DK0804417T3 - Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler - Google Patents
Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidlerInfo
- Publication number
- DK0804417T3 DK0804417T3 DK96900349T DK96900349T DK0804417T3 DK 0804417 T3 DK0804417 T3 DK 0804417T3 DK 96900349 T DK96900349 T DK 96900349T DK 96900349 T DK96900349 T DK 96900349T DK 0804417 T3 DK0804417 T3 DK 0804417T3
- Authority
- DK
- Denmark
- Prior art keywords
- levobupivacaine
- racemization
- anesthetics
- preparation
- carboxanilide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title abstract 2
- 229960004288 levobupivacaine Drugs 0.000 title abstract 2
- 229940035674 anesthetics Drugs 0.000 title 1
- 239000003193 general anesthetic agent Substances 0.000 title 1
- UICIJOHWFFTRLI-UHFFFAOYSA-N n-phenylpiperidine-1-carboxamide Chemical compound C1CCCCN1C(=O)NC1=CC=CC=C1 UICIJOHWFFTRLI-UHFFFAOYSA-N 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- -1 piperidine-2-carboxanilide compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Rolling Contact Bearings (AREA)
- Optical Head (AREA)
- Beans For Foods Or Fodder (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9501071.6A GB9501071D0 (en) | 1995-01-18 | 1995-01-18 | Racemisation |
| PCT/GB1996/000067 WO1996022281A1 (en) | 1995-01-18 | 1996-01-12 | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0804417T3 true DK0804417T3 (da) | 2003-10-06 |
Family
ID=10768271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96900349T DK0804417T3 (da) | 1995-01-18 | 1996-01-12 | Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0804417B1 (es) |
| JP (1) | JP4015696B2 (es) |
| KR (1) | KR100404390B1 (es) |
| CN (1) | CN1172912C (es) |
| AT (1) | ATE242214T1 (es) |
| AU (1) | AU701221B2 (es) |
| BR (1) | BR9606821A (es) |
| CA (1) | CA2208522C (es) |
| DE (1) | DE69628540T2 (es) |
| DK (1) | DK0804417T3 (es) |
| ES (1) | ES2201166T3 (es) |
| FI (1) | FI117437B (es) |
| GB (1) | GB9501071D0 (es) |
| HU (1) | HU227426B1 (es) |
| MX (1) | MX9705428A (es) |
| NO (1) | NO308843B1 (es) |
| PL (1) | PL184091B1 (es) |
| PT (1) | PT804417E (es) |
| WO (1) | WO1996022281A1 (es) |
| ZA (1) | ZA96403B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| SI2415484T1 (sl) | 2004-09-17 | 2014-10-30 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| JP2011506319A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法 |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| AU2014233453A1 (en) | 2013-03-15 | 2015-10-01 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| CN106187864B (zh) * | 2016-07-11 | 2018-11-23 | 江苏天和制药有限公司 | 一种由盐酸布比卡因制备高纯度布比卡因碱的方法 |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
| WO2023158722A2 (en) * | 2022-02-16 | 2023-08-24 | Teva Pharmaceuticals International Gmbh | Processes for preparation of avacopan and intermediates thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2301498A1 (fr) * | 1975-02-20 | 1976-09-17 | Maggioni & C Spa | Methode pour la racemisation d'une lysine optiquement active |
-
1995
- 1995-01-18 GB GBGB9501071.6A patent/GB9501071D0/en active Pending
-
1996
- 1996-01-12 ES ES96900349T patent/ES2201166T3/es not_active Expired - Lifetime
- 1996-01-12 CA CA002208522A patent/CA2208522C/en not_active Expired - Lifetime
- 1996-01-12 AU AU43948/96A patent/AU701221B2/en not_active Expired
- 1996-01-12 PL PL96321378A patent/PL184091B1/pl unknown
- 1996-01-12 KR KR1019970704822A patent/KR100404390B1/ko not_active Expired - Lifetime
- 1996-01-12 JP JP52210296A patent/JP4015696B2/ja not_active Expired - Lifetime
- 1996-01-12 HU HU9901418A patent/HU227426B1/hu unknown
- 1996-01-12 EP EP96900349A patent/EP0804417B1/en not_active Expired - Lifetime
- 1996-01-12 MX MX9705428A patent/MX9705428A/es unknown
- 1996-01-12 DK DK96900349T patent/DK0804417T3/da active
- 1996-01-12 CN CNB961915242A patent/CN1172912C/zh not_active Expired - Lifetime
- 1996-01-12 PT PT96900349T patent/PT804417E/pt unknown
- 1996-01-12 BR BR9606821A patent/BR9606821A/pt unknown
- 1996-01-12 AT AT96900349T patent/ATE242214T1/de active
- 1996-01-12 DE DE69628540T patent/DE69628540T2/de not_active Expired - Lifetime
- 1996-01-12 WO PCT/GB1996/000067 patent/WO1996022281A1/en not_active Ceased
- 1996-01-18 ZA ZA96403A patent/ZA96403B/xx unknown
-
1997
- 1997-07-17 FI FI973040A patent/FI117437B/fi not_active IP Right Cessation
- 1997-07-17 NO NO973312A patent/NO308843B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69628540T2 (de) | 2004-01-08 |
| PL321378A1 (en) | 1997-12-08 |
| NO308843B1 (no) | 2000-11-06 |
| FI117437B (fi) | 2006-10-13 |
| MX9705428A (es) | 1997-11-29 |
| HU227426B1 (en) | 2011-05-30 |
| NO973312D0 (no) | 1997-07-17 |
| ZA96403B (en) | 1997-01-20 |
| AU4394896A (en) | 1996-08-07 |
| DE69628540D1 (de) | 2003-07-10 |
| HUP9901418A2 (hu) | 1999-08-30 |
| EP0804417A1 (en) | 1997-11-05 |
| NO973312L (no) | 1997-07-17 |
| CA2208522A1 (en) | 1996-07-25 |
| ES2201166T3 (es) | 2004-03-16 |
| ATE242214T1 (de) | 2003-06-15 |
| CA2208522C (en) | 2007-03-13 |
| BR9606821A (pt) | 1997-12-23 |
| WO1996022281A1 (en) | 1996-07-25 |
| KR19980701432A (ko) | 1998-05-15 |
| CN1172912C (zh) | 2004-10-27 |
| AU701221B2 (en) | 1999-01-21 |
| GB9501071D0 (en) | 1995-03-08 |
| HUP9901418A3 (en) | 2001-01-29 |
| FI973040A0 (fi) | 1997-07-17 |
| JP4015696B2 (ja) | 2007-11-28 |
| PT804417E (pt) | 2003-09-30 |
| CN1168134A (zh) | 1997-12-17 |
| KR100404390B1 (ko) | 2004-01-31 |
| PL184091B1 (pl) | 2002-08-30 |
| EP0804417B1 (en) | 2003-06-04 |
| JPH11501905A (ja) | 1999-02-16 |
| FI973040L (fi) | 1997-07-17 |
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