GR3019438T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9207428A (es) | 1993-06-01 |
| AU662379B2 (en) | 1995-08-31 |
| HU9401842D0 (en) | 1994-09-28 |
| IL104122A0 (en) | 1993-05-13 |
| NZ246115A (en) | 1996-02-27 |
| KR100250099B1 (ko) | 2000-04-01 |
| JP3127436B2 (ja) | 2001-01-22 |
| US5216022A (en) | 1993-06-01 |
| ZA929697B (en) | 1993-06-22 |
| JPH07502505A (ja) | 1995-03-16 |
| CA2126195A1 (en) | 1993-06-24 |
| NO942308D0 (no) | 1994-06-17 |
| EP0618899B1 (en) | 1996-03-13 |
| ATE135344T1 (de) | 1996-03-15 |
| GR3019438T3 (en) | 1996-06-30 |
| DE69209092T2 (de) | 1996-07-25 |
| FI942928A7 (fi) | 1994-06-20 |
| FI942928L (fi) | 1994-06-20 |
| AU3151093A (en) | 1993-07-19 |
| TW211562B (da) | 1993-08-21 |
| CA2126195C (en) | 2004-11-09 |
| EP0618899A4 (en) | 1994-11-02 |
| EP0618899A1 (en) | 1994-10-12 |
| WO1993011760A1 (en) | 1993-06-24 |
| FI942928A0 (fi) | 1994-06-17 |
| NO942308L (no) | 1994-06-17 |
| IL104122A (en) | 1998-03-10 |
| DE69209092D1 (de) | 1996-04-18 |
| HUT71518A (en) | 1995-12-28 |
| ES2087568T3 (es) | 1996-07-16 |
| NO302518B1 (no) | 1998-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO942308D0 (no) | Aromatiske estere av fenylendialkanoater som inhibitorer av human, nöytrofil elastase | |
| EA200000334A1 (ru) | Производные карбоксамидотиазолов, их получение, содержащие их фармацевтические композиции | |
| SE8201145L (sv) | Nya aminometyl-5 oxazolidiniska derivat, deras framstellningssett och derasterapeutiska anvendning | |
| ES8103744A1 (es) | Un metodo para la preparacion de derivados de ftalimidina | |
| BR8303135A (pt) | Composicao herbicida e inibidora do crescimento de plantas, processo para a preparacao de compostos e utilizacao | |
| DK71780A (da) | Fremgangsmaade til fremstilling af difenylhydantoinderivater | |
| YU47219B (sh) | Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanje | |
| ES475635A1 (es) | Procedimiento para preparar derivados de imidazol. | |
| EA200000101A1 (ru) | Производные бензотиофена, их применение и композиции | |
| ES2089041T5 (es) | Compuestos de piridinasulfonamida sustituida, composiciones herbicidas que los contienen, y procedimiento para su preparacion. | |
| SE8001556L (sv) | Tetrahydrobensotiazolylimidazolidinoner | |
| ATE18195T1 (de) | Dioxybenzoletherderivate, diese enthaltende arzneimittel, verfahren zu ihrer herstellung und ihre verwendung. | |
| ES545314A0 (es) | Procedimiento para la preparacion de un nuevo derivado de lafenil-3 propeno-2 amina | |
| ATE69611T1 (de) | Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen. | |
| ATE112769T1 (de) | Benzoxazepinderivate. | |
| SE8302824D0 (sv) | New herbicidal compounds | |
| ES520059A0 (es) | Un procedimiento para la preparacion de pirimidin-2-onas sustituidas. | |
| SE8302547L (sv) | Heterocykliska amider av fenoxifenoxialkansyror | |
| DK256982A (da) | Fremgangsmaade til fremstilling af n-phthalidyl-5-flyoruracilderivater | |
| ES8800663A1 (es) | Procedimiento para preparar compuestos arilsulfonicos. | |
| DK0839142T3 (da) | Hidtil ukendt asymmetrisk syntese af R- og S-warfarin og dens analoger | |
| EA199900691A1 (ru) | Инсектицидные соединения оксадиазина | |
| ATE148462T1 (de) | Isoxazole derivate als lichtschutzmittel |