DK0877602T3 - Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater - Google Patents

Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater

Info

Publication number
DK0877602T3
DK0877602T3 DK97902186T DK97902186T DK0877602T3 DK 0877602 T3 DK0877602 T3 DK 0877602T3 DK 97902186 T DK97902186 T DK 97902186T DK 97902186 T DK97902186 T DK 97902186T DK 0877602 T3 DK0877602 T3 DK 0877602T3
Authority
DK
Denmark
Prior art keywords
preparation
pulmonary surfactant
lung surfactant
surfactant preparations
powdered
Prior art date
Application number
DK97902186T
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Application granted granted Critical
Publication of DK0877602T3 publication Critical patent/DK0877602T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK97902186T 1996-01-24 1997-01-18 Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater DK0877602T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06
PCT/EP1997/000230 WO1997026863A1 (de) 1996-01-24 1997-01-18 Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen

Publications (1)

Publication Number Publication Date
DK0877602T3 true DK0877602T3 (da) 2002-05-06

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97902186T DK0877602T3 (da) 1996-01-24 1997-01-18 Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater

Country Status (15)

Country Link
US (1) US6315983B1 (da)
EP (1) EP0877602B1 (da)
JP (1) JP3725166B2 (da)
KR (1) KR100449789B1 (da)
AT (1) ATE212220T1 (da)
CA (1) CA2244767C (da)
CY (1) CY2366B1 (da)
CZ (1) CZ292186B6 (da)
DE (1) DE59706180D1 (da)
DK (1) DK0877602T3 (da)
ES (1) ES2171883T3 (da)
PT (1) PT877602E (da)
TR (1) TR199801408T2 (da)
UA (1) UA59358C2 (da)
WO (1) WO1997026863A1 (da)

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US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
JP4416325B2 (ja) * 1998-08-25 2010-02-17 アルカーメス，インコーポレイテッド 安定な噴霧乾燥タンパク質製剤
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
JP2002529394A (ja) * 1998-11-10 2002-09-10 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 肺サーファクタント組成物を含有する治療セット
JP2003501481A (ja) * 1999-06-11 2003-01-14 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング サーファクタントタンパク質ｂ（ｓｐ−ｂ）改変体およびサーファクタントタンパク質ｃ（ｓｐ−ｃ）改変体を含有する医薬品製剤
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
EP1210069B1 (en) * 1999-08-25 2004-12-29 Advanced Inhalation Research, Inc. Large porous particles obtainable by spray-drying and suitable for pulmonary administration
AU6083899A (en) 1999-09-16 2001-04-17 Aventis Behring Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
DE50214446D1 (de) 2001-10-11 2010-07-01 Nycomed Gmbh Neue verwendung von lungensurfactant
JP4368198B2 (ja) 2001-11-20 2009-11-18 アルカーメス，インコーポレイテッド 肺送達用の改良された粒状組成物
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
KR20040093155A (ko) * 2002-03-18 2004-11-04 야마노우치세이야쿠 가부시키가이샤 흡입용 분말 의약조성물 및 이의 제조방법
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
CA2567334A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
JP5108515B2 (ja) * 2004-08-06 2012-12-26 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタント及びｔｎｆ由来ペプチドを含有する組成物
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
CN101094651B (zh) * 2004-12-30 2011-03-09 多贝尔有限公司 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
SI2265309T1 (sl) 2008-03-17 2016-04-29 Discovery Laboratories, Inc. Adapter za cevje ventilatorja in sistem za proksimalno dovajanje aerosola
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
EP2370068A4 (en) 2008-12-10 2015-09-23 Paka Pulmonary Pharmaceuticals Inc METHOD AND COMPOSITIONS FOR DELIVERING MEDICAMENTS TO THE LUNG
MX354829B (es) * 2009-03-26 2018-03-22 Pulmatrix Operating Co Inc Formulaciones de polvo seco y metodos para el tratamiento de enfermedades pulmonares.
EP2711004A1 (en) * 2009-10-05 2014-03-26 Nutri-Fit GmbH & Co. KG Methods for increasing physical capacity of mammalian livestock
US9693955B2 (en) 2010-08-23 2017-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidified particles comprising a therapeutically active substance
DK2723323T3 (da) 2012-03-28 2016-01-11 Discovery Lab Inc Frysetørring af syntetisk liposomal pulmonært overfladeaktivt stof
US11123513B2 (en) 2014-03-05 2021-09-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
ES2778679T3 (es) 2014-03-05 2020-08-11 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung Ev Dispositivo para proporcionar una cantidad constante de aerosol y sistema de control
ES2665180T3 (es) * 2014-03-18 2018-04-24 Apeptico Forschung Und Entwicklung Gmbh Medicamento de péptido en forma de polvo seco
CA3028724A1 (en) * 2016-06-24 2017-12-28 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
JP7419253B2 (ja) * 2017-12-21 2024-01-22 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤
WO2019126289A1 (en) * 2017-12-21 2019-06-27 Civitas Therapeutics, Inc. Surfactant formulations for inhalation

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JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
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US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
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EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
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AU5806998A (en) 1996-12-31 1998-07-31 Inhale Therapeutic Systems Processes for spray drying solutions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
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Also Published As

Publication number Publication date
CZ233898A3 (cs) 1999-02-17
ATE212220T1 (de) 2002-02-15
KR100449789B1 (ko) 2005-02-03
KR19990081886A (ko) 1999-11-15
UA59358C2 (uk) 2003-09-15
ES2171883T3 (es) 2002-09-16
EP0877602B1 (de) 2002-01-23
PT877602E (pt) 2002-07-31
TR199801408T2 (xx) 1998-10-21
JP3725166B2 (ja) 2005-12-07
EP0877602A1 (de) 1998-11-18
DE59706180D1 (de) 2002-03-14
JP2000503976A (ja) 2000-04-04
CA2244767C (en) 2005-11-22
CY2366B1 (en) 2004-06-04
WO1997026863A1 (de) 1997-07-31
US6315983B1 (en) 2001-11-13
CA2244767A1 (en) 1997-07-31
CZ292186B6 (cs) 2003-08-13

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