DK0620743T3 - Kontrastmidler bestående af galactosepartikler og en amfifil carboxylsyre - Google Patents

Kontrastmidler bestående af galactosepartikler og en amfifil carboxylsyre

Info

Publication number
DK0620743T3
DK0620743T3 DK93902155T DK93902155T DK0620743T3 DK 0620743 T3 DK0620743 T3 DK 0620743T3 DK 93902155 T DK93902155 T DK 93902155T DK 93902155 T DK93902155 T DK 93902155T DK 0620743 T3 DK0620743 T3 DK 0620743T3
Authority
DK
Denmark
Prior art keywords
contrast agents
pct
carboxylic acid
agents consisting
sec
Prior art date
Application number
DK93902155T
Other languages
English (en)
Inventor
Jo Klaveness
Pal Rongved
Lars Stubberud
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Application granted granted Critical
Publication of DK0620743T3 publication Critical patent/DK0620743T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DK93902155T 1992-01-09 1993-01-08 Kontrastmidler bestående af galactosepartikler og en amfifil carboxylsyre DK0620743T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929200387A GB9200387D0 (en) 1992-01-09 1992-01-09 Improvements in or relating to contrast agents
PCT/EP1993/000026 WO1993013802A1 (en) 1992-01-09 1993-01-08 Contrast agents consisting of galactose particles and an amphiphilic carboxylic acid

Publications (1)

Publication Number Publication Date
DK0620743T3 true DK0620743T3 (da) 1999-02-01

Family

ID=10708316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93902155T DK0620743T3 (da) 1992-01-09 1993-01-08 Kontrastmidler bestående af galactosepartikler og en amfifil carboxylsyre

Country Status (12)

Country Link
US (3) US5567412A (da)
EP (1) EP0620743B1 (da)
JP (1) JP3383954B2 (da)
AT (1) ATE168564T1 (da)
AU (1) AU676146B2 (da)
CA (1) CA2127704A1 (da)
DE (1) DE69319888T2 (da)
DK (1) DK0620743T3 (da)
ES (1) ES2120493T3 (da)
GB (1) GB9200387D0 (da)
NO (1) NO306198B1 (da)
WO (1) WO1993013802A1 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
SK281535B6 (sk) * 1993-01-25 2001-04-09 Sonus Pharmaceuticals, Inc. Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE4406474A1 (de) 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6521211B1 (en) * 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
EP0935415B1 (en) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro methods for delivering nucleic acids into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
CA2345458A1 (en) * 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
JP3819845B2 (ja) * 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
US7087212B2 (en) * 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
JP3664401B2 (ja) * 2003-01-22 2005-06-29 独立行政法人科学技術振興機構 Ｎ−グリコシド型糖脂質及びこれから成る中空繊維状有機ナノチューブ
EP1592456A1 (en) * 2003-02-13 2005-11-09 BRACCO IMAGING S.p.A. Contrast enhanced x-ray phase imaging
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US20040258760A1 (en) * 2003-03-20 2004-12-23 Wheatley Margaret A. Isolated nanocapsule populations and surfactant-stabilized microcapsules and nanocapsules for diagnostic imaging and drug delivery and methods for their production
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
WO2007137236A2 (en) * 2006-05-19 2007-11-29 Drexel University Drug loaded contrast agents: combining diagnosis and therapy
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
US5315997A (en) * 1990-06-19 1994-05-31 Molecular Biosystems, Inc. Method of magnetic resonance imaging using diamagnetic contrast

Also Published As

Publication number Publication date
EP0620743B1 (en) 1998-07-22
EP0620743A1 (en) 1994-10-26
JP3383954B2 (ja) 2003-03-10
NO942560L (no) 1994-07-07
GB9200387D0 (en) 1992-02-26
ES2120493T3 (es) 1998-11-01
CA2127704A1 (en) 1993-07-22
NO306198B1 (no) 1999-10-04
US5637289A (en) 1997-06-10
US5567412A (en) 1996-10-22
NO942560D0 (no) 1994-07-07
US5614169A (en) 1997-03-25
JPH07505135A (ja) 1995-06-08
ATE168564T1 (de) 1998-08-15
DE69319888T2 (de) 1999-02-11
AU3348393A (en) 1993-08-03
DE69319888D1 (de) 1998-08-27
WO1993013802A1 (en) 1993-07-22
HK1002102A1 (en) 1998-07-31
AU676146B2 (en) 1997-03-06

Similar Documents

Publication Publication Date Title
DK0620743T3 (da) Kontrastmidler bestående af galactosepartikler og en amfifil carboxylsyre
EE03079B1 (et) Kontrastaine ja meetod selle valmistamiseks
EP0675708A1 (en) PHARMACEUTICAL AND DERMOCOSMETIC AGENTS CONTAINING HORSE DECOLOSTRUM.
DK0620744T3 (da) Forbedringer i eller i forbindelse med kontrastmidler
FI953124A0 (fi) Vesipitoiset ruiskutettavat formuloinnit, joita voidaan käyttää röntgentutkimuksiin, jotka käsittävät jodattuja aromaattisia yhdisteitä, joita käytetään kontrastiväliaineina röntgentutkimuksiin
DK0586524T3 (da)
NO942562L (no) Mikropartikulære kontrastmidler
ATE169317T1 (de) Pyridobismidazole enthaltendes rigid-rod-polymer
MD940199A (ro) Agenţi contrastanţi şi aplicarea acestora
DE69320173D1 (de) Kontrastmittel
GR3020473T3 (en) Dermatological and/or cosmetological composition containing retinoids.
NO924481L (no) Innkapslede partikler egnet som kontrastmidler i ultralyd- og roentgenavbildningssammensetninger og -fremgangsmaater
AU2320392A (en) Hydroxamate and hydrazide derivatives of polyamines and their medical use as chelating agents
ATE134725T1 (de) Verwendung von fettsäure-2-ethylhexylestern als kaltreinigungsmittel
MX9203100A (es) Nuevos peptidos, su preparacion y su aplicacion.
DE69219901D1 (de) Adenosinderivate, Verfahren zu deren Herstellung und pharmazeutische Mittel
EA199800881A1 (ru) Способ т1 - взвешенной магниторезонансной визуализации органов ретикуло-эндотелиальной системы
ITMI913305A1 (it) 5, 5'-(1, 3-propandiil) bis (imino (2-osso-2, 1-etandiil)acetilimino)-bis (2, 4, 6-triiodo-1, 3-benzendicarbossiamidi), loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
ATE207480T1 (de) Substituierte aminoalkylaminopyridine
Fribush et al. Field analytical methods for superfund.