DK0875508T3 - Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll - Google Patents

Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll

Info

Publication number: DK0875508T3
Authority: DK; Denmark
Prior art keywords: iii; derivatives; preparation; deacetylbaccatin; baccatin
Prior art date: 1997-05-02

Application number

DK97201315T

Other languages

English (en)

Inventor

Eric Wilhelmus Petrus Damen

Johan Wilhelm Scheeren

Vos Dick De

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-02

Filing date

1997-05-02

Publication date

2004-01-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0875508(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-02 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

2004-01-26 Application granted granted Critical

2004-01-26 Publication of DK0875508T3 publication Critical patent/DK0875508T3/da

Links

YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 4
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title abstract 4
229930014667 baccatin III Natural products 0.000 title abstract 2
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
239000002841 Lewis acid Substances 0.000 abstract 1
-1 acetic anhydride) Chemical class 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
229910052761 rare earth metal Inorganic materials 0.000 abstract 1
150000002910 rare earth metals Chemical class 0.000 abstract 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK97201315T 1997-05-02 1997-05-02 Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll DK0875508T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97201315A EP0875508B1 (en)	1997-05-02	1997-05-02	Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III

Publications (1)

Publication Number	Publication Date
DK0875508T3 true DK0875508T3 (da)	2004-01-26

Family

ID=8228291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97201315T DK0875508T3 (da)	1997-05-02	1997-05-02	Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll

Country Status (10)

Country	Link
US (1)	US5874595A (da)
EP (1)	EP0875508B1 (da)
JP (1)	JP4144919B2 (da)
AT (1)	ATE252569T1 (da)
CA (1)	CA2205745C (da)
DE (1)	DE69725700T2 (da)
DK (1)	DK0875508T3 (da)
ES (1)	ES2210451T3 (da)
PT (1)	PT875508E (da)
SI (1)	SI0875508T1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5750736A (en) *	1996-07-11	1998-05-12	Napro Biotherapeutics, Inc.	Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US7288665B1 (en)	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
US20040132991A1 (en) *	2002-10-09	2004-07-08	Phytogen Life Sciences Inc.	Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
CN1303077C (zh)	2004-01-16	2007-03-07	桂林晖昂生化药业有限责任公司	合成紫杉烷的制备工艺
US20050240036A1 (en) *	2004-04-23	2005-10-27	Phytogen Life Sciences Inc.	Semi-synthesis of taxane intermediates from a mixture of taxanes
US20050250954A1 (en) *	2004-05-04	2005-11-10	Phytogen Life Sciences Inc.	Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US20050272807A1 (en) *	2004-06-04	2005-12-08	Phytogen Life Sciences Inc.	Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
CZ298333B6 (cs) *	2005-09-26	2007-08-29	Zentiva, A. S	Zpusob prípravy 7-trialkylsilylbaccatinu III
CN101143858B (zh) *	2006-09-15	2010-05-12	中国科学院大连化学物理研究所	一种选择性酰化紫杉烷c(10)和c(2')位羟基的方法
CN101274923B (zh) *	2007-03-27	2011-02-02	中国科学院大连化学物理研究所	一种制备紫杉醇，巴卡亭ⅲ及其衍生物的方法
CN101508645B (zh) *	2009-03-23	2012-05-23	浙江工业大学	一种二乙酰大黄酸的制备方法
US8791279B2 (en) *	2010-12-13	2014-07-29	Yung Shin Pharm. Ind. Co., Ltd.	Process for preparing taxoids from baccatin derivatives using lewis acid catalyst

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
IL109926A (en) *	1993-06-15	2000-02-29	Bristol Myers Squibb Co	Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
US5629433A (en) *	1994-07-18	1997-05-13	Hauser, Inc.	Selective process for the deacylation and deacetylation of taxol and taxanes
FR2743074B1 (fr) *	1995-12-27	1998-03-27	Seripharm	Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes

1997
- 1997-05-02 SI SI9730600T patent/SI0875508T1/xx unknown
- 1997-05-02 AT AT97201315T patent/ATE252569T1/de active
- 1997-05-02 PT PT97201315T patent/PT875508E/pt unknown
- 1997-05-02 DK DK97201315T patent/DK0875508T3/da active
- 1997-05-02 DE DE69725700T patent/DE69725700T2/de not_active Expired - Lifetime
- 1997-05-02 ES ES97201315T patent/ES2210451T3/es not_active Expired - Lifetime
- 1997-05-02 EP EP97201315A patent/EP0875508B1/en not_active Expired - Lifetime
- 1997-05-21 US US08/861,053 patent/US5874595A/en not_active Expired - Fee Related
- 1997-05-21 CA CA002205745A patent/CA2205745C/en not_active Expired - Lifetime
- 1997-07-04 JP JP18019397A patent/JP4144919B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69725700T2 (de)	2004-07-22
SI0875508T1 (en)	2004-04-30
CA2205745A1 (en)	1998-11-02
EP0875508A1 (en)	1998-11-04
EP0875508B1 (en)	2003-10-22
JPH10298171A (ja)	1998-11-10
ES2210451T3 (es)	2004-07-01
JP4144919B2 (ja)	2008-09-03
DE69725700D1 (de)	2003-11-27
ATE252569T1 (de)	2003-11-15
CA2205745C (en)	2006-05-09
PT875508E (pt)	2004-02-27
US5874595A (en)	1999-02-23

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