DK0775156T3 - Farmaceutiske sammensætninger med estra-1,3,5(19)-trien-derivater - Google Patents

Farmaceutiske sammensætninger med estra-1,3,5(19)-trien-derivater

Info

Publication number: DK0775156T3
Authority: DK; Denmark
Prior art keywords: estra; pharmaceutical compositions; triene derivatives; whereinr; group
Prior art date: 1994-08-09

Application number

DK95925680T

Other languages

English (en)

Inventor

Sigfrid Schwarz

Walter Elger

Hans-Joachim Siemann

Gudrun Reddersen

Birgitt Schneider

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-09

Filing date

1995-07-03

Publication date

2003-12-29

1995-07-03 Application filed by Schering Ag filed Critical Schering Ag

2003-12-29 Application granted granted Critical

2003-12-29 Publication of DK0775156T3 publication Critical patent/DK0775156T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical compound C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000002154 estra-1,3,5(10)-trienes Chemical class 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
-1 polymethylene Polymers 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000009256 replacement therapy Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK95925680T 1994-08-09 1995-07-03 Farmaceutiske sammensætninger med estra-1,3,5(19)-trien-derivater DK0775156T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4429398A DE4429398C2 (de)	1994-08-09	1994-08-09	Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
PCT/DE1995/000879 WO1996005217A1 (de)	1994-08-09	1995-07-03	Pharmazeutische zusammensetzungen mit estra-1,3,5(10)-trien-derivaten

Publications (1)

Publication Number	Publication Date
DK0775156T3 true DK0775156T3 (da)	2003-12-29

Family

ID=6526061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95925680T DK0775156T3 (da)	1994-08-09	1995-07-03	Farmaceutiske sammensætninger med estra-1,3,5(19)-trien-derivater

Country Status (23)

Country	Link
US (2)	US6569844B1 (da)
EP (1)	EP0775156B1 (da)
JP (1)	JP4023820B2 (da)
KR (1)	KR100243537B1 (da)
CN (1)	CN1160404A (da)
AT (1)	ATE248853T1 (da)
AU (1)	AU2974295A (da)
BG (1)	BG63273B1 (da)
BR (1)	BR9508868A (da)
CA (1)	CA2196678A1 (da)
CZ (1)	CZ289452B6 (da)
DE (4)	DE4429398C2 (da)
DK (1)	DK0775156T3 (da)
ES (1)	ES2206515T3 (da)
IL (1)	IL114780A0 (da)
MY (1)	MY114394A (da)
NO (1)	NO970569L (da)
PL (1)	PL181636B1 (da)
PT (1)	PT775156E (da)
RU (1)	RU2179442C2 (da)
SK (1)	SK283644B6 (da)
UA (1)	UA48143C2 (da)
WO (1)	WO1996005217A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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GB9625334D0 (en) *	1996-12-05	1997-01-22	Imperial College	Compound
US6642220B1 (en)	1996-12-05	2003-11-04	Sterix Limited	Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
DE19712488A1 (de)	1997-03-25	1998-10-01	Knoell Hans Forschung Ev	Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
DE19753363A1 (de) *	1997-12-02	1999-06-10	Jenapharm Gmbh	15-Methyl-cyclopropanosteroide und Verfahren zu ihrer Herstellung
DE19821831A1 (de) *	1998-05-15	1999-11-18	Jenapharm Gmbh	Pharmazeutische Präparate zur gezielten Substitution des Estrogenmangels im Zentralnervensystem
CA2329005C (en) *	1998-04-17	2006-01-03	Ortho-Mcneil Pharmaceutical, Inc.	Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
DE19834931A1 (de) *	1998-07-28	2000-02-24	Jenapharm Gmbh	Verwendung von biogenen Estrogenen zur Hormonsubstitutionstherapie
DE19906152B4 (de)	1999-02-10	2005-02-10	Jenapharm Gmbh & Co. Kg	Wirkstoffhaltige Laminate für Transdermalsysteme
EP1605949A2 (en)	1999-08-31	2005-12-21	Schering Aktiengesellschaft	Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
DE10027887A1 (de) *	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0025788D0 (en) *	2000-10-20	2000-12-06	Sterix Ltd	Use
WO2003006027A1 (en) *	2001-07-13	2003-01-23	Schering Aktiengesellschaft	Combination of drospirenone and an estrogen sulphamate for hrt
DE10139494A1 (de) *	2001-08-13	2003-03-06	Jenapharm Gmbh	Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en)	2001-08-13	2011-09-27	Sterix Limited	Antitumor-active 2-alkoxyestradiol sulfamates
TWI252111B (en) *	2001-12-14	2006-04-01	Solvay Pharm Gmbh	Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
EP1358882A1 (en) *	2002-04-30	2003-11-05	Schering Aktiengesellschaft	Use of estriol sulfamate prodrugs for the treatment of autoimmune diseases
DE10307103A1 (de) *	2003-02-19	2004-09-09	Schering Ag	Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) *	2003-02-19	2004-09-09	Schering Ag	Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de)	2003-02-19	2004-09-23	Schering Ag	Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
WO2004098538A2 (en) *	2003-03-13	2004-11-18	Nitromed, Inc.	Nitrosated and nitrosylated compounds, compositions and methods of use
US20050277625A1 (en) *	2004-05-21	2005-12-15	Ralf Wyrwa	Estriol and estetrol prodrugs
US7534780B2 (en) *	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
US20070197488A1 (en) *	2005-11-29	2007-08-23	Olaf Peters	Prodrugs of ERbeta-selective substances, process for their production, and pharmaceutical compositions that contain these compounds
US20070123500A1 (en) *	2005-11-29	2007-05-31	Gerd Mueller	Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds
US20070135399A1 (en) *	2005-11-30	2007-06-14	Ralf Wyrwa	Heteroaromatic sulphonamide prodrugs
US20070135375A1 (en) *	2005-11-30	2007-06-14	Ralf Wyrwa	Sulfamoyl sulfonate prodrugs
MX364743B (es)	2013-07-11	2019-05-06	Evestra Inc	Profármacos de formación de compuestos.
CN105753924B (zh) *	2016-02-03	2017-11-10	中国药科大学	新型甾体类选择性雌激素受体调节剂、其制备方法及其医药用途
BR112020007673A2 (pt)	2017-10-19	2020-10-13	Evestra, Inc.	contraceptivos pró-fármaco de progestina de ação prolongada

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DE207447C (da) *
DE114806C (da) *
FR2133484A2 (en) *	1969-04-29	1972-12-01	Jenapharm Veb	3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration
GB1317373A (en) *	1971-03-11	1973-05-16	Jenapharm Veb	Steroid esters
GB1398026A (en) *	1972-11-10	1975-06-18	Jenapharm Veb	Steroid esters
DE2426777A1 (de) *	1974-05-31	1975-12-18	Schering Ag	1.3-oxygenierte 8 alpha-oestratriene
US3911841A (en) *	1974-07-24	1975-10-14	Singer Co	Looptaker drive for a sewing machine
DD114806A1 (da) *	1974-10-11	1975-08-20
DD145919B1 (de) *	1978-06-28	1982-06-30	Kurt Ponsold	Verfahren zur herstellung von 14,1 -methylenderivaten der oestranreihe
DD201143B1 (de) *	1981-11-17	1986-12-17	Jenapharm Veb	Verfahren zur herstellung von 9,11-tritiummarkierten gonatriensulfonaten
DD207447A3 (de) *	1982-04-02	1984-02-29	Jenapharm Veb	Mittel zur chemosterilisation von schadnagetieren
US4970205A (en) *	1988-12-23	1990-11-13	Smithkline Beecham Corporation	Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
RU2087479C1 (ru) *	1989-11-29	1997-08-20	Шеринг Аг	Эстратриены, содержащие мостик
GB9118478D0 (en) *	1991-08-29	1991-10-16	Imperial College	Steroid sulphatase inhibitors
JP2700595B2 (ja) *	1992-05-21	1998-01-21	呉羽化学工業株式会社	アゾール誘導体を含有する抗アロマターゼ剤
DE4222316A1 (de) *	1992-07-03	1994-01-05	Schering Ag	Verfahren zur Herstellung von Etheno- und Ethano-16â,17µ-Steroiddiolen und deren Derivaten

1994
- 1994-08-09 DE DE4429398A patent/DE4429398C2/de not_active Expired - Fee Related
- 1994-08-09 DE DE4447715A patent/DE4447715C2/de not_active Expired - Fee Related
- 1994-08-09 DE DE4447714A patent/DE4447714C2/de not_active Expired - Fee Related
1995
- 1995-03-07 UA UA97031027A patent/UA48143C2/uk unknown
- 1995-07-03 CA CA002196678A patent/CA2196678A1/en not_active Abandoned
- 1995-07-03 AT AT95925680T patent/ATE248853T1/de active
- 1995-07-03 WO PCT/DE1995/000879 patent/WO1996005217A1/de not_active Ceased
- 1995-07-03 BR BR9508868A patent/BR9508868A/pt not_active Application Discontinuation
- 1995-07-03 EP EP95925680A patent/EP0775156B1/de not_active Expired - Lifetime
- 1995-07-03 CZ CZ1997273A patent/CZ289452B6/cs not_active IP Right Cessation
- 1995-07-03 RU RU97104120/14A patent/RU2179442C2/ru not_active IP Right Cessation
- 1995-07-03 JP JP50689996A patent/JP4023820B2/ja not_active Expired - Lifetime
- 1995-07-03 PT PT95925680T patent/PT775156E/pt unknown
- 1995-07-03 DK DK95925680T patent/DK0775156T3/da active
- 1995-07-03 US US08/750,930 patent/US6569844B1/en not_active Expired - Lifetime
- 1995-07-03 AU AU29742/95A patent/AU2974295A/en not_active Abandoned
- 1995-07-03 DE DE59510788T patent/DE59510788D1/de not_active Expired - Lifetime
- 1995-07-03 CN CN95195001A patent/CN1160404A/zh active Pending
- 1995-07-03 SK SK162-97A patent/SK283644B6/sk unknown
- 1995-07-03 PL PL95318530A patent/PL181636B1/pl not_active IP Right Cessation
- 1995-07-03 KR KR1019970700812A patent/KR100243537B1/ko not_active Expired - Fee Related
- 1995-07-03 ES ES95925680T patent/ES2206515T3/es not_active Expired - Lifetime
- 1995-07-30 IL IL11478095A patent/IL114780A0/xx unknown
- 1995-07-31 MY MYPI95002212A patent/MY114394A/en unknown
1997
- 1997-02-04 BG BG101190A patent/BG63273B1/bg unknown
- 1997-02-07 NO NO970569A patent/NO970569L/no unknown
2001
- 2001-11-21 US US09/999,087 patent/US6841548B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BG101190A (en)	1998-03-31
AU2974295A (en)	1996-03-07
MY114394A (en)	2002-10-31
SK283644B6 (sk)	2003-11-04
US6841548B2 (en)	2005-01-11
UA48143C2 (uk)	2002-08-15
DE59510788D1 (de)	2003-10-09
ES2206515T3 (es)	2004-05-16
BG63273B1 (bg)	2001-08-31
NO970569L (no)	1997-04-08
SK16297A3 (en)	1997-08-06
EP0775156A1 (de)	1997-05-28
JP4023820B2 (ja)	2007-12-19
KR100243537B1 (ko)	2000-02-01
DE4447714C2 (de)	1998-02-05
CZ27397A3 (en)	1997-08-13
CN1160404A (zh)	1997-09-24
RU2179442C2 (ru)	2002-02-20
CZ289452B6 (cs)	2002-01-16
IL114780A0 (en)	1995-11-27
ATE248853T1 (de)	2003-09-15
DE4429398A1 (de)	1996-02-15
US6569844B1 (en)	2003-05-27
PL181636B1 (pl)	2001-08-31
PL318530A1 (en)	1997-06-23
NO970569D0 (no)	1997-02-07
JPH10507741A (ja)	1998-07-28
CA2196678A1 (en)	1996-02-22
DE4429398C2 (de)	1997-09-11
WO1996005217A1 (de)	1996-02-22
US20020061868A1 (en)	2002-05-23
KR970704771A (ko)	1997-09-06
EP0775156B1 (de)	2003-09-03
BR9508868A (pt)	1997-10-28
PT775156E (pt)	2004-01-30
DE4447715C2 (de)	1998-02-05

Publication	Publication Date	Title
NO970569D0 (no)	1997-02-07	Farmsöytiske sammensetninger inneholdende östra-1,3,5(10)-trienderivater
RU97104120A (ru)	1999-04-20	Фармацевтические композиции, содержащие производные эстра-1,3,5(10)-триена
ES2174629T3 (es)	2002-11-01	14,15-ciclopropano-esteroides de la serie de los 19-nor-androstanos, procedimiento para su preparacion y formulaciones farmaceuticas que contienen estos compuestos.
BRPI0416924A (pt)	2007-01-16	preparação farmacêutica para tratamento hormonal contìnuo durante um perìodo de mais do que 21-28 dias compreendendo duas composições de estrogênio e/ou progestina
CY1105276T1 (el)	2010-03-03	Τριφασικο στοματικο αντισυλληπτικο
DK0728140T3 (da)	2001-12-10	Hidtil ukendte steroider med radikofile substituenter, fremgangsmåde til deres fremstilling og lægemidler indholdende disse forbindelser
FI970526A7 (fi)	1997-02-07	Estra-1,3,5(10)-trieenijohdannaiset, niiden valmistusmenetelmät sekä n äitä yhdisteitä sisältävät farmaseuttiset koostumukset
AP2001002054A0 (en)	2001-03-31	Use of biogenic estrogen sulfamates for hormone replacement therapy.
HUP0003274A2 (hu)	2001-05-28	Fenil-metil-benzokinon-származékok, és ezeket a vegyületeket tartalmazó NF-kB inhibitor hatású gyógyszerkészítmények
MX9207394A (es)	1993-07-30	Esteroides de 17-espirofuran-3'-ilideno.
ES8502709A1 (es)	1985-02-01	Procedimiento para la preparacion de 1-alquil-androsta-1,4-dien-3,17-dionas
ES2107806T3 (es)	1997-12-01	Nuevos esteroides.
FR2623504B1 (fr)	1990-03-09	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DK0533827T3 (da)	1994-09-26	Oxazolderivater, deres fremstilling og farmaceutiske præparater deraf
IL95762A0 (en)	1991-06-30	Benzanilides,their preparation and pharmaceutical compositions containing the same
CA2486495A1 (en)	2003-12-18	9-alpha-substituted estratrienes as selectively active estrogens
TR200003142T2 (tr)	2001-03-21	Yeni oktahidro-6,10-diokso-6H-piridazino [1,2-A] [1,2] diazepin-1-karboksilik asit türevleri.
AR010857A1 (es)	2000-07-12	Esteroides sustituidos en la posicion 11, su procedimiento de preparacion, su aplicacion como medicamento y las composiciones farmaceuticas que loscontienen
ES2104736T3 (es)	1997-10-16	Esteroides con puente de 2beta,19-metileno-amino utilizados como inhibidores de aromatasa.
CA2208605A1 (en)	1996-07-04	14.alpha.,17.alpha.-c2-bridged 19-nor-progesterone derivatives
IE34308L (en)	1970-12-16	11ß, 13ß-DIALKYLGONA-1,3,5(10)-TRIEN-3-OL 3-CYCLOALKYL¹ETHERS
DK1219632T3 (da)	2006-12-04	Steroider, deres fremstilling, farmaceutiske præparater deraf og anvendelser af forbindelserne
AR034194A1 (es)	2004-02-04	Un compuesto esteroide, su uso, una composicion farmaceutica que lo comprende y un kit para la anticoncepcion masculina
AU2291183A (en)	1984-07-05	4-hydroxy-benzhydrol derivatives
TR200003857T2 (tr)	2001-06-21	17 Konumunda halojenlenmiş yeni 19-nor steroitler.