DK0824357T3 - Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel - Google Patents

Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel

Info

Publication number: DK0824357T3
Authority: DK; Denmark
Prior art keywords: growth factor; epidermal growth; egf; therapeutic agent; animal
Prior art date: 1995-05-10

Application number

DK96913397T

Other languages

English (en)

Inventor

Andre G Buret

D Grant Gall

James A Hardin

Merle E Olson

Original Assignee

Univ Technologies Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-10

Filing date

1996-05-09

Publication date

2001-10-08

1996-05-09 Application filed by Univ Technologies Int filed Critical Univ Technologies Int

2001-10-08 Application granted granted Critical

2001-10-08 Publication of DK0824357T3 publication Critical patent/DK0824357T3/da

Links

VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title abstract 4
102000009024 Epidermal Growth Factor Human genes 0.000 title abstract 3
101800003838 Epidermal growth factor Proteins 0.000 title abstract 3
229940116977 epidermal growth factor Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
230000002496 gastric effect Effects 0.000 title 1
229940124597 therapeutic agent Drugs 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
208000000103 Anorexia Nervosa Diseases 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
238000009360 aquaculture Methods 0.000 abstract 1
244000144974 aquaculture Species 0.000 abstract 1
239000003651 drinking water Substances 0.000 abstract 1
235000020188 drinking water Nutrition 0.000 abstract 1
239000002778 food additive Substances 0.000 abstract 1
235000013373 food additive Nutrition 0.000 abstract 1
208000015380 nutritional deficiency disease Diseases 0.000 abstract 1
230000004584 weight gain Effects 0.000 abstract 1
235000019786 weight gain Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Food Science & Technology (AREA)
Animal Husbandry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Birds (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fodder In General (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK96913397T 1995-05-10 1996-05-09 Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel DK0824357T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/438,901 US5753622A (en)	1995-05-10	1995-05-10	Use of epidermal growth factor as a gastrointestinal therapeutic agent
PCT/CA1996/000291 WO1996035445A1 (en)	1995-05-10	1996-05-09	The use of epidermal growth factor as a gastrointestinal therapeutic agent

Publications (1)

Publication Number	Publication Date
DK0824357T3 true DK0824357T3 (da)	2001-10-08

Family

ID=23742496

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK00123426T DK1092437T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel
DK96913397T DK0824357T3 (da)	1995-05-10	1996-05-09	Anvendelsen af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel
DK04019831T DK1479394T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor (EGF) til ögning af vækstforögelse hos et dyr

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK00123426T DK1092437T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04019831T DK1479394T3 (da)	1995-05-10	1996-05-09	Anvendelse af epidermal vækstfaktor (EGF) til ögning af vækstforögelse hos et dyr

Country Status (12)

Country	Link
US (2)	US5753622A (da)
EP (3)	EP0824357B1 (da)
JP (1)	JP3549541B2 (da)
AT (3)	ATE278415T1 (da)
AU (1)	AU704675B2 (da)
CA (2)	CA2492724C (da)
DE (3)	DE69633583T2 (da)
DK (3)	DK1092437T3 (da)
ES (2)	ES2285320T3 (da)
NZ (2)	NZ307134A (da)
PT (1)	PT1479394E (da)
WO (1)	WO1996035445A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5753622A (en) *	1995-05-10	1998-05-19	University Technologies International, Inc.	Use of epidermal growth factor as a gastrointestinal therapeutic agent
US6313103B1 (en)	1998-05-13	2001-11-06	Carrington Laboratories, Inc.	Pectic substance as a growth factor stabilizer
US7022683B1 (en)	1998-05-13	2006-04-04	Carrington Laboratories, Inc.	Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US5929051A (en) *	1998-05-13	1999-07-27	Carrington Laboratories, Inc.	Aloe pectins
US20060014684A1 (en) *	2000-03-03	2006-01-19	University Technologies International Inc.	Novel uses of EGF
US7494669B2 (en)	2001-02-28	2009-02-24	Carrington Laboratories, Inc.	Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6967090B2 (en) *	2001-05-18	2005-11-22	Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food	Nucleic acid and protein sequences of bovine epidermal growth factor
CA2464609A1 (en) *	2001-10-26	2003-05-01	University Technologies International, Inc.	Use of egf to inhibit pathogenic infections of the urogenital tract
CA2427190A1 (en) *	2002-04-30	2003-10-30	Alberta Research Council Inc.	Production of recombinant epidermal growth factor in plants
DE60319822T2 (de)	2002-06-19	2009-06-04	Actogenix Nv	Verfahren und mittel zur erhöhung der darmabsorption
CA2582958A1 (en) *	2004-09-30	2006-04-06	University Technologies International Inc.	Rehydration compositions comprising epidermal growth factor
WO2007011702A2 (en) *	2005-07-15	2007-01-25	The University Of North Carolina At Chapel Hill	Use of egfr inhibitors to prevent or treat obesity
DK2119450T3 (da)	2005-11-29	2013-05-06	Actogenix Nv	Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
BRPI0807857A2 (pt)	2007-01-25	2014-05-27	Actogenix Nv	Tratamento de doença imune por meio de distribuição através da mucosa de antígenos.
US20110275566A1 (en) *	2008-10-10	2011-11-10	Nationwide Children's Hospital Inc.	Methods of treating necrotizing enterocolitis using heparin binding epidermal growth factor (hb-egf)
CN102696887B (zh) *	2012-06-20	2013-07-31	湖南海谷生物技术有限公司	一种具有营养保健促生长功能的饲料活性蛋粉及其生产方法
US11241480B2 (en) *	2017-01-26	2022-02-08	Washington University	Methods for modulation of dietary and microbial exposure with compositions comprising an EGFR ligand
CN113813369B (zh) *	2021-11-09	2023-09-22	浙江省农业科学院	用于预防/治疗仔猪肠道损伤的egf/mmt复合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8409960D0 (en) *	1984-04-17	1984-05-31	Searle & Co	Therapeutic method
JPH01501707A (ja) *	1986-12-11	1989-06-15	ブリティッシュ・テクノロジー・グループ・リミテッド	表皮成長因子の使用におけるまたは関する改良
ATE161181T1 (de)	1992-07-06	1998-01-15	Nestle Sa	Lactobacillus acidophilus enthaltende antigastritis-mittel
US5753622A (en) *	1995-05-10	1998-05-19	University Technologies International, Inc.	Use of epidermal growth factor as a gastrointestinal therapeutic agent

1995
- 1995-05-10 US US08/438,901 patent/US5753622A/en not_active Expired - Lifetime
1996
- 1996-05-09 AU AU56411/96A patent/AU704675B2/en not_active Ceased
- 1996-05-09 DE DE69633583T patent/DE69633583T2/de not_active Expired - Fee Related
- 1996-05-09 CA CA2492724A patent/CA2492724C/en not_active Expired - Fee Related
- 1996-05-09 EP EP96913397A patent/EP0824357B1/en not_active Expired - Lifetime
- 1996-05-09 DE DE69614377T patent/DE69614377T2/de not_active Expired - Fee Related
- 1996-05-09 NZ NZ307134A patent/NZ307134A/en not_active IP Right Cessation
- 1996-05-09 WO PCT/CA1996/000291 patent/WO1996035445A1/en not_active Ceased
- 1996-05-09 AT AT00123426T patent/ATE278415T1/de not_active IP Right Cessation
- 1996-05-09 DK DK00123426T patent/DK1092437T3/da active
- 1996-05-09 AT AT04019831T patent/ATE357927T1/de not_active IP Right Cessation
- 1996-05-09 CA CA002220434A patent/CA2220434C/en not_active Expired - Fee Related
- 1996-05-09 JP JP53362496A patent/JP3549541B2/ja not_active Expired - Fee Related
- 1996-05-09 ES ES04019831T patent/ES2285320T3/es not_active Expired - Lifetime
- 1996-05-09 DE DE69637002T patent/DE69637002T2/de not_active Expired - Fee Related
- 1996-05-09 EP EP04019831A patent/EP1479394B1/en not_active Expired - Lifetime
- 1996-05-09 ES ES00123426T patent/ES2226681T3/es not_active Expired - Lifetime
- 1996-05-09 DK DK96913397T patent/DK0824357T3/da active
- 1996-05-09 AT AT96913397T patent/ATE203912T1/de not_active IP Right Cessation
- 1996-05-09 PT PT04019831T patent/PT1479394E/pt unknown
- 1996-05-09 NZ NZ501482A patent/NZ501482A/xx not_active IP Right Cessation
- 1996-05-09 DK DK04019831T patent/DK1479394T3/da active
- 1996-05-09 EP EP00123426A patent/EP1092437B1/en not_active Expired - Lifetime
2000
- 2000-03-03 US US09/518,135 patent/US6656907B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69614377T2 (de)	2002-05-23
EP1092437B1 (en)	2004-10-06
PT1479394E (pt)	2007-04-30
ATE278415T1 (de)	2004-10-15
DK1092437T3 (da)	2005-01-31
NZ307134A (en)	2000-02-28
EP0824357B1 (en)	2001-08-08
DK1479394T3 (da)	2007-06-11
CA2220434C (en)	2005-02-22
EP1479394A1 (en)	2004-11-24
EP1479394B1 (en)	2007-03-28
DE69633583T2 (de)	2006-02-23
DE69637002T2 (de)	2007-08-16
US6656907B1 (en)	2003-12-02
CA2492724A1 (en)	1996-11-14
ATE357927T1 (de)	2007-04-15
ES2285320T3 (es)	2007-11-16
HK1072894A1 (en)	2005-09-16
CA2220434A1 (en)	1996-11-14
NZ501482A (en)	2004-12-24
CA2492724C (en)	2010-08-03
ATE203912T1 (de)	2001-08-15
ES2226681T3 (es)	2005-04-01
DE69633583D1 (de)	2004-11-11
DE69637002D1 (de)	2007-05-10
JP3549541B2 (ja)	2004-08-04
EP0824357A1 (en)	1998-02-25
JPH11505528A (ja)	1999-05-21
AU704675B2 (en)	1999-04-29
WO1996035445A1 (en)	1996-11-14
US5753622A (en)	1998-05-19
DE69614377D1 (de)	2001-09-13
EP1092437A1 (en)	2001-04-18
AU5641196A (en)	1996-11-29

Publication	Publication Date	Title
DK1092437T3 (da)	2005-01-31	Anvendelse af epidermal vækstfaktor som et gastrointestinalt terapeutisk middel
AU1017088A (en)	1988-07-14	Sustained release growth hormone compositions for parenteral administration and their use
AU2118488A (en)	1989-02-23	Improvements in or relating to methods of treating damaged skin
NZ251320A (en)	1999-08-30	Bis-aromatic alpha,beta-unsaturated ketones, preparation and use in pharmaceutical compositions
DE69109284D1 (de)	1995-06-01	Verwendung von fluorierten löslichen tensiden zur herstellung von aerosolarzneimitteln mit dosierter abgabe.
FI925211A0 (fi)	1992-11-17	Isoxazol-4-karboxylsyraamider och hydroxialkylidencyanaettiksyraamider,laekemedel innehaollande dessa och anvaendning av dessa
CS782686A2 (en)	1990-05-14	Method of benzimidazole derivatives production
ATE177421T1 (de)	1999-03-15	Wasserlösliches nimesulid-salz, sowie dessen verwendung zur behandlung von entzündungen
ATE234615T1 (de)	2003-04-15	Verwendung von acetylcystein zur herstellung eines arzneimittels zur behandlung von chronischen geschwüren
DE59712094D1 (de)	2004-12-30	Mittel zur herstellung von aquarien- und gartenteichwasser und verwendung davon
ATE137965T1 (de)	1996-06-15	Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
DE69130497D1 (de)	1998-12-24	Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
YU78092A (sh)	1995-10-03	Postupak za dobijanje derivata beta-fenilizoserina i njihova primena
ATE89728T1 (de)	1993-06-15	Verwendung von dihydroergotamin und seinen salzen zur lokalen behandlung trophischer stoerungen.
DE59505618D1 (de)	1999-05-20	Orale Verwendung von Calciumformiat zur Behandlung von Calciumdefizienz bei Tieren
ATE83480T1 (de)	1993-01-15	Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen.
DE68905657D1 (de)	1993-05-06	Verwendung von arginin-aspartat zur herstellung eines arzneimittels zur behandlung gewisser gedaechtnisstoerungen.
DE3686097D1 (de)	1992-08-27	Verwendung von dopamin-agonisten zur herstellung eines arzneimittels zur behandlung von psychostimulant-sucht.
ATE99687T1 (de)	1994-01-15	Strobilurinderivate, ihre herstellung und verwendung.
ATE173921T1 (de)	1998-12-15	Verwendung von deoxyspergualin zur herstellung eines arzneimittels zur behandlung von entzündlich-hyperreaktiven erkrankungen
DE69313850D1 (de)	1997-10-16	Veterinaerprodukt zur rehydration
SU1522498A1 (ru)	1996-02-10	Дезинфицирующее средство
IT1247508B (it)	1994-12-17	Composizioni farmaceutiche contenenti l'estere 4-(2 metilamminoetil)- 1,2- fenilenicodell`acido 2-metilpropanoico per il trattamento della neurootticopatia glaucomatosa
CA2031825A1 (en)	1991-06-09	Bath additive and its use
ATE124264T1 (de)	1995-07-15	Verwendung eines polypeptids mit humaner interleukin-2 aktivität zur herstellung pharmazeutischer zusammensetzungen zur behandlung von pneumothoraxen.