DK0733049T3 - Tricykliske derivater og deres anvendelse i farmaceutika - Google Patents

Tricykliske derivater og deres anvendelse i farmaceutika

Info

Publication number
DK0733049T3
DK0733049T3 DK95903169T DK95903169T DK0733049T3 DK 0733049 T3 DK0733049 T3 DK 0733049T3 DK 95903169 T DK95903169 T DK 95903169T DK 95903169 T DK95903169 T DK 95903169T DK 0733049 T3 DK0733049 T3 DK 0733049T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
formula
disclosed
methods
tricyclic derivatives
Prior art date
Application number
DK95903169T
Other languages
Danish (da)
English (en)
Inventor
Wing C Tom
Pauline C Ting
Richard J Friary
Joe F Lee
Vera A Seidl
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0733049T3 publication Critical patent/DK0733049T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/31—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by at least three rings
    • C07C211/32—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by at least three rings containing dibenzocycloheptane or dibenzocycloheptene ring systems or condensed derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95903169T 1993-12-06 1994-12-05 Tricykliske derivater og deres anvendelse i farmaceutika DK0733049T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/162,686 US5574173A (en) 1993-12-06 1993-12-06 Tricyclic derivatives, compositions and methods of use
PCT/US1994/013661 WO1995015959A1 (en) 1993-12-06 1994-12-05 Tricyclic derivatives and their use in pharmaceuticals

Publications (1)

Publication Number Publication Date
DK0733049T3 true DK0733049T3 (da) 1999-09-27

Family

ID=22586705

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903169T DK0733049T3 (da) 1993-12-06 1994-12-05 Tricykliske derivater og deres anvendelse i farmaceutika

Country Status (9)

Country Link
US (1) US5574173A (de)
EP (1) EP0733049B1 (de)
JP (1) JP2793914B2 (de)
AT (1) ATE177425T1 (de)
DE (1) DE69417060T2 (de)
DK (1) DK0733049T3 (de)
ES (1) ES2128701T3 (de)
GR (1) GR3030036T3 (de)
WO (1) WO1995015959A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087765B2 (en) * 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en) * 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
JPH09176038A (ja) * 1995-09-18 1997-07-08 Hisamitsu Pharmaceut Co Inc 抗炎症性アンチセンス薬物
WO1997042820A1 (en) * 1996-05-16 1997-11-20 Duke University Tristetraprolin
WO1998056752A1 (en) * 1997-06-11 1998-12-17 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
JP4728997B2 (ja) * 2007-04-06 2011-07-20 出光興産株式会社 レジスト剥離剤及びその製造方法
EP4508043A4 (de) * 2022-04-14 2026-04-01 Mayo Found Medical Education & Res Verfahren zur behandlung von fibrotischen augenerkrankungen

Family Cites Families (33)

* Cited by examiner, † Cited by third party
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BE641498A (de) * 1962-03-13
US3922305A (en) * 1962-08-09 1975-11-25 Merck & Co Inc Chemical compounds
FR88751E (de) * 1963-07-09 1967-06-07
US3978121A (en) * 1963-07-25 1976-08-31 Merck & Co., Inc. 5H Dibenzo[a,d]cycloheptene derivatives
US3981917A (en) * 1963-07-25 1976-09-21 Merck & Co., Inc. Chemical compounds
BE650988A (de) * 1963-07-25 1965-01-25
NL138423C (de) * 1966-07-14
NL130988C (de) * 1966-07-21 Boehringer Mannheim Gmbh
DE1543388B1 (de) * 1966-12-23 1970-10-01 Boehringer Mannheim Gmbh Basisch substituierte,tricyclische heterocyclische Verbindungen und deren pharmakologisch nicht giftige Salze sowie Verfahren zu ihrer Herstellung
GB1274262A (en) * 1968-05-03 1972-05-17 Hoffmann La Roche Dibenzocycloheptene derivatives
US3595865A (en) * 1968-09-12 1971-07-27 Searle & Co 5-(4-pyridyl)-5h-dibenzo(a,b)cycloheptenes
US3674841A (en) * 1969-03-03 1972-07-04 Roussel Uclaf 10,11-DIHYDRO-,9,10-DIHYDRO-10,10-DIMETHYL-5-OR 9-{8 3-AMINO-2-oxo -OR-HYDROXY-PROPYLIDENE{9 {11 -5H-DIBENZO{8 a,d{9 {11 CYCLOHEPTENES AND-ANTHRACENES
US3927128A (en) * 1971-01-18 1975-12-16 Hoffmann La Roche Tricyclic amines and processes for the preparation thereof
US3965181A (en) * 1973-07-06 1976-06-22 Syntex (U.S.A.) Inc. Tricyclic pharmacological agents, intermediates and methods of making
DE2335943C3 (de) * 1973-07-14 1979-08-09 Boehringer Mannheim Gmbh, 6800 Mannheim Tricyclisch substituierte Aminoalkohole und ihre nichttoxischen Salze, Verfahren zu deren Herstellung und deren Verwendung bei der Bekämpfung von Herz- und Kreislauferkrankungen
US4585788A (en) * 1973-09-06 1986-04-29 American Hoechst Corporation 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
GB1483343A (en) * 1973-10-22 1977-08-17 Res Inst Medicine Chem Derivatives of amitriptyline and pharmaceutical uses thereof
US5140027A (en) * 1977-12-13 1992-08-18 Hoechst-Roussel Pharmaceuticals Inc. Aminoalkylthiodibenzoxepins and pharmaceutical use
FR2512024A1 (fr) * 1981-08-27 1983-03-04 Adir Ethers tricycliques, leur preparation et les compositions pharmaceutiques les contenant
US4626542A (en) * 1984-04-05 1986-12-02 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
SE8500273D0 (sv) * 1985-01-22 1985-01-22 Leo Ab Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JPH07116174B2 (ja) * 1987-02-27 1995-12-13 協和醗酵工業株式会社 ジベンズ〔ｂ，ｅ〕オキセピン誘導体
EP0411048A1 (de) * 1988-04-28 1991-02-06 Schering Corporation Benzopyridopiperidin-, -piperidyliden- und -piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung
SG44477A1 (en) * 1988-04-28 1997-12-19 Schering Corp Fused polycyclic compounds compositions methods of manufacture and their use as paf antaginists anthihistamines and/or antiinflammatory agents
US5104876A (en) * 1988-04-28 1992-04-14 Schering Corporation Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
CA2059127A1 (en) * 1989-06-19 1990-12-20 Oscar William Lever Medicaments useful in cancer therapy and having antihistaminic properties
US4996321A (en) * 1990-02-26 1991-02-26 Merck & Co., Inc. Dibenzo[a,d]cycloheptenylidene compounds
DE69120430D1 (de) * 1990-12-18 1996-07-25 Wellcome Found Mittel zur verstaerkung der wirkung von antitumoralen mittel und zur widerstandsbekaempfung von vielfachdrogen
JPH0578292A (ja) * 1991-04-05 1993-03-30 Hokuriku Seiyaku Co Ltd 三環系化合物
WO1992020681A1 (en) * 1991-05-23 1992-11-26 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use

Also Published As

Publication number Publication date
JP2793914B2 (ja) 1998-09-03
WO1995015959A1 (en) 1995-06-15
ES2128701T3 (es) 1999-05-16
EP0733049B1 (de) 1999-03-10
ATE177425T1 (de) 1999-03-15
US5574173A (en) 1996-11-12
JPH09500655A (ja) 1997-01-21
DE69417060T2 (de) 1999-07-15
DE69417060D1 (de) 1999-04-15
GR3030036T3 (en) 1999-07-30
EP0733049A1 (de) 1996-09-25

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