DK0710230T3 - Som CCK- eller gastrinantagonister anvendelige 1,5-benzodiazepinderivater - Google Patents

Som CCK- eller gastrinantagonister anvendelige 1,5-benzodiazepinderivater

Info

Publication number: DK0710230T3
Authority: DK; Denmark
Prior art keywords: cck; derivatives useful; benzodiazepine derivatives; gastrin antagonists; gastrin
Prior art date: 1993-07-20

Application number

DK94924257T

Other languages

English (en)

Inventor

Daniele Donati

Antonella Ursini

Mauro Corsi

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-18

Publication date

1999-06-14

1994-07-18 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0710230T3 publication Critical patent/DK0710230T3/da

Links

ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical class N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 title 1
102100021022 Gastrin Human genes 0.000 title 1
108010052343 Gastrins Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Toxicology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK94924257T 1993-07-20 1994-07-18 Som CCK- eller gastrinantagonister anvendelige 1,5-benzodiazepinderivater DK0710230T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939314981A GB9314981D0 (en)	1993-07-20	1993-07-20	Chemical compounds
PCT/EP1994/002353 WO1995003285A1 (en)	1993-07-20	1994-07-18	1,5-benzodiazepine derivatives useful as cck or gastrin antagonists

Publications (1)

Publication Number	Publication Date
DK0710230T3 true DK0710230T3 (da)	1999-06-14

Family

ID=10739096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94924257T DK0710230T3 (da)	1993-07-20	1994-07-18	Som CCK- eller gastrinantagonister anvendelige 1,5-benzodiazepinderivater

Country Status (32)

Country	Link
US (1)	US5716953A (da)
EP (1)	EP0710230B1 (da)
JP (1)	JP3587849B2 (da)
KR (1)	KR100347287B1 (da)
CN (1)	CN1050835C (da)
AP (1)	AP492A (da)
AT (1)	ATE171167T1 (da)
AU (1)	AU687858B2 (da)
CA (1)	CA2167308A1 (da)
CO (1)	CO4290299A1 (da)
CZ (1)	CZ290472B6 (da)
DE (1)	DE69413405T2 (da)
DK (1)	DK0710230T3 (da)
EC (1)	ECSP941120A (da)
ES (1)	ES2123812T3 (da)
FI (1)	FI960223A7 (da)
GB (1)	GB9314981D0 (da)
HR (1)	HRP940411B1 (da)
HU (1)	HU222439B1 (da)
IL (1)	IL110366A (da)
IS (1)	IS4190A (da)
MY (1)	MY118638A (da)
NO (1)	NO313288B1 (da)
NZ (1)	NZ271075A (da)
PE (1)	PE8295A1 (da)
PL (1)	PL175609B1 (da)
RU (1)	RU2135485C1 (da)
SI (1)	SI0710230T1 (da)
SV (1)	SV1994000031A (da)
TW (1)	TW290542B (da)
WO (1)	WO1995003285A1 (da)
ZA (1)	ZA945238B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
WO1998002419A1 (en) *	1996-07-12	1998-01-22	Chugai Seiyaku Kabushiki Kaisha	Cancer cell proliferation inhibitors
US6683075B1 (en)	1996-12-23	2004-01-27	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US20030190307A1 (en)	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
US6569851B1 (en)	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en)	1998-06-22	2005-10-25	Elan Pharmaceuticals, Inc.	Polycyclic α-amino-ε-caprolactams and related compounds
MXPA02003740A (es) *	1999-10-15	2002-09-30	Hoffmann La Roche	Derivados de benzodiazepina.
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
PT1673347E (pt) *	2003-10-06	2015-11-02	Hoffmann La Roche	Derivados de dibenzo-azepina e benzo-diazepina substituídos, úteis como inibidores de secretase gama
AU2005218326A1 (en) *	2004-02-27	2005-09-15	Aortx, Inc.	Prosthetic heart valve delivery systems and methods
JP2010524879A (ja) *	2007-04-19	2010-07-22	エフ．ホフマン−ラロシュアーゲー	ジヒドロ−ベンゾ［ｂ］［１，４］ジアゼピン−２−オンスルホンアミド誘導体
RU2540464C2 (ru) *	2012-05-28	2015-02-10	Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации	Водорастворимое производное амида салициловой кислоты, обладающее транквилизирующей, ноотропной и анальгезирующей активностью
CN103435562B (zh) *	2013-08-26	2016-02-24	华东理工大学	6-取代苯并二氮卓-2,4-二酮类化合物及其用途
RU2702359C1 (ru) *	2019-06-04	2019-10-08	Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук	Способ получения 2,2,4-триалкил-2,3-дигидро-1Н-1,5-бензодиазепинов

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2103745A1 (de) *	1971-01-27	1972-08-10	CH. Boehringer Sohn, 6507 Ingelheim	Neue 5-AryJ-(bzw. Heteroaryl)-3-hydroxylH-l,5-benzodiazepin-2,4-(3H,5H)-dioneund Verfahren zu ihrer Herstellung
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
CA2068355A1 (en) *	1991-05-14	1992-11-15	Mark S. Chambers	Benzodiazephine derivatives, compositions containing them and their use in therapy
GB9201181D0 (en) *	1992-01-21	1992-03-11	Glaxo Spa	Chemical compounds
GB9201180D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds
GB9225492D0 (en) *	1992-12-05	1993-01-27	Glaxo Group Ltd	Amine derivatives

1993
- 1993-07-20 GB GB939314981A patent/GB9314981D0/en active Pending
1994
- 1994-07-15 IS IS4190A patent/IS4190A/is unknown
- 1994-07-18 CA CA002167308A patent/CA2167308A1/en not_active Abandoned
- 1994-07-18 ZA ZA945238A patent/ZA945238B/xx unknown
- 1994-07-18 RU RU96102670A patent/RU2135485C1/ru not_active IP Right Cessation
- 1994-07-18 AP APAP/P/1994/000657A patent/AP492A/en active
- 1994-07-18 US US08/578,535 patent/US5716953A/en not_active Expired - Fee Related
- 1994-07-18 ES ES94924257T patent/ES2123812T3/es not_active Expired - Lifetime
- 1994-07-18 HR HR940411A patent/HRP940411B1/xx not_active IP Right Cessation
- 1994-07-18 HU HU9600124A patent/HU222439B1/hu not_active IP Right Cessation
- 1994-07-18 KR KR1019960700279A patent/KR100347287B1/ko not_active Expired - Fee Related
- 1994-07-18 DE DE69413405T patent/DE69413405T2/de not_active Expired - Fee Related
- 1994-07-18 CN CN94193283A patent/CN1050835C/zh not_active Expired - Fee Related
- 1994-07-18 EC EC1994001120A patent/ECSP941120A/es unknown
- 1994-07-18 DK DK94924257T patent/DK0710230T3/da active
- 1994-07-18 AT AT94924257T patent/ATE171167T1/de not_active IP Right Cessation
- 1994-07-18 PL PL94312659A patent/PL175609B1/pl not_active IP Right Cessation
- 1994-07-18 MY MYPI94001865A patent/MY118638A/en unknown
- 1994-07-18 NZ NZ271075A patent/NZ271075A/en unknown
- 1994-07-18 PE PE1994246888A patent/PE8295A1/es not_active Application Discontinuation
- 1994-07-18 JP JP50492695A patent/JP3587849B2/ja not_active Expired - Fee Related
- 1994-07-18 WO PCT/EP1994/002353 patent/WO1995003285A1/en not_active Ceased
- 1994-07-18 AU AU74589/94A patent/AU687858B2/en not_active Ceased
- 1994-07-18 EP EP94924257A patent/EP0710230B1/en not_active Expired - Lifetime
- 1994-07-18 CO CO94031454A patent/CO4290299A1/es unknown
- 1994-07-18 SI SI9430207T patent/SI0710230T1/xx not_active IP Right Cessation
- 1994-07-18 CZ CZ1996173A patent/CZ290472B6/cs not_active IP Right Cessation
- 1994-07-19 IL IL11036694A patent/IL110366A/en not_active IP Right Cessation
- 1994-07-19 SV SV1994000031A patent/SV1994000031A/es active IP Right Grant
- 1994-07-22 TW TW083106738A patent/TW290542B/zh active
1996
- 1996-01-17 FI FI960223A patent/FI960223A7/fi unknown
- 1996-01-19 NO NO19960237A patent/NO313288B1/no unknown

Also Published As

Publication number	Publication date
FI960223A7 (fi)	1996-03-19
PE8295A1 (es)	1995-04-20
NO960237L (no)	1996-03-19
AP492A (en)	1996-05-13
AP9400657A0 (en)	1994-07-31
ECSP941120A (es)	1995-01-16
NO960237D0 (no)	1996-01-19
DE69413405D1 (de)	1998-10-22
DE69413405T2 (de)	1999-04-15
MY118638A (en)	2004-12-31
CA2167308A1 (en)	1995-02-02
EP0710230A1 (en)	1996-05-08
CN1050835C (zh)	2000-03-29
GB9314981D0 (en)	1993-09-01
CO4290299A1 (es)	1996-04-17
HUT73499A (en)	1996-08-28
KR100347287B1 (ko)	2002-12-06
ES2123812T3 (es)	1999-01-16
JPH09502428A (ja)	1997-03-11
CZ17396A3 (en)	1996-07-17
FI960223A0 (fi)	1996-01-17
SV1994000031A (es)	1995-10-04
TW290542B (da)	1996-11-11
EP0710230B1 (en)	1998-09-16
US5716953A (en)	1998-02-10
IL110366A0 (en)	1994-10-21
SI0710230T1 (en)	1999-02-28
AU687858B2 (en)	1998-03-05
AU7458994A (en)	1995-02-20
HRP940411A2 (en)	1997-04-30
NZ271075A (en)	1998-06-26
JP3587849B2 (ja)	2004-11-10
ATE171167T1 (de)	1998-10-15
HRP940411B1 (en)	2000-12-31
ZA945238B (en)	1995-02-09
PL175609B1 (pl)	1999-01-29
HU222439B1 (hu)	2003-07-28
IS4190A (is)	1995-01-21
NO313288B1 (no)	2002-09-09
WO1995003285A1 (en)	1995-02-02
HU9600124D0 (en)	1996-03-28
RU2135485C1 (ru)	1999-08-27
CZ290472B6 (cs)	2002-07-17
CN1138853A (zh)	1996-12-25
IL110366A (en)	1999-01-26
PL312659A1 (en)	1996-04-29

Publication	Publication Date	Title
ATE340176T1 (de)	2006-10-15	Substituierte 6,5-heterobicyclische-derivate
DK0925298T3 (da)	2004-08-09	Substituerede 6,6-heterobicykliske derivater
FI954853A0 (fi)	1995-10-12	1,5-bentsodiatsepiinijohdannaisia, joilla on CCK-antagonistinen tai agonistinen aktiivisuus
DE69409503D1 (de)	1998-05-14	1,6-diaminopurin-derivate
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
FI954651A7 (fi)	1995-09-29	Mahdollisesti substituoidut 6,8-kinoliinit
FI961809L (fi)	1996-05-20	Uudet (R)-5-karbamoyyli-8-fluori-3-N,N-disubstituoitu-amino 3,4-dihydro-2H-1-bentsopyraanit
NO960237D0 (no)	1996-01-19	1,5-Benzodiazepinderivater anvendelige som CCK - eller gastrinantagonister
DE69718771D1 (de)	2003-03-06	Substituierte 1,2,3,4-tetrahydronaphthalinderivate
FI952424L (fi)	1995-11-20	11,21-bisfenyyli-19-norpregaanijohdannaisia
FI943941L (fi)	1994-10-26	CCK-reseptoriantagonisteina käyttökelpoiset bentsodiatsepiinijohdannaiset
EP0684823A4 (en)	1997-07-09	FIBRINOGEN RECEPTOR ANTAGONISTS.
FI960836A7 (fi)	1996-04-22	Bentsodiatsepiiniyhdisteet, jotka ovat käyttökelpoisia CCK- tai gastriiniantagonisteina
MA23504A1 (fr)	1995-12-31	Derives de la 1,5 benzodiazepine
FI960571A7 (fi)	1996-02-07	Kolekystokiniini- ja gastriiniantagonisteina käyttökelpoisia bisyklo(2.2.2)oktaanijohdannaisia
FI954852A0 (fi)	1995-10-12	1,5-bentsodiatsepiinijohdannaisia, joilla on CCK- ja/tai gastriiniantagonistinen aktiivisuus
ATE199901T1 (de)	2001-04-15	10,11-dihydro-10-oxo-5h-dibenz(b,f)azepin-5- carboxamidderivate
AU7228994A (en)	1995-02-20	1,5-benzodiazepine derivatives useful as cck or gastrin antagonists
DE69722064D1 (de)	2003-06-26	1,25-Dihydroxy-16,22,23-trisdehydro-Cholecalciferol-Derivate
FI961199A7 (fi)	1996-05-13	Substituoidut tiatsolo(3,2-alfa)atsepiinijohdannaiset
LV10616A (lv)	1995-04-20	Aizvietoti ciklopropilamino-1,3,5-triazini
HUP9903001A3 (en)	2000-06-28	Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives