DK0815095T3 - 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma - Google Patents

10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma

Info

Publication number: DK0815095T3
Authority: DK; Denmark
Prior art keywords: iii; deacetyl; 14beta; pharmaceuticals; preparation
Prior art date: 1995-03-17

Application number

DK96904100T

Other languages

English (en)

Inventor

Ezio Bombardelli

Bellis Paolo De

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-04

Publication date

2000-08-07

1996-03-04 Application filed by Indena Spa filed Critical Indena Spa

2000-08-07 Application granted granted Critical

2000-08-07 Publication of DK0815095T3 publication Critical patent/DK0815095T3/da

Links

YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 3
FNZPZCTVRVPPAB-YZSQHPIKSA-N (2ar,4s,4as,6r,9r,10s,11r,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,10,11-pentahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxet-5-one Chemical class O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)[C@H](O)[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 FNZPZCTVRVPPAB-YZSQHPIKSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK96904100T 1995-03-17 1996-03-04 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma DK0815095T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI000533A IT1275936B1 (it)	1995-03-17	1995-03-17	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
PCT/EP1996/000904 WO1996029321A1 (en)	1995-03-17	1996-03-04	10-DEACETYLBACCATINE III AND 10-DEACETYL 14β-HYDROXYBACCATINE III DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number	Publication Date
DK0815095T3 true DK0815095T3 (da)	2000-08-07

Family

ID=11370949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96904100T DK0815095T3 (da)	1995-03-17	1996-03-04	10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma

Country Status (17)

Country	Link
US (2)	US5750562A (da)
EP (1)	EP0815095B1 (da)
JP (4)	JP4101289B2 (da)
KR (2)	KR100388877B1 (da)
CN (2)	CN1176914C (da)
AT (1)	ATE193286T1 (da)
AU (1)	AU705923B2 (da)
CA (1)	CA2215682C (da)
DE (1)	DE69608548T2 (da)
DK (1)	DK0815095T3 (da)
ES (1)	ES2146389T3 (da)
GR (1)	GR3033742T3 (da)
IT (1)	IT1275936B1 (da)
NO (1)	NO317056B1 (da)
PT (1)	PT815095E (da)
RU (1)	RU2152936C1 (da)
WO (1)	WO1996029321A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1283633B1 (it) *	1996-05-10	1998-04-23	Indena Spa	Derivati tassanici loro sintesi e formulazioni che li contengono
ITMI991483A1 (it) *	1999-07-06	2001-01-06	Indena Spa	Derivati tassanici e procedimenti per la loro preparazione
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
IT1318678B1 (it)	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012185A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) *	2002-09-10	2004-03-11	Indena Spa	Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
AU2004275881A1 (en)	2003-09-25	2005-04-07	Tapestry Pharmaceuticals, Inc.	9,10-alpha,alpha-OH-taxane analogs and methods for production thereof
US20090306400A1 (en) *	2006-03-27	2009-12-10	Henri John T	Convergent process for the synthesis of taxane derivatives.
US7847111B2 (en)	2006-06-19	2010-12-07	Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2007143839A1 (en) *	2006-06-12	2007-12-21	6570763 Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
WO2008109360A1 (en)	2007-02-28	2008-09-12	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer
EP2080764B1 (en)	2008-01-18	2012-08-22	INDENA S.p.A.	Solid forms of ortataxel

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
US5380916A (en) *	1990-11-02	1995-01-10	University Of Florida	Method for the isolation and purification of taxane derivatives
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
IT1254517B (it) *	1992-03-06	1995-09-25	Indena Spa	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5200534A (en) *	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol
DE69333339T2 (de) *	1992-07-01	2004-09-23	Bristol-Myers Squibb Co.	7,8-Zyclopropataxane mit Antitumorwirkung
US5319112A (en) *	1992-08-18	1994-06-07	Virgnia Tech Intellectual Properties, Inc.	Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
IL107950A (en) *	1992-12-15	2001-04-30	Upjohn Co	7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO310238B1 (no) *	1992-12-24	2001-06-11	Bristol Myers Squibb Co	Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) *	1993-05-20	1996-05-29		Tassano ad attivita' antitumorale.
DE69424166T2 (de) *	1993-06-11	2000-10-05	Pharmacia & Upjohn Co., Kalamazoo	Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL109926A (en) *	1993-06-15	2000-02-29	Bristol Myers Squibb Co	Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2707293A1 (fr) *	1993-07-08	1995-01-13	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.

1995
- 1995-03-17 IT IT95MI000533A patent/IT1275936B1/it active IP Right Grant
- 1995-06-06 US US08/471,137 patent/US5750562A/en not_active Expired - Lifetime
1996
- 1996-03-04 CN CNB01137067XA patent/CN1176914C/zh not_active Expired - Lifetime
- 1996-03-04 DE DE69608548T patent/DE69608548T2/de not_active Expired - Lifetime
- 1996-03-04 AT AT96904100T patent/ATE193286T1/de active
- 1996-03-04 RU RU97117166/04A patent/RU2152936C1/ru active
- 1996-03-04 US US08/913,861 patent/US5973163A/en not_active Expired - Lifetime
- 1996-03-04 AU AU48320/96A patent/AU705923B2/en not_active Expired
- 1996-03-04 CA CA002215682A patent/CA2215682C/en not_active Expired - Lifetime
- 1996-03-04 KR KR10-2002-7014226A patent/KR100388877B1/ko not_active Expired - Lifetime
- 1996-03-04 CN CNB961926074A patent/CN100335470C/zh not_active Expired - Lifetime
- 1996-03-04 KR KR1019970706439A patent/KR100388878B1/ko not_active Expired - Lifetime
- 1996-03-04 PT PT96904100T patent/PT815095E/pt unknown
- 1996-03-04 EP EP96904100A patent/EP0815095B1/en not_active Expired - Lifetime
- 1996-03-04 WO PCT/EP1996/000904 patent/WO1996029321A1/en not_active Ceased
- 1996-03-04 JP JP52801996A patent/JP4101289B2/ja not_active Expired - Lifetime
- 1996-03-04 ES ES96904100T patent/ES2146389T3/es not_active Expired - Lifetime
- 1996-03-04 DK DK96904100T patent/DK0815095T3/da active
1997
- 1997-09-16 NO NO19974266A patent/NO317056B1/no not_active IP Right Cessation
2000
- 2000-06-22 GR GR20000401437T patent/GR3033742T3/el unknown
2007
- 2007-02-28 JP JP2007049738A patent/JP2007137898A/ja not_active Withdrawn
2010
- 2010-12-06 JP JP2010271599A patent/JP2011046744A/ja active Pending
2012
- 2012-04-13 JP JP2012091985A patent/JP2012140465A/ja active Pending

Also Published As

Publication number	Publication date
WO1996029321A1 (en)	1996-09-26
HK1005242A1 (en)	1998-12-31
CA2215682A1 (en)	1996-09-26
ATE193286T1 (de)	2000-06-15
KR100388878B1 (ko)	2003-10-04
KR100388877B1 (ko)	2003-06-25
AU705923B2 (en)	1999-06-03
JP2007137898A (ja)	2007-06-07
CN100335470C (zh)	2007-09-05
IT1275936B1 (it)	1997-10-24
KR19980703031A (ko)	1998-09-05
AU4832096A (en)	1996-10-08
DE69608548D1 (de)	2000-06-29
PT815095E (pt)	2000-09-29
RU2152936C1 (ru)	2000-07-20
CN1178528A (zh)	1998-04-08
JP2011046744A (ja)	2011-03-10
CN1410421A (zh)	2003-04-16
CN1176914C (zh)	2004-11-24
NO317056B1 (no)	2004-08-02
DE69608548T2 (de)	2001-02-01
NO974266D0 (no)	1997-09-16
EP0815095B1 (en)	2000-05-24
US5973163A (en)	1999-10-26
NO974266L (no)	1997-09-16
US5750562A (en)	1998-05-12
CA2215682C (en)	2008-01-29
JPH11502206A (ja)	1999-02-23
ES2146389T3 (es)	2000-08-01
GR3033742T3 (en)	2000-10-31
EP0815095A1 (en)	1998-01-07
ITMI950533A0 (it)	1995-03-17
ITMI950533A1 (it)	1996-09-17
JP2012140465A (ja)	2012-07-26
JP4101289B2 (ja)	2008-06-18

Publication	Publication Date	Title
DE69507702D1 (de)	1999-03-18	Semisynthetisch taxal derivate mit antitumor wirkung
IT1275936B1 (it)	1997-10-24	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
ATE161193T1 (de)	1998-01-15	Taxan-derivate enthaltende arzneimittel
NL980012I2 (nl)	2004-11-01	Mometasonfuroaat-monohydraat, werkwijze om zulks te bereiden en farmaceutische samenstellingen.
SI0801649T1 (en)	2002-12-31	Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
DE69604653D1 (de)	1999-11-18	Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
DE59209907D1 (de)	2001-08-09	Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
FI955424A0 (fi)	1995-11-10	Syklodekstriinien kanssa muodostettuja taksoli- ja taksoteeri- tai Taxus-uuteinkluusiokomplekseja ja niiden valmistus ja käyttö
DE69231663D1 (de)	2001-03-01	Konjugate bestehend aus polysaccharid und protein
GR3034575T3 (en)	2001-01-31	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
HUP9701660A2 (hu)	1998-05-28	10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények
IL88971A (en)	1993-07-08	Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing them
DE3770726D1 (de)	1991-07-18	Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.
DE69627184D1 (de)	2003-05-08	3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften
IT1278108B1 (it)	1997-11-17	Secotassani dotati di attivita' antitumorale.
IT1244755B (it)	1994-08-08	Azoto ossidi di derivati aza- e diaza-antracenedionici come farmaci antitumorali
DE3880348D1 (de)	1993-05-27	N-substituierte alpha-mercaptomethylbenzenpropanamid-derivate, ihre herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
UA18224A (uk)	1997-12-25	Спосіб лікуваhhя дерматозів
IT1274356B (it)	1997-07-17	Tassani semisintetici odtati di attivita' antitumorale
DE68907765D1 (de)	1993-09-02	2-pyridylessigsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.