DK0751785T3 - Kombinationer af thrombolytisk aktive proteiner og antikoagulationsmidler samt anvendelse heraf - Google Patents

Kombinationer af thrombolytisk aktive proteiner og antikoagulationsmidler samt anvendelse heraf

Info

Publication number: DK0751785T3
Authority: DK; Denmark
Prior art keywords: thrombolytically; thrombolytically active; anticoagulants; combinations; anticoagulant
Prior art date: 1994-03-25

Application number

DK95912261T

Other languages

English (en)

Other versions

DK0751785T4 (da

Inventor

Ulrich Martin

Stephan Fischer

Original Assignee

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-25

Filing date

1995-03-22

Publication date

1999-04-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22811809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0751785(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-03-22 Application filed by Boehringer Mannheim Gmbh, Roche Diagnostics Gmbh filed Critical Boehringer Mannheim Gmbh

1999-04-06 Publication of DK0751785T3 publication Critical patent/DK0751785T3/da

2002-04-15 Application granted granted Critical

2002-04-15 Publication of DK0751785T4 publication Critical patent/DK0751785T4/da

Links

239000003146 anticoagulant agent Substances 0.000 title abstract 6
229940127219 anticoagulant drug Drugs 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
238000009512 pharmaceutical packaging Methods 0.000 abstract 2
238000002560 therapeutic procedure Methods 0.000 abstract 2
230000002537 thrombolytic effect Effects 0.000 abstract 2
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK95912261T 1994-03-25 1995-03-22 Kombinationer af thrombolytisk aktive proteiner og antikoagulationsmidler samt anvendelse heraf DK0751785T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/217,618 US5510330A (en)	1994-03-25	1994-03-25	Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
PCT/EP1995/001061 WO1995026202A1 (en)	1994-03-25	1995-03-22	Combinations of thrombolytically active proteins and anticoagulants, and uses thereof

Publications (2)

Publication Number	Publication Date
DK0751785T3 true DK0751785T3 (da)	1999-04-06
DK0751785T4 DK0751785T4 (da)	2002-04-15

Family

ID=22811809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95912261T DK0751785T4 (da)	1994-03-25	1995-03-22	Kombinationer af thrombolytisk aktive proteiner og antikoagulationsmidler samt anvendelse heraf

Country Status (21)

Country	Link
US (1)	US5510330A (da)
EP (2)	EP0850648A3 (da)
JP (1)	JPH09510439A (da)
KR (1)	KR100366982B1 (da)
CN (1)	CN1090029C (da)
AT (1)	ATE167631T1 (da)
AU (1)	AU702470B2 (da)
BR (1)	BR9507189A (da)
CA (1)	CA2186390A1 (da)
CZ (1)	CZ279596A3 (da)
DE (1)	DE69503120T3 (da)
DK (1)	DK0751785T4 (da)
ES (1)	ES2119411T5 (da)
FI (1)	FI120182B (da)
MX (1)	MX9603925A (da)
NO (1)	NO316584B1 (da)
NZ (1)	NZ282417A (da)
PL (1)	PL182165B1 (da)
RU (1)	RU2166326C2 (da)
UA (1)	UA41398C2 (da)
WO (1)	WO1995026202A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7896914B2 (en) *	1995-06-07	2011-03-01	Cook Incorporated	Coated implantable medical device
US6774278B1 (en) *	1995-06-07	2004-08-10	Cook Incorporated	Coated implantable medical device
US7611533B2 (en) *	1995-06-07	2009-11-03	Cook Incorporated	Coated implantable medical device
US20070203520A1 (en) *	1995-06-07	2007-08-30	Dennis Griffin	Endovascular filter
US7550005B2 (en)	1995-06-07	2009-06-23	Cook Incorporated	Coated implantable medical device
US7846202B2 (en)	1995-06-07	2010-12-07	Cook Incorporated	Coated implantable medical device
US7867275B2 (en) *	1995-06-07	2011-01-11	Cook Incorporated	Coated implantable medical device method
US5840733A (en) *	1996-07-01	1998-11-24	Redcell, Canada, Inc.	Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US6010911A (en) *	1997-04-30	2000-01-04	Medtronic, Inc.	Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6750201B1 (en) *	1997-10-17	2004-06-15	The Trustees Of The University Of Pennsylvania	Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US6517814B2 (en)	2001-01-09	2003-02-11	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants useful for metallopharmaceuticals
DE10115740A1 (de) *	2001-03-26	2002-10-02	Ulrich Speck	Zubereitung für die Restenoseprophylaxe
DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
FI20020197A0 (fi) *	2002-02-01	2002-02-01	Orion Corp	Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7084118B2 (en)	2002-02-22	2006-08-01	Genentech, Inc.	Combination treatment with t-PA variant and low molecular weight heparin
CA2484383C (en) *	2002-07-12	2016-05-31	Cook Incorporated	Medical device coated with a bioactive agent
DE10244847A1 (de) *	2002-09-20	2004-04-01	Ulrich Prof. Dr. Speck	Medizinische Vorrichtung zur Arzneimittelabgabe
JP2007538257A (ja) *	2004-05-17	2007-12-27	メドトロニック・インコーポレーテッド	ポイント・オブ・ヘパリン測定システム
US20060222640A1 (en) *	2005-03-29	2006-10-05	Boehringer Ingelheim International Gmbh	New pharmaceutical compositions for treatment of thrombosis
WO2008044631A1 (en) *	2006-10-06	2008-04-17	Asahi Kasei Pharma Corporation	Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
RU2371215C2 (ru) *	2007-08-13	2009-10-27	ГОУ ВПО "Саратовский ГМУ Росздрава"	Способ коррекции нарушенной функциональной активности гликопротеидных рецепторов тромбоцитов
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2231702A1 (en) *	2007-12-21	2010-09-29	Ifxa A/s	Protease inhibitor
RU2394611C1 (ru) *	2009-06-05	2010-07-20	Алексей Николаевич Иванов	Способ коррекции нарушенной функциональной активности гликопротеидных рецепторов эритроцитов
EP3708226A1 (en)	2014-11-03	2020-09-16	Thrombolytic Science, LLC	Methods and compositions for safe and effective thrombolysis
WO2016122288A2 (ko) *	2015-01-30	2016-08-04	고려대학교산학협력단	베르베논 유도체 및 재관류 치료제를 포함하는 뇌혈관 질환, 동맥경화증 또는 심혈관 질환 치료 또는 예방용 병용 제제
RU2622006C2 (ru) *	2015-06-15	2017-06-08	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ)	Применение рекомбинантного штамма bacillus subtilis eo-11 вкпм в-11978 в качестве продуцента субтилизиноподобной протеиназы, вещества с тромболитическими и антикоагулянтными свойствами
CN105396127A (zh) *	2015-11-13	2016-03-16	中国人民解放军第四军医大学	一种用于急性心肌梗死的冠状动脉溶栓剂
WO2018232305A1 (en) *	2017-06-16	2018-12-20	Thrombolytic Science, Llc	Methods and compositions for thrombolysis
CN114292765B (zh) *	2021-09-24	2023-04-07	江西康之康中药科技有限公司	枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8508717D0 (en) *	1985-04-03	1985-05-09	Beecham Group Plc	Composition
DK43387A (da) †	1986-01-29	1987-07-30	Beecham Group Plc	Fibrinolytisk enzym
US5084274A (en) *	1987-11-17	1992-01-28	Scripps Clinic And Research Foundation	Inhibition of arterial thrombotic occlusion or thromboembolism
DE3804600A1 (de) *	1988-02-13	1989-08-24	Basf Ag	Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8822147D0 (en) *	1988-09-21	1988-10-26	Ciba Geigy Ag	Pharmaceutically active combination
US5204323B1 (en) *	1988-10-06	1995-07-18	Ciba Geigy Corp	Hirudin antidotal compositions and methods
GB8826428D0 (en) *	1988-11-11	1988-12-14	Biopharm Ltd	Antithrombin
US4980165A (en) *	1989-01-27	1990-12-25	Genetics Institute, Inc.	Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) *	1989-02-07	1990-08-16	Boehringer Mannheim Gmbh	Gewebs-plasminogenaktivator-derivat
CA2064231A1 (en) *	1989-07-20	1991-01-21	John M. Maraganore	Combinations and methods for treating or preventing thrombotic diseases
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
US5049132A (en) *	1990-01-08	1991-09-17	Cordis Corporation	Balloon catheter for delivering therapeutic agents
US5189019A (en) *	1990-04-23	1993-02-23	Merck & Co., Inc.	Antistasin derived anticoagulant protein
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
US5242688A (en) *	1990-12-24	1993-09-07	Eli Lilly And Company	Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DK0580685T3 (da) †	1991-04-16	1996-03-04	Boehringer Mannheim Gmbh	Farmaceutisk emballageenhed indeholdende plasminogenaktivatorer til flerfoldig bolusindgift
DE69333127T2 (de) †	1992-06-03	2004-05-06	Genentech, Inc., South San Francisco	Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
GB9303275D0 (en) *	1993-02-18	1993-04-07	Ciba Geigy Ag	Pharmaceutical compositions
IT1266561B1 (it) *	1993-07-22	1997-01-09	Mini Ricerca Scient Tecnolog	Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione

1994
- 1994-03-25 US US08/217,618 patent/US5510330A/en not_active Expired - Lifetime
1995
- 1995-03-22 UA UA96104031A patent/UA41398C2/uk unknown
- 1995-03-22 AU AU19511/95A patent/AU702470B2/en not_active Ceased
- 1995-03-22 WO PCT/EP1995/001061 patent/WO1995026202A1/en not_active Ceased
- 1995-03-22 CA CA002186390A patent/CA2186390A1/en not_active Abandoned
- 1995-03-22 RU RU96119944/14A patent/RU2166326C2/ru not_active IP Right Cessation
- 1995-03-22 AT AT95912261T patent/ATE167631T1/de active
- 1995-03-22 EP EP98102473A patent/EP0850648A3/en not_active Ceased
- 1995-03-22 BR BR9507189A patent/BR9507189A/pt not_active Application Discontinuation
- 1995-03-22 DK DK95912261T patent/DK0751785T4/da active
- 1995-03-22 MX MX9603925A patent/MX9603925A/es not_active IP Right Cessation
- 1995-03-22 CN CN95192275A patent/CN1090029C/zh not_active Expired - Fee Related
- 1995-03-22 JP JP7519775A patent/JPH09510439A/ja active Pending
- 1995-03-22 PL PL95316449A patent/PL182165B1/pl not_active IP Right Cessation
- 1995-03-22 KR KR1019960705381A patent/KR100366982B1/ko not_active Expired - Fee Related
- 1995-03-22 DE DE69503120T patent/DE69503120T3/de not_active Expired - Lifetime
- 1995-03-22 EP EP95912261A patent/EP0751785B2/en not_active Expired - Lifetime
- 1995-03-22 ES ES95912261T patent/ES2119411T5/es not_active Expired - Lifetime
- 1995-03-22 NZ NZ282417A patent/NZ282417A/en not_active IP Right Cessation
- 1995-03-22 CZ CZ962795A patent/CZ279596A3/cs unknown
1996
- 1996-09-24 FI FI963802A patent/FI120182B/fi not_active IP Right Cessation
- 1996-09-24 NO NO19964007A patent/NO316584B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2166326C2 (ru)	2001-05-10
UA41398C2 (uk)	2001-09-17
PL316449A1 (en)	1997-01-20
DE69503120T3 (de)	2003-08-14
DE69503120D1 (de)	1998-07-30
ATE167631T1 (de)	1998-07-15
NO964007D0 (no)	1996-09-24
EP0751785B1 (en)	1998-06-24
EP0850648A3 (en)	2004-03-31
CN1090029C (zh)	2002-09-04
MX9603925A (es)	1997-04-30
FI963802L (fi)	1996-09-24
CZ279596A3 (cs)	1998-01-14
AU1951195A (en)	1995-10-17
WO1995026202A1 (en)	1995-10-05
NO964007L (no)	1996-11-25
AU702470B2 (en)	1999-02-25
KR100366982B1 (ko)	2003-08-02
NO316584B1 (no)	2004-03-01
ES2119411T3 (es)	1998-10-01
PL182165B1 (pl)	2001-11-30
CA2186390A1 (en)	1995-10-05
BR9507189A (pt)	1997-09-09
ES2119411T5 (es)	2002-08-01
JPH09510439A (ja)	1997-10-21
FI963802A0 (fi)	1996-09-24
EP0850648A2 (en)	1998-07-01
DK0751785T4 (da)	2002-04-15
DE69503120T2 (de)	1998-11-12
CN1144489A (zh)	1997-03-05
EP0751785B2 (en)	2001-12-19
NZ282417A (en)	1998-02-26
US5510330A (en)	1996-04-23
EP0751785A1 (en)	1997-01-08
FI120182B (fi)	2009-07-31

Publication	Publication Date	Title
DK0751785T4 (da)	2002-04-15	Kombinationer af thrombolytisk aktive proteiner og antikoagulationsmidler samt anvendelse heraf
DK0839026T3 (da)	2002-01-21	Micellære polyether-blokcopolymerkompositioner til målretning af biologiske midler
PT88417A (pt)	1989-07-31	Stabilisierte humanprotein-praeparate
CY1113355T1 (el)	2016-06-22	Χρηση θεραπειας νευροτοξινης για θεραπευτικη αγωγη ουρολογικων και σχετικων διαταραχων
IT8819693A0 (it)	1988-03-08	Apparecchio atto ad operare, in modo pressoche' istantaneo, la distruzione completa dell'ago di siringhe per iniezione, subito dopo il loro impiego.
DE69524864D1 (de)	2002-02-07	4-amino-derivate der mycophenolsäure mit immun suppressiver wirkung
CY1107314T1 (el)	2012-11-21	Μεθοδος θεpαπευτικης αγωγης ασθενων προσβεβλημενων με σκληρυνση κατα πλακας χρησιμοποιωντας συναινετικη ιντepφepονη
DE69233760D1 (de)	2009-06-25	Inhibitoren der menschlichen Elastase von Neutrophilen
FR2793678B1 (fr)	2001-07-06	Manchon elastique a garniture viscoelastique pour la protection ou le soin de doigts ou d'orteils
DE69130071D1 (de)	1998-10-01	Zusammensetzung verwendbar als therapeutisches mittel gegen chronische virale leberkrankheiten
NO972391D0 (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
DK0558529T3 (da)	1996-06-03	Farmaceutisk præparat til behandling af forlænget koagulationstid
NO882853D0 (no)	1988-06-28	Korreksjon med dobbeltraadet rna av unormale tilstander i immunkomplekser som er i omloep, og i monocytfunkjon.
ATE173627T1 (de)	1998-12-15	Medizinische zusammensetzung
DE69008513D1 (de)	1994-06-01	Pharmazeutische formulierung von plasminogenaktivatorproteinen.
PT88539A (pt)	1988-10-01	Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen
DE69417340D1 (de)	1999-04-29	Spritze für medizinische zwecke
ATE187890T1 (de)	2000-01-15	Ligandgerichtete enzyme-prodrug therapie
ATE143809T1 (de)	1996-10-15	Placentaextrakt und verfahren zu seiner herstellung
ATE87905T1 (de)	1993-04-15	Anticonvulsive agenzien.
DK491289D0 (da)	1989-10-05	Modgift mod antikoaguleringsmidler
ATE67674T1 (de)	1991-10-15	Pharmazeutische zubereitungen mit heilender aktivitaet.
EA199800820A1 (ru)	1999-02-25	Способ лечения злоупотребления лекарственными средствами
ES2101982T3 (es)	1997-07-16	Composicion conteniendo una alta dosis de vitamina a.
IT9041714A0 (it)	1990-10-15	Linfa del libro dell'abete rosso (abies picea) per la cura di malattie neoplastiche e da virus in genere