DK0678518T3 - Fremgangsmåde til fremstilling af mellemprodukter til syntesen af glucose-6-phosphatase-inhibitorer samt nye mellemprodukte - Google Patents
Fremgangsmåde til fremstilling af mellemprodukter til syntesen af glucose-6-phosphatase-inhibitorer samt nye mellemprodukteInfo
- Publication number
- DK0678518T3 DK0678518T3 DK95105544T DK95105544T DK0678518T3 DK 0678518 T3 DK0678518 T3 DK 0678518T3 DK 95105544 T DK95105544 T DK 95105544T DK 95105544 T DK95105544 T DK 95105544T DK 0678518 T3 DK0678518 T3 DK 0678518T3
- Authority
- DK
- Denmark
- Prior art keywords
- intermediates
- formula
- preparation
- iii
- glucose
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 2
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 title 1
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000002596 lactones Chemical group 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4413402A DE4413402A1 (de) | 1994-04-18 | 1994-04-18 | Verfahren zur Herstellung von Zwischenprodukten für die Synthese von Glucose-6-Phosphatase-Inhibitoren sowie neue Zwischenprodukte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0678518T3 true DK0678518T3 (da) | 1998-09-28 |
Family
ID=6515746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95105544T DK0678518T3 (da) | 1994-04-18 | 1995-04-12 | Fremgangsmåde til fremstilling af mellemprodukter til syntesen af glucose-6-phosphatase-inhibitorer samt nye mellemprodukte |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5608086A (da) |
| EP (1) | EP0678518B1 (da) |
| JP (1) | JPH07285961A (da) |
| AT (1) | ATE163931T1 (da) |
| DE (2) | DE4413402A1 (da) |
| DK (1) | DK0678518T3 (da) |
| ES (1) | ES2116641T3 (da) |
| GR (1) | GR3026497T3 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4416433A1 (de) * | 1994-05-10 | 1995-11-16 | Hoechst Ag | Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten |
| JP4743673B2 (ja) * | 1999-04-30 | 2011-08-10 | プロゲン ファーマシューティカルズ， インコーポレイテッド | ポリアミンおよび治療におけるそれらの使用 |
| AU2001297817A1 (en) * | 2000-11-08 | 2002-11-25 | Eli Lilly And Company | Antiviral therapies using polyamine or polyamine analog-amino acid conjugates |
| MXPA04005509A (es) | 2001-12-07 | 2004-12-06 | Slil Biomedical Corp | Poliaminas sustituidas con cicloalquilo para terapia de cancer y metodos de sintesis de las mismas. |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| KR100703058B1 (ko) * | 2005-06-10 | 2007-04-06 | 주식회사 엘컴사이언스 | 신규 스피로 화합물 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW399041B (en) * | 1992-09-09 | 2000-07-21 | Hoechst Ag | Substituted cyclohexane derivatives, the preparation and the use for treating diseases |
-
1994
- 1994-04-18 DE DE4413402A patent/DE4413402A1/de not_active Withdrawn
-
1995
- 1995-04-12 DK DK95105544T patent/DK0678518T3/da active
- 1995-04-12 AT AT95105544T patent/ATE163931T1/de not_active IP Right Cessation
- 1995-04-12 ES ES95105544T patent/ES2116641T3/es not_active Expired - Lifetime
- 1995-04-12 DE DE59501585T patent/DE59501585D1/de not_active Expired - Fee Related
- 1995-04-12 EP EP95105544A patent/EP0678518B1/de not_active Expired - Lifetime
- 1995-04-14 US US08/421,974 patent/US5608086A/en not_active Expired - Fee Related
- 1995-04-17 JP JP7090426A patent/JPH07285961A/ja not_active Abandoned
-
1998
- 1998-04-03 GR GR980400680T patent/GR3026497T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE163931T1 (de) | 1998-03-15 |
| ES2116641T3 (es) | 1998-07-16 |
| DE4413402A1 (de) | 1995-10-19 |
| GR3026497T3 (en) | 1998-07-31 |
| JPH07285961A (ja) | 1995-10-31 |
| DE59501585D1 (de) | 1998-04-16 |
| US5608086A (en) | 1997-03-04 |
| EP0678518A1 (de) | 1995-10-25 |
| EP0678518B1 (de) | 1998-03-11 |
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