DK0674516T3 - Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser - Google Patents

Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser

Info

Publication number: DK0674516T3
Authority: DK; Denmark
Prior art keywords: compounds; selenopyrimidinone; thiapyrimidinone; disclosed; antiproliferative
Prior art date: 1992-12-16

Application number

DK94904399T

Other languages

English (en)

Inventor

Judith G Deal

Michael D Varney

William H Romines

Cynthia L Palmer

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-16

Filing date

1993-12-10

Publication date

2000-07-24

1993-12-10 Application filed by Agouron Pharma filed Critical Agouron Pharma

2000-07-24 Application granted granted Critical

2000-07-24 Publication of DK0674516T3 publication Critical patent/DK0674516T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
230000001028 anti-proliverative effect Effects 0.000 title abstract 2
HUTLODTYVWHFRI-UHFFFAOYSA-N 1,3,5-thiadiazin-4-one Chemical class O=C1N=CSC=N1 HUTLODTYVWHFRI-UHFFFAOYSA-N 0.000 title 1
101000606741 Homo sapiens Phosphoribosylglycinamide formyltransferase Proteins 0.000 abstract 2
NOTGFIUVDGNKRI-UUOKFMHZSA-N AICA ribonucleotide Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 NOTGFIUVDGNKRI-UUOKFMHZSA-N 0.000 abstract 1
108010072462 Hydroxymethyl and Formyl Transferases Proteins 0.000 abstract 1
102000006933 Hydroxymethyl and Formyl Transferases Human genes 0.000 abstract 1
102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK94904399T 1992-12-16 1993-12-10 Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser DK0674516T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99125992A	1992-12-16	1992-12-16
PCT/US1993/011795 WO1994013295A1 (en)	1992-12-16	1993-12-10	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds

Publications (1)

Publication Number	Publication Date
DK0674516T3 true DK0674516T3 (da)	2000-07-24

Family

ID=25537030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94904399T DK0674516T3 (da)	1992-12-16	1993-12-10	Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser

Country Status (13)

Country	Link
US (5)	US5739141A (da)
EP (1)	EP0674516B1 (da)
JP (1)	JPH08504765A (da)
AT (1)	ATE189390T1 (da)
AU (1)	AU5846494A (da)
CA (1)	CA2151588C (da)
DE (1)	DE69327796T2 (da)
DK (1)	DK0674516T3 (da)
ES (1)	ES2145122T3 (da)
GR (1)	GR3033314T3 (da)
PT (1)	PT674516E (da)
SG (1)	SG52739A1 (da)
WO (1)	WO1994013295A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5945427A (en) *	1995-06-07	1999-08-31	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5739141A (en)	1992-12-16	1998-04-14	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5594139A (en) *	1993-01-29	1997-01-14	Agouron Pharmaceuticals, Inc.	Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) *	1994-07-28	1997-03-04	Agouron Pharmaceuticals, Inc.	Compounds useful as antiproliferative agents and GARFT inhibitors
DE69432801T2 (de) *	1994-07-28	2003-12-04	Agouron Pharmaceuticals, Inc.	Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sind
CN1053448C (zh) *	1994-07-28	2000-06-14	阿格罗尼制药公司	用作抗增殖药物及garft抑制剂的化合物
US5831100A (en) *	1995-06-07	1998-11-03	Agouron Pharmaceuticals, Inc.	Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
AUPO227896A0 (en) *	1996-09-13	1996-10-03	Fujisawa Pharmaceutical Co., Ltd.	Novel compounds and their preparation
WO1999049856A2 (en) *	1998-03-27	1999-10-07	Genentech, Inc.	Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
WO2000013688A1 (en) *	1998-09-04	2000-03-16	Agouron Pharmaceuticals, Inc.	Compounds useful as aicarft inhibitors
US6423720B1 (en) *	2001-02-01	2002-07-23	Duquesne University Of The Holy Ghost	Pyrimidine compounds and methods for making and using the same
US20040043959A1 (en) *	2002-03-04	2004-03-04	Bloom Laura A.	Combination therapies for treating methylthioadenosine phosphorylase deficient cells
US7700307B2 (en)	2003-03-08	2010-04-20	Auvation Limited	Mitochondrial stress-70 protein markers for colorectal cancer
JP2008534601A (ja)	2005-03-28	2008-08-28	ペリコーセラピューティクス，インコーポレイテッド	患者における副作用を予防または減少するための方法、組成物および処方物
US20070082859A1 (en) *	2005-10-07	2007-04-12	Stover Richard R	Formulations of AICA riboside
WO2008086341A1 (en) *	2007-01-09	2008-07-17	Pericor Therapeutics, Inc.	Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
US8063033B2 (en)	2008-01-18	2011-11-22	Allergan, Inc.	Therapeutic beta-lactams
US7956051B2 (en)	2008-01-24	2011-06-07	Allergan, Inc.	Therapeutic amides and related compounds
US7705001B2 (en)	2008-03-18	2010-04-27	Allergan, Inc	Therapeutic substituted gamma lactams
EP2285782A2 (en)	2008-05-09	2011-02-23	Allergan, Inc.	Therapeutic n-aryl or n-heteroaryl pyrazolidine and pyrazolidinone derivatives
US7985765B2 (en)	2008-08-20	2011-07-26	Allergan, Inc.	Therapeutic substituted pyrroles
WO2010040110A1 (en) *	2008-10-03	2010-04-08	Pericor Therapeutics, Inc.	Methods and compositions for treatment of acute heart failure
US9090584B2 (en) *	2010-01-26	2015-07-28	Allergan, Inc.	Therapeutic agents for treatment of ocular hypertension
EP3227279B1 (en) *	2014-12-02	2019-02-13	Eli Lilly and Company	1-oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as aicarft inhibitors in the treatment of cancers
DE102017221259A1 (de) *	2017-11-28	2019-05-29	Evonik Degussa Gmbh	Silanmischungen und Verfahren zu deren Herstellung
CN112321425B (zh) *	2020-10-23	2022-08-09	上海毕得医药科技股份有限公司	一种4-(3-溴丙基)苯甲酸甲酯的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3222914A1 (de) *	1982-06-18	1983-12-22	Beiersdorf Ag, 2000 Hamburg	Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8625019D0 (en) *	1986-10-18	1986-11-19	Wellcome Found	Compounds
US4871743A (en) *	1988-01-19	1989-10-03	The Trustees Of Princeton University	L-glutamic acid derivatives
EP0341837A3 (en) *	1988-04-15	1990-08-16	The Wellcome Foundation Limited	Glutamic acid derivatives
US4971973A (en) *	1989-05-17	1990-11-20	Burroughs Wellcome Co.	Glutamic acid derivatives
US4921836A (en) *	1989-05-17	1990-05-01	Burroughs Wellcome Co.	Substituted glutamic acids
US4920125A (en) *	1989-08-29	1990-04-24	The Trustees Of Princeton University	L-glutamic acid derivatives
US5013738A (en) *	1990-04-18	1991-05-07	The Trustees Of Princeton University	L-glutamic acid derivatives
US5262385A (en) *	1990-07-24	1993-11-16	Mitsubishi Petrochemical Co., Ltd.	Halogen-containing compounds, herbicidal composition containing the same as an active ingredient, and intermediary compounds therefor
US5945427A (en)	1995-06-07	1999-08-31	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5739141A (en)	1992-12-16	1998-04-14	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5426110A (en) *	1993-10-06	1995-06-20	Eli Lilly And Company	Pyrimidinyl-glutamic acid derivatives

1993
- 1993-12-10 US US08/448,556 patent/US5739141A/en not_active Expired - Fee Related
- 1993-12-10 DE DE69327796T patent/DE69327796T2/de not_active Expired - Fee Related
- 1993-12-10 ES ES94904399T patent/ES2145122T3/es not_active Expired - Lifetime
- 1993-12-10 WO PCT/US1993/011795 patent/WO1994013295A1/en not_active Ceased
- 1993-12-10 AT AT94904399T patent/ATE189390T1/de not_active IP Right Cessation
- 1993-12-10 AU AU58464/94A patent/AU5846494A/en not_active Abandoned
- 1993-12-10 SG SG1996008590A patent/SG52739A1/en unknown
- 1993-12-10 CA CA002151588A patent/CA2151588C/en not_active Expired - Fee Related
- 1993-12-10 JP JP6514288A patent/JPH08504765A/ja active Pending
- 1993-12-10 EP EP94904399A patent/EP0674516B1/en not_active Expired - Lifetime
- 1993-12-10 DK DK94904399T patent/DK0674516T3/da active
- 1993-12-10 PT PT94904399T patent/PT674516E/pt unknown
1995
- 1995-05-24 US US08/449,602 patent/US5726312A/en not_active Expired - Fee Related
2000
- 2000-04-26 GR GR20000400998T patent/GR3033314T3/el not_active IP Right Cessation
- 2000-06-07 US US09/588,654 patent/US6207670B1/en not_active Expired - Fee Related
2001
- 2001-02-14 US US09/782,284 patent/US6323210B2/en not_active Expired - Fee Related
- 2001-10-23 US US10/047,935 patent/US20020173515A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JPH08504765A (ja)	1996-05-21
EP0674516B1 (en)	2000-02-02
EP0674516A1 (en)	1995-10-04
US6323210B2 (en)	2001-11-27
CA2151588A1 (en)	1994-06-23
DE69327796T2 (de)	2000-06-21
WO1994013295A1 (en)	1994-06-23
PT674516E (pt)	2000-05-31
US5726312A (en)	1998-03-10
SG52739A1 (en)	1998-09-28
AU5846494A (en)	1994-07-04
DE69327796D1 (de)	2000-03-09
CA2151588C (en)	2002-03-19
US6207670B1 (en)	2001-03-27
ES2145122T3 (es)	2000-07-01
US5739141A (en)	1998-04-14
US20010018443A1 (en)	2001-08-30
US20020173515A1 (en)	2002-11-21
EP0674516A4 (da)	1995-10-25
ATE189390T1 (de)	2000-02-15
GR3033314T3 (en)	2000-09-29

Publication	Publication Date	Title
DE69327796D1 (de)	2000-03-09	Antiproliferative substituierte 5-thiapyrimidinon- und 5-selenopyrimidinonverbindungen
DK0741694T3 (da)	2003-04-22	Phenyleddikesyrederivater, fremgangsmåder og mellemprodukter til deres fremstilling og midler indeholdende disse
BG101833A (bg)	1998-04-30	Гуаниново производно
IE840302L (en)	1984-08-10	3-(5-aminopentyl)amino-1-benzazepin-2-one-1-alkanoic acids.
DE69516866D1 (de)	2000-06-15	Stereochemische wortmanninderivate
KR950700323A (ko)	1995-01-16	엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE)
HUT63419A (en)	1993-08-30	Process for producing mercaptoacetamide derivatives of pyrrolo-, pyrido- and oxazinobenzazepine having encephalinase- and angiotensin-converting enzyme-inhibiting activity
ATE211732T1 (de)	2002-01-15	N-benzylpiperidin- und tetrahydropyridin-derivate
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
EP0975353A4 (en)	2001-11-28	PEPTIDYL-2-AMINO-1HYDROXYALKANESULPHONIC ACIDS AS CYSTEIN PROTEASE INHIBITORS
HU9500559D0 (en)	1995-04-28	New mercapto-acetamide tricyclic derivatives as enkephalinase-inhibitors
MX9801190A (es)	1998-04-30	Inhibidores de prolil endopeptidasa.
ZA945246B (en)	1995-03-20	Novel 9-N-Bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
CA2154668A1 (en)	1994-08-04	Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
NO974155L (no)	1997-11-07	Ny fremgangsmåte for fremstilling av 2,3-dihydrobenzofuranolderivater
MX9603348A (es)	1997-12-31	Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa.
DK0783507T3 (da)	2003-09-15	Forbindelser, der er anvendelige som antiproliferative midler og GARFT-inhibitorer
HU9201134D0 (en)	1992-07-28	Process for the production of an anti-metastatic substance
HUP0002727A2 (hu)	2001-08-28	Eljárás fibrinogén csökkentésére benzotiofénszármazékok felhasználásával
AP9400608A0 (en)	1995-07-12	"New nicotinic acid derivative".
FR2426685A2 (fr)	1979-12-21	Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
GR1001393B (el)	1993-10-29	Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
UA9674A (uk)	1996-09-30	Стабілізатор протеолітичних ферментів тваринного походження