DK0743301T3 - Fluorholdige benzoylguanidiner - Google Patents

Fluorholdige benzoylguanidiner

Info

Publication number: DK0743301T3
Authority: DK; Denmark
Prior art keywords: cnfmh2n; mop; opt; het; halo
Prior art date: 1995-05-16

Application number

DK96106881T

Other languages

Danish (da)

English (en)

Inventor

Dieter Dr Dorsch

Manfred Dr Baumgarth

Rolf Dr Gericke

Norbert Dr Beier

Klaus-Otto Dr Minck

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-16

Filing date

1996-05-02

Publication date

2001-11-26

1996-05-02 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2001-11-26 Application granted granted Critical

2001-11-26 Publication of DK0743301T3 publication Critical patent/DK0743301T3/da

Links

AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Phenolic Resins Or Amino Resins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK96106881T 1995-05-16 1996-05-02 Fluorholdige benzoylguanidiner DK0743301T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19517848A DE19517848A1 (de)	1995-05-16	1995-05-16	Fluorhaltige Benzoylguanidine

Publications (1)

Publication Number	Publication Date
DK0743301T3 true DK0743301T3 (da)	2001-11-26

Family

ID=7761987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96106881T DK0743301T3 (da)	1995-05-16	1996-05-02	Fluorholdige benzoylguanidiner

Country Status (23)

Country	Link
US (1)	US5747539A (pl)
EP (1)	EP0743301B1 (pl)
JP (1)	JPH08311011A (pl)
KR (1)	KR960041154A (pl)
CN (1)	CN1064955C (pl)
AT (1)	ATE204856T1 (pl)
AU (1)	AU713743B2 (pl)
CA (1)	CA2176553A1 (pl)
CZ (1)	CZ287750B6 (pl)
DE (2)	DE19517848A1 (pl)
DK (1)	DK0743301T3 (pl)
ES (1)	ES2161936T3 (pl)
GR (1)	GR3037033T3 (pl)
HU (1)	HU223046B1 (pl)
NO (1)	NO306157B1 (pl)
PL (1)	PL184192B1 (pl)
PT (1)	PT743301E (pl)
RU (1)	RU2159230C2 (pl)
SI (1)	SI0743301T1 (pl)
SK (1)	SK282052B6 (pl)
TW (1)	TW363052B (pl)
UA (1)	UA44260C2 (pl)
ZA (1)	ZA963870B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4328352A1 (de) *	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19606509A1 (de) *	1996-02-22	1997-08-28	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161A1 (de)	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5747639A (en) *	1996-03-06	1998-05-05	Amgen Boulder Inc.	Use of hydrophobic interaction chromatography to purify polyethylene glycols
DE19713427A1 (de) *	1997-04-01	1998-10-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN1328452A (zh) *	1998-11-26	2001-12-26	默克专利股份公司	苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途
US7375138B2 (en)	2002-05-18	2008-05-20	Sanofi-Aventis Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
DE10222192A1 (de) *	2002-05-18	2003-11-27	Aventis Pharma Gmbh	Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10226462A1 (de) *	2002-06-13	2003-12-24	Aventis Pharma Gmbh	Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
US20050124666A1 (en) *	2003-11-13	2005-06-09	Aventis Pharma Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
OA13285A (en) *	2003-11-13	2007-01-31	Sanofi Aventis Deutschland	Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same.
DE10353204A1 (de) *	2003-11-13	2005-06-16	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (de) *	1992-02-15	1996-06-19	Hoechst Aktiengesellschaft	3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DK0556673T3 (da) *	1992-02-15	1998-04-14	Hoechst Ag	o-Substituerede benzoylguanidiner til behandling og profylakse af hjerterytmeforstyrrelser og iskæmisk inducerede skader samt til inhiberering af celleproliferation
DK0589336T3 (da) *	1992-09-22	1997-06-16	Hoechst Ag	Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
TW250477B (pl) *	1992-12-15	1995-07-01	Hoechst Ag
TW250479B (pl) *	1992-12-15	1995-07-01	Hoechst Ag
ATE157351T1 (de) *	1993-02-20	1997-09-15	Hoechst Ag	Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
DE4318756A1 (de) *	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate

1995
- 1995-05-16 DE DE19517848A patent/DE19517848A1/de not_active Withdrawn
1996
- 1996-03-25 TW TW085103561A patent/TW363052B/zh active
- 1996-05-02 AT AT96106881T patent/ATE204856T1/de not_active IP Right Cessation
- 1996-05-02 DK DK96106881T patent/DK0743301T3/da active
- 1996-05-02 ES ES96106881T patent/ES2161936T3/es not_active Expired - Lifetime
- 1996-05-02 DE DE59607559T patent/DE59607559D1/de not_active Expired - Fee Related
- 1996-05-02 PT PT96106881T patent/PT743301E/pt unknown
- 1996-05-02 EP EP96106881A patent/EP0743301B1/de not_active Expired - Lifetime
- 1996-05-02 SI SI9630361T patent/SI0743301T1/xx unknown
- 1996-05-09 SK SK590-96A patent/SK282052B6/sk unknown
- 1996-05-13 CN CN961058854A patent/CN1064955C/zh not_active Expired - Fee Related
- 1996-05-13 UA UA96051860A patent/UA44260C2/uk unknown
- 1996-05-13 AU AU52252/96A patent/AU713743B2/en not_active Ceased
- 1996-05-14 CA CA002176553A patent/CA2176553A1/en not_active Abandoned
- 1996-05-15 ZA ZA963870A patent/ZA963870B/xx unknown
- 1996-05-15 US US08/647,789 patent/US5747539A/en not_active Expired - Fee Related
- 1996-05-15 RU RU96109204/04A patent/RU2159230C2/ru not_active IP Right Cessation
- 1996-05-15 KR KR1019960016096A patent/KR960041154A/ko not_active Abandoned
- 1996-05-15 CZ CZ19961408A patent/CZ287750B6/cs not_active IP Right Cessation
- 1996-05-15 NO NO961997A patent/NO306157B1/no not_active IP Right Cessation
- 1996-05-15 HU HU9601305A patent/HU223046B1/hu not_active IP Right Cessation
- 1996-05-15 PL PL96314259A patent/PL184192B1/pl unknown
- 1996-05-16 JP JP8144881A patent/JPH08311011A/ja active Pending
2001
- 2001-10-30 GR GR20010401903T patent/GR3037033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU223046B1 (hu)	2004-03-01
RU2159230C2 (ru)	2000-11-20
AU5225296A (en)	1996-11-28
HUP9601305A2 (en)	1997-05-28
HU9601305D0 (en)	1996-07-29
TW363052B (en)	1999-07-01
GR3037033T3 (en)	2002-01-31
US5747539A (en)	1998-05-05
EP0743301A2 (de)	1996-11-20
SI0743301T1 (en)	2002-02-28
PL314259A1 (en)	1996-11-25
JPH08311011A (ja)	1996-11-26
NO961997D0 (no)	1996-05-15
CN1143632A (zh)	1997-02-26
EP0743301B1 (de)	2001-08-29
NO306157B1 (no)	1999-09-27
SK282052B6 (sk)	2001-10-08
NO961997L (no)	1996-11-18
ATE204856T1 (de)	2001-09-15
HUP9601305A3 (en)	1997-11-28
EP0743301A3 (de)	1997-06-11
ES2161936T3 (es)	2001-12-16
PT743301E (pt)	2002-01-30
DE59607559D1 (de)	2001-10-04
CA2176553A1 (en)	1996-11-17
AU713743B2 (en)	1999-12-09
ZA963870B (en)	1996-11-21
SK59096A3 (en)	1996-12-04
PL184192B1 (pl)	2002-09-30
KR960041154A (ko)	1996-12-19
CZ287750B6 (en)	2001-01-17
UA44260C2 (uk)	2002-02-15
CN1064955C (zh)	2001-04-25
CZ140896A3 (en)	1997-02-12
DE19517848A1 (de)	1996-11-21

Publication	Publication Date	Title
NO961997D0 (no)	1996-05-15	Fluorholdige benzoylguanidiner
PT618190E (pt)	2004-08-31	9-¬glicil substituido)amido\|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas
ATE168992T1 (de)	1998-08-15	7-substituierte-9-substituierte glycylamido-6- demethyl-6-deoxytetracycline
FI942291A0 (fi)	1994-05-17	Uudet herbisidit
FI942290A0 (fi)	1994-05-17	Uudet herbisidit
ES2103408T3 (es)	1997-09-16	Analogos de oligorribonucleotidos y ribozimas con uniones terminales en 3'-3' o 5'-5' respectivamente.
ATE59842T1 (de)	1991-01-15	Indanamin-derivate als antiarrhythmische mittel.
DE69030249D1 (de)	1997-04-24	Stabilisierung von Überzügen mit hohem Festkörpergehalt mit flüssigen Zusammenstellungen von UV absorbierenden Triazinen
MY129992A (en)	2007-05-31	Benzanilide herbicides and process for the preparation thereof
GB9325618D0 (en)	1994-02-16	New herbicides
DK0566175T3 (da)	1998-01-26	3,4-diaryl-(5H)-furan-2-on-baserede forbindelser med fungicid aktivitet
AU5213093A (en)	1994-07-14	Chemical compounds
TR25218A (tr)	1992-11-26	DIEN üNITESININ BITISIGINDE YER ALAN VE ONU BIR UCTA BULUNAN GRUBA BIRLESTIRILEN BIR 1,2 SIKLOPROPIL HALKASINI HAIZ OLAN VE PERTISID ÖZELLIK ARZEDEN DOYMAMIS AMIDLER.
DK0708088T3 (da)	1999-10-11	Alkyl-5-methylsulfonyl-benzoyl-guanidinderivater
GB9520092D0 (en)	1995-12-06	Chemical compounds
BR9303455A (pt)	1994-03-22	Emprego de compostos,dispositivos e agentes de combate de baratas,compostos e processo para sua preparacao
EP0645374A4 (en)	1995-02-14	5-AMINO-2-PHENOXYSULFONANILIDE DERIVATIVES.
DK0533089T3 (da)	1995-12-27	Flydende peroxidiske sammensætninger
CA2110132A1 (en)	1994-06-19	Inorganic/organic inhibitor for corrosion of iron containing materials in sulfur environment
ES2025201B3 (es)	1992-03-16	Preparacion de intermediarios fosforados para uso herbicida.
DE59002904D1 (de)	1993-11-04	Cyclopropanthiocarbonsaeureamide.
ATE159253T1 (de)	1997-11-15	2-thiazolylpyrroleakrylate mit fungizider wirkung
ITPG910013A0 (it)	1991-09-04	L'autorotante con cannocchiale, molle, senza attrito