DK0826681T3 - Epoxyravsyrederivater - Google Patents

Epoxyravsyrederivater

Info

Publication number: DK0826681T3
Authority: DK; Denmark
Prior art keywords: aralkyl; alkyl; acid derivatives; epoxysuccinic acid; aryl
Prior art date: 1995-03-31

Application number

DK96907747T

Other languages

English (en)

Inventor

Yutaka Nomura

Toshihiro Takahashi

Kaoru Hara

Yasushi Yoshino

Mitsuo Masaki

Original Assignee

Nippon Chemiphar Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-31

Filing date

1996-04-01

Publication date

2003-02-17

1996-04-01 Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co

2003-02-17 Application granted granted Critical

2003-02-17 Publication of DK0826681T3 publication Critical patent/DK0826681T3/da

Links

DCEMCPAKSGRHCN-UHFFFAOYSA-N oxirane-2,3-dicarboxylic acid Chemical class OC(=O)C1OC1C(O)=O DCEMCPAKSGRHCN-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
206010002027 Amyotrophy Diseases 0.000 abstract 1
208000009137 Behcet syndrome Diseases 0.000 abstract 1
208000020084 Bone disease Diseases 0.000 abstract 1
102000004172 Cathepsin L Human genes 0.000 abstract 1
108090000624 Cathepsin L Proteins 0.000 abstract 1
102000005600 Cathepsins Human genes 0.000 abstract 1
108010084457 Cathepsins Proteins 0.000 abstract 1
208000037147 Hypercalcaemia Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000000148 hypercalcaemia Effects 0.000 abstract 1
208000030915 hypercalcemia disease Diseases 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1
201000006938 muscular dystrophy Diseases 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Resins (AREA)

DK96907747T 1995-03-31 1996-04-01 Epoxyravsyrederivater DK0826681T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP10050495		1995-03-31
PCT/JP1996/000889 WO1996030354A1 (en)	1995-03-31	1996-04-01	Epoxysuccinic acid derivatives

Publications (1)

Publication Number	Publication Date
DK0826681T3 true DK0826681T3 (da)	2003-02-17

Family

ID=14275780

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96907747T DK0826681T3 (da)	1995-03-31	1996-04-01	Epoxyravsyrederivater

Country Status (13)

Country	Link
US (1)	US5843992A (da)
EP (1)	EP0826681B1 (da)
KR (1)	KR100381275B1 (da)
CN (1)	CN1087295C (da)
AT (1)	ATE225781T1 (da)
AU (1)	AU716620B2 (da)
CA (1)	CA2217051C (da)
DE (1)	DE69624235T2 (da)
DK (1)	DK0826681T3 (da)
EA (1)	EA000438B1 (da)
ES (1)	ES2184855T3 (da)
PT (1)	PT826681E (da)
WO (1)	WO1996030354A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000513373A (ja) *	1996-07-02	2000-10-10	ジュウ，サング，スプ	オキシランカルボキシル酸誘導体及びその製造方法
JP2002512603A (ja) *	1997-02-26	2002-04-23	イーライ・リリー・アンド・カンパニー	医薬化合物の製造方法
EP1342720A3 (en)	1997-09-04	2004-02-11	Nippon Chemiphar Co., Ltd.	Epoxysuccinamide derivatives
WO2008045017A2 (en) *	2005-06-22	2008-04-17	Diamond Scott L	Sars and ebola inhibitors and use thereof, and methods for their discovery
WO2007038772A1 (en) *	2005-09-28	2007-04-05	American Life Science Pharmaceuticals	Novel drugs for dementia
CA2652600A1 (en) *	2006-05-22	2007-11-29	Velcura Therapeutics, Inc.	Use of cathepsin k antagonists in bone production
US20100216875A1 (en) *	2006-12-20	2010-08-26	Gregory Hook	Methods of treating alzheimer's disease
WO2008149971A1 (ja)	2007-06-08	2008-12-11	Kyoto University	脳動脈瘤の治療または予防薬
US20100331545A1 (en)	2007-10-24	2010-12-30	Nippon Chemiphar Co., Ltd.	Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
RU2756956C2 (ru) *	2020-03-26	2021-10-07	Публичное акционерное общество «СИБУР Холдинг»	Способ получения кристаллической формы цис-2,3-эпоксисукцината кальция

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5547668A (en) *	1978-09-30	1980-04-04	Taisho Pharmaceut Co Ltd	Epoxysuccinamic acid
US4418705A (en) *	1979-05-22	1983-12-06	G. D. Societa Per Azioni	Method and relative manufacturing machine for simultaneously producing two continuous cigarette rods
EP0269311A3 (en) *	1986-11-17	1990-06-06	Merck & Co. Inc.	Methods of treating bone diseases by administration of a cysteine proteinase inhibitor
AU5123196A (en) *	1995-03-31	1996-10-16	Nippon Chemiphar Co. Ltd.	Bisphosphonic acid derivatives
US5733911A (en) *	1996-01-26	1998-03-31	Hitachi Chemical Co., Ltd.	Method for inducing death of neoplastic cells using piperazne derivatives

1996
- 1996-04-01 EP EP96907747A patent/EP0826681B1/en not_active Expired - Lifetime
- 1996-04-01 DE DE69624235T patent/DE69624235T2/de not_active Expired - Lifetime
- 1996-04-01 AU AU51232/96A patent/AU716620B2/en not_active Ceased
- 1996-04-01 WO PCT/JP1996/000889 patent/WO1996030354A1/ja not_active Ceased
- 1996-04-01 KR KR1019970706889A patent/KR100381275B1/ko not_active Expired - Fee Related
- 1996-04-01 CA CA002217051A patent/CA2217051C/en not_active Expired - Fee Related
- 1996-04-01 US US08/930,509 patent/US5843992A/en not_active Expired - Lifetime
- 1996-04-01 CN CN96194051A patent/CN1087295C/zh not_active Expired - Fee Related
- 1996-04-01 PT PT96907747T patent/PT826681E/pt unknown
- 1996-04-01 EA EA199800181A patent/EA000438B1/ru not_active IP Right Cessation
- 1996-04-01 ES ES96907747T patent/ES2184855T3/es not_active Expired - Lifetime
- 1996-04-01 AT AT96907747T patent/ATE225781T1/de active
- 1996-04-01 DK DK96907747T patent/DK0826681T3/da active

Also Published As

Publication number	Publication date
PT826681E (pt)	2003-02-28
US5843992A (en)	1998-12-01
CN1087295C (zh)	2002-07-10
KR100381275B1 (ko)	2003-08-19
DE69624235T2 (de)	2003-06-26
EP0826681A1 (en)	1998-03-04
EP0826681A4 (da)	1998-03-18
ATE225781T1 (de)	2002-10-15
ES2184855T3 (es)	2003-04-16
DE69624235D1 (de)	2002-11-14
AU716620B2 (en)	2000-03-02
EA000438B1 (ru)	1999-08-26
CN1185151A (zh)	1998-06-17
AU5123296A (en)	1996-10-16
EA199800181A1 (ru)	1998-08-27
WO1996030354A1 (en)	1996-10-03
KR19980703485A (ko)	1998-11-05
CA2217051A1 (en)	1996-10-03
CA2217051C (en)	2006-05-30
EP0826681B1 (en)	2002-10-09

Publication	Publication Date	Title
DE69201948D1 (de)	1995-05-11	Verwendung von 1,3-oxathiolanalogen von nukleosiden zur herstellung eines arzneimittels zur behandlung von hepatitis-b.
IL101860A0 (en)	1992-12-30	Heterocyclic derivatives
DK0826681T3 (da)	2003-02-17	Epoxyravsyrederivater
EP1184388A4 (en)	2002-10-16	SULPHOSTIN ANALOGA AND METHOD FOR PRODUCING SULPHOSTIN AND ANALOGA THEREOF
IL104154A0 (en)	1993-05-13	Saccharin derivatives,their preparation and pharmaceutical compositions containing them
AU4523797A (en)	1998-05-21	Atherosclerosis treatment
GR3024691T3 (en)	1997-12-31	Hydantoin compounds
AU667593B2 (en)	1996-03-28	Inhibitors of HIV protease useful for the treatment of AIDS
BR0212107A (pt)	2004-08-24	Análogos da ciclopropil e da ciclobutil epotilona
FI102896B1 (fi)	1999-03-15	Menetelmä farmaseuttisesti aktiivisen, rikkiä sisältävän heterosyklisen yhdisteen valmistamiseksi
MY103790A (en)	1993-09-30	Novel compound for the treatment of several bone affecting diseases
ATE267832T1 (de)	2004-06-15	Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
HU9203052D0 (en)	1992-12-28	Method for treatment of hypertension
ATE4422T1 (de)	1983-08-15	Substituierte 5-((7-chlor-4-chinolinyl)amino)-3(aminomethyl)-(1,1'-biphenyl)-2-ol-verbindungen verfahren zu ihrer herstellung; und die verbindungen enthaltende pharmazeutische zusammensetzungen.
GR3031908T3 (en)	2000-02-29	Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl cyclopentaneperhydrophenanthrene derivatives active on the cardiovascular system, a process for their preparation and pharmaceutical compositions containing same
DE69319356D1 (de)	1998-08-06	Thiolderivate von Gallensäure
JO1648B1 (en)	1991-11-27	Nitrogen compounds