DK0682026T3 - Stabil krystallinsk (6S)- og (6R)-tetrahydrofolsyre - Google Patents

Stabil krystallinsk (6S)- og (6R)-tetrahydrofolsyre

Info

Publication number: DK0682026T3
Authority: DK; Denmark
Prior art keywords: tetrahydrofolic acid; stable crystalline; crystalline; stable; tetrahydrofolic
Prior art date: 1994-05-09

Application number

DK95106285T

Other languages

English (en)

Other versions

DK0682026T4 (da

Inventor

Hans Rudolf Mueller

Martin Ulmann

Rudolf Moser

Thomas Ammann

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-09

Filing date

1995-04-27

Publication date

2000-04-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4210562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0682026(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-04-27 Application filed by Eprova Ag filed Critical Eprova Ag

2000-04-17 Application granted granted Critical

2000-04-17 Publication of DK0682026T3 publication Critical patent/DK0682026T3/da

2003-02-24 Publication of DK0682026T4 publication Critical patent/DK0682026T4/da

Links

MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 title abstract 3
MSTNYGQPCMXVAQ-NEPJUHHUSA-N 6R-Tetrahydrofolic acid Chemical compound C([C@@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-NEPJUHHUSA-N 0.000 title abstract 3

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK95106285T 1994-05-09 1995-04-27 Stabil krystallinsk (6S)- og (6R)-tetrahydrofolsyre DK0682026T4 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH144294A CH686369A5 (de)	1994-05-09	1994-05-09	Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.

Publications (2)

Publication Number	Publication Date
DK0682026T3 true DK0682026T3 (da)	2000-04-17
DK0682026T4 DK0682026T4 (da)	2003-02-24

Family

ID=4210562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95106285T DK0682026T4 (da)	1994-05-09	1995-04-27	Stabil krystallinsk (6S)- og (6R)-tetrahydrofolsyre

Country Status (19)

Country	Link
US (2)	US6271374B1 (da)
EP (1)	EP0682026B2 (da)
JP (2)	JP3419585B2 (da)
KR (1)	KR950032192A (da)
CN (1)	CN1063444C (da)
AT (1)	ATE188699T1 (da)
AU (1)	AU704363B2 (da)
CA (1)	CA2148671C (da)
CH (1)	CH686369A5 (da)
DE (1)	DE59507591D1 (da)
DK (1)	DK0682026T4 (da)
ES (1)	ES2144066T5 (da)
FI (1)	FI120585B (da)
GR (1)	GR3032984T3 (da)
HU (1)	HUT71612A (da)
NO (1)	NO313673B1 (da)
PT (1)	PT682026E (da)
RU (1)	RU2165422C2 (da)
ZA (1)	ZA953673B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH689831A5 (de) *	1995-11-07	1999-12-15	Eprova Ag	Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de)	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) *	1999-07-14	2006-01-31	Merck Eprova Ag	Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de)	1999-07-14	2004-10-15	Eprova Ag	Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it)	2002-01-25	2003-07-25	Gmt Fine Chemicals Sa	Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
KR20070005550A (ko)	2003-11-17	2007-01-10	바이오마린 파머수티컬 인크.	대사 장애 치료를 위한 조성물 및 방법
KR20060051135A (ko) *	2004-09-15	2006-05-19	니프로 가부시키가이샤	안정화된 주사용 수용액 제재
EP1819340A2 (en) *	2004-12-08	2007-08-22	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of pulmonary hypertension of the newborn
NZ598171A (en)	2009-07-10	2014-11-28	Linzy O Scott Iii	Methods and compositions for treating thyroid-related medical conditions with reduced folates
AU2011215669B2 (en) *	2010-02-12	2015-06-04	HedoniaUSA, Inc.	Compositions and methods for treating depression
JP5925381B2 (ja) *	2012-04-13	2016-05-25	▲連雲▼港金康和信▲薬業▼有限公司ＬｉａｎｙｕｎｇａｎｇＪｉｎｋａｎｇＨｅｘｉｎＰｈａｒｍａｃｅｕｔｉｃａｌＣｏ．，Ｌｔｄ．	化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
US9492421B1 (en)	2013-11-14	2016-11-15	Argent Development Group, Llc	Nutritional supplements for treatment of iron deficiency anemia
US9629846B1 (en)	2013-11-14	2017-04-25	Argent Development Group, Llc	Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
WO2016185413A1 (en)	2015-05-20	2016-11-24	Nestec S.A.	Modified release formulations
US10059710B2 (en)	2016-02-17	2018-08-28	Merck & Cie	Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2017397463B2 (en)	2016-11-03	2022-01-06	HedoniaUSA, Inc.	Compositions and methods for treating depression
RU2019134064A (ru)	2017-03-31	2021-04-30	Мерк Патент Гмбх	Кристаллическая натриевая соль 5-метил-(6s)-тетрагидрофолиевой кислоты
CA3058287A1 (en)	2017-03-31	2018-10-04	Merck Patent Gmbh	Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
EP4501315A1 (en)	2023-08-04	2025-02-05	Lesaffre et Compagnie	Liquid formulations of folates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS497416A (da) *	1972-05-12	1974-01-23
US4665176A (en) *	1984-10-23	1987-05-12	Mitsui Toatsu Chemicals, Incorporated	Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (da) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (da) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
ATE139799T1 (de) *	1989-12-11	1996-07-15	American Cyanamid Co	Verfahren zur herstellung von optisch reinen diastereoisomeren von tetrahydrofolatverbindungen
CH680731A5 (da) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (da) *	1991-01-16	1993-02-26	Eprova Ag
CH683261A5 (it) *	1991-10-10	1994-02-15	Applied Pharma Res	Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
US5198547A (en) *	1992-03-16	1993-03-30	South Alabama Medical Science Foundation, Usa	Process for N5-formylating tetrahydropteridines
US5698693A (en) *	1992-11-16	1997-12-16	The United States Of America As Represented By The Department Of Health And Human Services	Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
WO2001070922A1 (en)	2000-03-21	2001-09-27	Bbj Environmental Solutions Inc.	Aqueous cleaning composition with controlled ph

1994
- 1994-05-09 CH CH144294A patent/CH686369A5/de not_active IP Right Cessation
1995
- 1995-04-27 DK DK95106285T patent/DK0682026T4/da active
- 1995-04-27 PT PT95106285T patent/PT682026E/pt unknown
- 1995-04-27 DE DE59507591T patent/DE59507591D1/de not_active Expired - Lifetime
- 1995-04-27 EP EP95106285A patent/EP0682026B2/de not_active Expired - Lifetime
- 1995-04-27 ES ES95106285T patent/ES2144066T5/es not_active Expired - Lifetime
- 1995-04-27 AT AT95106285T patent/ATE188699T1/de active
- 1995-05-02 JP JP10888195A patent/JP3419585B2/ja not_active Expired - Fee Related
- 1995-05-04 CA CA002148671A patent/CA2148671C/en not_active Expired - Lifetime
- 1995-05-05 RU RU95107144/04A patent/RU2165422C2/ru active
- 1995-05-08 CN CN95106005A patent/CN1063444C/zh not_active Expired - Lifetime
- 1995-05-08 ZA ZA953673A patent/ZA953673B/xx unknown
- 1995-05-08 NO NO19951796A patent/NO313673B1/no not_active IP Right Cessation
- 1995-05-08 HU HU9501348A patent/HUT71612A/hu unknown
- 1995-05-08 AU AU17931/95A patent/AU704363B2/en not_active Ceased
- 1995-05-08 FI FI952198A patent/FI120585B/fi not_active IP Right Cessation
- 1995-05-09 KR KR1019950011214A patent/KR950032192A/ko not_active Ceased
1998
- 1998-01-26 US US09/013,266 patent/US6271374B1/en not_active Expired - Lifetime
2000
- 2000-03-16 GR GR20000400684T patent/GR3032984T3/el not_active IP Right Cessation
2001
- 2001-01-08 US US09/755,072 patent/US6596721B2/en not_active Expired - Fee Related
2003
- 2003-01-28 JP JP2003019261A patent/JP4898081B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK0682026T4 (da)	2003-02-24
ES2144066T5 (es)	2003-11-01
US6271374B1 (en)	2001-08-07
FI120585B (fi)	2009-12-15
AU704363B2 (en)	1999-04-22
RU2165422C2 (ru)	2001-04-20
KR950032192A (ko)	1995-12-20
CH686369A5 (de)	1996-03-15
PT682026E (pt)	2000-05-31
US6596721B2 (en)	2003-07-22
CN1063444C (zh)	2001-03-21
FI952198A0 (fi)	1995-05-08
CN1122337A (zh)	1996-05-15
DE59507591D1 (de)	2000-02-17
JP3419585B2 (ja)	2003-06-23
CA2148671C (en)	2000-08-15
CA2148671A1 (en)	1995-11-10
NO951796D0 (no)	1995-05-08
RU95107144A (ru)	1997-03-20
NO313673B1 (no)	2002-11-11
ZA953673B (en)	1996-01-12
US20010002398A1 (en)	2001-05-31
FI952198L (fi)	1995-11-10
AU1793195A (en)	1995-11-16
JP4898081B2 (ja)	2012-03-14
NO951796L (no)	1995-11-10
ATE188699T1 (de)	2000-01-15
HUT71612A (en)	1996-01-29
EP0682026B1 (de)	2000-01-12
JPH0841062A (ja)	1996-02-13
GR3032984T3 (en)	2000-07-31
JP2003201291A (ja)	2003-07-18
EP0682026A1 (de)	1995-11-15
ES2144066T3 (es)	2000-06-01
EP0682026B2 (de)	2003-02-05

Publication	Publication Date	Title
DK0682026T4 (da)	2003-02-24	Stabil krystallinsk (6S)- og (6R)-tetrahydrofolsyre
GB8802792D0 (en)	1988-03-09	Distributed fet amplifier & bias voltage supply circuit therefor
AU6307586A (en)	1987-03-26	Quinoline derivatives
GB8827928D0 (en)	1989-01-05	Pyrimidine derivatives
AU2030988A (en)	1989-02-23	Pyrimidine derivatives
AU1631788A (en)	1988-11-24	Pyrimidine derivatives
AU1097988A (en)	1988-08-04	Alkylmelatonins
AU563849B2 (en)	1987-07-23	Imidazo(1,5-alpha)pyrimidine derivatives
AU2237788A (en)	1989-03-23	Partially saturated diazepine, pyrimidine and imidazoline derivatives
EP0317175A3 (en)	1989-10-11	Pyrimidine derivatives
AU8214987A (en)	1988-06-16	Triazine derivatives
PT640608E (pt)	2002-04-29	Intermediarios na sintese de cefalosporinas
GB8703254D0 (en)	1987-03-18	Lasers & amplifiers
GB8827462D0 (en)	1988-12-29	Pyrimidine derivatives
AU1174588A (en)	1988-08-25	Anticonvulsant agents
AU1032488A (en)	1988-08-04	Pyrimidine derivatives
IN172911B (da)	1994-01-01
AU2700988A (en)	1989-06-22	N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
AU1738988A (en)	1988-12-22	Pyrimidine derivatives
PY0101566A (es)	2002-01-01	[7-(3-disustituidos amino)phenyl]pyrazolo [1,5-a] pyrimidines
EP0443238A3 (en)	1992-01-08	Precision switched current source
ZA918346B (en)	1993-04-19	Ergoline derivatives.
FI954340A0 (fi)	1995-09-15	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2,4-triazolo(1,5-a)-pyrimidinderivat
NO157309C (no)	1988-02-24	Armatur for lysroer e.l. stavformete lyskilder.
AU2693288A (en)	1989-06-22	Ethanolamine derivatives