DK0858328T3 - Stabile præparater indeholdende N-propargyl-1-aminoindan - Google Patents

Stabile præparater indeholdende N-propargyl-1-aminoindan

Info

Publication number: DK0858328T3
Authority: DK; Denmark
Prior art keywords: pct; aminoindan; propargyl; preparations containing; sec
Prior art date: 1995-09-20

Application number

DK96930344T

Other languages

English (en)

Inventor

Peskin Tirtsah Berger

Fanny Caciularu

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-20

Filing date

1996-09-18

Publication date

2007-09-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11068003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0858328(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-09-18 Application filed by Teva Pharma filed Critical Teva Pharma

2007-09-03 Application granted granted Critical

2007-09-03 Publication of DK0858328T3 publication Critical patent/DK0858328T3/da

Links

RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
235000019359 magnesium stearate Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Solid Fuels And Fuel-Associated Substances (AREA)

DK96930344T 1995-09-20 1996-09-18 Stabile præparater indeholdende N-propargyl-1-aminoindan DK0858328T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL11535795A IL115357A (en)	1995-09-20	1995-09-20	Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols
PCT/IL1996/000115 WO1997012583A2 (en)	1995-09-20	1996-09-18	Stable compositions containing n-propargyl-1-aminoindan

Publications (1)

Publication Number	Publication Date
DK0858328T3 true DK0858328T3 (da)	2007-09-03

Family

ID=11068003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96930344T DK0858328T3 (da)	1995-09-20	1996-09-18	Stabile præparater indeholdende N-propargyl-1-aminoindan

Country Status (13)

Country	Link
US (1)	US6126968A (da)
EP (1)	EP0858328B1 (da)
JP (1)	JP4108750B2 (da)
AT (1)	ATE362755T1 (da)
AU (1)	AU728524B2 (da)
CA (1)	CA2232310C (da)
DE (1)	DE69637096T2 (da)
DK (1)	DK0858328T3 (da)
ES (1)	ES2287940T3 (da)
HU (1)	HU225859B1 (da)
IL (1)	IL115357A (da)
PT (1)	PT858328E (da)
WO (1)	WO1997012583A2 (da)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5744500A (en)	1990-01-03	1998-04-28	Teva Pharmaceutical Industries, Ltd.	Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
IL118836A (en)	1996-07-11	2001-01-11	Teva Pharma	Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
IL149308A0 (en)	1999-10-27	2002-11-10	Teva Pharma	Use of 1-aminoindan derivatives for treatment of manic disorders
SI1567152T1 (sl) *	2002-11-15	2013-10-30	Teva Pharmaceutical Industries Ltd.	Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze
GB2411355B (en)	2004-02-27	2006-02-22	Niche Generics Ltd	Pharmaceutical composition
WO2006014973A2 (en) *	2004-07-26	2006-02-09	Teva Pharmaceutical Industries, Ltd.	Pharmaceutical dosage forms including rasagiline
US8367105B2 (en)	2004-11-10	2013-02-05	Teva Pharmaceutical Industries, Ltd.	Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
DE602004007302T2 (de) *	2004-11-10	2008-03-20	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung von komprimierten festen dosierungsformen, das gut zur verwendung mit schlecht wasserlöslichen arzneistoffen geeignet ist, und danach hergestellte komprimierte feste dosierungsformen
CN103494766A (zh) *	2004-11-24	2014-01-08	特瓦制药工业有限公司	雷沙吉兰经口崩解组合物
WO2006089164A1 (en) *	2005-02-17	2006-08-24	Teva Pharmaceutical Industries, Ltd.	Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
US20100167983A1 (en) *	2007-10-22	2010-07-01	Teva Pharmaceutical Industries, Ltd.	Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
CA2901244A1 (en) *	2005-02-23	2006-08-31	Teva Pharmaceutical Industries, Ltd.	Rasagiline formulations of improved content uniformity
EP1954667B1 (en) *	2005-11-17	2017-02-08	Teva Pharmaceutical Industries Ltd	Methods for isolating propargylated aminoindans
US7572834B1 (en)	2005-12-06	2009-08-11	Teva Pharmaceutical Industries, Ltd.	Rasagiline formulations and processes for their preparation
AU2006326642B2 (en)	2005-12-09	2012-05-03	Technion Research And Development Foundation Ltd.	Use of low-dose ladostigil for neuroprotection
JP5701485B2 (ja)	2006-02-21	2015-04-15	テバファーマシューティカルインダストリーズリミティド	多系統萎縮症の治療のためのラサギリンの使用
TW200744576A (en)	2006-02-24	2007-12-16	Teva Pharma	Propargylated aminoindans, processes for preparation, and uses thereof
CA2646250A1 (en) *	2006-04-03	2007-10-18	Teva Pharmaceutical Industries Ltd.	Use of rasagiline for the treatment of restless legs syndrome
DE202006020710U1 (de)	2006-05-09	2009-12-31	Teva Pharmaceutical Industries Ltd.	Zusammensetzungen mit Rosiglitazonmaleat
EP1892233A1 (de) *	2006-08-18	2008-02-27	Ratiopharm GmbH	Neue Salze des Wirkstoffs Rasagilin
JP5356248B2 (ja) *	2006-12-14	2013-12-04	テバファーマシューティカルインダストリーズリミティド	ラサギリンのタンニン酸塩
ZA200903903B (en) *	2006-12-14	2010-08-25	Teva Pharma	Crystalline solid rasagiline base
EP1987816A1 (de) *	2007-04-30	2008-11-05	Ratiopharm GmbH	Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
AU2008296908B2 (en) *	2007-09-05	2014-01-09	Teva Pharmaceutical Industries, Ltd.	Method of treating glaucoma using rasagiline
US8188149B2 (en) *	2007-09-17	2012-05-29	Teva Pharmaceutical Industries, Ltd.	Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
US20090181086A1 (en) *	2008-01-11	2009-07-16	Muhammad Safadi	Rasagiline formulations, their preparation and use
US20090247537A1 (en) *	2008-03-25	2009-10-01	William Dale Overfield	Methods for preventing or treating bruxism using dopaminergic agents
WO2009122301A2 (en) *	2008-03-31	2009-10-08	Actavis Group Ptc Ehf	Rasagiline mesylate particles and process for the preparation thereof
JP2011522892A (ja) *	2008-06-13	2011-08-04	テバファーマシューティカルインダストリーズリミティド	パーキンソン病緩和のためのラサギリン
MX2010013875A (es)	2008-06-19	2011-01-20	Teva Pharma	Proceso para preparar y secar base de rasagilina solida.
AU2009260733B2 (en) *	2008-06-19	2015-01-29	Teva Pharmaceutical Industries, Ltd.	Process for purifying rasagiline base
US20100189790A1 (en) *	2009-01-23	2010-07-29	Teva Pharmaceutical Industries, Ltd.	Delayed release rasagiline formulation
EP2218444A3 (en)	2009-01-23	2010-08-25	Teva Pharmaceutical Industries, Ltd.	Delayed release rasagiline formulation
US20120122993A1 (en)	2009-03-05	2012-05-17	Sandoz Ag	Pharmaceutical composition containing 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-(1r)-, methanesulfonate
SI2451771T1 (sl)	2009-07-09	2014-10-30	Ratiopharm Gmbh	Soli rasagilina in njihovi farmacevtski pripravki
CN102048717B (zh) †	2009-10-29	2014-02-19	重庆医药工业研究院有限责任公司	一种稳定的雷沙吉兰组合物
AU2010341499A1 (en)	2009-12-22	2012-08-09	Teva Pharmaceutical Industries Ltd.	3-keto-N-propargyl-1-aminoindan
ES2608782T3 (es)	2010-04-30	2017-04-17	Teikoku Pharma Usa, Inc.	Composiciones transdérmicas de propinilaminoindano
EP2389927A1 (en)	2010-05-30	2011-11-30	Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi	Pharmaceutical formulations of rasagiline
AU2011282716A1 (en)	2010-07-27	2013-03-14	Teva Pharmaceutical Industries Ltd.	Dispersions of rasagiline citrate
CA2806740A1 (en)	2010-07-27	2012-02-02	Teva Pharmaceutical Industries Ltd.	Use of rasagiline for the treatment of olfactory dysfunction
EP2688561B1 (en)	2011-03-24	2018-08-22	Teikoku Pharma USA, Inc.	Transdermal compositions comprising an active agent layer and an active agent conversion layer
JP2014534197A (ja)	2011-10-10	2014-12-18	テバファーマシューティカルインダストリーズリミティド	Ｒ（＋）−ｎ−メチル−プロパルギルアミノインダン
CN103857389A (zh) *	2011-10-10	2014-06-11	泰华制药工业有限公司	雷沙吉兰柠檬酰胺
WO2013055687A2 (en)	2011-10-10	2013-04-18	Teva Pharmaceutical Industries Ltd.	R(+)-n-formyl-propargyl-aminoindan
JP5913614B2 (ja)	2011-11-09	2016-04-27	テイコクファーマユーエスエーインコーポレーテッド	皮膚新生物の処置方法
DE102012000786A1 (de)	2012-01-18	2013-07-18	Stada Arzneimittel Ag	Verfahren zur Herstellung einer festen pharmazeutischen Zusammensetzung, enthaltend den Wirkstoff Rasagilin
EA201491734A1 (ru)	2012-03-21	2015-01-30	Синтон Бв	Стабилизированные фармацевтические композиции, содержащие соли разагилина
WO2013175493A1 (en)	2012-04-09	2013-11-28	Cadila Healthcare Limited	Stable oral pharmaceutical compositions
US9308182B2 (en)	2012-08-17	2016-04-12	Teva Pharmaceutical Industries, Ltd.	Parenteral formulations of rasagiline
AU2013338243B2 (en)	2012-11-02	2016-09-29	Teikoku Seiyaku Co., Ltd.	Propynylaminoindan transdermal compositions
EP2796130A3 (en) *	2013-02-06	2015-02-25	Galenicum Health S.L.	Immediate release tablets of rasagiline hemitartrate
ES2502140T1 (es) *	2013-02-06	2014-10-02	Galenicum Health S.L.	Comprimidos de liberación inmediata de rasagilina hemitartrato
CN115400090A (zh) *	2022-10-09	2022-11-29	北京新领先医药科技发展有限公司	一种雷沙吉兰的口崩片组合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1187017A (en) *	1966-07-16	1970-04-08	Aspro Nicholas Ltd	Substituted 1-Amino Indanes and Tetrahydronaphthalens
GB8909793D0 (en) *	1989-04-28	1989-06-14	Beecham Group Plc	Pharmaceutical formulation
IL92952A (en) *	1990-01-03	1994-06-24	Teva Pharma	R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
CA2039742A1 (en) *	1990-04-23	1991-10-24	Andrew B. Dennis	Tablet composition and method for problem pharmaceutical materials
IL99759A (en) *	1991-10-16	1997-06-10	Teva Pharma	Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
IL111240A (en) *	1993-10-18	2001-10-31	Teva Pharma	Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
IL112779A (en) *	1994-03-01	1999-11-30	Gergely Gerhard	Granular product or tablet containing an efferescent system and an active pharmaceutical substance and its preparation
ATE241346T1 (de) *	1995-03-02	2003-06-15	Scherer Technologies Inc R P	Arzneimittel enthaltend monoaminooxidase-b-hemmer

1995
- 1995-09-20 IL IL11535795A patent/IL115357A/xx not_active IP Right Cessation
1996
- 1996-09-18 JP JP51411997A patent/JP4108750B2/ja not_active Expired - Lifetime
- 1996-09-18 DE DE69637096T patent/DE69637096T2/de not_active Expired - Lifetime
- 1996-09-18 HU HU9802999A patent/HU225859B1/hu unknown
- 1996-09-18 CA CA002232310A patent/CA2232310C/en not_active Expired - Lifetime
- 1996-09-18 EP EP96930344A patent/EP0858328B1/en not_active Expired - Lifetime
- 1996-09-18 ES ES96930344T patent/ES2287940T3/es not_active Expired - Lifetime
- 1996-09-18 PT PT96930344T patent/PT858328E/pt unknown
- 1996-09-18 WO PCT/IL1996/000115 patent/WO1997012583A2/en not_active Ceased
- 1996-09-18 AT AT96930344T patent/ATE362755T1/de active
- 1996-09-18 US US09/043,475 patent/US6126968A/en not_active Expired - Lifetime
- 1996-09-18 DK DK96930344T patent/DK0858328T3/da active
- 1996-09-18 AU AU69427/96A patent/AU728524B2/en not_active Expired

Also Published As

Publication number	Publication date
CA2232310A1 (en)	1997-04-10
ATE362755T1 (de)	2007-06-15
HUP9802999A2 (hu)	1999-04-28
HU225859B1 (en)	2007-11-28
PT858328E (pt)	2007-08-20
JP4108750B2 (ja)	2008-06-25
AU6942796A (en)	1997-04-28
ES2287940T3 (es)	2007-12-16
EP0858328B1 (en)	2007-05-23
WO1997012583A2 (en)	1997-04-10
JPH11512736A (ja)	1999-11-02
US6126968A (en)	2000-10-03
WO1997012583A3 (en)	1997-06-05
DE69637096T2 (de)	2008-01-31
EP0858328A2 (en)	1998-08-19
HUP9802999A3 (en)	1999-05-28
IL115357A0 (en)	1995-12-31
IL115357A (en)	2000-01-31
AU728524B2 (en)	2001-01-11
CA2232310C (en)	2008-01-08
DE69637096D1 (de)	2007-07-05
EP0858328A4 (en)	2001-07-11

Publication	Publication Date	Title
DK0858328T3 (da)	2007-09-03	Stabile præparater indeholdende N-propargyl-1-aminoindan
UA26455C2 (uk)	1999-08-30	Лікарський препарат у формі таблеток із сповільhеhим вивільhеhhям активhого іhгредієhта
FR2688422B1 (da)	1995-03-10
YU13695A (sh)	1999-07-28	Upotreba 2-fenil-3-aroilbenzotiofena i njihove farmaceutske formulacije
ZA948670B (en)	1995-07-04	New benzoyl guanidine derivatives,the preparation thereof and their use in pharmaceutical compositions
EP1468679A3 (en)	2004-11-24	Controlled release formulation containing tramadol
PT881901E (pt)	2002-09-30	Novas associacoes de principios activos contendo clopidogrel e um agente anti-trombotico
CA2081068A1 (en)	1993-04-24	Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-d-neuraminic acid
FI972434A0 (fi)	1997-06-06	Lamotrigiiniä sisältävä farmaseuttinen koostumus
CA2203310A1 (fr)	1997-10-24	Comprime matriciel permettant la liberation prolongee du sel de sodium de tianeptine apres administration par voie orale
IT1272149B (it)	1997-06-11	Composizione farmeceutiche ad attivita' analgesica
ES2062137T3 (es)	1994-12-16	Utilizacion de 5'-deoxi-5'-metil-tioadenosina, s-adenosilmetionina y sus sales para la preparacion de composiciones farmaceuticas reductoras de seborrea.
CA2152998A1 (en)	1996-01-02	Anti-hyperglycemia pharmaceutical composition
HUP9902415A2 (hu)	1999-11-29	Azonnal felszabaduló szilárd beadási formák és eljárás azok előállítására
ZA922910B (en)	1994-01-24	Heterocylic pharmaceutical compounds preparation and use
ATE246515T1 (de)	2003-08-15	Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
AU2774292A (en)	1993-05-21	Toiletries composition
NO950177D0 (no)	1995-01-17	Farmakologisk aktive erivater
AU7470098A (en)	1998-11-24	Antithrombotic agents
GB9513750D0 (en)	1995-09-06	Use of allylamines
AU3749195A (en)	1996-05-06	Bis-2-aminopyridines, preparation method therefor and use tereof for controlling parasitic infections
KR950700743A (ko)	1995-02-20	프로스타사이클린류를 활성성분으로서 함유하는 외용 피부치료제 조성물(dermatologic preparation composition containing prostacyclin as active ingredient)
TW333453B (en)	1998-06-11	Pharmaceutical composition comprising toremifene for use in the treatment of autoimmune diseases
AU7274198A (en)	1998-11-24	Antithrombotic agents
JO1750B1 (en)	1993-10-30	Substituted benzimidazole compounds, practical to prepare and use