DK0830137T3 - Iioniske molekylkonjugater af N-acylerede derivater af poly(2-amino-2-deoxy-D-glucose) og polypeptider - Google Patents

Iioniske molekylkonjugater af N-acylerede derivater af poly(2-amino-2-deoxy-D-glucose) og polypeptider

Info

Publication number
DK0830137T3
DK0830137T3 DK96920510T DK96920510T DK0830137T3 DK 0830137 T3 DK0830137 T3 DK 0830137T3 DK 96920510 T DK96920510 T DK 96920510T DK 96920510 T DK96920510 T DK 96920510T DK 0830137 T3 DK0830137 T3 DK 0830137T3
Authority
DK
Denmark
Prior art keywords
deoxy
polypeptides
glucose
poly
amino
Prior art date
Application number
DK96920510T
Other languages
Danish (da)
English (en)
Inventor
Shalaby W Shalaby
Steven A Jackson
Francis Ignatious
Jeaques-Pierre Moreau
Original Assignee
Kinerton Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinerton Ltd filed Critical Kinerton Ltd
Application granted granted Critical
Publication of DK0830137T3 publication Critical patent/DK0830137T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Saccharide Compounds (AREA)
DK96920510T 1995-06-06 1996-05-24 Iioniske molekylkonjugater af N-acylerede derivater af poly(2-amino-2-deoxy-D-glucose) og polypeptider DK0830137T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/468,947 US5665702A (en) 1995-06-06 1995-06-06 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
PCT/US1996/007756 WO1996039160A1 (en) 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Publications (1)

Publication Number Publication Date
DK0830137T3 true DK0830137T3 (da) 2003-11-03

Family

ID=23861854

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96920510T DK0830137T3 (da) 1995-06-06 1996-05-24 Iioniske molekylkonjugater af N-acylerede derivater af poly(2-amino-2-deoxy-D-glucose) og polypeptider

Country Status (21)

Country Link
US (2) US5665702A (de)
EP (1) EP0830137B1 (de)
JP (1) JPH11508289A (de)
KR (1) KR19990022399A (de)
CN (1) CN1192152A (de)
AT (1) ATE245031T1 (de)
AU (1) AU717188B2 (de)
BR (1) BR9609031A (de)
CA (1) CA2222995C (de)
CZ (1) CZ391697A3 (de)
DE (1) DE69629114T2 (de)
DK (1) DK0830137T3 (de)
ES (1) ES2201188T3 (de)
HU (1) HUP9901627A3 (de)
NZ (1) NZ308909A (de)
PL (1) PL323735A1 (de)
PT (1) PT830137E (de)
RU (1) RU2172323C2 (de)
SI (1) SI9620090A (de)
SK (1) SK168397A3 (de)
WO (1) WO1996039160A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6479457B2 (en) * 1995-06-06 2002-11-12 Kinerton Limited Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
CA2318152A1 (en) * 1998-01-29 1999-08-05 Poly-Med Inc. Absorbable microparticles
JP2002501907A (ja) 1998-01-29 2002-01-22 キナートン・リミテッド 吸収可能なマイクロ粒子の製造法
PL205713B1 (pl) 1998-12-07 2010-05-31 Sod Conseils Rech Applic Związki stanowiące analogi GLP-1, kompozycje farmaceutyczne zawierające takie związki oraz zastosowanie tych związków
JP4532618B2 (ja) * 1999-02-25 2010-08-25 株式会社グライコメディクス 新規糖鎖プライマー
AU2001289079A1 (en) 2000-09-13 2002-03-26 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained drug delivery
US7122622B2 (en) * 2002-04-16 2006-10-17 Biosynthema Inc. Peptide compounds having improved binding affinity to somatostatin receptors
US7244445B2 (en) 2002-07-29 2007-07-17 Poly Med, Inc Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
WO2004039410A2 (en) * 2002-10-31 2004-05-13 Pfizer Products Inc. Liquid conjugates of solid pharmaceuticals
CN1747747B (zh) 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
EP1711523B1 (de) 2003-12-16 2012-10-10 Ipsen Pharma Glp-1-analoga
KR100997177B1 (ko) 2005-07-08 2010-11-29 입센 파마 에스.에이.에스 멜라노코르틴 수용체 리간드
JP5436856B2 (ja) 2005-07-15 2014-03-05 アンジオケム インコーポレーティッド 薬学的複合体における担体としてのアプロチニンポリペプチドの使用
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
JP2010538069A (ja) 2007-09-07 2010-12-09 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ エキセンディン−４およびエキセンディン−３の類似体
TR201815292T4 (tr) 2007-11-05 2018-11-21 Board Of Supervisors Of Louisiana State Univ And Agriculture And Mechanical College İnsüli̇n duyarliliğinin tedavi̇si̇nde melanokorti̇nleri̇n kullanimi.
EP2260060A4 (de) * 2008-04-01 2013-01-16 Univ Cornell Organisch lösliche chitosansalze und daraus hergestellte chitosan-abgeleitete biomaterialien
EP2316970A2 (de) 2008-07-04 2011-05-04 Traslational Cancer Drugs Pharma, S.L. Verfahren zur behandlung und diagnose von krebs
EA020018B1 (ru) 2008-08-07 2014-08-29 Ипсен Фарма С.А.С. Процессированные аналоги глюкозозависимого инсулинотропного полипептида
MX2011001031A (es) 2008-08-07 2011-04-26 Ipsen Pharma Sas Analogos de polipeptidos insulinotropicos dependientes de glucosa.
CA2733006A1 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
WO2010092218A2 (es) 2009-02-12 2010-08-19 Proyecto De Biomedicina Cima, S.L. Uso de la cardiotrofina-1 para el tratamiento de enfermedades metabólicas
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
US8759299B2 (en) 2009-07-22 2014-06-24 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59
BR112013027222B1 (pt) 2011-06-14 2022-07-12 Ipsen Pharma S.A.S. Composição de liberação sustentada que contém peptídeos como ingrediente ativo
US9962401B2 (en) * 2011-09-27 2018-05-08 Purdue Research Foundation Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS63258579A (ja) * 1987-04-15 1988-10-26 Fuji Boseki Kk 生理活性物質固定化用担体の製造法
SU1558927A1 (ru) * 1988-03-30 1990-04-23 Симферопольский государственный университет им.М.В.Фрунзе Способ получени гидрохлорида @ -6-аминогексилгликозида-N-ацетилмурамоил-L-аланил-Д-изоглутамина
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
ATE152455T1 (de) * 1990-08-17 1997-05-15 Drug Delivery System Inst Ltd N-acetylcarboxymethylchitosanderivat und verfahren zur herstellung
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release

Also Published As

Publication number Publication date
SK168397A3 (en) 1998-04-08
HUP9901627A1 (hu) 1999-09-28
CN1192152A (zh) 1998-09-02
EP0830137A1 (de) 1998-03-25
ES2201188T3 (es) 2004-03-16
CZ391697A3 (cs) 1998-05-13
PT830137E (pt) 2003-10-31
HUP9901627A3 (en) 1999-11-29
KR19990022399A (ko) 1999-03-25
SI9620090A (sl) 1998-08-31
DE69629114D1 (de) 2003-08-21
EP0830137B1 (de) 2003-07-16
NZ308909A (en) 1999-06-29
BR9609031A (pt) 1999-12-14
EP0830137A4 (de) 2002-06-26
DE69629114T2 (de) 2004-04-22
CA2222995C (en) 2005-05-10
US5821221A (en) 1998-10-13
JPH11508289A (ja) 1999-07-21
AU717188B2 (en) 2000-03-23
CA2222995A1 (en) 1996-12-12
PL323735A1 (en) 1998-04-14
ATE245031T1 (de) 2003-08-15
US5665702A (en) 1997-09-09
AU5878996A (en) 1996-12-24
WO1996039160A1 (en) 1996-12-12
RU2172323C2 (ru) 2001-08-20

Similar Documents

Publication Publication Date Title
PT830137E (pt) Conjugados ionicos moleculares de derivados n-acilados de poli(2-amino-2-desoxi-d-glucose) e polipeptidos
DE69434046D1 (de) Nicht-antigene verzweigte Polymerconjugate
DK0792288T3 (da) Konjugater af BDNF og NT-3 med en vandopløselig polymer
YU46598A (sh) Jonski konjugat zadržanog oslobađanja
NO964976D0 (no) Kopolymer-1-forbedringer kopolymerpreparater
DK0973819T3 (da) Ikke-antigene forgrenede polymerkonjugater
FR2734496B1 (fr) Composition emulsionnante a base d'alkylpolyglycosides, et ses utilisations
DK0678018T3 (da) Ion molekylærkonjugater af bionedbrydelige polyestere og bioaktive polypeptider
DE69635829D1 (de) Pelletformige polymerzusammensetzung
FR2724261B1 (fr) Compositions d'electrolyte acep a base de melanges de copolymeres et de reseaux interpenetres.
ID20450A (id) Komposisi-komposisi polimer
NO914261L (no) Bindemiddelsammensetning basert paa en akrylatpolymer og et tverrbindingsmiddel basert paa en aceto-acetatforbindelse
ATA903396A (de) Zwei-komponenten-polymerzusammensetzung
BR9405897A (pt) Polímero de butadieno e composição polimérica
ID19676A (id) Komposisi-komposisi polimer heteromorfik
NO20011744L (no) Ioniske molekyl¶re konjugater av N-acylerte derivater av poly(2-amino-2-deoksy-d-glukose) og polypeptider
DE69720914D1 (de) Polyalkylphenoxyalkanole und poly(oxyalkylenen)amine enthaltende treibstoffadditivzusammensetzungen.
ITMI950507A0 (it) Composizioni polimeriche autoestinguenti
DE69411518D1 (de) Vulkanisierbare Epichlorhydrinpolymerzusammensetzung
EA199900864A1 (ru) Полимерные амины
DE68913175D1 (de) Zusammensetzung auf der Basis eines N-substituierten Maleinsäureimidpolymers.
ID16309A (id) Isolator polimer
DE69517449D1 (de) Glanzarme, witterungsbeständige polymerzusammensetzung
NO963216L (no) Kondensasjons- og addisjonspolymerer med N,N'-brodannede bis-tetrametylpiperidinyloksygrupper