DK0802257T3 - Udødeliggjort cellelinie fra epitelceller i human colon - Google Patents

Udødeliggjort cellelinie fra epitelceller i human colon

Info

Publication number: DK0802257T3
Authority: DK; Denmark
Prior art keywords: human colon; epithelial cells; colon epithelial; cells; cell line
Prior art date: 1996-04-19

Application number

DK96201064T

Other languages

Danish (da)

English (en)

Inventor

Stephanie Blum

Andrea Pfeifer

Yvonne Troumvoukis

Original Assignee

Nestle Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-19

Filing date

1996-04-19

Publication date

2002-10-28

1996-04-19 Application filed by Nestle Sa filed Critical Nestle Sa

2002-10-28 Application granted granted Critical

2002-10-28 Publication of DK0802257T3 publication Critical patent/DK0802257T3/da

Links

210000002919 epithelial cell Anatomy 0.000 title abstract 6
210000001072 colon Anatomy 0.000 title abstract 5
210000004027 cell Anatomy 0.000 title abstract 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
238000012258 culturing Methods 0.000 abstract 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
241000283690 Bos taurus Species 0.000 abstract 1
108091003079 Bovine Serum Albumin Proteins 0.000 abstract 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 abstract 1
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 abstract 1
102000004338 Transferrin Human genes 0.000 abstract 1
108090000901 Transferrin Proteins 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
229930003268 Vitamin C Natural products 0.000 abstract 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 abstract 1
229940024606 amino acid Drugs 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
229940098773 bovine serum albumin Drugs 0.000 abstract 1
229960003957 dexamethasone Drugs 0.000 abstract 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000008472 epithelial growth Effects 0.000 abstract 1
229940031098 ethanolamine Drugs 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
229960001031 glucose Drugs 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
229960000890 hydrocortisone Drugs 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
235000014655 lactic acid Nutrition 0.000 abstract 1
239000004310 lactic acid Substances 0.000 abstract 1
239000002609 medium Substances 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
229930002330 retinoic acid Natural products 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000004017 serum-free culture medium Substances 0.000 abstract 1
229940054269 sodium pyruvate Drugs 0.000 abstract 1
239000011573 trace mineral Substances 0.000 abstract 1
235000013619 trace mineral Nutrition 0.000 abstract 1
239000012581 transferrin Substances 0.000 abstract 1
229960001727 tretinoin Drugs 0.000 abstract 1
229940035722 triiodothyronine Drugs 0.000 abstract 1
229930003231 vitamin Natural products 0.000 abstract 1
239000011782 vitamin Substances 0.000 abstract 1
235000013343 vitamin Nutrition 0.000 abstract 1
229940088594 vitamin Drugs 0.000 abstract 1
235000019154 vitamin C Nutrition 0.000 abstract 1
239000011718 vitamin C Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Prostheses (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK96201064T 1996-04-19 1996-04-19 Udødeliggjort cellelinie fra epitelceller i human colon DK0802257T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96201064A EP0802257B1 (de)	1996-04-19	1996-04-19	Menschliche immortalisierte Colon-Epithelialzellen

Publications (1)

Publication Number	Publication Date
DK0802257T3 true DK0802257T3 (da)	2002-10-28

Family

ID=8223895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96201064T DK0802257T3 (da)	1996-04-19	1996-04-19	Udødeliggjort cellelinie fra epitelceller i human colon

Country Status (14)

Country	Link
US (3)	US6194203B1 (de)
EP (1)	EP0802257B1 (de)
JP (1)	JP3931212B2 (de)
AT (1)	ATE222598T1 (de)
AU (1)	AU733913B2 (de)
CA (1)	CA2202923C (de)
DE (1)	DE69623109T2 (de)
DK (1)	DK0802257T3 (de)
ES (1)	ES2180689T3 (de)
FI (1)	FI120352B (de)
NO (1)	NO319494B1 (de)
NZ (1)	NZ314614A (de)
PT (1)	PT802257E (de)
RU (1)	RU2220201C2 (de)

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US9181337B2 (en)	2013-10-18	2015-11-10	Abbvie, Inc.	Modulated lysine variant species compositions and methods for producing and using the same
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1996
- 1996-04-19 AT AT96201064T patent/ATE222598T1/de active
- 1996-04-19 DE DE69623109T patent/DE69623109T2/de not_active Expired - Lifetime
- 1996-04-19 DK DK96201064T patent/DK0802257T3/da active
- 1996-04-19 EP EP96201064A patent/EP0802257B1/de not_active Expired - Lifetime
- 1996-04-19 PT PT96201064T patent/PT802257E/pt unknown
- 1996-04-19 ES ES96201064T patent/ES2180689T3/es not_active Expired - Lifetime
1997
- 1997-04-16 CA CA002202923A patent/CA2202923C/en not_active Expired - Fee Related
- 1997-04-16 RU RU97106170/13A patent/RU2220201C2/ru not_active IP Right Cessation
- 1997-04-16 NZ NZ314614A patent/NZ314614A/en not_active IP Right Cessation
- 1997-04-17 AU AU18933/97A patent/AU733913B2/en not_active Ceased
- 1997-04-17 NO NO19971757A patent/NO319494B1/no not_active IP Right Cessation
- 1997-04-17 FI FI971628A patent/FI120352B/fi not_active IP Right Cessation
- 1997-04-17 US US08/839,271 patent/US6194203B1/en not_active Expired - Lifetime
- 1997-04-18 JP JP10217297A patent/JP3931212B2/ja not_active Expired - Fee Related
2000
- 2000-06-14 US US09/593,135 patent/US6399381B1/en not_active Expired - Lifetime
- 2000-06-14 US US09/593,134 patent/US6395542B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU733913B2 (en)	2001-05-31
ATE222598T1 (de)	2002-09-15
JPH1028580A (ja)	1998-02-03
US6399381B1 (en)	2002-06-04
NO971757L (no)	1997-10-20
RU2220201C2 (ru)	2003-12-27
EP0802257B1 (de)	2002-08-21
ES2180689T3 (es)	2003-02-16
AU1893397A (en)	1997-10-23
FI971628A0 (fi)	1997-04-17
CA2202923C (en)	2008-06-10
EP0802257A1 (de)	1997-10-22
NO319494B1 (no)	2005-08-22
NZ314614A (en)	1999-04-29
FI120352B (fi)	2009-09-30
JP3931212B2 (ja)	2007-06-13
FI971628A7 (fi)	1997-10-20
DE69623109D1 (de)	2002-09-26
NO971757D0 (no)	1997-04-17
DE69623109T2 (de)	2002-12-12
CA2202923A1 (en)	1997-10-19
US6395542B1 (en)	2002-05-28
US6194203B1 (en)	2001-02-27
PT802257E (pt)	2003-01-31

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