DK0638548T3 - Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s - Google Patents
Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum sInfo
- Publication number
- DK0638548T3 DK0638548T3 DK94112383T DK94112383T DK0638548T3 DK 0638548 T3 DK0638548 T3 DK 0638548T3 DK 94112383 T DK94112383 T DK 94112383T DK 94112383 T DK94112383 T DK 94112383T DK 0638548 T3 DK0638548 T3 DK 0638548T3
- Authority
- DK
- Denmark
- Prior art keywords
- processes
- alk
- drugs
- formula
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4327244A DE4327244A1 (de) | 1993-08-13 | 1993-08-13 | Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0638548T3 true DK0638548T3 (da) | 1998-11-23 |
Family
ID=6495131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94112383T DK0638548T3 (da) | 1993-08-13 | 1994-08-08 | Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5559153A (da) |
| EP (1) | EP0638548B1 (da) |
| JP (1) | JP3647901B2 (da) |
| CN (1) | CN1060763C (da) |
| AT (1) | ATE165342T1 (da) |
| AU (1) | AU683273B2 (da) |
| CA (1) | CA2130031C (da) |
| DE (2) | DE4327244A1 (da) |
| DK (1) | DK0638548T3 (da) |
| ES (1) | ES2115115T3 (da) |
| FI (1) | FI943716L (da) |
| HU (1) | HU217628B (da) |
| IL (1) | IL110625A (da) |
| NO (1) | NO300680B1 (da) |
| NZ (1) | NZ264216A (da) |
| ZA (1) | ZA946074B (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
| EP0738712B1 (en) * | 1995-04-18 | 1999-08-18 | Hoechst Aktiengesellschaft | Anti-arrhythmic and cardioprotective substituted indenoylguanidines |
| US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
| US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
| DE19527305A1 (de) * | 1995-07-26 | 1997-01-30 | Hoechst Ag | Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| JPH11502876A (ja) * | 1996-01-26 | 1999-03-09 | 藤沢薬品工業株式会社 | グアニジン誘導体 |
| DE19603425A1 (de) * | 1996-01-31 | 1997-08-07 | Hoechst Ag | Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19622370A1 (de) * | 1996-06-04 | 1997-12-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6820824B1 (en) | 1998-01-14 | 2004-11-23 | 3M Innovative Properties Company | Apparatus for spraying liquids, disposable containers and liners suitable for use therewith |
| DE19713427A1 (de) * | 1997-04-01 | 1998-10-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
| GB1311432A (en) * | 1971-01-07 | 1973-03-28 | Ici Ltd | Guanidine derivatives their preparation and antiviral compositions containing them |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| US5276907A (en) * | 1991-01-07 | 1994-01-04 | Motorola Inc. | Method and apparatus for dynamic distribution of a communication channel load in a cellular radio communication system |
| DK0556674T3 (da) * | 1992-02-15 | 1996-10-14 | Hoechst Ag | 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation |
-
1993
- 1993-08-13 DE DE4327244A patent/DE4327244A1/de not_active Withdrawn
-
1994
- 1994-08-08 DK DK94112383T patent/DK0638548T3/da active
- 1994-08-08 EP EP94112383A patent/EP0638548B1/de not_active Expired - Lifetime
- 1994-08-08 ES ES94112383T patent/ES2115115T3/es not_active Expired - Lifetime
- 1994-08-08 AT AT94112383T patent/ATE165342T1/de not_active IP Right Cessation
- 1994-08-08 DE DE59405764T patent/DE59405764D1/de not_active Expired - Lifetime
- 1994-08-11 CN CN94109503A patent/CN1060763C/zh not_active Expired - Fee Related
- 1994-08-11 US US08/289,674 patent/US5559153A/en not_active Expired - Lifetime
- 1994-08-11 FI FI943716A patent/FI943716L/fi unknown
- 1994-08-11 IL IL11062594A patent/IL110625A/en not_active IP Right Cessation
- 1994-08-11 AU AU70223/94A patent/AU683273B2/en not_active Ceased
- 1994-08-11 NZ NZ264216A patent/NZ264216A/en unknown
- 1994-08-12 ZA ZA946074A patent/ZA946074B/xx unknown
- 1994-08-12 HU HU9402346A patent/HU217628B/hu not_active IP Right Cessation
- 1994-08-12 CA CA002130031A patent/CA2130031C/en not_active Expired - Fee Related
- 1994-08-12 JP JP18972594A patent/JP3647901B2/ja not_active Expired - Fee Related
- 1994-08-12 NO NO942985A patent/NO300680B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59405764D1 (de) | 1998-05-28 |
| US5559153A (en) | 1996-09-24 |
| CA2130031A1 (en) | 1995-02-14 |
| EP0638548B1 (de) | 1998-04-22 |
| IL110625A (en) | 1999-03-12 |
| ATE165342T1 (de) | 1998-05-15 |
| CN1060763C (zh) | 2001-01-17 |
| FI943716A7 (fi) | 1995-02-14 |
| JPH0776566A (ja) | 1995-03-20 |
| HUT71816A (en) | 1996-02-28 |
| CN1111618A (zh) | 1995-11-15 |
| EP0638548A1 (de) | 1995-02-15 |
| NO300680B1 (no) | 1997-07-07 |
| ES2115115T3 (es) | 1998-06-16 |
| DE4327244A1 (de) | 1995-02-16 |
| HU9402346D0 (en) | 1994-10-28 |
| NO942985D0 (no) | 1994-08-12 |
| AU683273B2 (en) | 1997-11-06 |
| HU217628B (hu) | 2000-03-28 |
| NZ264216A (en) | 1995-10-26 |
| CA2130031C (en) | 2005-11-15 |
| JP3647901B2 (ja) | 2005-05-18 |
| FI943716A0 (fi) | 1994-08-11 |
| ZA946074B (en) | 1995-03-20 |
| FI943716L (fi) | 1995-02-14 |
| AU7022394A (en) | 1995-02-23 |
| IL110625A0 (en) | 1994-11-11 |
| NO942985L (no) | 1995-02-14 |
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