DK0667341T3 - 4-Amino-1-piperidylbenzoylguanidiner som Na+/H+-antiporter-inhibitorer - Google Patents
4-Amino-1-piperidylbenzoylguanidiner som Na+/H+-antiporter-inhibitorerInfo
- Publication number
- DK0667341T3 DK0667341T3 DK95101575T DK95101575T DK0667341T3 DK 0667341 T3 DK0667341 T3 DK 0667341T3 DK 95101575 T DK95101575 T DK 95101575T DK 95101575 T DK95101575 T DK 95101575T DK 0667341 T3 DK0667341 T3 DK 0667341T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- alk
- hal
- opt
- alkylene
- Prior art date
Links
- BEDVALDDNUBBNZ-UHFFFAOYSA-N n-(4-aminopiperidin-1-yl)-n-carbamimidoylbenzamide Chemical class C1CC(N)CCN1N(C(N)=N)C(=O)C1=CC=CC=C1 BEDVALDDNUBBNZ-UHFFFAOYSA-N 0.000 title abstract 2
- 102000003669 Antiporters Human genes 0.000 title 1
- 108090000084 Antiporters Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 tetrahydroquinolyl Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4404183A DE4404183A1 (de) | 1994-02-10 | 1994-02-10 | 4-Amino-1-piperidylbenzoylguanidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0667341T3 true DK0667341T3 (da) | 2001-10-22 |
Family
ID=6509922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95101575T DK0667341T3 (da) | 1994-02-10 | 1995-02-07 | 4-Amino-1-piperidylbenzoylguanidiner som Na+/H+-antiporter-inhibitorer |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5461066A (da) |
| EP (1) | EP0667341B1 (da) |
| JP (1) | JPH07267926A (da) |
| KR (1) | KR950321212A (da) |
| CN (1) | CN1082948C (da) |
| AT (1) | ATE204864T1 (da) |
| AU (1) | AU693496B2 (da) |
| CA (1) | CA2142070A1 (da) |
| CZ (1) | CZ286681B6 (da) |
| DE (2) | DE4404183A1 (da) |
| DK (1) | DK0667341T3 (da) |
| ES (1) | ES2161789T3 (da) |
| GR (1) | GR3036839T3 (da) |
| HU (1) | HU215601B (da) |
| NO (1) | NO303685B1 (da) |
| PL (1) | PL179255B1 (da) |
| PT (1) | PT667341E (da) |
| RU (1) | RU2140412C1 (da) |
| SK (1) | SK281721B6 (da) |
| TW (1) | TW291476B (da) |
| UA (1) | UA43834C2 (da) |
| ZA (1) | ZA951059B (da) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4421495A1 (de) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidine |
| DE4430212A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Ortho-substituierte Benzoesäure-Derivate |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19859727A1 (de) * | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| US7620611B1 (en) * | 1999-07-20 | 2009-11-17 | Trilithic, Inc. | Neural networks for ingress monitoring |
| ES2278729T3 (es) * | 2000-03-06 | 2007-08-16 | Acadia Pharmaceuticals Inc. | Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina. |
| CN1479737A (zh) * | 2001-01-31 | 2004-03-03 | �Ʒ� | 钠-质子交换蛋白1型抑制剂的乙醇盐 |
| MXPA04006280A (es) * | 2001-12-28 | 2004-09-27 | Acadia Pharm Inc | Compuestos espiroazaciclicos como moduladores de receptor de monoamina. |
| EP1562937A2 (en) * | 2002-06-24 | 2005-08-17 | Acadia Pharmaceuticals Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| EP1693061A1 (en) * | 2002-10-04 | 2006-08-23 | Ucb, S.A. | Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases |
| DK2009000T3 (da) * | 2003-01-16 | 2011-09-05 | Acadia Pharm Inc | Selektive serotonin 2A/2C-receptor invers-agonister som terapeutika for neurodegenerative sygdomme |
| US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| MX2007001634A (es) * | 2004-08-11 | 2007-04-23 | Kyorin Seiyaku Kk | Nuevo derivado de acido amino benzoico ciclico. |
| CA2580129A1 (en) * | 2004-09-27 | 2006-04-06 | Acadia Pharmaceuticals Inc. | Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation |
| US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| CA2681506C (en) | 2007-03-19 | 2016-05-24 | Perry Peters | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
| JP2010540454A (ja) * | 2007-09-21 | 2010-12-24 | アカディア ファーマシューティカルズ，インコーポレーテッド | ピマバンセリンと他の薬剤との併用投与 |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CA3070513C (en) | 2010-05-05 | 2023-01-03 | Boehringer Ingelheim International Gmbh | A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| DK2731947T3 (da) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | Substitueret dimerisk quinazolin-derivat, fremstilling og andvendelse deraf i farmaceutiske sammensætninger til behandling af type i- og type ii-diabetes |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| ES2890492T3 (es) | 2015-07-20 | 2022-01-20 | Acadia Pharm Inc | Métodos para preparar N-(4-fluorobencil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metilpropiloxi)fenilmetil)carbamida y su sal de tartrato y forma polimórfica C |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
| EP3558311A1 (en) | 2016-12-20 | 2019-10-30 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
| EP3615028A1 (en) | 2017-04-28 | 2020-03-04 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DE4117904A1 (de) * | 1991-05-31 | 1992-12-03 | Basf Ag | Substituierte n-phenylpiperidine |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| DE59305042D1 (de) * | 1992-09-22 | 1997-02-20 | Hoechst Ag | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
| ATE176476T1 (de) * | 1992-12-02 | 1999-02-15 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung |
-
1994
- 1994-02-10 DE DE4404183A patent/DE4404183A1/de not_active Withdrawn
-
1995
- 1995-02-06 AU AU11571/95A patent/AU693496B2/en not_active Ceased
- 1995-02-07 ES ES95101575T patent/ES2161789T3/es not_active Expired - Lifetime
- 1995-02-07 EP EP95101575A patent/EP0667341B1/de not_active Expired - Lifetime
- 1995-02-07 AT AT95101575T patent/ATE204864T1/de not_active IP Right Cessation
- 1995-02-07 CN CN95101910A patent/CN1082948C/zh not_active Expired - Fee Related
- 1995-02-07 SK SK157-95A patent/SK281721B6/sk unknown
- 1995-02-07 PT PT95101575T patent/PT667341E/pt unknown
- 1995-02-07 DE DE59509543T patent/DE59509543D1/de not_active Expired - Fee Related
- 1995-02-07 TW TW084100981A patent/TW291476B/zh active
- 1995-02-07 DK DK95101575T patent/DK0667341T3/da active
- 1995-02-08 CZ CZ1995327A patent/CZ286681B6/cs not_active IP Right Cessation
- 1995-02-08 UA UA95028120A patent/UA43834C2/uk unknown
- 1995-02-08 CA CA002142070A patent/CA2142070A1/en not_active Abandoned
- 1995-02-09 US US08/385,790 patent/US5461066A/en not_active Expired - Fee Related
- 1995-02-09 NO NO950485A patent/NO303685B1/no not_active IP Right Cessation
- 1995-02-09 RU RU95101843A patent/RU2140412C1/ru active
- 1995-02-09 PL PL95307190A patent/PL179255B1/pl unknown
- 1995-02-09 KR KR1019950002288A patent/KR950321212A/ko not_active Abandoned
- 1995-02-09 ZA ZA951059A patent/ZA951059B/xx unknown
- 1995-02-09 HU HU9500396A patent/HU215601B/hu not_active IP Right Cessation
- 1995-02-10 JP JP7022475A patent/JPH07267926A/ja active Pending
-
2001
- 2001-10-09 GR GR20010401701T patent/GR3036839T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA951059B (en) | 1995-10-13 |
| HUT72306A (en) | 1996-04-29 |
| PL307190A1 (en) | 1995-08-21 |
| SK281721B6 (sk) | 2001-07-10 |
| ES2161789T3 (es) | 2001-12-16 |
| DE4404183A1 (de) | 1995-08-17 |
| RU95101843A (ru) | 1997-03-10 |
| PL179255B1 (pl) | 2000-08-31 |
| GR3036839T3 (en) | 2002-01-31 |
| CN1112550A (zh) | 1995-11-29 |
| KR950321212A (ko) | 1995-12-20 |
| DE59509543D1 (de) | 2001-10-04 |
| AU1157195A (en) | 1995-08-17 |
| US5461066A (en) | 1995-10-24 |
| CZ286681B6 (en) | 2000-06-14 |
| RU2140412C1 (ru) | 1999-10-27 |
| SK15795A3 (en) | 1995-09-13 |
| UA43834C2 (uk) | 2002-01-15 |
| CA2142070A1 (en) | 1995-08-11 |
| AU693496B2 (en) | 1998-07-02 |
| ATE204864T1 (de) | 2001-09-15 |
| JPH07267926A (ja) | 1995-10-17 |
| NO950485L (no) | 1995-08-11 |
| EP0667341B1 (de) | 2001-08-29 |
| PT667341E (pt) | 2001-12-28 |
| CZ32795A3 (en) | 1995-10-18 |
| HU9500396D0 (en) | 1995-03-28 |
| NO950485D0 (no) | 1995-02-09 |
| NO303685B1 (no) | 1998-08-17 |
| CN1082948C (zh) | 2002-04-17 |
| EP0667341A1 (de) | 1995-08-16 |
| HU215601B (hu) | 1999-01-28 |
| TW291476B (da) | 1996-11-21 |
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