DK0866870T3 - Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla - Google Patents

Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla

Info

Publication number
DK0866870T3
DK0866870T3 DK96940592T DK96940592T DK0866870T3 DK 0866870 T3 DK0866870 T3 DK 0866870T3 DK 96940592 T DK96940592 T DK 96940592T DK 96940592 T DK96940592 T DK 96940592T DK 0866870 T3 DK0866870 T3 DK 0866870T3
Authority
DK
Denmark
Prior art keywords
factor
inhibitors
fusion proteins
domain fusion
kunitz domain
Prior art date
Application number
DK96940592T
Other languages
English (en)
Inventor
Robert F Kelley
Robert A Lazarus
Geoffrey F Lee
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/566,800 external-priority patent/US5736364A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0866870T3 publication Critical patent/DK0866870T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96940592T 1995-12-01 1996-11-22 Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla DK0866870T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56645995A 1995-12-01 1995-12-01
US08/566,800 US5736364A (en) 1995-12-04 1995-12-04 Factor viia inhibitors
PCT/US1996/018756 WO1997020939A1 (en) 1995-12-01 1996-11-22 TISSUE FACTOR - KUNITZ DOMAIN FUSION PROTEINS AS FACTOR VIIa INHIBITORS

Publications (1)

Publication Number Publication Date
DK0866870T3 true DK0866870T3 (da) 2003-06-23

Family

ID=27074189

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96940592T DK0866870T3 (da) 1995-12-01 1996-11-22 Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla

Country Status (8)

Country Link
EP (1) EP0866870B1 (da)
AT (1) ATE234359T1 (da)
AU (1) AU1023497A (da)
DE (1) DE69626671T2 (da)
DK (1) DK0866870T3 (da)
ES (1) ES2195025T3 (da)
PT (1) PT866870E (da)
WO (1) WO1997020939A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214333B1 (en) * 1997-07-08 2001-04-10 Texas Heart Institute Vasoprotective recombinant adenovirus vector containing a human TFPI gene
US6596847B2 (en) 1998-07-15 2003-07-22 Genentech, Inc. Tissue factor protein variants
IL147269A0 (en) 1999-07-02 2002-08-14 Genentech Inc FVIIa ANTAGONISTS
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
MXPA03001984A (es) 2000-09-13 2003-08-29 Novo Nordisk Healthcare Ag Variantes de factor vii de coagulacion humano.
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
ES2381110T3 (es) 2003-09-09 2012-05-23 Novo Nordisk Health Care Ag Polipéptidos de factor VII de coagulación
US20110040073A1 (en) * 2006-04-07 2011-02-17 Novo Nordisk Healthcare A/G Covalent Factor VII-Tissue Factor Complex
IL301956A (en) * 2020-10-07 2023-06-01 Dren Bio Inc Antibodies against dectin-1 and methods of using them
WO2022106648A1 (en) 2020-11-20 2022-05-27 Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Inhibitors of the tissue factor-protease activated receptor 2 (tf-par2) signaling pathway for use in the treatment or prevention of heart failure (hf) and associated or resulting diseases
GB202402535D0 (en) * 2024-02-22 2024-04-10 Imperial College Innovations Ltd Fusion proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69117545T2 (de) * 1990-01-25 1996-10-31 Univ Washington Faktor X-LACI-Hybridprotein
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
US5726147A (en) * 1993-06-01 1998-03-10 The Scripps Research Institute Human mutant tissue factor compositions useful as tissue factor antagonists
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins

Also Published As

Publication number Publication date
AU1023497A (en) 1997-06-27
DE69626671T2 (de) 2004-03-18
EP0866870B1 (en) 2003-03-12
DE69626671D1 (de) 2003-04-17
PT866870E (pt) 2003-08-29
EP0866870A1 (en) 1998-09-30
WO1997020939A1 (en) 1997-06-12
ES2195025T3 (es) 2003-12-01
ATE234359T1 (de) 2003-03-15

Similar Documents

Publication Publication Date Title
DK0866870T3 (da) Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla
DK0760661T3 (da) Farmaceutiske sammensætninger omfattende en opiat-antagonist og calciumsalte, deres anvendelse til behandling af endorfin-m
CY1108725T1 (el) Συνδυασμος ανταγωνιστου-nmda και αναστολεων ακετυλοχολινεστερασης δια την θεραπειαν της νοσου alzheimer
DE69805973D1 (de) Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin-abhängigen protein kinase
DK0719154T3 (da) Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangel
RU95108387A (ru) Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
ID29393A (id) Komposisi pengobatan kanker dan metoda penggunaan minyak-minyak esensil tanaman alamiah
ATE333896T1 (de) Vaskularisierungsinhibitoren
MY124648A (en) Inhibitor of factor xa alone or in combination with an anti-platelet aggregation agent, for combating arterial thrombosis.
ATE291914T1 (de) Zolmitriptanhaltige arzneizusammensetzungen
BR0110506A (pt) Uso de inibidores de il-18 para o tratamento e/ou prevenção da aterosclerose
NO20004419D0 (no) Ny anvendelse
HUP0004544A2 (hu) Angiotenzin-átalakító enzim inhibitora és diuretikum kombinációjának alkalmazása mikrokeringési rendellenességek kezelésére szolgáló gyógyászati készítmény előállítására
TR200000349T2 (tr) Fizyolojik olarak kabul edilebilir vanadyum bileşimlerinin, tuzlarının ve komplekslerinin kullanımı.
ATE266420T1 (de) Kombinationspräparat, das selektive nmda nr2b- antagonisten und cox-2 inhibitoren enthält
YU16399A (sh) ) UPOTREBA INHIBITOR H +, K+ - ATP- aze I FARMACEUTSKA FORMULACIJA ZA SIMULTANU, SEPARATNU ILI SEKVENCIJALNU UPOTREBU, KOJA SADRZI INHIBITOR H +, K+-ATP- aze I GLUKOKORTIKOID INHIBITOR H +, K+- ATP- aze
ES2088128T3 (es) Aminosulfonilureas inhibidoras de acat.
SE9802209D0 (sv) Novel compounds
BR0108980A (pt) Aplicação e formulação farmacêuticas compreendendo inibidor de reabsorção de norepinefrina
ES2175153T3 (es) Uso de inhibidores de colinesterasa para la fabricacion de un medicamento para el tratamiento de la xerostomia.
BG105984A (bg) Използване на озанетант за приготвяне на лекарствени средства полезни за лечение на разстройства на настроението
BR0113886A (pt) Composição, composição farmacêutica, tratamento de combinação para prevenir ou inibir a geração ou atividade de trombina num paciente, método para inibir ou prevenir a geração ou atividade de trombina num paciente, uso de uma composição ou tratamento de combinação, uso de uma composição, uso e kit
DE69824862D1 (de) Zusammenstellungen zur verbesserten wundheilung
NO20001846L (no) Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
AU8900498A (en) Compounds and pharmaceutical compositions thereof for eliciting analgesic effects