DK0625050T3 - TGF-BETA til forbedring af regenerering af nervevæv - Google Patents

TGF-BETA til forbedring af regenerering af nervevæv

Info

Publication number: DK0625050T3
Authority: DK; Denmark
Prior art keywords: tgf; beta; tissue regeneration; nerve tissue; improve nerve
Prior art date: 1991-11-22

Application number

DK92925330T

Other languages

English (en)

Inventor

Peter Gluckman

Karoly Nikolics

Christopher Williams

Original Assignee

Auckland Uniservices Ltd

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-22

Filing date

1992-11-20

Publication date

1999-10-25

1992-11-20 Application filed by Auckland Uniservices Ltd, Genentech Inc filed Critical Auckland Uniservices Ltd

1999-10-25 Application granted granted Critical

1999-10-25 Publication of DK0625050T3 publication Critical patent/DK0625050T3/da

Links

210000000944 nerve tissue Anatomy 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
230000017423 tissue regeneration Effects 0.000 title 1
102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 3
101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 3
210000003169 central nervous system Anatomy 0.000 abstract 3
208000027418 Wounds and injury Diseases 0.000 abstract 2
230000006378 damage Effects 0.000 abstract 2
208000014674 injury Diseases 0.000 abstract 2
208000001738 Nervous System Trauma Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000028412 nervous system injury Diseases 0.000 abstract 1
229940099456 transforming growth factor beta 1 Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK92925330T 1991-11-22 1992-11-20 TGF-BETA til forbedring af regenerering af nervevæv DK0625050T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NZ24069691		1991-11-22
PCT/US1992/009974 WO1993009802A2 (en)	1991-11-22	1992-11-20	Tgf-beta to improve neural outcome

Publications (1)

Publication Number	Publication Date
DK0625050T3 true DK0625050T3 (da)	1999-10-25

Family

ID=19923808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92925330T DK0625050T3 (da)	1991-11-22	1992-11-20	TGF-BETA til forbedring af regenerering af nervevæv

Country Status (9)

Country	Link
EP (1)	EP0625050B1 (da)
JP (2)	JP4101284B2 (da)
AT (1)	ATE178801T1 (da)
CA (1)	CA2122058C (da)
DE (1)	DE69228949T2 (da)
DK (1)	DK0625050T3 (da)
ES (1)	ES2133333T3 (da)
GR (1)	GR3030651T3 (da)
WO (1)	WO1993009802A2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150328A (en)	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
US6294346B1 (en)	1991-07-08	2001-09-25	Neurospheres Holdings, Ltd.	Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US5851832A (en) *	1991-07-08	1998-12-22	Neurospheres, Ltd.	In vitro growth and proliferation of multipotent neural stem cells and their progeny
US7361505B1 (en)	1991-07-08	2008-04-22	Neurospheres Holdings Ltd.	Multipotent neural stem cell compositions
US5750376A (en) *	1991-07-08	1998-05-12	Neurospheres Holdings Ltd.	In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US6071889A (en) *	1991-07-08	2000-06-06	Neurospheres Holdings Ltd.	In vivo genetic modification of growth factor-responsive neural precursor cells
US5980885A (en) *	1991-07-08	1999-11-09	Neurospheres Holdings Ltd.	Growth factor-induced proliferation of neural precursor cells in vivo
US6399369B1 (en)	1991-07-08	2002-06-04	Neurospheres Holdings Ltd.	Multipotent neural stem cell cDNA libraries
US7166277B1 (en)	1991-07-08	2007-01-23	Neurospheres Holdings Ltd.	Remyelination of neurons using multipotent neural stem cell progeny
US6497872B1 (en)	1991-07-08	2002-12-24	Neurospheres Holdings Ltd.	Neural transplantation using proliferated multipotent neural stem cells and their progeny
US6395494B1 (en)	1993-05-13	2002-05-28	Neorx Corporation	Method to determine TGF-β
US6291206B1 (en)	1993-09-17	2001-09-18	Genetics Institute, Inc.	BMP receptor proteins
DE69434651T2 (de)	1993-12-07	2007-03-08	Genetics Institute, Inc., Cambridge	Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5650396A (en) *	1994-03-15	1997-07-22	Celtrix Pharmaceuticals, Inc.	Methods of modulating inflammatory cytokines in the CNS using TGF-β
KR20000064752A (ko) *	1996-03-22	2000-11-06	더 제네랄 호스피탈 코포레이션	중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US7544511B2 (en)	1996-09-25	2009-06-09	Neuralstem Biopharmaceuticals Ltd.	Stable neural stem cell line methods
US6123956A (en) *	1997-07-10	2000-09-26	Keith Baker	Methods for universally distributing therapeutic agents to the brain
US5968829A (en) *	1997-09-05	1999-10-19	Cytotherapeutics, Inc.	Human CNS neural stem cells
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
PT1223990E (pt)	1999-10-15	2004-12-31	Fidia Advanced Biopolymers Srl	Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
EP1399023B1 (en)	2001-06-01	2008-04-30	Wyeth	COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9;
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
US8293488B2 (en)	2002-12-09	2012-10-23	Neuralstem, Inc.	Method for screening neurogenic agents
AU2003293409A1 (en)	2002-12-09	2004-06-30	Karl K. Johe	Method for discovering neurogenic agents
CA2569978C (en)	2004-06-09	2017-06-06	The University Court Of The University Of Edinburgh	Neural stem cells
CN101084303A (zh)	2004-11-17	2007-12-05	神经干公司	用于治疗神经变性症状的人类神经细胞的移植
US20100158878A1 (en)	2008-12-23	2010-06-24	Alexandra Capela	Target populations of oligodendrocyte precursor cells and methods of making and using same
CN103237553A (zh)	2010-07-28	2013-08-07	神经干细胞公司	治疗和/或逆转神经退行性疾病和/或病症的方法
MX382488B (es)	2014-10-20	2025-03-13	Neuralstem Inc	Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.

1992
- 1992-11-20 DE DE69228949T patent/DE69228949T2/de not_active Expired - Lifetime
- 1992-11-20 WO PCT/US1992/009974 patent/WO1993009802A2/en not_active Ceased
- 1992-11-20 DK DK92925330T patent/DK0625050T3/da active
- 1992-11-20 CA CA002122058A patent/CA2122058C/en not_active Expired - Lifetime
- 1992-11-20 JP JP50951593A patent/JP4101284B2/ja not_active Expired - Lifetime
- 1992-11-20 ES ES92925330T patent/ES2133333T3/es not_active Expired - Lifetime
- 1992-11-20 EP EP92925330A patent/EP0625050B1/en not_active Expired - Lifetime
- 1992-11-20 AT AT92925330T patent/ATE178801T1/de active
1999
- 1999-06-30 GR GR990401737T patent/GR3030651T3/el unknown
2003
- 2003-11-13 JP JP2003384121A patent/JP2004115532A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DE69228949T2 (de)	1999-09-16
CA2122058C (en)	2001-07-31
ES2133333T3 (es)	1999-09-16
JP2004115532A (ja)	2004-04-15
EP0625050B1 (en)	1999-04-14
DE69228949D1 (de)	1999-05-20
GR3030651T3 (en)	1999-10-29
EP0625050A1 (en)	1994-11-23
JPH07501080A (ja)	1995-02-02
CA2122058A1 (en)	1993-05-27
JP4101284B2 (ja)	2008-06-18
WO1993009802A2 (en)	1993-05-27
ATE178801T1 (de)	1999-04-15

Publication	Publication Date	Title
DK0625050T3 (da)	1999-10-25	TGF-BETA til forbedring af regenerering af nervevæv
PT840601E (pt)	2002-04-29	Thip para o tratamento de desordens do sono
BR9306226A (pt)	1996-12-03	Composiçao de cura de feridas e tratamento de distúrbios fibróticos e método para a sua preparaçao
PT777483E (pt)	2003-09-30	Metodos e meio para administrar farmacos
DE69232008D1 (de)	2001-09-20	Verwendung von insulinähnlichen Wachstumsfaktoren und Analogen zur BEHANDLUNG VON ERKRANKUNGEN DER SEHNERVEN
DK1574209T3 (da)	2010-05-31	Fremgangsmåde til behandling af ophthalmiske sygdomme
DK202882A (da)	1982-11-09	Fremgangsmaade til fremstilling af 1-alkyl-2-aminotetralinderivater
AR013742A1 (es)	2001-01-10	Metodo para el tratamiento de la hipercolesterolemia con polidialilamina no substituida
ATE110958T1 (de)	1994-09-15	Verwendung von sertralin zur behandlung verfrühter ejakulation.
DK0863760T3 (da)	2002-04-02	Anvendelse af forbindelser med antimineralcorticoid virkning over for narkotikafvænning
DK586387A (da)	1988-05-12	Piperidinderivater til behandling af smertetilstande
ATE137965T1 (de)	1996-06-15	Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
DK1237562T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af mikania-ekstrakter, som indeholder mikanolid og dihydromikanolid, og anvendelse i behandlingen af prolifererende sygdomme
PT655243E (pt)	2002-11-29	Derivados da melatonina para utilizacao no tratamento de disturbios do sono
ATE289809T1 (de)	2005-03-15	Verwendung von valin zur herstellung eines medikaments zur leberregeneration
FR2725990B1 (fr)	1997-01-10	Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
DE69210286D1 (de)	1996-06-05	Behandlung von intraocularem Druck mit einer synergistischen Kombination
RU97101420A (ru)	1998-09-10	Способ лечения тонзиллита
ATE306278T1 (de)	2005-10-15	Behandlung von knochenleiden mit adrenomedullin
SE9101341D0 (sv)	1991-05-03	New medicinal use
DE69941134D1 (de)	2009-08-27	Verwendung von R (+)- g(a)-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol zur Behandlung von Schlafstörungen
DE69218544D1 (de)	1997-04-30	Verwendung von BMY 14802 zur Behandlung von Angstzuständen bei Patienten mit Benzodiazepin-Entzugserscheinungen
RU2002101347A (ru)	2003-09-10	Способ лечения хронического простатита
UA29157A (uk)	2000-10-16	Спосіб лікування захворювань головного мозку