DK0664287T3 - Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse - Google Patents

Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse

Info

Publication number: DK0664287T3
Authority: DK; Denmark
Prior art keywords: groups; individually; vitamin; preparing; compounds
Prior art date: 1994-01-20

Application number

DK95200063T

Other languages

English (en)

Inventor

Mercedes Torneiro

Yagamare Fall

Antonio Mourino

Jan Zorgdrager

De Velde Jan-Paul Van

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-20

Filing date

1995-01-12

Publication date

1999-04-19

1995-01-12 Application filed by Duphar Int Res filed Critical Duphar Int Res

1999-04-19 Application granted granted Critical

1999-04-19 Publication of DK0664287T3 publication Critical patent/DK0664287T3/da

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
-1 Vitamin D compounds Chemical class 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002373 hemiacetals Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK95200063T 1994-01-20 1995-01-12 Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse DK0664287T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94200131		1994-01-20

Publications (1)

Publication Number	Publication Date
DK0664287T3 true DK0664287T3 (da)	1999-04-19

Family

ID=8216601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95200063T DK0664287T3 (da)	1994-01-20	1995-01-12	Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse

Country Status (9)

Country	Link
EP (1)	EP0664287B1 (da)
JP (1)	JP3855280B2 (da)
AT (1)	ATE168367T1 (da)
CA (1)	CA2140382C (da)
DE (1)	DE69503394T2 (da)
DK (1)	DK0664287T3 (da)
ES (1)	ES2120122T3 (da)
IL (1)	IL112362A (da)
PL (1)	PL179063B1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5763429A (en)	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
BR9509739A (pt) *	1994-11-21	1997-10-21	Wisconsin Alumni Res Found	Compostos 18,19-dinor-vitamina d
US6242434B1 (en) *	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
DE19519273A1 (de) *	1995-05-22	1996-11-28	Schering Ag	Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
US5747479A (en) *	1996-01-03	1998-05-05	Hoffmann-La Roche Inc.	Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
US6566353B2 (en)	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en)	1996-12-30	2003-06-03	Bone Care International, Inc.	Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en)	1996-12-30	2003-01-07	Bone Care International, Inc.	Method of treating hyperproliferative diseases using active vitamin D analogues
AU750451B2 (en)	1997-02-13	2002-07-18	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
HUP0204117A3 (en) *	2000-01-10	2004-09-28	Leo Pharma As	Novel vitamin d analogues, pharmaceutical compositions containing them and their use
IL153378A0 (en)	2000-07-18	2003-07-06	Bone Care Internat Inc	STABILIZED 1alpha-HYDROXY VITAMIN D
US7148211B2 (en)	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
US4505906A (en) *	1984-01-30	1985-03-19	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 isomers
NZ232734A (en) *	1989-03-09	1991-11-26	Wisconsin Alumni Res Found	19-nor vitamin d derivatives and pharmaceutical compositions

1995
- 1995-01-12 EP EP95200063A patent/EP0664287B1/en not_active Expired - Lifetime
- 1995-01-12 ES ES95200063T patent/ES2120122T3/es not_active Expired - Lifetime
- 1995-01-12 DK DK95200063T patent/DK0664287T3/da active
- 1995-01-12 AT AT95200063T patent/ATE168367T1/de not_active IP Right Cessation
- 1995-01-12 DE DE69503394T patent/DE69503394T2/de not_active Expired - Fee Related
- 1995-01-17 CA CA002140382A patent/CA2140382C/en not_active Expired - Fee Related
- 1995-01-17 PL PL95306849A patent/PL179063B1/pl not_active IP Right Cessation
- 1995-01-17 IL IL11236295A patent/IL112362A/en not_active IP Right Cessation
- 1995-01-18 JP JP02236395A patent/JP3855280B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3855280B2 (ja)	2006-12-06
PL306849A1 (en)	1995-07-24
EP0664287A1 (en)	1995-07-26
CA2140382C (en)	2007-11-20
IL112362A0 (en)	1995-03-30
PL179063B1 (pl)	2000-07-31
ATE168367T1 (de)	1998-08-15
JPH07206813A (ja)	1995-08-08
DE69503394T2 (de)	1999-03-11
CA2140382A1 (en)	1995-07-21
EP0664287B1 (en)	1998-07-15
ES2120122T3 (es)	1998-10-16
DE69503394D1 (de)	1998-08-20
IL112362A (en)	2001-10-31

Publication	Publication Date	Title
DE68906552D1 (de)	1993-06-24	Camptothecin-derivate und verfahren zu ihrer herstellung.
DK0742203T5 (da)	2000-09-04	Vitamin D-forbindelser og fremgangsmåde til fremstilling deraf
ES2120122T3 (es)	1998-10-16	Compuestos de vitamina d y metodo de preparar estos compuestos.
PL303652A1 (en)	1994-12-12	Derivatives of vitamin d and method of obtaining such compounds
TW352383B (en)	1999-02-11	Hydroximic acid derivatives, processes for their preparation, and compositions comprising them
DK1026167T3 (da)	2003-05-26	Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
ATE296300T1 (de)	2005-06-15	Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
DK0784055T3 (da)	2003-06-02	Pyrimidinylpyrazolderivater
ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
FI890302A0 (fi)	1989-01-20	Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä
AR000795A1 (es)	1997-08-06	Derivados de piridina y pirimidina, procedimiento e intermediarios para prepararlos, composicion herbicida que los comprende, metodo para combatir con los mismos el crecimiento de plantas indeseadas, y uso de dichos derivados para controlar el crecimiento de plantas indeseadas
GR3005961T3 (da)	1993-06-07
DK0781764T3 (da)	2000-07-10	Fremgangsmåde til fremstilling af alkoxyiminoacetamid-derivater
BR0211180A (pt)	2004-08-10	Compostos, processo para preparar os mesmos, intermediários, e, composição adequada e método para controlar fungos fitopatogênicos
DK508484D0 (da)	1984-10-25	N-substituerede isoquinolinderivater og farmaceutisk praeparat indeholdende dem
DK0613896T3 (da)	1999-04-26	Fremgangsmåde til fremstilling af sulfonylurinstofderivater
BG102429A (en)	1999-03-31	Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means
ATE136036T1 (de)	1996-04-15	Androst-4-en(4,5-b>-pyrrol-derivate und ein verfahren zu ihrer herstellung
AU2639999A (en)	1999-09-15	Intermediate compounds in the synthesis of the a ring moiety of 2-substituted vitamin d derivatives
ATE139767T1 (de)	1996-07-15	Verfahren zur herstellung 5-pyrazolomerkaptan- derivate und dessen zwischenprodukte
TW349935B (en)	1999-01-11	Oxime ether compounds, their intermediates and their use as pesticides
DK0885232T3 (da)	2003-05-05	Nye 1(2H)quinolincarboxylsyrederivater, fremgangsmåde til deres fremstilling og deres anvendelse ved syntesen af stoffer med antibiotiske egenskaber
DE60105402D1 (en)	2004-10-14	Arthropodische carboxanilide
MX9700662A (es)	1998-06-28	Procedimiento para la preparacion estereoselectivade un enantiomero de alcohol hetero-biciclico.