DK0700393T3 - Flourholdige, makrocykliske metalkomplekser - Google Patents

Flourholdige, makrocykliske metalkomplekser

Info

Publication number
DK0700393T3
DK0700393T3 DK94915566T DK94915566T DK0700393T3 DK 0700393 T3 DK0700393 T3 DK 0700393T3 DK 94915566 T DK94915566 T DK 94915566T DK 94915566 T DK94915566 T DK 94915566T DK 0700393 T3 DK0700393 T3 DK 0700393T3
Authority
DK
Denmark
Prior art keywords
pct
metal complexes
agents
flourous
macrocyclic metal
Prior art date
Application number
DK94915566T
Other languages
English (en)
Inventor
Johannes Platzek
Chel Bernd Rad
Ulrich Niedballa
Hanns-Joachim Weinmann
Klaus Roth
Hans Bauer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0700393T3 publication Critical patent/DK0700393T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4804—Spatially selective measurement of temperature or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94915566T 1993-05-24 1994-04-29 Flourholdige, makrocykliske metalkomplekser DK0700393T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4317588A DE4317588C2 (de) 1993-05-24 1993-05-24 Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
PCT/EP1994/001377 WO1994027978A1 (de) 1993-05-24 1994-04-29 Fluorhaltige makrocyclische metallkomplexe

Publications (1)

Publication Number Publication Date
DK0700393T3 true DK0700393T3 (da) 1998-07-20

Family

ID=6489003

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94915566T DK0700393T3 (da) 1993-05-24 1994-04-29 Flourholdige, makrocykliske metalkomplekser

Country Status (11)

Country Link
US (1) US5690909A (da)
EP (1) EP0700393B1 (da)
JP (1) JPH08511248A (da)
AT (1) ATE159522T1 (da)
CA (1) CA2163643A1 (da)
DE (2) DE4317588C2 (da)
DK (1) DK0700393T3 (da)
ES (1) ES2110753T3 (da)
GR (1) GR3025610T3 (da)
NO (1) NO301983B1 (da)
WO (1) WO1994027978A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1265440B1 (it) * 1993-12-24 1996-11-22 Bracco Spa Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6180113B1 (en) * 1996-02-23 2001-01-30 Schering Ag Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
GB0009353D0 (en) 2000-04-14 2000-05-31 Nycomed Imaging As Method
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
NO20015814D0 (no) * 2001-11-28 2001-11-28 Amersham Health As Metallkompleksforbindelser
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
DE102005033902B3 (de) * 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102005033903B4 (de) * 2005-07-15 2007-08-09 Bayer Schering Pharma Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
GB0708411D0 (en) * 2007-05-01 2007-06-06 Univ Durham Lanthanide probes
WO2009113704A2 (en) * 2008-03-11 2009-09-17 Kyoto University Fluorine-containing compound and method for detecting biomolecule using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IE61746B1 (en) * 1987-07-16 1994-11-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
DE3927444A1 (de) * 1989-08-16 1991-02-28 Schering Ag Verwendung von amid-komplexverbindungen
NZ236267A (en) * 1989-12-22 1992-12-23 Squibb & Sons Inc 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe

Also Published As

Publication number Publication date
ES2110753T3 (es) 1998-02-16
DE4317588C2 (de) 1998-04-16
EP0700393A1 (de) 1996-03-13
DE59404438D1 (de) 1997-11-27
US5690909A (en) 1997-11-25
NO954736L (no) 1995-11-23
JPH08511248A (ja) 1996-11-26
WO1994027978A1 (de) 1994-12-08
ATE159522T1 (de) 1997-11-15
NO954736D0 (no) 1995-11-23
DE4317588A1 (de) 1994-12-01
GR3025610T3 (en) 1998-03-31
EP0700393B1 (de) 1997-10-22
CA2163643A1 (en) 1994-12-08
NO301983B1 (no) 1998-01-05

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