DK0874640T3 - Cyclosporinformulering - Google Patents

Cyclosporinformulering

Info

Publication number: DK0874640T3
Authority: DK; Denmark
Prior art keywords: pct; weight; compositions; dimethyl; sec
Prior art date: 1996-01-18

Application number

DK97901147T

Other languages

English (en)

Inventor

Milan Stuchlik

Tomas Andrysek

Alexander Jegorov

Ales Husek

Vladimir Matha

Josef Stuchlik

Original Assignee

Ivax Pharmaceuticals Sro

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-18

Filing date

1997-01-17

Publication date

2003-11-17

1997-01-17 Application filed by Ivax Pharmaceuticals Sro filed Critical Ivax Pharmaceuticals Sro

2003-11-17 Application granted granted Critical

2003-11-17 Publication of DK0874640T3 publication Critical patent/DK0874640T3/da

Links

239000000203 mixture Substances 0.000 title abstract 5
238000009472 formulation Methods 0.000 title 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 2
-1 dimethyl isoidide Chemical compound 0.000 abstract 2
239000000194 fatty acid Substances 0.000 abstract 2
229930195729 fatty acid Natural products 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000000796 flavoring agent Substances 0.000 abstract 1
235000013355 food flavoring agent Nutrition 0.000 abstract 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 1
229920000570 polyether Polymers 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
239000003381 stabilizer Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
239000002562 thickening agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK97901147T 1996-01-18 1997-01-17 Cyclosporinformulering DK0874640T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CZ1996169A CZ288631B6 (cs)	1996-01-18	1996-01-18	Léčivé přípravky s obsahem cyklosporinu
PCT/GB1997/000131 WO1997026003A1 (en)	1996-01-18	1997-01-17	Cyclosporin formulation

Publications (1)

Publication Number	Publication Date
DK0874640T3 true DK0874640T3 (da)	2003-11-17

Family

ID=5461334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97901147T DK0874640T3 (da)	1996-01-18	1997-01-17	Cyclosporinformulering

Country Status (12)

Country	Link
US (1)	US6046163A (da)
EP (1)	EP0874640B1 (da)
JP (1)	JP4005134B2 (da)
KR (1)	KR100471680B1 (da)
AT (1)	ATE245436T1 (da)
AU (1)	AU1449497A (da)
CZ (1)	CZ288631B6 (da)
DE (1)	DE69723671T2 (da)
DK (1)	DK0874640T3 (da)
ES (1)	ES2207714T3 (da)
PT (1)	PT874640E (da)
WO (1)	WO1997026003A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5858401A (en)	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
CZ288739B6 (cs) *	1996-08-01	2001-08-15	Galena, A. S.	Cyklosporin obsahující léčivé přípravky
US6465016B2 (en) *	1996-08-22	2002-10-15	Research Triangle Pharmaceuticals	Cyclosporiine particles
CZ283516B6 (cs) *	1996-09-12	1998-04-15	Galena A.S.	Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
WO1999029316A1 (en)	1997-12-10	1999-06-17	Severson, Mary, L.	Pharmaceutical compositions containing an omega-3 fatty acid oil
US6136985A (en) *	1997-12-23	2000-10-24	Dcv, Inc.	CLA esters and uses thereof
EP1058711B1 (en) *	1998-03-04	2003-04-09	Ato B.V.	Bicyclooctane derivatives as plasticisers
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
KR100635456B1 (ko)	1998-05-29	2006-10-18	스키에파마 캐나다 인코포레이티드	열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법
GB9811854D0 (en) *	1998-06-02	1998-07-29	Ciba Geigy Ag	Organic compounds
DE69912441T2 (de)	1998-08-19	2004-08-19	Skyepharma Canada Inc., Verdun	Injizierbare wässerige propofoldispersionen
IL143197A0 (en)	1998-11-20	2002-04-21	Rtp Pharma Inc	Dispersible phospholipid stabilized microparticles
ATE404172T1 (de)	1998-12-30	2008-08-15	Dexcel Ltd	Dispergierbares konzentrat zur verabreichung von cyclosporin
GB2355656B (en) *	1999-08-17	2004-04-07	Galena As	Pharmaceutical compositions for oral and topical administration
AU7984200A (en) *	1999-09-21	2001-04-24	Skyepharma Canada Inc.	Surface modified particulate compositions of biologically active substances
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
AUPQ877300A0 (en) *	2000-07-13	2000-08-03	Johnson & Johnson Pacific Pty Limited	Topical treatment of skin
IL160761A0 (en) *	2001-10-19	2004-08-31	Isotechnika Inc	Novel cyclosporin analog microemulsion preconcentrates
ES2524000T3 (es) *	2002-06-05	2014-12-03	Teva Czech Industries S.R.O.	Reducción de la reticulación de la gelatina
ATE376415T1 (de) *	2003-01-08	2007-11-15	Swiss Caps Rechte & Lizenzen	Formkörper bestehend aus gelatinfreiem material und gefüllt mit einer flüssigen füllmasse
US20050059583A1 (en) *	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
US7151085B2 (en) *	2004-11-15	2006-12-19	Allergan, Inc.	Therapeutic methods using cyclosporine components
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
FR2971941B1 (fr) *	2011-02-24	2013-08-02	Physica Pharma	Compositions pharmaceutiques administrables par voie cutanee et destinees au traitement local de la dermatite atopique canine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
ES2033086T3 (es) *	1988-01-29	1993-03-01	Sankyo Company Limited	Un procedimiento para la preparacion de una composicion farmaceutica.
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
DE59101481D1 (de) *	1990-02-23	1994-06-01	Basf Ag	Verwendung von Mischungen aus Polyglycerinfettsäureestern als Emulgatoren in kosmetischen und pharmazeutischen Zubereitungen.
CZ278863B6 (en) *	1992-09-07	1994-07-13	Galena	Medicinal preparations with n-methylated cyclic undecapeptides
CN1077800C (zh) *	1993-07-01	2002-01-16	韩美药品工业株式会社	环孢菌素软胶囊组合物
DE4322826A1 (de) *	1993-07-08	1995-01-12	Galenik Labor Freiburg Gmbh	Pharmazeutisches Präparat
WO1995017850A1 (en) *	1993-12-24	1995-07-06	Philips Electronics N.V.	Grase mri with read gradient polarity correction and t2 measurement
US5603951A (en) *	1994-11-09	1997-02-18	Hanmi Pharm. Ind. Co., Ltd.	Cyclosporin-containing soft capsule compositions
KR0167613B1 (ko) *	1994-12-28	1999-01-15	한스 루돌프 하우스, 니콜 케르커	사이클로스포린-함유 연질캅셀제 조성물

1996
- 1996-01-18 CZ CZ1996169A patent/CZ288631B6/cs not_active IP Right Cessation
1997
- 1997-01-17 ES ES97901147T patent/ES2207714T3/es not_active Expired - Lifetime
- 1997-01-17 US US09/101,653 patent/US6046163A/en not_active Expired - Fee Related
- 1997-01-17 EP EP97901147A patent/EP0874640B1/en not_active Expired - Lifetime
- 1997-01-17 KR KR1019980705509A patent/KR100471680B1/ko not_active Expired - Fee Related
- 1997-01-17 AT AT97901147T patent/ATE245436T1/de not_active IP Right Cessation
- 1997-01-17 AU AU14494/97A patent/AU1449497A/en not_active Abandoned
- 1997-01-17 PT PT97901147T patent/PT874640E/pt unknown
- 1997-01-17 JP JP52579197A patent/JP4005134B2/ja not_active Expired - Fee Related
- 1997-01-17 DK DK97901147T patent/DK0874640T3/da active
- 1997-01-17 WO PCT/GB1997/000131 patent/WO1997026003A1/en not_active Ceased
- 1997-01-17 DE DE69723671T patent/DE69723671T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6046163A (en)	2000-04-04
EP0874640A1 (en)	1998-11-04
JP2000503314A (ja)	2000-03-21
KR19990077360A (ko)	1999-10-25
JP4005134B2 (ja)	2007-11-07
DE69723671T2 (de)	2004-04-22
PT874640E (pt)	2003-12-31
DE69723671D1 (de)	2003-08-28
CZ16996A3 (en)	1997-08-13
ATE245436T1 (de)	2003-08-15
AU1449497A (en)	1997-08-11
EP0874640B1 (en)	2003-07-23
KR100471680B1 (ko)	2007-04-25
WO1997026003A1 (en)	1997-07-24
CZ288631B6 (cs)	2001-08-15
ES2207714T3 (es)	2004-06-01

Publication	Publication Date	Title
ATE245436T1 (de)	2003-08-15	Cyclosüporin formulierung
ES2153385T3 (es)	2001-03-01	Composicion acuosa a base de hormona del crecimiento humana.
ES2183865T3 (es)	2003-04-01	Preparaciones de doble capa de galactolipido que contienen digalactosildiacilglicerol.
PE799A1 (es)	1999-04-08	Composicion cosmetica que contiene un antagonista de los receptores del neuropeptido y
CY2233B1 (en)	2003-04-18	Compositions to treat onychomycoses
PT786986E (pt)	2002-07-31	Formulacoes farmaceuticas
AR030933A1 (es)	2003-09-03	Derivados del triazol y composiciones farmaceuticas que los contienen
ATE286500T1 (de)	2005-01-15	1,2,3,4-tetrahydroisochinolin-derivate
IL139960A0 (en)	2002-02-10	Macrocylic analogs and methods of their use and preparation
CO5160321A1 (es)	2002-05-30	Novedosas composiciones de tipranavir y ritonavir
FI955403A0 (fi)	1995-11-09	Valeltavia koostumuksia, jotka sisältävät polymeerimateriaalia, glykoleja ja glyseridejä
ES2131515T3 (es)	1999-08-01	Formulados inyectables de accion prolongada que contienen aceite de ricino hidrogenado.
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
MXPA03000606A (es)	2004-04-02	Derivados de benzofurano y su uso como agentes antibacterianos.
DE50204884D1 (de)	2005-12-15	Kosmetische formulierung enthaltend dihydroxyaceton
ES2078378T3 (es)	1995-12-16	Composiciones que tienen actividad herbicida conteniendo n-alquil-amidas como ingrediente activo.
DE69207777D1 (de)	1996-02-29	Körperpflegemittel
IL77151A0 (en)	1986-04-29	Triazole derivatives,their use as fungicides and pharmaceutical compositions containing them
AU1085392A (en)	1992-08-20	Alkyl ether carboxylic acid taurides
ES2006521A6 (es)	1989-05-01	Composicion de control de plagas procedimiento derivados benzopiranicos y benzotiopiranicos y metodo de preparar dicha composicion
ES2074985T3 (es)	1995-10-01	Derivados de benzopiran (4,3-d)-tiazol con actividad anti-alergica, anti-anafilactica y anti-artritica y composiciones que lo contienen.
KR970702691A (ko)	1997-06-10	유기조직의 보존을 위한 디알킬 (c₁-c6)-케톤 퍼옥시드 조성물, 그리고 보존시의 조성물의 사용 및 동물 또는 인간 유기 조직들의 해부 준비(compositions containing dialkyl(c₁-c6)-ketone peroxide for the preservation of organic tissues, and application of said compositions to the preservation and anatomical preparation of organic tissues of animal or human origin)
MX9705592A (es)	1997-11-29	Composiciones farmaceuticas que contienen corticosteroides y preparacion de las mismas.