DK0633473T3 - Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin - Google Patents

Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin

Info

Publication number: DK0633473T3
Authority: DK; Denmark
Prior art keywords: aptt; step reaction; partial thromboplastin; thromboplastin time; activated partial
Prior art date: 1993-06-30

Application number

DK93110471T

Other languages

English (en)

Inventor

Dieter Josef

Original Assignee

Stiftung F R Diagnostische For

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-30

Filing date

1993-06-30

Publication date

1999-08-09

1993-06-30 Application filed by Stiftung F R Diagnostische For filed Critical Stiftung F R Diagnostische For

1999-08-09 Application granted granted Critical

1999-08-09 Publication of DK0633473T3 publication Critical patent/DK0633473T3/da

Links

PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 2
102000002262 Thromboplastin Human genes 0.000 title abstract 2
108010000499 Thromboplastin Proteins 0.000 title abstract 2
238000005259 measurement Methods 0.000 title 1
239000003153 chemical reaction reagent Substances 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Urology & Nephrology (AREA)
Zoology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Neurosurgery (AREA)
Biophysics (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

DK93110471T 1993-06-30 1993-06-30 Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin DK0633473T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93110471A EP0633473B1 (de)	1993-06-30	1993-06-30	Messung des aktivierten partiellen Thromboplastinzeit (APTT) in einer Einstufen-Reaktion

Publications (1)

Publication Number	Publication Date
DK0633473T3 true DK0633473T3 (da)	1999-08-09

Family

ID=8213025

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93110471T DK0633473T3 (da)	1993-06-30	1993-06-30	Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin

Country Status (8)

Country	Link
US (1)	US5506146A (da)
EP (1)	EP0633473B1 (da)
JP (1)	JPH07151763A (da)
AT (1)	ATE177536T1 (da)
DE (1)	DE59309435D1 (da)
DK (1)	DK0633473T3 (da)
ES (1)	ES2131543T3 (da)
GR (1)	GR3029654T3 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6898532B1 (en) *	1995-06-07	2005-05-24	Biomerieux, Inc.	Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US6429017B1 (en) *	1999-02-04	2002-08-06	Biomerieux	Method for predicting the presence of haemostatic dysfunction in a patient sample
US5780255A (en) *	1995-06-09	1998-07-14	Instrumentation Laboratory, S.P.A.	Protein C pathway screening test
AT405692B (de) *	1997-03-27	1999-10-25	Immuno Ag	Reagens zur bestimmung der aptt
ATE282208T1 (de) *	1999-02-04	2004-11-15	Bio Merieux Inc	Verfahren und vorrichtung zum vorhersagen von haemostatischer funktionsstörung in patientenproben
US6451610B1 (en) *	1999-04-14	2002-09-17	International Technidyne Corporation	Method and apparatus for coagulation based assays
US7179612B2 (en)	2000-06-09	2007-02-20	Biomerieux, Inc.	Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
US6632678B2 (en)	2001-01-03	2003-10-14	Sienco, Inc.	Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
WO2006129703A1 (ja) *	2005-05-31	2006-12-07	Kurume University	活性化部分トロンボプラスチン時間の検査方法
CN101221189B (zh) *	2007-01-12	2012-08-15	上海太阳生物技术有限公司	一种用于测定活化部分凝血活酶时间aptt的体外诊断试剂盒
GB0701821D0 (en) *	2007-02-01	2007-03-14	Pentapharm Ag	Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid
CN101226201B (zh) *	2008-02-05	2011-05-11	长安大学	活化部分凝血活酶时间(aptt)测定试剂
JP2011133396A (ja) *	2009-12-25	2011-07-07	Sysmex Corp	活性化部分トロンボプラスチン時間測定試薬、活性化部分トロンボプラスチン時間測定方法、及び血液凝固抑制物質の有無の判定方法
JP5911345B2 (ja) *	2012-03-27	2016-04-27	シスメックス株式会社	凝固時間測定用試薬、凝固時間測定用試薬キットおよび凝固時間の測定方法
US10001495B2 (en)	2012-07-25	2018-06-19	Bioverativ Therapeutics Inc.	Blood factor monitoring assay and uses thereof
CN105445478B (zh) *	2015-11-12	2017-08-29	武汉中太生物技术有限公司	活化部分凝血活酶时间测定试剂盒及其制备方法
CN107748267B (zh) *	2017-10-13	2019-02-26	山东艾科达生物科技有限公司	一种测定活化部分凝血活酶时间（aptt）的试剂盒
CN108226540B (zh) *	2018-02-08	2020-07-03	武汉市长立生物技术有限责任公司	一种鞣花酸试剂及其配制方法与活化部分凝血活酶时间测定试剂、aptt试剂盒
JP7444572B2 (ja) *	2019-09-24	2024-03-06	シスメックス株式会社	活性化部分トロンボプラスチン時間測定用試薬及び試薬キット、並びにエラグ酸化合物の沈殿を抑制する方法
WO2026094429A1 (ja) *	2024-10-31	2026-05-07	積水メディカル株式会社	凝固時間測定用試薬及び凝固時間測定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4480029A (en) *	1981-04-27	1984-10-30	Baxter Travenol Laboratories, Inc.	Biological indicators and their use
US4495278A (en) *	1981-04-27	1985-01-22	Baxter Travenol Laboratories, Inc.	Process for making novel blood clotting enzyme compositions
US4470968A (en) *	1983-01-13	1984-09-11	Miles Laboratories, Inc.	Pasteurized therapeutically active blood coagulation factor concentrates
DE3311287A1 (de) *	1983-03-28	1984-10-04	Behringwerke Ag, 3550 Marburg	Verfahren zur fotometrischen bestimmung der aktivierten partiellen thromboplastinzeit und reagenz dazu
DE3516579A1 (de) *	1984-11-19	1986-05-22	Boehringer Mannheim Gmbh, 6800 Mannheim	Gerinnungstest auf teststreifen
US5086002A (en) *	1987-09-07	1992-02-04	Agen Biomedical, Ltd.	Erythrocyte agglutination assay
US5055412A (en) *	1989-03-21	1991-10-08	Proksch Gary J	Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
US5039617A (en) *	1989-04-20	1991-08-13	Biotrack, Inc.	Capillary flow device and method for measuring activated partial thromboplastin time
IT1230744B (it) *	1989-07-07	1991-10-29	Instrumentation Lab Spa	Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
US5091304A (en) *	1989-08-21	1992-02-25	International Technidyne Corporation	Whole blood activated partial thromboplastin time test and associated apparatus
US5169786A (en) *	1989-12-19	1992-12-08	Ortho Diagnostic Systems, Inc.	Method of determining levels of extrinsic and intrinsic clotting factors and protein c
US5288612A (en) *	1991-07-03	1994-02-22	The Scripps Research Institute	Assay methods for detecting serum proteases, particularly activated protein C
JP3180824B2 (ja) *	1991-08-30	2001-06-25	シスメックス株式会社	血液凝固試薬

1993
- 1993-06-30 EP EP93110471A patent/EP0633473B1/de not_active Expired - Lifetime
- 1993-06-30 AT AT93110471T patent/ATE177536T1/de not_active IP Right Cessation
- 1993-06-30 DE DE59309435T patent/DE59309435D1/de not_active Expired - Fee Related
- 1993-06-30 ES ES93110471T patent/ES2131543T3/es not_active Expired - Lifetime
- 1993-06-30 DK DK93110471T patent/DK0633473T3/da active
1994
- 1994-06-28 US US08/266,704 patent/US5506146A/en not_active Expired - Lifetime
- 1994-06-30 JP JP6149568A patent/JPH07151763A/ja active Pending
1999
- 1999-03-11 GR GR990400713T patent/GR3029654T3/el unknown

Also Published As

Publication number	Publication date
ES2131543T3 (es)	1999-08-01
US5506146A (en)	1996-04-09
EP0633473A1 (de)	1995-01-11
GR3029654T3 (en)	1999-06-30
ATE177536T1 (de)	1999-03-15
EP0633473B1 (de)	1999-03-10
JPH07151763A (ja)	1995-06-16
DE59309435D1 (de)	1999-04-15

Publication	Publication Date	Title
DE59309435D1 (de)	1999-04-15	Messung des aktivierten partiellen Thromboplastinzeit (APTT) in einer Einstufen-Reaktion
ATE300054T1 (de)	2005-08-15	Verfahren, reagenz, messkartusche und vorrichtung zur fibrinogenbestimmung
ATE111224T1 (de)	1994-09-15	Kapillare durchflussvorrichtung und verfahren zur messung der aktivierten partiellen thromboplastinzeit.
FI101575B1 (fi)	1998-07-15	Menetelmä reagenssin pitoisuuden mittaamiseksi reaktioseoksessa
ES2088992T3 (es)	1996-10-01	Metodo para determinar los niveles de factores de coagulacion intrinsecos y extrinsecos y proteina c.
DE3580640D1 (de)	1991-01-03	Testverfahren.
ATE35000T1 (de)	1988-06-15	Reagenz zur bestimmung der thromboplastinzeit.
ATE253543T1 (de)	2003-11-15	Verfahren zur umsetzung einer ein gemisch enthaltenden lösung
DK0509086T3 (da)	1995-07-03	Fremgangsmåde til bestemmelse af koncentrationen af antikoagulanter
DK314987A (da)	1987-12-22	Fremgangsmaade til specifik bestemmelse af serumfructosaminindhold samt hertil egnet reagensblanding
DK162179C (da)	1992-03-02	Reagens til ettrinsbestemmelse af den aktiverede partielle thromboplastintid samt reagensets anvendelse
JPS57178161A (en)	1982-11-02	Reagent for optically measuring blood coagulation reaction
ATE147513T1 (de)	1997-01-15	Testverfahren, die ein lösliches fibrinähnliches monomer nutzen
DK0418486T3 (da)	1994-11-21	Reagens anvendeligt til påvisning og kvantitativ bestemmelse af leukocyter i biologiske væsker samt fremgangsmåde til anvendelse deraf
KR920704117A (ko)	1992-12-19	피브리노겐 직접 분석 방법
NO903748D0 (no)	1990-08-27	Fremgangsmaate ved enzymatisk bestemmelse av analyttkonsentrasjoner.
CZ146198A3 (cs)	1998-12-16	Reagenční směs pro stanovení hemoglobinu, obsahující kyanid a metoda, zajišťující přijatelnou přesnost měření, přesnost výsledků a eliminaci interference bílých krvinek na automatických hematologických analyzátorech
ATE80665T1 (de)	1992-10-15	Verfahren und reagens zur bestimmung von ld-1isoenzym.
RU94043623A (ru)	1996-10-20	Способ фотометрического определения химических загрязнителей воды
DK0570355T3 (da)	1999-08-30	Anvendelse af prothrombin-fragmenter
ATE364716T1 (de)	2007-07-15	Stabilisiertes reagenz und verfahren zur bestimmung von creatin-kinase
DE50115123D1 (de)	2009-11-05	Verfahren zur vermeidung von kontaminationen von negativem probenmaterial durch analythaltige proben bei der verwendung von pipettierautomaten
ATE199781T1 (de)	2001-03-15	Verfahren zur beseitigung von hämoglobin- störungen bei der bestimmung von albumin