DK0850062T3 - Anvendelse af halofuginon til fremstilling af et medikament til svækkelse af neovaskularisering og til behandling af maligne tumorer hos mennesker - Google Patents

Anvendelse af halofuginon til fremstilling af et medikament til svækkelse af neovaskularisering og til behandling af maligne tumorer hos mennesker

Info

Publication number: DK0850062T3
Authority: DK; Denmark
Prior art keywords: halofuginone; humans; drug; manufacture; treatment
Prior art date: 1995-08-15

Application number

DK96928874T

Other languages

English (en)

Inventor

Israel Vlodavsky

Aron Nagler

Shimon Slavin

Mark Pines

Original Assignee

Agricultural Res Org

Hadasit Med Res Service

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-15

Filing date

1996-08-12

Publication date

2005-02-07

1996-08-12 Application filed by Agricultural Res Org, Hadasit Med Res Service filed Critical Agricultural Res Org

2005-02-07 Application granted granted Critical

2005-02-07 Publication of DK0850062T3 publication Critical patent/DK0850062T3/da

Links

206010029113 Neovascularisation Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
LVASCWIMLIKXLA-LSDHHAIUSA-N halofuginone Chemical compound O[C@@H]1CCCN[C@H]1CC(=O)CN1C(=O)C2=CC(Cl)=C(Br)C=C2N=C1 LVASCWIMLIKXLA-LSDHHAIUSA-N 0.000 title 1
229950010152 halofuginone Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
-1 hydroxy, acetoxy Chemical group 0.000 abstract 1
230000036210 malignancy Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK96928874T 1995-08-15 1996-08-12 Anvendelse af halofuginon til fremstilling af et medikament til svækkelse af neovaskularisering og til behandling af maligne tumorer hos mennesker DK0850062T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL11495195A IL114951A (en)	1995-08-15	1995-08-15	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization
PCT/US1996/013210 WO1997006805A1 (en)	1995-08-15	1996-08-12	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating human malignancies

Publications (1)

Publication Number	Publication Date
DK0850062T3 true DK0850062T3 (da)	2005-02-07

Family

ID=11067877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96928874T DK0850062T3 (da)	1995-08-15	1996-08-12	Anvendelse af halofuginon til fremstilling af et medikament til svækkelse af neovaskularisering og til behandling af maligne tumorer hos mennesker

Country Status (11)

Country	Link
EP (1)	EP0850062B1 (da)
JP (1)	JP4101875B2 (da)
CN (1)	CN1113652C (da)
AT (1)	ATE279925T1 (da)
AU (1)	AU705955B2 (da)
CA (1)	CA2228524C (da)
DE (1)	DE69633673T2 (da)
DK (1)	DK0850062T3 (da)
ES (1)	ES2231824T3 (da)
IL (1)	IL114951A (da)
WO (1)	WO1997006805A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998014169A1 (en)	1996-09-30	1998-04-09	Brigham & Women's Hospital	Methods and compounds for treatment of abnormal uterine bleeding
US6028075A (en) *	1997-02-11	2000-02-22	Pines; Mark	Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
IT1316986B1 (it) *	2000-01-25	2003-05-26	Sigma Tau Ind Farmaceuti	Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
IL147416A (en) *	2001-12-31	2008-11-26	Israel State	Combined modalities for improved cancer treatment
CN100434425C (zh) *	2005-03-09	2008-11-19	首都师范大学	4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
CN102653521B (zh) *	2012-04-27	2014-08-06	首都师范大学	吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途
AR110963A1 (es)	2017-02-07	2019-05-22	Dae Woong Pharma	Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3320124A (en) *	1964-07-20	1967-05-16	American Cyanamid Co	Method for treating coccidiosis with quinazolinones
DE2934069A1 (de) *	1979-08-23	1981-03-12	Hoechst Ag, 6000 Frankfurt	Mittel gegen theileriosen und seine verwendung.
DE3638446A1 (de) *	1986-11-11	1988-05-26	Hoechst Ag	Coccidiozide mittel
CA2113229C (en) *	1994-01-11	1999-04-20	Mark Pines	Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
IL110831A (en) *	1994-08-31	1998-12-27	Hadasit Med Res Service	Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis
IL112125A (en) *	1994-12-22	1998-02-08	Hadasit Med Res Service	Quinazolinone-containing pharmaceutical compositions

1995
- 1995-08-15 IL IL11495195A patent/IL114951A/xx not_active IP Right Cessation
1996
- 1996-08-12 WO PCT/US1996/013210 patent/WO1997006805A1/en not_active Ceased
- 1996-08-12 CA CA002228524A patent/CA2228524C/en not_active Expired - Fee Related
- 1996-08-12 CN CN96196609A patent/CN1113652C/zh not_active Expired - Fee Related
- 1996-08-12 DE DE69633673T patent/DE69633673T2/de not_active Expired - Fee Related
- 1996-08-12 AU AU68469/96A patent/AU705955B2/en not_active Ceased
- 1996-08-12 AT AT96928874T patent/ATE279925T1/de not_active IP Right Cessation
- 1996-08-12 DK DK96928874T patent/DK0850062T3/da active
- 1996-08-12 ES ES96928874T patent/ES2231824T3/es not_active Expired - Lifetime
- 1996-08-12 EP EP96928874A patent/EP0850062B1/en not_active Expired - Lifetime
- 1996-08-12 JP JP50946697A patent/JP4101875B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0850062A4 (en)	2000-03-15
ES2231824T3 (es)	2005-05-16
IL114951A (en)	1999-08-17
CA2228524A1 (en)	1997-02-27
AU705955B2 (en)	1999-06-03
EP0850062A1 (en)	1998-07-01
AU6846996A (en)	1997-03-12
JP4101875B2 (ja)	2008-06-18
EP0850062B1 (en)	2004-10-20
DE69633673D1 (de)	2004-11-25
CN1113652C (zh)	2003-07-09
ATE279925T1 (de)	2004-11-15
DE69633673T2 (de)	2006-02-09
WO1997006805A1 (en)	1997-02-27
CN1194583A (zh)	1998-09-30
JPH11511172A (ja)	1999-09-28
IL114951A0 (en)	1995-12-08
CA2228524C (en)	2003-01-07

Publication	Publication Date	Title
CA2280850A1 (en)	1998-08-13	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
EP0787000A4 (en)	1997-11-12	CHINAZOLINONE MEDICINES AND THEIR USE
BR9707233A (pt)	1999-07-20	Fenantridinas
TR199800697T2 (xx)	1998-07-21	Farmas�tik olarak aktif kinazolin bile�imleri.
DK0889886T5 (da)	2003-02-24	Hidtil ukendte, i 6-stilling substituerede phenanthridiner
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
TR200001840T2 (tr)	2000-12-21	Arile bağlı azopolisiklik bileşikler
LU91928I2 (fr)	2012-03-09	Ipilimumab et ses dérivés pharmaceutiquement acceptables (YERVOY®)
BR0211305A (pt)	2004-07-13	Composto, composição farmacêutica, método de tratamento ou prevenção de doenças ou condições e uso de um composto
DE69720709D1 (de)	2003-05-15	Substituierte tetracyclische tetrahydrofuranderivate
SE9802208D0 (sv)	1998-06-22	Novel compounds
NZ512981A (en)	2002-10-25	Use of pyridazino[4,5-b]indole-1-acetamide derivatives for treating diseases related to the dysfunction of peripheral benzodiazepine receptors
DK0850062T3 (da)	2005-02-07	Anvendelse af halofuginon til fremstilling af et medikament til svækkelse af neovaskularisering og til behandling af maligne tumorer hos mennesker
SI1147105T1 (en)	2004-08-31	Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatement of vascular diseases
PT986393E (pt)	2004-06-30	Utilizacao de um nitroxido ou de um seu pro-farmaco no tratamento profilactico e terapeutico do cancro
SE9802209D0 (sv)	1998-06-22	Novel compounds
AR021094A1 (es)	2002-06-12	Compuestos heterociclicos inhibidores de la fosfodiesterasa iv y su uso para el tratamiento de enfermedades inflamatorias
PT1068199E (pt)	2003-02-28	N-ariloxietil-indoli-alquilaminas para o tratamento da depressao
MX9705379A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis vasodilatadora.