DK0753301T3 - Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika - Google Patents

Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika

Info

Publication number: DK0753301T3
Authority: DK; Denmark
Prior art keywords: sup; group; angiotensin; compound; antagonistic activity
Prior art date: 1993-06-07

Application number

DK96115146T

Other languages

Danish (da)

English (en)

Inventor

Yoshiyuki Inada

Keiji Kubo

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-07

Filing date

1994-06-07

Publication date

2003-07-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15153791&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0753301(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-06-07 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2003-07-21 Application granted granted Critical

2003-07-21 Publication of DK0753301T3 publication Critical patent/DK0753301T3/da

Links

102000005862 Angiotensin II Human genes 0.000 title abstract 3
101800000733 Angiotensin-2 Proteins 0.000 title abstract 3
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 3
229950006323 angiotensin ii Drugs 0.000 title abstract 3
230000003042 antagnostic effect Effects 0.000 title abstract 2
230000001882 diuretic effect Effects 0.000 title abstract 2
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
239000002934 diuretic Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
150000001450 anions Chemical class 0.000 abstract 1
230000002213 calciumantagonistic effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

DK96115146T 1993-06-07 1994-06-07 Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika DK0753301T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP13552493		1993-06-07

Publications (1)

Publication Number	Publication Date
DK0753301T3 true DK0753301T3 (da)	2003-07-21

Family

ID=15153791

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96115146T DK0753301T3 (da)	1993-06-07	1994-06-07	Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika

Country Status (9)

Country	Link
EP (6)	EP1306089B1 (fr)
AT (4)	ATE239471T1 (fr)
CA (1)	CA2125251C (fr)
CY (1)	CY2370B1 (fr)
DE (4)	DE69434560T2 (fr)
DK (1)	DK0753301T3 (fr)
ES (1)	ES2193217T3 (fr)
PT (1)	PT753301E (fr)
SG (1)	SG45336A1 (fr)

Families Citing this family (28)

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WO1995033456A2 (fr) *	1994-06-07	1995-12-14	Telor Ophthalmic Pharmaceuticals, Inc.	Reduction de la pression intraoculaire au moyen d'acide aryloxyacetique et d'acide arylacetique
US5763491A (en) *	1994-12-09	1998-06-09	The Regents Of The University Of California	Method for enhancing outflow of aqueous humor in treatment of glaucoma
US6228873B1 (en)	1994-12-09	2001-05-08	The Regents Of The University Of California	Method for enhancing outflow of aqueous humor in treatment of glaucoma
WO1996018386A1 (fr) *	1994-12-14	1996-06-20	Enbalt Trading Limited	Formulations de comprimes pharmaceutiques elabores par compression directe
DK0831910T3 (da) *	1995-06-07	2002-05-21	Searle & Co	Kombinationsterapi med epoxy-steroid aldosteronantagonist og angiotensin II-receptorantagonist til behandling af kongestivt hjertesvigt
WO1996040256A1 (fr) *	1995-06-07	1996-12-19	G.D. Searle & Co.	Procede de traitement de la cardiofibrose avec une combinaison de spironolactone et d'un antagoniste de l'angiotensive ii
WO1996040258A2 (fr) *	1995-06-07	1996-12-19	G.D. Searle & Co.	Therapie mixte a base de spironolactone et d'un antagoniste de l'angiotensine ii pour le traitement de l'insuffisance cardiaque globale
PL189066B1 (pl) *	1996-04-05	2005-06-30	Takeda Pharmaceutical	Kompozycja farmaceutyczna do zapobiegania lub zwalczania chorób związanych z angiotensyną II oraz stosowanie związków do wytwarzania leku do zapobiegania lub zwalczania chorób związanych z angiotensyną II
WO1999012534A1 (fr) *	1997-09-10	1999-03-18	Ono Pharmaceutical Co., Ltd.	Regulateurs des recepteurs actives par le proliferateur des peroxisomes
NZ509260A (en) *	1998-07-10	2003-09-26	Novartis Ag	Pharmaceutical composition containing valsartan and a calcium channel blocker
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
WO2001055093A1 (fr) *	2000-01-25	2001-08-02	Japan Tobacco Inc.	Composes a base de n-arylhydrazide et leur utilisation en tant que medicaments
EP1329218A4 (fr) *	2000-10-25	2007-04-04	Takeda Pharmaceutical	Agents preventifs/remedes destines a l'hypertension portale
US20040087484A1 (en) *	2000-12-01	2004-05-06	Sahota Pritam Singh	Combination of organic compounds
WO2003047573A1 (fr) *	2001-12-03	2003-06-12	Takeda Chemical Industries, Ltd.	Agents pour améliorer l'état de résistance à l'insuline
WO2003049745A1 (fr)	2001-12-12	2003-06-19	Pharmacia Corporation	Methode de traitement de troubles ophtalmiques a l'aide d'antagonistes epoxy-steroidiens des recepteurs de l'aldosterone
EG24716A (en)	2002-05-17	2010-06-07	Novartis Ag	Combination of organic compounds
MXPA05008142A (es) *	2003-01-31	2005-09-30	Sankyo Co	Medicamento para la profilaxis y el tratamiento de arteriosclerosis e hipertension.
CA2525970C (fr)	2003-05-15	2011-03-22	Roskamp Research, Llc	Utilisation de nilvadipine comme moyen de reduire le depot de substances amyloides, la neurotoxicite de substances amyloides et la microgliose
GB0322552D0 (en)	2003-09-26	2003-10-29	Astrazeneca Uk Ltd	Therapeutic treatment
TWI500422B (zh)	2007-10-05	2015-09-21	Alzheimer S Inst Of America Inc	以（－）－尼代地平（ｎｉｌｖａｄｉｐｉｎｅ）對映異構物減低類澱粉沉積、類澱粉神經毒性及微神經膠細胞增生之方法
AR072883A1 (es) *	2008-07-31	2010-09-29	Takeda Pharmaceutical	COMPOSICIoN FARMACÉUTICA SoLIDA CON EL COMPUESTO (5-METIL-2-OXO-1,3-DIOXOL-4-IL)METIL2-ETOXI-1-{[2' -(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-1H-BENCIMIDAZOL-7-CARBOXILATO Y UN DIURÉTICO PARA LA PROFILAXIS O TRATAMIENTO DE ENFERMEDADES DEL APARATO CIRCULATORIO.
TW201014850A (en)	2008-09-25	2010-04-16	Takeda Pharmaceutical	Solid pharmaceutical composition
DE102008059206A1 (de)	2008-11-27	2010-06-10	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
WO2010075347A2 (fr) *	2008-12-23	2010-07-01	Takeda Pharmaceutical Company Limited	Méthode de traitement de l'hypertension avec au moins un agent bloquant les récepteurs d'angiotensine ii et de la chlorthalidone
AU2010242308A1 (en) *	2009-04-30	2011-12-01	Takeda Pharmaceutical Company Limited	Solid preparation
TR201004754A1 (tr) *	2010-06-11	2012-01-23	Sanovel �La� San. Ve T�C. A.�.	Yeni Farmasötik Kombinasyonlar
CA2872542A1 (fr)	2012-05-07	2013-11-14	Bayer Pharma Aktiengesellschaft	Procede pour fabriquer une forme pharmaceutique comprenant de la nifedipine et du candesartan cilexetil

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0400835A1 (fr) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Benzimidazoles substitués comme antagoniste d'angiotensine II
IL95975A (en)	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5196444A (en)	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
ES2121773T3 (es) *	1990-06-08	1998-12-16	Hoechst Marion Roussel Inc	Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
AU656551B2 (en) *	1990-12-14	1995-02-09	Smithkline Beecham Corporation	Angiotensin II receptor blocking compositions
FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
TW300219B (fr) *	1991-09-14	1997-03-11	Hoechst Ag
TW284688B (fr) *	1991-11-20	1996-09-01	Takeda Pharm Industry Co Ltd
GB2270841A (en) *	1992-09-09	1994-03-30	Merck & Co Inc	Compositions for Treating vascular restenosis
AU5449194A (en) *	1992-10-26	1994-05-24	Merck & Co., Inc.	Combinations of angiotensin-ii receptor antagonists and diuretics
CA2181461A1 (fr) *	1994-02-08	1995-08-17	Alica Huxley	Antagonistes de l'angiotensine ii destines au traitement du glaucome normotensif

1994
- 1994-06-06 CA CA002125251A patent/CA2125251C/fr not_active Expired - Lifetime
- 1994-06-07 EP EP03001570A patent/EP1306089B1/fr not_active Expired - Lifetime
- 1994-06-07 EP EP10178599A patent/EP2277520A3/fr not_active Withdrawn
- 1994-06-07 EP EP03001569A patent/EP1306088B1/fr not_active Expired - Lifetime
- 1994-06-07 DE DE69434560T patent/DE69434560T2/de not_active Expired - Lifetime
- 1994-06-07 DE DE69435021T patent/DE69435021T2/de not_active Expired - Lifetime
- 1994-06-07 EP EP07014995A patent/EP1844774A3/fr not_active Ceased
- 1994-06-07 AT AT96115146T patent/ATE239471T1/de active
- 1994-06-07 ES ES96115146T patent/ES2193217T3/es not_active Expired - Lifetime
- 1994-06-07 EP EP94108687A patent/EP0628313B1/fr not_active Expired - Lifetime
- 1994-06-07 AT AT94108687T patent/ATE311188T1/de not_active IP Right Cessation
- 1994-06-07 EP EP96115146A patent/EP0753301B1/fr not_active Revoked
- 1994-06-07 AT AT03001570T patent/ATE372116T1/de not_active IP Right Cessation
- 1994-06-07 DE DE69432644T patent/DE69432644T2/de not_active Expired - Lifetime
- 1994-06-07 DE DE69435022T patent/DE69435022T2/de not_active Expired - Lifetime
- 1994-06-07 DK DK96115146T patent/DK0753301T3/da active
- 1994-06-07 SG SG1996003825A patent/SG45336A1/en unknown
- 1994-06-07 PT PT96115146T patent/PT753301E/pt unknown
- 1994-06-07 AT AT03001569T patent/ATE372115T1/de not_active IP Right Cessation
2003
- 2003-08-04 CY CY0300054A patent/CY2370B1/xx unknown

Also Published As

Publication number	Publication date
ATE311188T1 (de)	2005-12-15
EP2277520A2 (fr)	2011-01-26
EP1844774A2 (fr)	2007-10-17
EP2277520A3 (fr)	2011-08-24
ATE372116T1 (de)	2007-09-15
EP0628313A1 (fr)	1994-12-14
DE69434560D1 (de)	2006-01-05
DE69432644D1 (de)	2003-06-12
EP0628313B1 (fr)	2005-11-30
DE69435022T2 (de)	2008-05-29
DE69435022D1 (de)	2007-10-18
ATE239471T1 (de)	2003-05-15
EP1844774A3 (fr)	2008-08-20
DE69435021T2 (de)	2008-05-29
CA2125251A1 (fr)	1994-12-08
PT753301E (pt)	2003-08-29
EP1306088A1 (fr)	2003-05-02
SG45336A1 (en)	1998-01-16
EP1306089B1 (fr)	2007-09-05
CA2125251C (fr)	2005-04-26
ES2193217T3 (es)	2003-11-01
CY2370B1 (en)	2004-06-04
EP1306089A1 (fr)	2003-05-02
EP0753301B1 (fr)	2003-05-07
EP0753301A1 (fr)	1997-01-15
DE69432644T2 (de)	2003-11-27
EP1306088B1 (fr)	2007-09-05
DE69435021D1 (de)	2007-10-18
ATE372115T1 (de)	2007-09-15
DE69434560T2 (de)	2006-06-08

Publication	Publication Date	Title
DK0753301T3 (da)	2003-07-21	Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika
ES2065182T3 (es)	1995-02-01	Derivados de fenilamidinas utiles como inhibidores de la agregacion de plaquetas.
ATE273305T1 (de)	2004-08-15	Thrombin-inhibitoren
FI98367B (fi)	1997-02-28	Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksi
DK0889876T3 (da)	2001-09-24	Meta-substituerede phenylensulfonamidderivater
ATE297203T1 (de)	2005-06-15	Antithrombotische mitteln
ATE170845T1 (de)	1998-09-15	Plättchenaggregationsinhibitoren
ATE227293T1 (de)	2002-11-15	2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
CY2204B1 (en)	2002-11-08	Angiotensin ii antagonists as a prophylactic or therapeutic drug for renal diseases
EA199800602A1 (ru)	1998-12-24	N-ацил-2-замещенный-4-(бензимидазолил- или имидазопиридинил -замещенные остатки)-пиперидины как антагонисты тахикинина
ES2110115T3 (es)	1998-02-01	Inhibidores de la agregacion de plaquetas.
EP1329218A4 (fr)	2007-04-04	Agents preventifs/remedes destines a l'hypertension portale
FI935800A0 (fi)	1993-12-22	Antidepressiva och mot Parkisons sjukdom verksamma foereningar
KR970703301A (ko)	1997-07-03	신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative)
ATE73795T1 (de)	1992-04-15	Thioformamid-derivate.
DK378087D0 (da)	1987-07-20	Tetracycliske indolderivater
ATE109485T1 (de)	1994-08-15	Derivate von n-(vincristinyl-23) und n- (noranhydro-5-vinblastinyl-23) von amino-1- methylphosphonsäure, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
IT1274022B (it)	1997-07-14	Derivati della cumarina ad attivita' farmacologica, loro uso e composizioni farmaceutiche che li contengono
EA200200636A1 (ru)	2002-12-26	Новые соединения 3-имино-1,2-дитиола, способ их получения и фармацевтические композиции, их содержащие