DK0871626T3 - Triazoloner som apolipoprotein-B syntheseinhibitorer - Google Patents
Triazoloner som apolipoprotein-B syntheseinhibitorerInfo
- Publication number
- DK0871626T3 DK0871626T3 DK96910968T DK96910968T DK0871626T3 DK 0871626 T3 DK0871626 T3 DK 0871626T3 DK 96910968 T DK96910968 T DK 96910968T DK 96910968 T DK96910968 T DK 96910968T DK 0871626 T3 DK0871626 T3 DK 0871626T3
- Authority
- DK
- Denmark
- Prior art keywords
- 6alkyl
- formula
- substituted
- 6alkyloxy
- halo
- Prior art date
Links
- 101710095342 Apolipoprotein B Proteins 0.000 title 1
- 102100040202 Apolipoprotein B-100 Human genes 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201010 | 1995-04-20 | ||
| PCT/EP1996/001585 WO1996033193A1 (en) | 1995-04-20 | 1996-04-12 | Novel triazolones as apolipoprotein-b synthesis inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0871626T3 true DK0871626T3 (da) | 2002-02-25 |
Family
ID=8220206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96910968T DK0871626T3 (da) | 1995-04-20 | 1996-04-12 | Triazoloner som apolipoprotein-B syntheseinhibitorer |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5922718A (de) |
| EP (1) | EP0871626B1 (de) |
| JP (1) | JP3782455B2 (de) |
| KR (1) | KR100413219B1 (de) |
| CN (1) | CN1076727C (de) |
| AT (1) | ATE208386T1 (de) |
| AU (1) | AU699313B2 (de) |
| CA (1) | CA2217632A1 (de) |
| CZ (1) | CZ291737B6 (de) |
| DE (1) | DE69616825T2 (de) |
| DK (1) | DK0871626T3 (de) |
| ES (1) | ES2167555T3 (de) |
| HU (1) | HUP9801056A3 (de) |
| IL (1) | IL117980A (de) |
| NO (1) | NO312415B1 (de) |
| NZ (1) | NZ305869A (de) |
| PL (1) | PL183737B1 (de) |
| PT (1) | PT871626E (de) |
| TW (1) | TW457240B (de) |
| WO (1) | WO1996033193A1 (de) |
| ZA (1) | ZA963152B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003074474A2 (en) | 2002-03-01 | 2003-09-12 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| US20050025791A1 (en) | 2002-06-21 | 2005-02-03 | Julius Remenar | Pharmaceutical compositions with improved dissolution |
| JP5133561B2 (ja) | 2003-06-19 | 2013-01-30 | メルク セローノ ソシエテ アノニム | プリオン変換を調節する因子の使用 |
| WO2005090971A1 (en) * | 2004-03-18 | 2005-09-29 | Applied Research Systems Ars Holding N.V. | Anti-lipid rafts antibodies |
| WO2005118577A1 (en) * | 2004-04-22 | 2005-12-15 | Transform Pharmaceuticals, Inc. | Novel saperconazole crystalline forms and related processes, pharmaceutical compositions and methods |
| JP2008542255A (ja) * | 2005-05-27 | 2008-11-27 | ファイザー・プロダクツ・インク | 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用 |
| KR102240329B1 (ko) | 2013-06-07 | 2021-04-14 | 더 스크립스 리서치 인스티튜트 | 섬유증의 소분자 억제제 |
| ES2799404T3 (es) | 2014-07-15 | 2020-12-17 | Yissum Research And Development Company Of The Hebrew Univ Of Jerusalem Ltd | Polipéptidos de CD44 aislados y usos de los mismos |
| EP3250036B1 (de) | 2014-12-10 | 2021-05-12 | The Scripps Research Institute | Kleinmolekül-hemmer von fibrose |
| TWI771402B (zh) | 2017-04-11 | 2022-07-21 | 日商三井化學Agro股份有限公司 | 吡啶酮化合物及以吡啶酮化合物作為有效成分的農園藝用殺菌劑 |
| CA3163507A1 (en) | 2019-12-04 | 2021-06-10 | The Scripps Research Institute | Peptide conjugates and methods of use |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101666A (en) * | 1975-10-06 | 1978-07-18 | Janssen Pharmaceutica N.V. | 1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles |
| US3936470A (en) * | 1975-01-27 | 1976-02-03 | Janssen Pharmaceutica N.V. | 1,3-Dioxolan-2-ylmethylimidazoles |
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4321272A (en) * | 1980-08-25 | 1982-03-23 | Syntex (U.S.A.) Inc. | Derivatives of substituted N-alkylimidazoles |
| DE3144318A1 (de) * | 1981-11-07 | 1983-05-19 | Bayer Ag, 5090 Leverkusen | 2-imidazolylmethyl-2-phenyl-1, 3-dioxolane, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| CA1292472C (en) * | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| NZ278882A (en) * | 1994-01-24 | 1997-06-24 | Janssen Pharmaceutica Nv | Piperazine-containing azole antifungal compounds |
-
1996
- 1996-03-22 TW TW085103449A patent/TW457240B/zh not_active IP Right Cessation
- 1996-04-12 PL PL96322872A patent/PL183737B1/pl not_active IP Right Cessation
- 1996-04-12 CA CA002217632A patent/CA2217632A1/en not_active Abandoned
- 1996-04-12 AU AU53998/96A patent/AU699313B2/en not_active Ceased
- 1996-04-12 EP EP96910968A patent/EP0871626B1/de not_active Expired - Lifetime
- 1996-04-12 AT AT96910968T patent/ATE208386T1/de not_active IP Right Cessation
- 1996-04-12 HU HU9801056A patent/HUP9801056A3/hu unknown
- 1996-04-12 CN CN96193235A patent/CN1076727C/zh not_active Expired - Fee Related
- 1996-04-12 CZ CZ19973288A patent/CZ291737B6/cs not_active IP Right Cessation
- 1996-04-12 DE DE69616825T patent/DE69616825T2/de not_active Expired - Fee Related
- 1996-04-12 US US08/930,847 patent/US5922718A/en not_active Expired - Fee Related
- 1996-04-12 NZ NZ305869A patent/NZ305869A/en unknown
- 1996-04-12 JP JP53146096A patent/JP3782455B2/ja not_active Expired - Fee Related
- 1996-04-12 ES ES96910968T patent/ES2167555T3/es not_active Expired - Lifetime
- 1996-04-12 PT PT96910968T patent/PT871626E/pt unknown
- 1996-04-12 WO PCT/EP1996/001585 patent/WO1996033193A1/en not_active Ceased
- 1996-04-12 KR KR1019970706751A patent/KR100413219B1/ko not_active Expired - Fee Related
- 1996-04-12 DK DK96910968T patent/DK0871626T3/da active
- 1996-04-19 ZA ZA9603152A patent/ZA963152B/xx unknown
- 1996-04-19 IL IL11798096A patent/IL117980A/xx not_active IP Right Cessation
-
1997
- 1997-10-10 NO NO19974690A patent/NO312415B1/no unknown
-
1999
- 1999-02-17 US US09/251,989 patent/US6197972B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2217632A1 (en) | 1996-10-24 |
| NO974690D0 (no) | 1997-10-10 |
| AU699313B2 (en) | 1998-12-03 |
| NO312415B1 (no) | 2002-05-06 |
| CZ328897A3 (cs) | 1998-01-14 |
| US5922718A (en) | 1999-07-13 |
| DE69616825T2 (de) | 2002-06-27 |
| PL183737B1 (pl) | 2002-07-31 |
| WO1996033193A1 (en) | 1996-10-24 |
| TW457240B (en) | 2001-10-01 |
| NZ305869A (en) | 1998-08-26 |
| EP0871626A1 (de) | 1998-10-21 |
| IL117980A (en) | 2000-02-17 |
| AU5399896A (en) | 1996-11-07 |
| JP3782455B2 (ja) | 2006-06-07 |
| PL322872A1 (en) | 1998-03-02 |
| ATE208386T1 (de) | 2001-11-15 |
| CZ291737B6 (cs) | 2003-05-14 |
| ZA963152B (en) | 1997-10-20 |
| NO974690L (no) | 1997-10-10 |
| CN1181079A (zh) | 1998-05-06 |
| EP0871626B1 (de) | 2001-11-07 |
| ES2167555T3 (es) | 2002-05-16 |
| CN1076727C (zh) | 2001-12-26 |
| HUP9801056A2 (hu) | 1999-06-28 |
| KR100413219B1 (ko) | 2004-05-31 |
| IL117980A0 (en) | 1996-08-04 |
| KR19980703346A (ko) | 1998-10-15 |
| PT871626E (pt) | 2002-04-29 |
| HK1012186A1 (en) | 1999-07-30 |
| DE69616825D1 (en) | 2001-12-13 |
| HUP9801056A3 (en) | 1999-09-28 |
| US6197972B1 (en) | 2001-03-06 |
| JPH11503739A (ja) | 1999-03-30 |
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