DK0762877T3 - Meta-substituerede arylalkylaminer og terapeutiske og diagnostiske anvendelser deraf - Google Patents

Meta-substituerede arylalkylaminer og terapeutiske og diagnostiske anvendelser deraf

Info

Publication number
DK0762877T3
DK0762877T3 DK95922166T DK95922166T DK0762877T3 DK 0762877 T3 DK0762877 T3 DK 0762877T3 DK 95922166 T DK95922166 T DK 95922166T DK 95922166 T DK95922166 T DK 95922166T DK 0762877 T3 DK0762877 T3 DK 0762877T3
Authority
DK
Denmark
Prior art keywords
meta
therapeutic
diagnostic uses
substituted arylalkylamines
compounds
Prior art date
Application number
DK95922166T
Other languages
English (en)
Inventor
David R Elmaleh
Allan J Fischman
Original Assignee
Thejmde Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/265,512 external-priority patent/US6004990A/en
Application filed by Thejmde Trust filed Critical Thejmde Trust
Application granted granted Critical
Publication of DK0762877T3 publication Critical patent/DK0762877T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
DK95922166T 1994-06-03 1995-06-02 Meta-substituerede arylalkylaminer og terapeutiske og diagnostiske anvendelser deraf DK0762877T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25403294A 1994-06-03 1994-06-03
US08/265,512 US6004990A (en) 1994-06-03 1994-06-24 Meta substituted arylalkylamines and therapeutic and diagnostic uses therefor
PCT/US1995/006950 WO1995033455A1 (en) 1994-06-03 1995-06-02 Meta substituted arylalkylamines and therapeutic and diagnostic uses thereof

Publications (1)

Publication Number Publication Date
DK0762877T3 true DK0762877T3 (da) 2001-07-16

Family

ID=26943786

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95922166T DK0762877T3 (da) 1994-06-03 1995-06-02 Meta-substituerede arylalkylaminer og terapeutiske og diagnostiske anvendelser deraf

Country Status (12)

Country Link
US (2) US5587398A (da)
EP (1) EP0762877B1 (da)
JP (1) JP3839049B2 (da)
AT (1) ATE199829T1 (da)
AU (1) AU707142B2 (da)
CA (1) CA2191996A1 (da)
DE (1) DE69520430T2 (da)
DK (1) DK0762877T3 (da)
ES (1) ES2157330T3 (da)
GR (1) GR3036072T3 (da)
PT (1) PT762877E (da)
WO (1) WO1995033455A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
CZ20003355A3 (cs) * 1998-03-17 2002-05-15 Pfizer Products Inc. Bicyklo[2,2,1]heptany a příbuzné sloučeniny, farmaceutické kompozice a způsoby léčení na jejich bázi
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
WO2003092614A2 (en) * 2002-05-02 2003-11-13 Hickle Randall S Lipid removal from the body
US8227499B2 (en) * 2008-01-18 2012-07-24 Allergan, Inc. Substituted-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
MX378188B (es) 2014-09-29 2025-03-10 Zogenix International Ltd Sistema de control para el control de distribucion de medicacion.
EP3170807B1 (en) 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine
WO2017112701A1 (en) * 2015-12-22 2017-06-29 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
HUE053114T2 (hu) * 2015-12-22 2021-06-28 Zogenix International Ltd Fenfluramin kompozíciók és eljárások azok elõállítására
WO2018037306A1 (en) 2016-08-24 2018-03-01 Zogenix International Limited Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
CA3097335A1 (en) 2018-05-11 2019-11-14 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
KR20210061332A (ko) 2018-07-27 2021-05-27 제논 파마슈티칼스 인크. 뇌전증 치료 방법
SG11202104378SA (en) 2018-11-19 2021-05-28 Zogenix International Ltd Methods of treating rett syndrome using fenfluramine
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6626M (da) * 1967-09-22 1969-01-13
DE1802297C3 (de) * 1967-10-25 1974-10-17 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt, Budapest Isopropylaminderivate und Verfahren zu ihrer Herstellung
US3573304A (en) * 1968-12-03 1971-03-30 Delalande Sa 1-dimethylamino - 3 - methyl-2(pyridyl or pyridazinyl) pentane and the corresponding non-toxic acid addition salts thereof
US3856857A (en) * 1970-02-13 1974-12-24 En Nom Collectif Science Union Amino acids and their derivatives
US3733339A (en) * 1970-10-05 1973-05-15 Abbott Lab Disubstituted propionamides
USB787097I5 (da) * 1971-06-04
BE791772A (fr) * 1971-06-11 1973-03-16 Buzas Andre Derives d'acides phenoxy-acetiques, leur preparation et leur application en therapeutique
BE795041A (fr) * 1972-02-07 1973-08-06 Science Union & Cie Nouveaux derives de l'amino-propane
GB1434088A (en) * 1973-08-16 1976-04-28 Science Union & Cie N-substituted glycinates a process for their preparation and pharmaceutical compositions containing them
US4025624A (en) * 1975-11-18 1977-05-24 A. H. Robins Company, Incorporated Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
US4115587A (en) * 1976-02-04 1978-09-19 A. H. Robins Company, Inc. Fatty acid amides of norfenfluramine and compositions and methods thereof
US4237165A (en) * 1976-06-04 1980-12-02 Science Union Et Cie Treatment of carbohydrate metabolism disorders
FR2508442A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation d'ethylamines b-cyclo-substituees et produits ainsi obtenus
HU207282B (en) * 1984-05-31 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them
HU197510B (en) * 1986-12-19 1989-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing phenyl-alkyl-amine derivatives, against motion-sick
US4857553A (en) * 1987-08-06 1989-08-15 A. H. Robins Company, Incorporated Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents
DE3856295T2 (de) * 1987-10-22 1999-06-17 Massachusetts Institute Of Technology, Cambridge, Mass. Behandlung des prämenstruellen oder späten lutealsphase-syndroms
GB8807504D0 (en) * 1988-03-29 1988-05-05 Sandoz Ltd Improvements in/relating to organic compounds
US4999382A (en) * 1988-10-26 1991-03-12 Massachusetts Institute Of Technology Compositions for treating tobacco withdrawal symptoms and methods for their use
GB9011767D0 (en) * 1990-05-25 1990-07-18 Britannia Pharmaceuticals Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
PT762877E (pt) 2001-08-30
DE69520430T2 (de) 2001-10-18
DE69520430D1 (de) 2001-04-26
US5587398A (en) 1996-12-24
JPH10501239A (ja) 1998-02-03
GR3036072T3 (en) 2001-09-28
ES2157330T3 (es) 2001-08-16
AU2695095A (en) 1996-01-04
EP0762877B1 (en) 2001-03-21
HK1014671A1 (en) 1999-09-30
JP3839049B2 (ja) 2006-11-01
WO1995033455A1 (en) 1995-12-14
CA2191996A1 (en) 1995-12-14
EP0762877A1 (en) 1997-03-19
US6313175B1 (en) 2001-11-06
ATE199829T1 (de) 2001-04-15
AU707142B2 (en) 1999-07-01

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