DK0830376T3 - Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner - Google Patents

Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner

Info

Publication number: DK0830376T3
Authority: DK; Denmark
Prior art keywords: free; host cell; animal proteins; protein; producing erythropoietin
Prior art date: 1995-05-11

Application number

DK96919753T

Other languages

English (en)

Inventor

Josef Burg

Walter Schneider

Alexander Wrba

Werner Fuerst

Karl-Heinz Sellinger

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-11

Filing date

1996-05-10

Publication date

2004-05-24

1996-05-10 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

2004-05-24 Application granted granted Critical

2004-05-24 Publication of DK0830376T3 publication Critical patent/DK0830376T3/da

Links

102000003951 Erythropoietin Human genes 0.000 title abstract 2
108090000394 Erythropoietin Proteins 0.000 title abstract 2
229940105423 erythropoietin Drugs 0.000 title abstract 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 2
235000021120 animal protein Nutrition 0.000 title 1
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK96919753T 1995-05-11 1996-05-10 Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner DK0830376T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP95107165		1995-05-11
DE19522461		1995-06-21
PCT/EP1996/001988 WO1996035718A1 (de)	1995-05-11	1996-05-10	Verfahren zur herstellung von erythropoietin frei von tierischen proteinen

Publications (1)

Publication Number	Publication Date
DK0830376T3 true DK0830376T3 (da)	2004-05-24

Family

ID=26016131

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK96919753T DK0830376T3 (da)	1995-05-11	1996-05-10	Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner
DK03016548T DK1394179T3 (da)	1995-05-11	1996-05-10	Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK03016548T DK1394179T3 (da)	1995-05-11	1996-05-10	Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner

Country Status (12)

Country	Link
US (2)	US6399333B1 (da)
EP (2)	EP1394179B1 (da)
JP (1)	JP3061200B2 (da)
AT (2)	ATE258189T1 (da)
AU (1)	AU5817496A (da)
CA (1)	CA2220515C (da)
DE (2)	DE59610898D1 (da)
DK (2)	DK0830376T3 (da)
ES (2)	ES2268232T3 (da)
IL (2)	IL118201A (da)
PT (2)	PT1394179E (da)
WO (1)	WO1996035718A1 (da)

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NZ335207A (en) *	1996-11-15	2000-09-29	Genentech Inc	Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin
US6548296B1 (en) *	1997-07-23	2003-04-15	Roche Diagnostics Gmbh	Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
ATE341625T1 (de) *	1997-07-23	2006-10-15	Roche Diagnostics Gmbh	Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren
TR200001580T2 (tr)	1997-12-03	2000-12-21	Roche Diagnostics Gmbh	Spesifik etkinliği yüksek eritropoyetin
BRPI9910332B8 (pt)	1998-05-06	2021-05-25	Genentech Inc	método para purificação de um polipeptídio a partir de uma composição
BR9905867A (pt) *	1998-11-06	2001-01-23	Bio Sidus S A	Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
BR9905868A (pt) *	1998-11-06	2001-01-23	Bio Sidus S A	Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento
BR9917606A (pt) *	1998-11-06	2002-12-31	Bio Sidus S A	Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
JO2291B1 (en)	1999-07-02	2005-09-12	اف . هوفمان لاروش ايه جي	Erythropoietin derivatives
CA2431964C (en)	2000-12-20	2013-09-10	F. Hoffmann-La Roche Ag	Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
PL370550A1 (en) *	2001-11-28	2005-05-30	Sandoz Ag	Method for producing a recombinant polypeptide
ATE363541T1 (de) *	2002-03-26	2007-06-15	Lek Tovarna Farmacevtskih	Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen
DK1428878T3 (da) *	2002-12-13	2008-12-08	Bioceuticals Arzneimittel Ag	Fremgangsmåde til produktion og oprensning af erythropoietin
US20050019914A1 (en) *	2003-07-24	2005-01-27	Aventis Pharma Deutschland Gmbh	Perfusion process for producing erythropoietin
US7354740B2 (en) *	2003-09-25	2008-04-08	Allergan, Inc.	Animal product free system and process for purifying a botulinum toxin
AU2003271194A1 (en) *	2003-10-09	2005-04-21	Daewoong Co., Ltd.	Process for purifying human thrombopoietin with high content of sialic acid
DE102004027816A1 (de)	2004-06-08	2006-01-05	Bioceuticals Arzneimittel Ag	Verfahren zur Reinigung von Erythropoietin
US7598356B2 (en) *	2004-07-08	2009-10-06	Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center	Method for purifying a protein of the cystine-knot superfamily
CN101061137A (zh) *	2004-11-09	2007-10-24	Usv有限公司	用于纯化人生长激素的新方法
SI1957630T2 (sl)	2005-12-08	2023-07-31	Amgen Inc.	Izboljšana proizvodnja glikoproteinov z uporabo mangana
WO2008019214A1 (en)	2006-08-04	2008-02-14	Prolong Pharmaceuticals, Inc.	Modified erythropoietin
EP2089424B1 (en) *	2006-12-06	2015-07-01	JCR PHARMACEUTICALS Co., LTD.	Method for production of human erythropoietin
KR100988706B1 (ko)	2007-03-07	2010-10-18	한미홀딩스 주식회사	재조합 에리트로포이에틴의 신규한 정제방법
CL2008002053A1 (es)	2007-07-17	2009-05-22	Hoffmann La Roche	Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
CL2008002054A1 (es) *	2007-07-17	2009-05-29	Hoffmann La Roche	Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
KR100900033B1 (ko)	2007-11-21	2009-06-01	한국생명공학연구원	인간 에리스로포이에틴의 정제방법
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
DE102008002210A1 (de) *	2008-06-04	2009-12-10	Evonik Degussa Gmbh	Verfahren zur fermentativen Herstellung von Erythropoietin
DE102008002209A1 (de)	2008-06-04	2009-12-10	Evonik Degussa Gmbh	Verfahren zur Aufreinigung von Erythropoietin
EP2334699B1 (en)	2008-09-23	2013-09-11	F. Hoffmann-La Roche AG	Purification of erythropoietin
PL2342223T3 (pl)	2008-09-26	2017-09-29	Ambrx, Inc.	Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
DE102008054716A1 (de)	2008-12-16	2010-06-17	Evonik Degussa Gmbh	Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
CN102471377B (zh)	2009-07-24	2015-04-22	霍夫曼-拉罗奇有限公司	优化抗体的生产
EA022396B1 (ru)	2009-09-23	2015-12-30	Ратиофарм Гмбх	Способ очистки рекомбинантного эритропоэтина человека (epo), эритропоэтин, очищенный данным способом, и фармацевтические композиции, содержащие такой эритропоэтин
KR101443257B1 (ko) *	2011-10-18	2014-09-19	주식회사 종근당	낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
EP2970420A4 (en) *	2013-03-15	2016-08-17	Apotex Inc	STABILITY OF THE ENHANCED LIQUID FORMULATION OF ERYTHROPOIETIN ALPHA VIA A PURIFICATION TREATMENT
WO2016116966A1 (en) *	2015-01-22	2016-07-28	Jcr Pharmaceuticals Co., Ltd.	Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
DK3613486T3 (da) *	2018-08-24	2021-01-04	Uga Biopharma Gmbh	Metode og anlæg til rengøring af epo og/eller et epo-derivat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ210501A (en) *	1983-12-13	1991-08-27	Kirin Amgen Inc	Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4677195A (en) *	1985-01-11	1987-06-30	Genetics Institute, Inc.	Method for the purification of erythropoietin and erythropoietin compositions
IL79176A (en) *	1985-06-20	1992-06-21	Kirin Amgen Inc	Process for the recovery of erythropoietin from a fluid
US4954437A (en)	1986-09-15	1990-09-04	Integrated Genetics, Inc.	Cell encoding recombinant human erythropoietin
AU4104889A (en) *	1988-09-07	1990-03-15	Bioclones (Pty) Ltd	Purification of erythropoietin
DE4115722A1 (de)	1991-05-14	1992-11-19	Boehringer Mannheim Gmbh	Serumfreies medium zur kultivierung von saeugerzellen

1996
- 1996-05-09 IL IL11820196A patent/IL118201A/en not_active IP Right Cessation
- 1996-05-10 DE DE59610898T patent/DE59610898D1/de not_active Expired - Lifetime
- 1996-05-10 PT PT03016548T patent/PT1394179E/pt unknown
- 1996-05-10 ES ES03016548T patent/ES2268232T3/es not_active Expired - Lifetime
- 1996-05-10 DK DK96919753T patent/DK0830376T3/da active
- 1996-05-10 AU AU58174/96A patent/AU5817496A/en not_active Abandoned
- 1996-05-10 DE DE59611371T patent/DE59611371D1/de not_active Expired - Lifetime
- 1996-05-10 PT PT96919753T patent/PT830376E/pt unknown
- 1996-05-10 EP EP03016548A patent/EP1394179B1/de not_active Expired - Lifetime
- 1996-05-10 WO PCT/EP1996/001988 patent/WO1996035718A1/de not_active Ceased
- 1996-05-10 AT AT96919753T patent/ATE258189T1/de active
- 1996-05-10 US US08/945,802 patent/US6399333B1/en not_active Expired - Lifetime
- 1996-05-10 CA CA002220515A patent/CA2220515C/en not_active Expired - Lifetime
- 1996-05-10 AT AT03016548T patent/ATE334146T1/de active
- 1996-05-10 JP JP8533775A patent/JP3061200B2/ja not_active Expired - Lifetime
- 1996-05-10 ES ES96919753T patent/ES2211961T3/es not_active Expired - Lifetime
- 1996-05-10 DK DK03016548T patent/DK1394179T3/da active
- 1996-05-10 EP EP96919753A patent/EP0830376B1/de not_active Expired - Lifetime
2002
- 2002-02-07 US US10/067,235 patent/US6471500B1/en not_active Expired - Lifetime
2003
- 2003-08-28 IL IL15764403A patent/IL157644A0/xx unknown

Also Published As

Publication number	Publication date
US6471500B1 (en)	2002-10-29
PT1394179E (pt)	2006-11-30
DE59611371D1 (de)	2006-09-07
PT830376E (pt)	2004-05-31
DK1394179T3 (da)	2006-11-20
ES2268232T3 (es)	2007-03-16
CA2220515A1 (en)	1996-11-14
ES2211961T3 (es)	2004-07-16
CA2220515C (en)	2003-07-22
IL118201A0 (en)	1996-09-12
WO1996035718A1 (de)	1996-11-14
JPH10506924A (ja)	1998-07-07
AU5817496A (en)	1996-11-29
ATE258189T1 (de)	2004-02-15
IL118201A (en)	2004-12-15
ATE334146T1 (de)	2006-08-15
US20020146771A1 (en)	2002-10-10
EP0830376B1 (de)	2004-01-21
US6399333B1 (en)	2002-06-04
JP3061200B2 (ja)	2000-07-10
EP0830376A1 (de)	1998-03-25
DE59610898D1 (de)	2004-02-26
EP1394179A1 (de)	2004-03-03
EP1394179B1 (de)	2006-07-26
IL157644A0 (en)	2004-03-28

Publication	Publication Date	Title
DK1394179T3 (da)	2006-11-20	Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner
PT850310E (pt)	2005-05-31	Molecula de dna circular com origem de replicacao condicional, metodo para a sua preparacao e utilizacao da mesma na terapia genica
LU90855I2 (en)	2002-01-24	Proteine 1 osteogenique recombinante humaine: bmp-7 et ses d-riv-s pharmaceutiquement acceptables
ATE232237T1 (de)	2003-02-15	Herstellung von funktionellen, menschlichen urokinaseproteinen
DK0454898T3 (da)	1996-04-15	Glycosaminoglycan-modificeret protein, fremgangsmåde til fremstilling af proteinet, farmaceutiske præparater indeholdende proteinet samt anvendelse af proteinet
DK374087D0 (da)	1987-07-17	Fremgangsmaade til fremstilling af proteiner med faktor viii-aktivitet ved hjaelp af mikrobielle voertsceller og ekspressionsvektorer, vaertsceller og antistoffer til anvendelse ved denne
DK42588A (da)	1988-01-28	Protein med prokoagulantaktivitet af human faktor viii:c-typen, dets fremstilling og anvendelse samt cdna, som koder det
NO993709L (no)	1999-09-28	Stabilisert blanding omfattende fibrinogen
NO904023D0 (no)	1990-09-14	Blanding som induserer binding.
DK388789A (da)	1990-02-10	Hybridderivat af humant protein d, dets fremstilling og anvendelse samt dna, som koder derfor, og genstruktur og vaertscelle indeholdende denne dna
DK619086D0 (da)	1986-12-19	Gm-csf-protein, derivater deraf, samt fremstilling og anvendelse af saadanne proteiner
DE3576361D1 (de)	1990-04-12	Rekombinante dna, damit transformierter mikroorganismus, und verfahren zur herstellung von menschlicher cu-zn superoxiddismutase unter verwendung des transformierten mikroorganismus.
NO963806D0 (no)	1996-09-11	Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet
DK595187D0 (da)	1987-11-13	Minactivin og fremgangsmaade til fremstilling deraf
IT1197891B (it)	1988-12-21	Metodo per la determinazione dell'attivita' biologica della proteina c nel plasma umano, e relativi reagenti
HUT49151A (en)	1989-08-28	Process for production of biotinilated proteins
DE69813573D1 (de)	2003-05-22	Verbesserungen der oder in bezug auf die regulierung der t-zellaktivation
NO179453C (no)	1996-10-09	Fremgangsmåte for fremstilling av terapeutisk aktivt amphiregulin, vertscelle som produserer proteinet, rekombinant vektor inneholdt i vertscellen, samt nukleotidsekvens som koder for proteiner med amphiregulinaktivitet
MA21449A1 (fr)	1989-07-01	Abri-serres pour culture haute : (bananier, papaye, ..)