DK0782573T3 - Brefeldin og analoger til forbedret synaptisk transmission - Google Patents

Brefeldin og analoger til forbedret synaptisk transmission

Info

Publication number: DK0782573T3
Authority: DK; Denmark
Prior art keywords: brefeldin; analogs; synaptic transmission; enhanced synaptic; enhanced
Prior art date: 1994-09-20

Application number

DK95930845T

Other languages

English (en)

Inventor

Katumi Sumikawa

Ken-Ichi Ito

James L Mcgaugh

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-20

Filing date

1995-08-16

Publication date

2000-06-05

1995-08-16 Application filed by Univ California filed Critical Univ California

2000-06-05 Application granted granted Critical

2000-06-05 Publication of DK0782573T3 publication Critical patent/DK0782573T3/da

Links

230000005062 synaptic transmission Effects 0.000 title 1
KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 abstract 1
JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 abstract 1
230000000971 hippocampal effect Effects 0.000 abstract 1
230000027928 long-term synaptic potentiation Effects 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicinal Preparation (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK95930845T 1994-09-20 1995-08-16 Brefeldin og analoger til forbedret synaptisk transmission DK0782573T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30987194A	1994-09-20	1994-09-20
PCT/US1995/010454 WO1996009299A1 (en)	1994-09-20	1995-08-16	Drugs to improved synaptic transmission

Publications (1)

Publication Number	Publication Date
DK0782573T3 true DK0782573T3 (da)	2000-06-05

Family

ID=23200041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95930845T DK0782573T3 (da)	1994-09-20	1995-08-16	Brefeldin og analoger til forbedret synaptisk transmission

Country Status (11)

Country	Link
US (2)	US6710073B1 (da)
EP (1)	EP0782573B1 (da)
JP (1)	JPH10508579A (da)
KR (1)	KR970706271A (da)
AT (1)	ATE190056T1 (da)
AU (1)	AU703667B2 (da)
DE (1)	DE69515321T2 (da)
DK (1)	DK0782573T3 (da)
ES (1)	ES2143068T3 (da)
NO (1)	NO315929B1 (da)
WO (1)	WO1996009299A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001512422A (ja) *	1997-02-05	2001-08-21	アレリツクス・フアーム−エコ・エル・ピー	記憶増強のための薬剤
GB0117645D0 (en) *	2001-07-19	2001-09-12	Isis Innovation	Therapeutic stratergies for prevention and treatment of alzheimers disease
WO2009019032A2 (en) *	2003-08-08	2009-02-12	Dsm Ip Assets B.V.	Novel method for screening brain-active compounds
ES2572831T3 (es)	2012-09-14	2016-06-02	Abbott Laboratories	Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
DK2708147T3 (da) *	2012-09-14	2020-05-18	Abbott Lab	Fremgangsmåder til forøgelse af hjernefunktionalitet under anvendelse af 2-fucosyl-lactose
CN112851622B (zh)	2019-11-28	2023-01-10	中国海洋大学	一种大环内酯布雷菲德菌素a酯类衍生物及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5611710B2 (da) *	1972-09-13	1981-03-16
JPS57159710A (en) *	1981-03-28	1982-10-01	Koki Yagishita	Antifungal germicide
DE3247379A1 (de) *	1982-12-22	1984-06-28	Basf Ag, 6700 Ludwigshafen	Brefeldin-a-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
MW187A1 (en) *	1986-01-23	1987-10-14	Hoffmann La Roche	Benzazecine derivatives
US5214039A (en) *	1990-02-02	1993-05-25	Taiho Pharmaceutical Co., Limited	Bicyclolactam derivative for improving cerebral function
US5242932A (en)	1991-12-17	1993-09-07	The Rockefeller University	Treatment of amyloidosis associated with alzheimer disease
DE4305249A1 (de) *	1993-02-20	1994-08-25	Hoechst Ag	Galaktosylbrefeldin A, ein neuer Metabolit mit pharmakologischer Wirkung, ein Verfahren zu seiner Herstellung und seine Verwendung

1995
- 1995-08-16 AU AU34076/95A patent/AU703667B2/en not_active Ceased
- 1995-08-16 DE DE69515321T patent/DE69515321T2/de not_active Expired - Fee Related
- 1995-08-16 EP EP95930845A patent/EP0782573B1/en not_active Expired - Lifetime
- 1995-08-16 AT AT95930845T patent/ATE190056T1/de not_active IP Right Cessation
- 1995-08-16 KR KR1019970701788A patent/KR970706271A/ko not_active Withdrawn
- 1995-08-16 JP JP8510883A patent/JPH10508579A/ja active Pending
- 1995-08-16 WO PCT/US1995/010454 patent/WO1996009299A1/en not_active Ceased
- 1995-08-16 ES ES95930845T patent/ES2143068T3/es not_active Expired - Lifetime
- 1995-08-16 DK DK95930845T patent/DK0782573T3/da active
1996
- 1996-12-02 US US08/756,930 patent/US6710073B1/en not_active Expired - Fee Related
1997
- 1997-03-19 NO NO19971274A patent/NO315929B1/no unknown
2004
- 2004-03-22 US US10/806,953 patent/US7081474B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0782573B1 (en)	2000-03-01
KR970706271A (ko)	1997-11-03
US6710073B1 (en)	2004-03-23
AU703667B2 (en)	1999-04-01
DE69515321T2 (de)	2000-08-24
WO1996009299A1 (en)	1996-03-28
JPH10508579A (ja)	1998-08-25
EP0782573A4 (en)	1998-01-14
AU3407695A (en)	1996-04-09
NO315929B1 (no)	2003-11-17
US20040242553A1 (en)	2004-12-02
NO971274L (no)	1997-03-19
DE69515321D1 (de)	2000-04-06
NO971274D0 (no)	1997-03-19
ES2143068T3 (es)	2000-05-01
US7081474B2 (en)	2006-07-25
ATE190056T1 (de)	2000-03-15
EP0782573A1 (en)	1997-07-09

Publication	Publication Date	Title
NO983266L (no)	1998-09-15	Distribuert Behandling
DK1275391T3 (da)	2011-07-11	Farmaceutiske sammensætninger indeholdende irbesartan og et diuretikum
DK0508658T4 (da)	2000-11-06	Aseptisk ventilkonstruktion
NL194741B (nl)	2002-09-02	Seismische bronnenreeks voor gebruik bij maritieme seismische opsporing.
DE69415126D1 (de)	1999-01-21	Gegenflusspipelineprozessor
DE69225596D1 (de)	1998-06-25	Rohruntersuchungsventil
DE69204933D1 (de)	1995-10-26	Rohrabsperrvorrichtung.
MC2112A1 (fr)	1991-07-05	Comprime effervescent
DK0782573T3 (da)	2000-06-05	Brefeldin og analoger til forbedret synaptisk transmission
FR2515405B1 (fr)	1991-04-26	Registre a decalage dynamique rapide utilisant des transistors mes
FI943120A7 (fi)	1994-06-29	Alfa-substituoituja bentseenimetanamiinijohdannaisia
DE69206031D1 (de)	1995-12-21	Tablettierhilfsstoff.
MX9201944A (es)	1992-11-01	Formulacion farmaceutica que contiene diritromicina.
DE69202124D1 (de)	1995-05-24	Neue Vitamin-D3-Derivate.
IT230189Y1 (it)	1999-05-05	Dispositivo per mantenere fresca una bottiglia.
DE59202012D1 (de)	1995-06-01	Absperrdichtung.
ES2105930B1 (es)	1998-06-01	Puya de picador perfeccionada.
DE68914434D1 (de)	1994-05-11	Doppelzylinder bioreaktor.
KR930006485U (ko)	1993-04-23	미술대 입시용 뎃생교재
ES1030301Y (es)	1996-02-01	Muñeco perfeccionado que simula beber.
KR930010703U (ko)	1993-06-23	학습용 노트
ES1031631Y (es)	1996-06-01	Dispositivo para producir efectos especiales en carteles.
ES1031632Y (es)	1996-06-01	Dispositivo para producir efectos especiales en carteles.
ES1031633Y (es)	1996-06-01	Dispositivo para producir efectos especiales en carteles.
KR950019652U (ko)	1995-07-24	유압 실린더의 패킹 분해 장치