DK0664799T3 - Amidderivater - Google Patents
AmidderivaterInfo
- Publication number
- DK0664799T3 DK0664799T3 DK93922576T DK93922576T DK0664799T3 DK 0664799 T3 DK0664799 T3 DK 0664799T3 DK 93922576 T DK93922576 T DK 93922576T DK 93922576 T DK93922576 T DK 93922576T DK 0664799 T3 DK0664799 T3 DK 0664799T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- formula
- date apr
- sec
- useful
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000011914 asymmetric synthesis Methods 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929221931A GB9221931D0 (en) | 1992-10-17 | 1992-10-17 | Piperazine derivatives |
| PCT/GB1993/002090 WO1994008983A1 (fr) | 1992-10-17 | 1993-10-08 | Derives d'amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0664799T3 true DK0664799T3 (da) | 1999-11-29 |
Family
ID=10723688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93922576T DK0664799T3 (da) | 1992-10-17 | 1993-10-08 | Amidderivater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5637701A (fr) |
| EP (1) | EP0664799B1 (fr) |
| JP (1) | JP3478827B2 (fr) |
| KR (1) | KR950703544A (fr) |
| AT (1) | ATE182144T1 (fr) |
| AU (1) | AU5152493A (fr) |
| CA (1) | CA2147155C (fr) |
| DE (1) | DE69325660T2 (fr) |
| DK (1) | DK0664799T3 (fr) |
| ES (1) | ES2133414T3 (fr) |
| GB (2) | GB9221931D0 (fr) |
| GR (1) | GR3031123T3 (fr) |
| MX (1) | MX9306421A (fr) |
| PH (1) | PH31583A (fr) |
| TW (1) | TW340844B (fr) |
| WO (1) | WO1994008983A1 (fr) |
| ZA (1) | ZA937516B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| US5525600A (en) * | 1994-11-28 | 1996-06-11 | American Home Products Corporation | (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides |
| DE19519245C2 (de) * | 1995-04-14 | 2003-04-30 | Boehringer Ingelheim Kg | Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| FR2744448B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| FR2757158B1 (fr) * | 1996-12-18 | 1999-04-02 | Lipha | Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques |
| US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| US20040072839A1 (en) * | 2002-06-14 | 2004-04-15 | Amedeo Leonardi | 1-Phenylalkylpiperazines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776282A (en) * | 1954-05-04 | 1957-01-01 | Searle & Co | Cyclic amides of alpha-toluic acids and derivatives thereof |
| GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
| FI102175B1 (fi) * | 1989-04-22 | 1998-10-30 | Wyeth John & Brother Ltd | Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi |
| FI93832C (fi) * | 1989-04-22 | 1995-06-12 | Wyeth John & Brother Ltd | Menetelmä terapeuttisesti aktiivisten piperatsiniijohdannaisten valmistamiseksi |
| GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1992
- 1992-10-17 GB GB929221931A patent/GB9221931D0/en active Pending
-
1993
- 1993-10-08 DK DK93922576T patent/DK0664799T3/da active
- 1993-10-08 EP EP93922576A patent/EP0664799B1/fr not_active Expired - Lifetime
- 1993-10-08 US US08/411,601 patent/US5637701A/en not_active Expired - Lifetime
- 1993-10-08 KR KR1019950701459A patent/KR950703544A/ko not_active Abandoned
- 1993-10-08 ES ES93922576T patent/ES2133414T3/es not_active Expired - Lifetime
- 1993-10-08 AT AT93922576T patent/ATE182144T1/de not_active IP Right Cessation
- 1993-10-08 GB GB9320819A patent/GB2272436B/en not_active Expired - Fee Related
- 1993-10-08 DE DE69325660T patent/DE69325660T2/de not_active Expired - Fee Related
- 1993-10-08 AU AU51524/93A patent/AU5152493A/en not_active Abandoned
- 1993-10-08 CA CA002147155A patent/CA2147155C/fr not_active Expired - Fee Related
- 1993-10-08 WO PCT/GB1993/002090 patent/WO1994008983A1/fr not_active Ceased
- 1993-10-08 JP JP50974494A patent/JP3478827B2/ja not_active Expired - Fee Related
- 1993-10-11 ZA ZA937516A patent/ZA937516B/xx unknown
- 1993-10-15 MX MX9306421A patent/MX9306421A/es not_active IP Right Cessation
- 1993-10-15 PH PH47088A patent/PH31583A/en unknown
- 1993-10-15 TW TW082108553A patent/TW340844B/zh active
-
1999
- 1999-08-31 GR GR990402205T patent/GR3031123T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2272436B (en) | 1997-06-18 |
| GB2272436A (en) | 1994-05-18 |
| KR950703544A (ko) | 1995-09-20 |
| WO1994008983A1 (fr) | 1994-04-28 |
| PH31583A (en) | 1998-11-03 |
| EP0664799A1 (fr) | 1995-08-02 |
| GB9221931D0 (en) | 1992-12-02 |
| GB9320819D0 (en) | 1993-12-01 |
| JP3478827B2 (ja) | 2003-12-15 |
| TW340844B (en) | 1998-09-21 |
| JPH08502738A (ja) | 1996-03-26 |
| ES2133414T3 (es) | 1999-09-16 |
| US5637701A (en) | 1997-06-10 |
| GR3031123T3 (en) | 1999-12-31 |
| DE69325660D1 (de) | 1999-08-19 |
| ZA937516B (en) | 1995-04-21 |
| EP0664799B1 (fr) | 1999-07-14 |
| AU5152493A (en) | 1994-05-09 |
| CA2147155A1 (fr) | 1994-04-28 |
| ATE182144T1 (de) | 1999-07-15 |
| DE69325660T2 (de) | 2000-03-09 |
| CA2147155C (fr) | 2005-01-04 |
| MX9306421A (es) | 1994-04-29 |
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