DK0638548T3 - Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s - Google Patents

Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s

Info

Publication number
DK0638548T3
DK0638548T3 DK94112383T DK94112383T DK0638548T3 DK 0638548 T3 DK0638548 T3 DK 0638548T3 DK 94112383 T DK94112383 T DK 94112383T DK 94112383 T DK94112383 T DK 94112383T DK 0638548 T3 DK0638548 T3 DK 0638548T3
Authority
DK
Denmark
Prior art keywords
processes
alk
drugs
formula
preparation
Prior art date
Application number
DK94112383T
Other languages
English (en)
Inventor
Jan-Robert Dr Schwark
Hans-Jochen Dr Lang
Heinz-Werner Dr Kleemann
Andreas Dr Weichert
Wolfgang Dr Scholz
Udo Dr Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0638548T3 publication Critical patent/DK0638548T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK94112383T 1993-08-13 1994-08-08 Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s DK0638548T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4327244A DE4327244A1 (de) 1993-08-13 1993-08-13 Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
DK0638548T3 true DK0638548T3 (da) 1998-11-23

Family

ID=6495131

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94112383T DK0638548T3 (da) 1993-08-13 1994-08-08 Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s

Country Status (16)

Country Link
US (1) US5559153A (da)
EP (1) EP0638548B1 (da)
JP (1) JP3647901B2 (da)
CN (1) CN1060763C (da)
AT (1) ATE165342T1 (da)
AU (1) AU683273B2 (da)
CA (1) CA2130031C (da)
DE (2) DE4327244A1 (da)
DK (1) DK0638548T3 (da)
ES (1) ES2115115T3 (da)
FI (1) FI943716L (da)
HU (1) HU217628B (da)
IL (1) IL110625A (da)
NO (1) NO300680B1 (da)
NZ (1) NZ264216A (da)
ZA (1) ZA946074B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
IL114670A0 (en) * 1994-08-05 1995-11-27 Fujisawa Pharmaceutical Co Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
EP0738712B1 (en) * 1995-04-18 1999-08-18 Hoechst Aktiengesellschaft Anti-arrhythmic and cardioprotective substituted indenoylguanidines
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
DE19527305A1 (de) * 1995-07-26 1997-01-30 Hoechst Ag Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
JPH11502876A (ja) * 1996-01-26 1999-03-09 藤沢薬品工業株式会社 グアニジン誘導体
DE19603425A1 (de) * 1996-01-31 1997-08-07 Hoechst Ag Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19622370A1 (de) * 1996-06-04 1997-12-11 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6820824B1 (en) 1998-01-14 2004-11-23 3M Innovative Properties Company Apparatus for spraying liquids, disposable containers and liners suitable for use therewith
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
GB1311432A (en) * 1971-01-07 1973-03-28 Ici Ltd Guanidine derivatives their preparation and antiviral compositions containing them
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5276907A (en) * 1991-01-07 1994-01-04 Motorola Inc. Method and apparatus for dynamic distribution of a communication channel load in a cellular radio communication system
DK0556674T3 (da) * 1992-02-15 1996-10-14 Hoechst Ag 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation

Also Published As

Publication number Publication date
DE59405764D1 (de) 1998-05-28
US5559153A (en) 1996-09-24
CA2130031A1 (en) 1995-02-14
EP0638548B1 (de) 1998-04-22
IL110625A (en) 1999-03-12
ATE165342T1 (de) 1998-05-15
CN1060763C (zh) 2001-01-17
FI943716A7 (fi) 1995-02-14
JPH0776566A (ja) 1995-03-20
HUT71816A (en) 1996-02-28
CN1111618A (zh) 1995-11-15
EP0638548A1 (de) 1995-02-15
NO300680B1 (no) 1997-07-07
ES2115115T3 (es) 1998-06-16
DE4327244A1 (de) 1995-02-16
HU9402346D0 (en) 1994-10-28
NO942985D0 (no) 1994-08-12
AU683273B2 (en) 1997-11-06
HU217628B (hu) 2000-03-28
NZ264216A (en) 1995-10-26
CA2130031C (en) 2005-11-15
JP3647901B2 (ja) 2005-05-18
FI943716A0 (fi) 1994-08-11
ZA946074B (en) 1995-03-20
FI943716L (fi) 1995-02-14
AU7022394A (en) 1995-02-23
IL110625A0 (en) 1994-11-11
NO942985L (no) 1995-02-14

Similar Documents

Publication Publication Date Title
DK0638548T3 (da) Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler eller diagnostikum s
NO932392L (no) 3,4,5-Substituerte benzoylguanidiner, fremgangsmaate for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende disse
NO934604D0 (no) Substituerte benzolguandiner, fremgangsmaater for fremstilling av disse, deres anvendelse som medikanementer eller diagnostikum saavel som medikamenter som inneholder dem
NO930510D0 (no) 3,5-substituerte benzoylguanidiner, fremgangsmaater for deres fremstilling, deres anvendelse som medikament eller diagnostikum, saavel som medikamenter som inneholder dem
ATE184273T1 (de) Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
NO942837L (no) Substituerte benzoylguanidiner, fremgangsmåte for fremstilling, deres anvendelse som medikament eller diagnostikum såvel som legemidler inneholdende dem
DK0627413T3 (da) Substituerede benzoylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel eller diagnostikum samt lægemiddel med indhold deraf
NO934634L (no) 3,5-substiturete aminobenzoylguanidiner, fremgangsmåte til fremstilling derav, deres anvendelse som medikament eller diagnostikum samt middel inneholdende forbindelsene
DE69000364D1 (de) Von benzocyclischen oder benzoheterocyclischen saeuren abgeleitete sulfonamide, ihre herstellung und ihre anwendung in der heilkunde.
KR950017942A (ko) 아미노-치환된 벤젠설포닐우레아 및 벤젠설포닐티오우레아, 이들의 제조방법 및 약제로서의 이들의 용도
TH4572A (th) เบนโซอิลยูเรียชนิดใหม่