DK0639976T3 - Anvendelse af terfenadin-derivater som antihistaminika i patienter med leversygdomme - Google Patents

Anvendelse af terfenadin-derivater som antihistaminika i patienter med leversygdomme

Info

Publication number: DK0639976T3
Authority: DK; Denmark
Prior art keywords: hydrogen; antihistamines; patients; liver disease; hydroxy
Prior art date: 1992-05-11

Application number

DK93909249T

Other languages

Danish (da)

English (en)

Inventor

James K Woodward

Richard R Okerholm

Mark G Eller

Bruce E Mcnutt

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-11

Filing date

1993-04-06

Publication date

1999-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27128589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0639976(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-04-06 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1999-02-15 Application granted granted Critical

1999-02-15 Publication of DK0639976T3 publication Critical patent/DK0639976T3/da

Links

239000000739 antihistaminic agent Substances 0.000 title abstract 2
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical class C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title 1
229940125715 antihistaminic agent Drugs 0.000 title 1
208000019423 liver disease Diseases 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
230000001387 anti-histamine Effects 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001771 impaired effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK93909249T 1992-05-11 1993-04-06 Anvendelse af terfenadin-derivater som antihistaminika i patienter med leversygdomme DK0639976T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US88080192A	1992-05-11	1992-05-11
US92289092A	1992-07-31	1992-07-31
PCT/US1993/003151 WO1993023047A1 (en)	1992-05-11	1993-04-06	Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient

Publications (1)

Publication Number	Publication Date
DK0639976T3 true DK0639976T3 (da)	1999-02-15

Family

ID=27128589

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93909249T DK0639976T3 (da)	1992-05-11	1993-04-06	Anvendelse af terfenadin-derivater som antihistaminika i patienter med leversygdomme

Country Status (16)

Country	Link
US (7)	US6037353A (de)
EP (1)	EP0639976B1 (de)
JP (1)	JPH07506828A (de)
KR (1)	KR950701525A (de)
AT (1)	ATE194913T1 (de)
AU (1)	AU679910B2 (de)
CA (1)	CA2134211C (de)
CL (1)	CL2004000304A1 (de)
DE (1)	DE69320952T2 (de)
DK (1)	DK0639976T3 (de)
ES (1)	ES2121084T3 (de)
HU (1)	HU223774B1 (de)
MX (1)	MX9302704A (de)
NO (1)	NO307688B1 (de)
NZ (1)	NZ251834A (de)
WO (1)	WO1993023047A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ251834A (en) *	1992-05-11	1997-07-27	Merrell Dow Pharma	Use of acid derivatives of terfenadine as antihistamines
RU2167657C2 (ru) *	1992-08-03	2001-05-27	Сепракор, Инк.	Фармацевтическая композиция для лечения аллергических заболеваний, способ антигистаминного лечения, применение композиции для получения лекарственного препарата
WO1995010278A1 (en) *	1993-10-15	1995-04-20	Hoechst Marion Roussel, Inc.	Treatment of allergic disorders with terfenadine carboxylate
IT1271417B (it) *	1993-10-15	1997-05-28	Erregierre Ind Chim	Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
US20030045722A1 (en) *	1994-05-18	2003-03-06	Henton Daniel R.	Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN1623985A (zh) *	1994-05-18	2005-06-08	阿温蒂斯药物公司	抗组胺哌啶衍生物，其多晶形物和假同晶物的无水和水合物形式的制备方法
DE69624559T2 (de)	1995-02-28	2003-07-10	Aventis Pharmaceuticals Inc., Bridgewater	Arzneizubereitungen für piperidinalkanolderivate
EP0998272B1 (de) *	1997-08-26	2003-05-02	Aventis Pharmaceuticals Inc.	Arzneimittel für die kombination piperidinoalkanol-dekongestivum
US6194431B1 (en)	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US20030021849A1 (en) *	2001-04-09	2003-01-30	Ben-Zion Dolitzky	Polymorphs of fexofenadine hydrochloride
MXPA03009259A (es) *	2001-04-09	2004-06-03	Teva Pharma	Polimorfos de clorhidrato de fexofenadina.
EP2316468A1 (de)	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
WO2003104197A1 (en) *	2002-06-10	2003-12-18	Teva Pharmaceutical Industries Ltd.	Polymorphic form xvi of fexofenadine hydrochloride
EP1393728A1 (de) *	2002-08-30	2004-03-03	Vrije Universiteit	Auf Virus-kodierte G Protein-gekoppelte Rezeptoren wirkende inverse Agonisten
US20050065183A1 (en) *	2003-07-31	2005-03-24	Indranil Nandi	Fexofenadine composition and process for preparing
WO2005102999A2 (en) *	2004-04-26	2005-11-03	Teva Pharmaceutical Industries Ltd.	Crystalline forms of fexofenadine hydrochloride and processes for their preparation
EP1685106A2 (de) *	2004-09-28	2006-08-02	Teva Pharmaceutical Industries, Inc.	Fexofendadin-kristallform und verfahren zu deren herstellung
US20090076080A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched fexofenadine
KR20110017365A (ko) *	2008-05-30	2011-02-21	페어필드 클리니컬 트라이얼즈 엘엘씨	피부 염증 및 변색을 위한 방법 및 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4254129A (en) *	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
US4285958A (en) *	1979-04-10	1981-08-25	Richardson-Merrell Inc.	1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
AR240018A1 (es) *	1987-10-07	1990-01-31	Merrell Pharma Inc	Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
US4929605A (en) *	1987-10-07	1990-05-29	Merrell Dow Pharmaceuticals Inc.	Pharmaceutical composition for piperidinoalkanol derivatives
NZ251834A (en) *	1992-05-11	1997-07-27	Merrell Dow Pharma	Use of acid derivatives of terfenadine as antihistamines
RU2167657C2 (ru) *	1992-08-03	2001-05-27	Сепракор, Инк.	Фармацевтическая композиция для лечения аллергических заболеваний, способ антигистаминного лечения, применение композиции для получения лекарственного препарата

1993
- 1993-04-06 NZ NZ251834A patent/NZ251834A/en not_active IP Right Cessation
- 1993-04-06 JP JP5520211A patent/JPH07506828A/ja active Pending
- 1993-04-06 KR KR1019940704016A patent/KR950701525A/ko not_active Ceased
- 1993-04-06 WO PCT/US1993/003151 patent/WO1993023047A1/en not_active Ceased
- 1993-04-06 EP EP93909249A patent/EP0639976B1/de not_active Expired - Lifetime
- 1993-04-06 DE DE69320952T patent/DE69320952T2/de not_active Expired - Lifetime
- 1993-04-06 AT AT93909249T patent/ATE194913T1/de active
- 1993-04-06 ES ES93909249T patent/ES2121084T3/es not_active Expired - Lifetime
- 1993-04-06 CA CA002134211A patent/CA2134211C/en not_active Expired - Lifetime
- 1993-04-06 AU AU39734/93A patent/AU679910B2/en not_active Expired
- 1993-04-06 HU HU9403234A patent/HU223774B1/hu active IP Right Grant
- 1993-04-06 DK DK93909249T patent/DK0639976T3/da active
- 1993-05-07 MX MX9302704A patent/MX9302704A/es unknown
1994
- 1994-11-10 NO NO944287A patent/NO307688B1/no not_active IP Right Cessation
1995
- 1995-03-02 US US08/397,542 patent/US6037353A/en not_active Expired - Lifetime
2000
- 2000-01-12 US US09/481,404 patent/US6187791B1/en not_active Expired - Fee Related
- 2000-02-11 US US09/502,331 patent/US20030055083A1/en not_active Abandoned
- 2000-09-15 US US09/663,343 patent/US6399632B1/en not_active Expired - Fee Related
2003
- 2003-02-25 US US10/372,307 patent/US20030130315A1/en not_active Abandoned
2004
- 2004-02-19 CL CL200400304A patent/CL2004000304A1/es unknown
2006
- 2006-05-15 US US11/433,433 patent/US20060205782A1/en not_active Abandoned
2009
- 2009-07-01 US US12/496,153 patent/US20100168166A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20100168166A1 (en)	2010-07-01
HU223774B1 (hu)	2005-01-28
DE69320952D1 (de)	1998-10-15
DE69320952T2 (de)	1999-05-27
HUT71402A (en)	1995-11-28
CL2004000304A1 (es)	2005-05-27
NO307688B1 (no)	2000-05-15
ES2121084T3 (es)	2002-02-16
NO944287L (no)	1994-11-10
ATE194913T1 (de)	2000-08-15
US20060205782A1 (en)	2006-09-14
MX9302704A (es)	1994-06-30
US6187791B1 (en)	2001-02-13
AU3973493A (en)	1993-12-13
NO944287D0 (no)	1994-11-10
KR950701525A (ko)	1995-04-28
WO1993023047A1 (en)	1993-11-25
US20030055083A1 (en)	2003-03-20
AU679910B2 (en)	1997-07-17
NZ251834A (en)	1997-07-27
JPH07506828A (ja)	1995-07-27
CA2134211C (en)	1999-06-29
EP0639976B1 (de)	2000-07-26
US20030130315A1 (en)	2003-07-10
US6037353A (en)	2000-03-14
EP0639976A1 (de)	1995-03-01
CA2134211A1 (en)	1993-11-25
US6399632B1 (en)	2002-06-04

Publication	Publication Date	Title
ATE194913T1 (de)	2000-08-15	Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
FI956248A0 (fi)	1995-12-22	Uusia välituotteita antihistamiinisten 4-difenyylimetyyli/difenyylimetoksipiperidiinijohdannaisten valmistusta varten
DE69415445D1 (de)	1999-02-04	Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische Zusammensetzungen
MY132056A (en)	2007-09-28	Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE68924681D1 (de)	1995-12-07	Heterocyclische Biphosphonsäurederivate.
KR890011592A (ko)	1989-08-21	기관내 허혈병의 치료용 조성물
ATE150301T1 (de)	1997-04-15	Aminoalkanesulfonsäurederivate und pharmazeutische zusammensetzungen davon zur prävention oder behandlung von herzerkrankungen
ES2148305T3 (es)	2000-10-16	Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep.
ES2055235T3 (es)	1994-08-16	Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
ATE172959T1 (de)	1998-11-15	Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
KR960700711A (ko)	1996-02-24	뇌혈관성 질환의 치료 또는 예방용 약제(Medicament for treating or preventing cerebrovascular diseases)
KR910015301A (ko)	1991-09-30	수면 무호흡증의 치료방법
KR970064604A (ko)	1997-10-13	벤조피란 유도체 및 그의 심장질환 치료제로서의 용도
KR930019683A (ko)	1993-10-18	사이클릭 아미노메틸렌 비스포스포네이트 유도체
FI962120A0 (fi)	1996-05-20	Estramustiiniformulaatiot, joilla on parannetut farmaseuttiset ominaisuudet
ATE231838T1 (de)	2003-02-15	N,n'-diacylthiocystine
EP0760375A4 (de)	2002-03-27	Antitumor-indolopyrolocarbazolderivate
ES2058315T3 (es)	1994-11-01	Compuestos eficaces contra insuficiencia cerebral.