DK0721506T3 - Bakterielle eksporterede proteiner og acellulære vacciner baseret derpå - Google Patents

Bakterielle eksporterede proteiner og acellulære vacciner baseret derpå

Info

Publication number
DK0721506T3
DK0721506T3 DK94927328T DK94927328T DK0721506T3 DK 0721506 T3 DK0721506 T3 DK 0721506T3 DK 94927328 T DK94927328 T DK 94927328T DK 94927328 T DK94927328 T DK 94927328T DK 0721506 T3 DK0721506 T3 DK 0721506T3
Authority
DK
Denmark
Prior art keywords
pct
proteins
exported proteins
nucleic acids
vaccines based
Prior art date
Application number
DK94927328T
Other languages
English (en)
Inventor
H Robert Masure
Barbara J Pearce
Elaine Tuomanen
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of DK0721506T3 publication Critical patent/DK0721506T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03003—Pyruvate oxidase (1.2.3.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94927328T 1993-09-01 1994-09-01 Bakterielle eksporterede proteiner og acellulære vacciner baseret derpå DK0721506T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11654193A 1993-09-01 1993-09-01
US08/245,511 US5928900A (en) 1993-09-01 1994-05-18 Bacterial exported proteins and acellular vaccines based thereon

Publications (1)

Publication Number Publication Date
DK0721506T3 true DK0721506T3 (da) 2006-10-30

Family

ID=26814346

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94927328T DK0721506T3 (da) 1993-09-01 1994-09-01 Bakterielle eksporterede proteiner og acellulære vacciner baseret derpå

Country Status (14)

Country Link
US (2) US5928900A (da)
EP (1) EP0721506B1 (da)
JP (1) JP3722834B2 (da)
AT (1) ATE332376T1 (da)
AU (1) AU709405B2 (da)
CA (1) CA2170726A1 (da)
DE (1) DE69434784T2 (da)
DK (1) DK0721506T3 (da)
ES (1) ES2267096T3 (da)
FI (1) FI960977L (da)
NO (1) NO321826B1 (da)
NZ (1) NZ273497A (da)
PT (1) PT721506E (da)
WO (1) WO1995006732A2 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0804582A1 (en) * 1994-05-16 1997-11-05 The Uab Research Foundation $i(STREPTOCOCCUS PNEUMONIAE) CAPSULAR POLYSACCHARIDE GENES AND FLANKING REGIONS
US5834278A (en) * 1996-05-01 1998-11-10 The Rockefeller University Bacterial peptide methionine sulfoxide reductase an adhesion-associated protein, and antibiotic therapies based thereon
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
US6165989A (en) * 1996-05-14 2000-12-26 Smithkline Beecham Corporation Era of Streptococcus pneumoniae
EP0956289A4 (en) * 1996-08-16 2004-10-13 Smithkline Beecham Corp NOVEL PROKARYOTA POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF
US5882871A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation Saliva binding protein
US5882896A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation M protein
US5928895A (en) * 1996-09-24 1999-07-27 Smithkline Beecham Corporation IgA Fc binding protein
JP4469026B2 (ja) 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン
WO1998021337A2 (en) 1996-11-12 1998-05-22 Regents Of The University Of Minnesota C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE)
US20040242522A1 (en) * 1997-02-14 2004-12-02 Volkin David B. Polynucleotide vaccine formulations
US6676943B1 (en) 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
WO2000005378A2 (en) * 1998-07-22 2000-02-03 Id-Lelystad Instituut Voor Dierhouderij En Diergezondheid B.V. Streptococcus suis vaccines and diagnostic tests
DE69935986D1 (de) * 1998-07-27 2007-06-14 Sanofi Pasteur Ltd Streptococcus pneumoniae proteine und nukleinsäuren
EP1783224A3 (en) * 1998-07-27 2007-08-15 Sanofi Pasteur Limited Streptococcus pneumoniae proteins and nucleic acid molecules
US20030134407A1 (en) 1998-07-27 2003-07-17 Le Page Richard William Falla Nucleic acids and proteins from Streptococcus pneumoniae
WO2000006736A2 (en) * 1998-07-27 2000-02-10 Microbial Technics Limited Nucleic acids and proteins from group b streptococcus
US7098182B2 (en) 1998-07-27 2006-08-29 Microbial Technics Limited Nucleic acids and proteins from group B streptococcus
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
CN1318103A (zh) * 1998-07-27 2001-10-17 微生物技术有限公司 肺炎链球菌的核酸和蛋白质
EP1624064A3 (en) * 1998-07-27 2006-05-10 Microbial Technics Limited Nucleic acids and proteins from streptococcus pneumoniae
EP1801218A3 (en) * 1998-07-27 2007-10-10 Sanofi Pasteur Limited Nucleic acids and proteins from streptococcus pneumoniae
ES2322306T3 (es) 1998-12-21 2009-06-18 Medimmune, Inc. Proteinas de streptpcpccus pneumoniae y fragmentos inmunogenicos para vacunas.
GB9921125D0 (en) * 1999-09-07 1999-11-10 Microbial Technics Limited Proteins
CA2399940A1 (en) 2000-04-13 2001-10-25 The Rockefeller University Enhancement of antibody-mediated immune responses
EP1205552A1 (en) * 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence of streptococci, involving ORFs from Streptococcus suis
WO2002061070A2 (en) 2001-02-02 2002-08-08 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Environmentally regulated genes, involved in the virulence of streptococcus suis
AU2002319764A1 (en) * 2001-08-03 2003-02-17 Elitra Pharmaceuticals, Inc. Nucleic acids of aspergillus fumigatus encoding industrial enzymes and methods of use
NO20026286D0 (no) * 2002-12-30 2002-12-30 Amersham Health As Nye peptider
RU2286576C2 (ru) * 2004-12-21 2006-10-27 Волгоградский научно-исследовательский противочумный институт Способ выявления перекрестнореагирующих антигенов возбудителей мелиоидоза, сапа, чумы, туляремии и туберкулеза
EP2023143A1 (en) * 2007-08-06 2009-02-11 Boehringer Ingelheim Vetmedica Gmbh Immunogenic streptococcus proteins
EP2897638A1 (en) 2012-09-24 2015-07-29 Montana State University-Bozeman Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274425B1 (en) * 1987-01-06 1993-12-15 Asahi Kasei Kogyo Kabushiki Kaisha Pyruvate oxidase, its preparation and use
RU2121481C1 (ru) * 1988-12-16 1998-11-10 Де Стат Дер Недерланден Вертегенвордигд Дор де Министр Ван Велзейн, Волксгезондхейд эн Кюлтюр Модифицированный пневмолизин, рекомбинантная плазмида, способ получения модифицированного пневмолизина, вакцина
DK0571538T5 (da) * 1991-02-15 2002-03-04 Uab Research Foundation Strukturgen for pneumokokprotein
AU3065892A (en) * 1991-11-14 1993-06-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Pneumococcal fimbrial protein a vaccines
JPH07502896A (ja) * 1992-01-08 1995-03-30 ザ ロックフェラー ユニバーシティ 連鎖球菌の多官能性表面タンパク

Also Published As

Publication number Publication date
US5928900A (en) 1999-07-27
FI960977A0 (fi) 1996-03-01
EP0721506B1 (en) 2006-07-05
DE69434784T2 (de) 2007-06-14
US5981229A (en) 1999-11-09
FI960977A7 (fi) 1996-04-30
NO960839D0 (no) 1996-02-29
AU7680994A (en) 1995-03-22
PT721506E (pt) 2006-10-31
CA2170726A1 (en) 1995-03-09
NO960839L (no) 1996-04-19
AU709405B2 (en) 1999-08-26
FI960977L (fi) 1996-04-30
EP0721506A1 (en) 1996-07-17
NO321826B1 (no) 2006-07-10
WO1995006732A3 (en) 1995-06-01
DE69434784D1 (de) 2006-08-17
JPH09504686A (ja) 1997-05-13
ES2267096T3 (es) 2007-03-01
ATE332376T1 (de) 2006-07-15
JP3722834B2 (ja) 2005-11-30
WO1995006732A2 (en) 1995-03-09
NZ273497A (en) 1998-03-25

Similar Documents

Publication Publication Date Title
DK0721506T3 (da) Bakterielle eksporterede proteiner og acellulære vacciner baseret derpå
EA200100565A1 (ru) Новые стрептококковые антигены
IL102712A0 (en) Variety of bacillus thuringiensis,insecticide derived therefrom and dna encoding the insecticide
GEP20032977B (en) Proteinase K-Resistant Surface Protein of Neisseria Meningitidis
DK0633313T3 (da) Vaccine mod Lyme-sygdom
DK0634490T3 (da) Xylanase afledt fra en bacillusart, udtrykkelsesvektorer for sådan en xylanase og andre proteiner, værtsorganismer derfor og anvendelse deraf
DK0686195T3 (da) Fremgangsmåde og system til forhöjet produktion af kommercielt vigtige exoproteiner i grampositive bakterier
DK22389A (da) Fremgangsmaade og middel til beskyttelse mod sygdomme foraarsaget af mikroorganismer, navnlig mycoplasma
SE8803071D0 (sv) Bakteriebehandling for att bevara hokvalitet genom att tillegga genius bacillus mikroorganismer
DK0418945T3 (da) Forgreningsenzym og dets anvendelse
GB9526178D0 (en) Novel polynuceotides and polypeptides in pathogenic mycobacteria and their use as diagnostics,vaccines and targets for chemotherapy
EP1575483A4 (en) GRAM NEGATIVE BACTERIA ATTENUATED
DK0840792T3 (da) (S)-hydroxynitrillyase fra Hevea brasiliensis
PT648836E (pt) Transactivador do mhc de classe ii (ciita) e suas utilizacoes
DE69116803D1 (de) Peroxidase-Gen von mikrobischem Ursprung
SG90030A1 (en) Methods for producing enhanced antigenic helocobacter sp. and vaccines comprising same
DE69332652D1 (de) Verbesserungen in bezug auf die herstellung von malariaimpstoffen
DE59408087D1 (de) Substituierte heteroarylalkylthiopyridine zur bekämpfung von helicobacter bakterien
DK0623170T3 (da) Vacciner baseret på streptokinase
WO1997014798A3 (de) Polynukleotide und die durch diese kodierrte proteine, geeignet zur bekämpfung von melolontha sp.käfern
AU6999287A (en) Insecticidal proteinaceous substance
DE60114876D1 (de) DEKONTAMINATION VON PRIONHALTIGEM (z.B. BSE-AGENS ENTHALTENDEM) TIERFUTTER
GB9401795D0 (en) Vaccines
UA839A1 (uk) Коhсорціум штамів бактерій аgrовастеrіuм sр. 172, васіllus меgатеrіuм 171, васіllus рuтіlus 123, що використовується для очистки стічhих вод від діетилеhгліколю