DK0648735T3 - Fremstilling af mellemprodukt til vitamin-A-acetat - Google Patents

Fremstilling af mellemprodukt til vitamin-A-acetat

Info

Publication number: DK0648735T3
Authority: DK; Denmark
Prior art keywords: formula; cho; methyl; preparation; acetoxytiglinaldehyde
Prior art date: 1993-10-13

Application number

DK94115331T

Other languages

English (en)

Inventor

Ulrich Zutter

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-13

Filing date

1994-09-29

Publication date

1998-09-23

1994-09-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-09-23 Application granted granted Critical

1998-09-23 Publication of DK0648735T3 publication Critical patent/DK0648735T3/da

Links

229960000342 retinol acetate Drugs 0.000 title abstract 2
235000019173 retinyl acetate Nutrition 0.000 title abstract 2
239000011770 retinyl acetate Substances 0.000 title abstract 2
QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 title abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
150000001299 aldehydes Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
ZIVBFCKAZCKNIS-UHFFFAOYSA-N 2-hydroxy-2-methylbut-3-enal Chemical compound C=CC(O)(C)C=O ZIVBFCKAZCKNIS-UHFFFAOYSA-N 0.000 abstract 1
VICRNLNIQVUYDG-UHFFFAOYSA-N 2-hydroxy-2-methylbut-3-ynal Chemical compound O=CC(O)(C)C#C VICRNLNIQVUYDG-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
238000006359 acetalization reaction Methods 0.000 abstract 1
230000021736 acetylation Effects 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000005949 ozonolysis reaction Methods 0.000 abstract 1
UEKFYTKHWWMAKN-UHFFFAOYSA-N pent-3-en-1-yn-3-ol Chemical compound C#CC(=CC)O UEKFYTKHWWMAKN-UHFFFAOYSA-N 0.000 abstract 1
230000008707 rearrangement Effects 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
-1 triphenylphosphonium halide Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK94115331T 1993-10-13 1994-09-29 Fremstilling af mellemprodukt til vitamin-A-acetat DK0648735T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH307793		1993-10-13

Publications (1)

Publication Number	Publication Date
DK0648735T3 true DK0648735T3 (da)	1998-09-23

Family

ID=4248122

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94115331T DK0648735T3 (da)	1993-10-13	1994-09-29	Fremstilling af mellemprodukt til vitamin-A-acetat

Country Status (7)

Country	Link
US (1)	US5453547A (da)
EP (1)	EP0648735B1 (da)
JP (1)	JPH07324056A (da)
AT (1)	ATE162785T1 (da)
DE (1)	DE59405165D1 (da)
DK (1)	DK0648735T3 (da)
ES (1)	ES2113022T3 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001231680A1 (en) *	2000-01-25	2001-08-07	Akzo Nobel N.V.	Process to make aminated polyolefins
CN101723827B (zh) *	2009-12-15	2012-11-21	上虞新和成生物化工有限公司	4-乙酰氧基-2-甲基-2-丁烯醛的制备方法
CN102924276B (zh) *	2011-08-10	2014-12-17	浙江医药股份有限公司维生素厂	2-甲基-2-乙酰氧基-3-丁烯-1-醛的制备方法及其中间体半缩醛
CN108997117B (zh) *	2018-07-09	2021-07-23	万华化学集团股份有限公司	一种制备4-乙酰氧基-2-甲基-2-丁烯醛的新方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE564339A (da) *	1957-02-05	1900-01-01
US3639437A (en) *	1967-08-08	1972-02-01	Basf Ag	Production of carboxylic esters of beth-formylcrotyl alcohol
CH495320A (de) *	1967-08-08	1970-08-31	Basf Ag	Verfahren zur Herstellung von Carbonsäureestern des B-Formylcrotylalkohols
GB1172969A (en) *	1968-08-02	1969-12-03	Nii Sint Spirtov I Orch Produk	Process for Ozonizing Unsaturated Compounds
CH605592A5 (da) *	1974-04-03	1978-09-29	Hoffmann La Roche
DE2513999A1 (de) *	1975-03-29	1976-10-07	Basf Ag	Verfahren zur herstellung von trans-3-methyl-2-buten-1,4-dial-1- acetalen
DE2711381A1 (de) *	1977-03-16	1978-09-21	Basf Ag	Verfahren zur herstellung von vinylmilchsaeure und ihren estern
SU825492A1 (ru) *	1979-01-08	1981-04-30	Nii Khim Pri Go G Univ Im N I	Способ получени ацетальдегида
FR2689346B1 (fr) *	1992-03-31	1994-06-10	Matra Communication	Procede de communication par radio a multiplexages temporels.

1994
- 1994-09-29 DE DE59405165T patent/DE59405165D1/de not_active Expired - Fee Related
- 1994-09-29 EP EP94115331A patent/EP0648735B1/de not_active Expired - Lifetime
- 1994-09-29 DK DK94115331T patent/DK0648735T3/da active
- 1994-09-29 ES ES94115331T patent/ES2113022T3/es not_active Expired - Lifetime
- 1994-09-29 AT AT94115331T patent/ATE162785T1/de active
- 1994-09-30 US US08/316,654 patent/US5453547A/en not_active Expired - Fee Related
- 1994-10-07 JP JP6268034A patent/JPH07324056A/ja active Pending

Also Published As

Publication number	Publication date
EP0648735A1 (de)	1995-04-19
JPH07324056A (ja)	1995-12-12
EP0648735B1 (de)	1998-01-28
ATE162785T1 (de)	1998-02-15
DE59405165D1 (de)	1998-03-05
ES2113022T3 (es)	1998-04-16
US5453547A (en)	1995-09-26

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