DK0649846T3 - Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number: DK0649846T3
Authority: DK; Denmark
Prior art keywords: compounds; pharmaceuticals; preparation; galanthamine derivatives; galanthamine
Prior art date: 1993-10-15

Application number

DK94115961T

Other languages

Danish (da)

English (en)

Inventor

W Jr Kosley Raymond

Larry Davis

Veronica Taberna

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-10

Publication date

2002-04-15

1994-10-10 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-04-15 Application granted granted Critical

2002-04-15 Publication of DK0649846T3 publication Critical patent/DK0649846T3/da

Links

239000003814 drug Substances 0.000 title 1
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical class O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
230000006949 cholinergic function Effects 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK94115961T 1993-10-15 1994-10-10 Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0649846T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/137,444 US6316439B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number	Publication Date
DK0649846T3 true DK0649846T3 (da)	2002-04-15

Family

ID=22477461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94115961T DK0649846T3 (da)	1993-10-15	1994-10-10	Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (23)

Country	Link
US (1)	US6316439B1 (de)
EP (1)	EP0649846B1 (de)
JP (1)	JP2664343B2 (de)
KR (1)	KR100227957B1 (de)
CN (1)	CN1039910C (de)
AT (1)	ATE211474T1 (de)
AU (1)	AU696170B2 (de)
CA (1)	CA2118172C (de)
CZ (1)	CZ283731B6 (de)
DE (1)	DE69429570T2 (de)
DK (1)	DK0649846T3 (de)
EG (1)	EG20726A (de)
ES (1)	ES2170759T3 (de)
FI (1)	FI108722B (de)
IL (1)	IL111275A (de)
NO (1)	NO307464B1 (de)
NZ (1)	NZ264682A (de)
PL (1)	PL177549B1 (de)
PT (1)	PT649846E (de)
RO (1)	RO114134B1 (de)
RU (1)	RU2109743C1 (de)
TW (1)	TW289754B (de)
ZA (1)	ZA948061B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
JP2003516947A (ja) *	1999-12-10	2003-05-20	デイビス、ボニー	ニコチン様物質受容体のモジュレーターとしてのガランタミンおよびリコラミンの類似物
MXPA03009925A (es) *	2001-04-30	2004-06-30	Bayer Pharmaceuticals Corp	Nuevas tiofeno [2,3-d]pirimidinas 4-amino-5,6-sustituidas.
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) *	2002-05-21	2004-12-16	Nastech Pharmaceutical Company Inc.	Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US20050191349A1 (en) *	2003-12-31	2005-09-01	Garth Boehm	Galantamine formulations
US20050142193A1 (en) *	2003-12-31	2005-06-30	Lijuan Tang	Galantamine formulations
EP1779867A4 (de) *	2004-07-01	2009-12-02	Eisai R&D Man Co Ltd	Mittel zur förderung der nervenreveneration
US20060142186A1 (en) *	2004-12-23	2006-06-29	Voyager Pharmaceutical Corporation	Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of alzheimer's disease
ATE478659T1 (de) *	2005-05-13	2010-09-15	Alza Corp	Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
US20120184532A1 (en) *	2009-07-23	2012-07-19	Shire Llc	Galantamine amino acid and peptide prodrugs and uses thereof
AU2015258814B2 (en) *	2014-05-16	2018-04-05	Synaptec Development Llc	Clearance of amyloid ss
EP4029867A1 (de)	2021-01-13	2022-07-20	Alpha Cognition Inc.	Feste formen von galantaminbenzoat-gluconat
US12551491B1 (en) *	2025-07-23	2026-02-17	Alpha Cognition Inc.	Dosage regimens for benzgalantamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
EP0363415B1 (de) *	1987-05-04	2008-10-15	Davis, Bonnie	Mittel zur behandlung der alzheimer-krankheit
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
WO1992020327A1 (en)	1991-05-14	1992-11-26	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,444 patent/US6316439B1/en not_active Expired - Lifetime
1994
- 1994-10-10 PT PT94115961T patent/PT649846E/pt unknown
- 1994-10-10 AT AT94115961T patent/ATE211474T1/de active
- 1994-10-10 DK DK94115961T patent/DK0649846T3/da active
- 1994-10-10 EP EP94115961A patent/EP0649846B1/de not_active Expired - Lifetime
- 1994-10-10 DE DE69429570T patent/DE69429570T2/de not_active Expired - Lifetime
- 1994-10-10 ES ES94115961T patent/ES2170759T3/es not_active Expired - Lifetime
- 1994-10-13 RU RU94036745A patent/RU2109743C1/ru active
- 1994-10-13 IL IL11127594A patent/IL111275A/xx not_active IP Right Cessation
- 1994-10-13 FI FI944823A patent/FI108722B/fi not_active IP Right Cessation
- 1994-10-13 NZ NZ264682A patent/NZ264682A/en not_active IP Right Cessation
- 1994-10-14 CZ CZ942545A patent/CZ283731B6/cs not_active IP Right Cessation
- 1994-10-14 NO NO943895A patent/NO307464B1/no not_active IP Right Cessation
- 1994-10-14 TW TW083109527A patent/TW289754B/zh not_active IP Right Cessation
- 1994-10-14 PL PL94305457A patent/PL177549B1/pl unknown
- 1994-10-14 CN CN94117062A patent/CN1039910C/zh not_active Expired - Lifetime
- 1994-10-14 KR KR1019940026305A patent/KR100227957B1/ko not_active Expired - Lifetime
- 1994-10-14 RO RO94-01670A patent/RO114134B1/ro unknown
- 1994-10-14 ZA ZA948061A patent/ZA948061B/xx unknown
- 1994-10-14 AU AU75813/94A patent/AU696170B2/en not_active Expired
- 1994-10-14 CA CA002118172A patent/CA2118172C/en not_active Expired - Lifetime
- 1994-10-15 EG EG64694A patent/EG20726A/xx active
- 1994-10-17 JP JP6250777A patent/JP2664343B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH07188239A (ja)	1995-07-25
EP0649846A1 (de)	1995-04-26
NO943895D0 (no)	1994-10-14
IL111275A0 (en)	1994-12-29
CA2118172A1 (en)	1995-04-16
RO114134B1 (ro)	1999-01-29
NO943895L (no)	1995-04-18
ES2170759T3 (es)	2002-08-16
US6316439B1 (en)	2001-11-13
PT649846E (pt)	2002-06-28
AU7581394A (en)	1995-05-04
PL305457A1 (en)	1995-04-18
DE69429570D1 (de)	2002-02-07
ZA948061B (en)	1995-06-06
AU696170B2 (en)	1998-09-03
CZ254594A3 (en)	1995-07-12
CN1039910C (zh)	1998-09-23
EG20726A (en)	1999-12-29
CZ283731B6 (cs)	1998-06-17
DE69429570T2 (de)	2002-08-29
FI944823L (fi)	1995-04-16
IL111275A (en)	2003-01-12
TW289754B (de)	1996-11-01
RU2109743C1 (ru)	1998-04-27
EP0649846B1 (de)	2002-01-02
CA2118172C (en)	2000-01-04
JP2664343B2 (ja)	1997-10-15
RU94036745A (ru)	1996-12-10
KR950011445A (ko)	1995-05-15
NO307464B1 (no)	2000-04-10
FI944823A0 (fi)	1994-10-13
CN1108657A (zh)	1995-09-20
PL177549B1 (pl)	1999-12-31
KR100227957B1 (ko)	1999-11-01
NZ264682A (en)	1995-07-26
ATE211474T1 (de)	2002-01-15
FI108722B (fi)	2002-03-15

Publication	Publication Date	Title
DK0649846T3 (da)	2002-04-15	Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
NO180583C (no)	1997-05-14	Arylsulfonamido-substituerte hydroksamsyrer, farmasöytiske preparater inneholdende forbindelsene og anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
TR200003478T2 (tr)	2001-03-21	Antikanser maddeleri olarak faydalı izotiyazol türevleri
DK256890D0 (da)	1990-10-25	Benzo-piperidin-, -piperidyliden- og piperazinforbindelser, kompositioner indeholdende forbindelserne og fremgangsmaader til forbindelsernes fremstilling og anvendelse
FI893751A0 (fi)	1989-08-09	Kemiska foereningar.
DE69008142D1 (de)	1994-05-19	4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
NO934196L (no)	1994-05-24	N,N-disubstituerte arylcykloalkylaminer, deres salter, legemidler inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for deres fremstilling
DK0535645T3 (da)	2001-08-13	Carbamatderivater af 4-amino-3-isoxazolidinoner og 3-amino-1-hydroxypyrrolidin-2-oner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
DK0632026T3 (da)	1998-07-27	Alfa-aminosyrederivater, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
DK0835868T3 (da)	2001-10-08	2-aryl-3-aminoaryloxynaphthylforbindelser, mellemprodukter, sammensætninger og fremgangsmåder
DK0564358T3 (da)	1999-07-19	3-aminochroman-spiro-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne
IL113780A (en)	1999-06-20	Glucopyranoside benzothiophenes process for their preparation and pharmaceutical compositions containing them
DK0462948T3 (da)	1995-03-20	Farmaceutiske præparater indeholdende 3-amino-epsilon-caprolac-tamer til forbedring af indlæring og hukommelse
ATE100463T1 (de)	1994-02-15	Renin-hemmende aminooligohydroxy-derivate.
DK0587048T3 (da)	1999-08-09	Heteroarenylpiperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
WO2000008006A3 (en)	2000-08-03	Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them
AU657423B2 (en)	1995-03-09	Novel piperidine derivatives and process for preparation thereof
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
ATE243219T1 (de)	2003-07-15	9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
EP0414913A4 (en)	1992-08-05	P-aminophenol derivative and production and application thereof
DK0635491T3 (da)	1997-11-03	(Thia)cycloalkylab indoler, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse forbindelser.
ZA923502B (en)	1993-10-04	1-amidoocthydropyrido[2,1-c][1,4]oxazine compounds, processes for preparing these and pharmaceutical compositions containing them