DK0744962T3 - Fremgangsmåde til lagring af ultralydsgassuspensioner - Google Patents

Fremgangsmåde til lagring af ultralydsgassuspensioner

Info

Publication number
DK0744962T3
DK0744962T3 DK95937158T DK95937158T DK0744962T3 DK 0744962 T3 DK0744962 T3 DK 0744962T3 DK 95937158 T DK95937158 T DK 95937158T DK 95937158 T DK95937158 T DK 95937158T DK 0744962 T3 DK0744962 T3 DK 0744962T3
Authority
DK
Denmark
Prior art keywords
microbubbles
suspensions
immobilised
disclosed
temperature
Prior art date
Application number
DK95937158T
Other languages
English (en)
Other versions
DK0744962T4 (da
Inventor
Michel Schneider
Jean Brochot
Feng Yan
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0744962(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of DK0744962T3 publication Critical patent/DK0744962T3/da
Application granted granted Critical
Publication of DK0744962T4 publication Critical patent/DK0744962T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK95937158T 1994-12-16 1995-12-14 Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner DK0744962T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16
PCT/IB1995/001124 WO1996018420A1 (en) 1994-12-16 1995-12-14 Method of storage of ultrasonic gas suspensions

Publications (2)

Publication Number Publication Date
DK0744962T3 true DK0744962T3 (da) 2001-12-31
DK0744962T4 DK0744962T4 (da) 2006-01-09

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95937158T DK0744962T4 (da) 1994-12-16 1995-12-14 Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner

Country Status (19)

Country Link
US (3) US5830435A (da)
EP (1) EP0744962B2 (da)
JP (1) JP3958358B2 (da)
KR (1) KR100382811B1 (da)
CN (1) CN1066965C (da)
AT (1) ATE205404T1 (da)
AU (1) AU701807B2 (da)
CA (1) CA2181340C (da)
CZ (1) CZ291540B6 (da)
DE (1) DE69522670T3 (da)
DK (1) DK0744962T4 (da)
ES (1) ES2162943T5 (da)
FI (1) FI120722B (da)
IL (1) IL116328A (da)
NO (1) NO313031B1 (da)
NZ (1) NZ295744A (da)
PT (1) PT744962E (da)
WO (1) WO1996018420A1 (da)
ZA (1) ZA9510721B (da)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
ZA9811087B (en) 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
ATE345359T1 (de) 1997-12-22 2006-12-15 Metabolix Inc Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
EP1159015A1 (en) 1999-03-04 2001-12-05 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
PT1163019E (pt) 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
EP1202670A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
US6387077B1 (en) 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
JP3819845B2 (ja) 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
DK1590006T3 (da) * 2003-02-04 2010-12-20 Bracco Suisse Sa Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
PT1638615E (pt) 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
WO2005070299A1 (en) * 2004-01-16 2005-08-04 The University Of Houston System Methods and apparatus for medical imaging
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
PT1778305E (pt) 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
US8295914B2 (en) 2004-11-16 2012-10-23 Medrad, Inc. Systems and methods of determining patient transfer functions and modeling patient response to a pharmaceutical injection
EP2990073B1 (en) 2004-11-24 2018-05-02 Bayer Healthcare LLC Devices and systems for fluid delivery
US20080045919A1 (en) * 2004-12-23 2008-02-21 Bracco Research S.A. Liquid Transfer Device for Medical Dispensing Containers
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
WO2007067979A2 (en) 2005-12-09 2007-06-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1797919A1 (en) * 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
JP5154554B2 (ja) 2006-08-01 2013-02-27 ボストン サイエンティフィック サイムド，インコーポレイテッド 非線形イメージングのためのパルスインバージョンシーケンス
JP5420410B2 (ja) 2006-09-05 2014-02-19 ブラッコ・シュイス・ソシエテ・アノニム ポリマー修飾脂質を含むガス封入微小胞
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008075192A2 (en) * 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
DK2097835T3 (da) 2006-12-29 2018-09-03 Bayer Healthcare Llc Patientbaserede parametergenereringssystemer til medicinske injektionsprocedurer
US8428694B2 (en) 2007-07-17 2013-04-23 Medrad, Inc. Methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010040772A2 (en) * 2008-10-07 2010-04-15 Bracco Research Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
WO2010069943A1 (en) 2008-12-16 2010-06-24 Bracco Research Sa Device for bolus administration of contrast agent
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
AU2011270772C1 (en) 2010-06-24 2017-04-20 Bayer Healthcare Llc Modeling of pharmaceutical propagation and parameter generation for injection protocols
DK2603242T3 (da) 2010-08-09 2018-06-18 Bracco Suisse Sa Målrettede gasfyldte microvesikler
WO2012020001A1 (en) 2010-08-09 2012-02-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
EP2654788B1 (en) 2010-12-24 2018-03-14 Bracco Suisse SA Gas-filled microvesicles for use as vaccine
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2013151682A1 (en) * 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US11045748B2 (en) 2012-04-30 2021-06-29 Ge Healthcare As Method for filling a container with a foamable composition
AU2012380327A1 (en) 2012-05-14 2014-11-27 Bayer Healthcare Llc Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
EP2968825A4 (en) 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
JP6803839B2 (ja) 2014-12-18 2020-12-23 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ 標的化されたガス入りの微小胞の製剤
JP2017537907A (ja) 2014-12-22 2017-12-21 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ワクチンとしての使用のためのガス入りの微小胞
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
CN105569124B (zh) * 2016-01-31 2017-12-01 天津市建筑设计院 一种变频调速变压供水装置及其控制方法
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質
EP3423130B1 (en) 2016-03-03 2025-05-14 Bayer Healthcare LLC System and method for improved fluid delivery in multi-fluid injector systems
JP7191821B2 (ja) 2016-11-14 2022-12-19 バイエル・ヘルスケア・エルエルシー 医用流体送出に使用されるシリンジの内容物を確認するための方法およびシステム
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
AU2018326485B2 (en) 2017-08-31 2024-01-04 Bayer Healthcare Llc Injector pressure calibration system and method
WO2019046299A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc FLUID PATH IMPEDANCE ASSESSMENT FOR IMPROVING FLUID DISTRIBUTION PERFORMANCE
EP3675930B1 (en) 2017-08-31 2024-01-17 Bayer Healthcare LLC Method for drive member position and fluid injector system mechanical calibration
EP3675927B1 (en) 2017-08-31 2023-12-13 Bayer Healthcare LLC Fluid injector system volume compensation system and method
AU2018326379B2 (en) 2017-08-31 2024-03-21 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
JP7754625B2 (ja) 2018-04-19 2025-10-15 バイエル・ヘルスケア・エルエルシー 流体インジェクタ内の空気を検出するためのシステムおよび方法
CN112823031B (zh) 2018-08-28 2023-08-15 拜耳医药保健有限责任公司 防止流体回流的流体注入器系统、方法和计算机程序产品
AU2019332923A1 (en) 2018-08-28 2021-02-11 Bayer Healthcare Llc Fluid injector system with improved ratio performance
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE218439C1 (sv) * 1964-12-23 1968-01-23 Hagstam H Röntgenkontrastmedel innehallande bariumsulfat jämte sätt för dess framställning
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4347707A (en) * 1981-03-31 1982-09-07 General Foods Corporation Gasified ice product and process having improved storage stability
DE4219724A1 (de) † 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
US5271961A (en) † 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5228446A (en) † 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
JP3247374B2 (ja) † 1990-10-05 2002-01-15 ブラッコ インターナショナル ベスローテン フェンノートシャップ 超音波エコグラフィーに適切な中空気体封入微小球の安定懸濁物の製造のための方法
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
SG54121A1 (en) † 1991-09-17 1998-11-16 Sonus Pharma Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
IL104084A (en) † 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them

Also Published As

Publication number Publication date
JP3958358B2 (ja) 2007-08-15
DE69522670T3 (de) 2006-06-14
EP0744962B1 (en) 2001-09-12
AU701807B2 (en) 1999-02-04
DE69522670T2 (de) 2002-06-20
IL116328A0 (en) 1996-03-31
CA2181340C (en) 2007-09-11
CZ242096A3 (en) 1996-11-13
AU3935295A (en) 1996-07-03
NO963327L (no) 1996-08-09
NZ295744A (en) 1997-08-22
DK0744962T4 (da) 2006-01-09
CA2181340A1 (en) 1996-06-20
FI120722B (fi) 2010-02-15
ZA9510721B (en) 1996-06-20
CN1141001A (zh) 1997-01-22
US5827504A (en) 1998-10-27
ATE205404T1 (de) 2001-09-15
US5961956A (en) 1999-10-05
US5830435A (en) 1998-11-03
FI963202A0 (fi) 1996-08-15
EP0744962B2 (en) 2005-09-07
CN1066965C (zh) 2001-06-13
IL116328A (en) 1999-09-22
ES2162943T5 (es) 2006-03-01
NO313031B1 (no) 2002-08-05
KR100382811B1 (ko) 2003-08-19
WO1996018420A1 (en) 1996-06-20
ES2162943T3 (es) 2002-01-16
CZ291540B6 (cs) 2003-03-12
JPH09509433A (ja) 1997-09-22
DE69522670D1 (de) 2001-10-18
NO963327D0 (no) 1996-08-09
PT744962E (pt) 2002-02-28
EP0744962A1 (en) 1996-12-04
KR970701066A (ko) 1997-03-17
FI963202L (fi) 1996-08-15
MX9603330A (es) 1997-12-31

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