DK0891362T3 - Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase - Google Patents

Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase

Info

Publication number: DK0891362T3
Authority: DK; Denmark
Prior art keywords: inhibitors; neutrophil elastase; pyrrolopyrrolone; derivatives; pyrrolopyrrolone derivatives
Prior art date: 1996-03-28

Application number

DK97915439T

Other languages

Danish (da)

English (en)

Inventor

Michael Dennis Dowle

Harry Finch

Lee Andrew Harrison

Graham George Adam Inglis

Martin Redpath Johnson

Simon John Fawcett Macdonald

Pritom Shah

Robin Andrew Smith

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-28

Filing date

1997-03-26

Publication date

2004-07-12

1996-03-28 Priority claimed from GBGB9606508.1A external-priority patent/GB9606508D0/en

1996-11-05 Priority claimed from GBGB9623001.6A external-priority patent/GB9623001D0/en

1997-03-26 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-07-12 Application granted granted Critical

2004-07-12 Publication of DK0891362T3 publication Critical patent/DK0891362T3/da

Links

ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
108010028275 Leukocyte Elastase Proteins 0.000 title 1
102000016799 Leukocyte elastase Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

DK97915439T 1996-03-28 1997-03-26 Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase DK0891362T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9606508.1A GB9606508D0 (en)	1996-03-28	1996-03-28	Chemical componds
GBGB9623001.6A GB9623001D0 (en)	1996-11-05	1996-11-05	Chemical compounds
PCT/EP1997/001530 WO1997036903A1 (fr)	1996-03-28	1997-03-26	Derives du pyrrolopyrrolone utilises comme inhibiteurs de l'elastase de neutrophiles

Publications (1)

Publication Number	Publication Date
DK0891362T3 true DK0891362T3 (da)	2004-07-12

Family

ID=26309008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97915439T DK0891362T3 (da)	1996-03-28	1997-03-26	Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase

Country Status (30)

Country	Link
US (3)	US5994344A (fr)
EP (1)	EP0891362B1 (fr)
JP (1)	JP4118337B2 (fr)
KR (1)	KR20000005039A (fr)
CN (1)	CN1067075C (fr)
AP (1)	AP823A (fr)
AR (1)	AR006401A1 (fr)
AT (1)	ATE261969T1 (fr)
AU (1)	AU726649B2 (fr)
BR (1)	BR9708449A (fr)
CA (1)	CA2250209A1 (fr)
CO (1)	CO4790152A1 (fr)
CZ (1)	CZ309798A3 (fr)
DE (1)	DE69728139T2 (fr)
DK (1)	DK0891362T3 (fr)
EA (1)	EA001437B1 (fr)
EE (1)	EE9800335A (fr)
ES (1)	ES2217404T3 (fr)
HU (1)	HUP9900567A3 (fr)
IL (1)	IL125859A0 (fr)
IS (1)	IS4837A (fr)
NO (1)	NO984470L (fr)
NZ (1)	NZ331490A (fr)
PE (1)	PE55298A1 (fr)
PL (1)	PL329153A1 (fr)
PT (1)	PT891362E (fr)
SK (1)	SK132498A3 (fr)
TR (1)	TR199801935T2 (fr)
WO (1)	WO1997036903A1 (fr)
YU (1)	YU41198A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9719189D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	New therapeutic method
GB9719172D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
PE107899A1 (es) *	1997-09-09	1999-11-17	Glaxo Group Ltd	Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719187D0 (en) *	1997-09-09	1997-11-12	Glaxo Group Ltd	Compounds
GB9821199D0 (en) *	1998-09-30	1998-11-25	Glaxo Group Ltd	Chemical compounds
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
WO2004081015A1 (fr) *	2003-03-10	2004-09-23	Hetero Drugs Limited	Hydrogene sulfate de clopidogrel amorphe
RU2366655C2 (ru)	2003-03-14	2009-09-10	Оно Фармасьютикал Ко., Лтд.	Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента
US8530509B2 (en)	2003-06-20	2013-09-10	Siga Technologies, Inc.	Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7692037B2 (en) *	2004-09-02	2010-04-06	Eastman Chemical Company	Optimized liquid-phase oxidation
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
US8143404B2 (en)	2004-09-13	2012-03-27	Ono Pharmaceutical Co., Ltd	Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
GB0512238D0 (en) *	2005-06-15	2005-07-27	Univ Cambridge Tech	Anti-inflammatory agents
CA2644368A1 (fr)	2006-03-10	2007-09-20	Ono Pharmaceutical Co., Ltd.	Derive heterocyclique azote et agent pharmaceutique comprenant le derive en tant que principe actif
CN104758281A (zh) *	2007-04-23	2015-07-08	西佳技术公司	用于治疗和预防正痘病毒感染和相关疾病的化合物、组合物和方法
NZ585298A (en)	2007-11-16	2012-08-31	Rigel Pharmaceuticals Inc	Carboxamide, sulfonamide and amine compounds for metabolic disorders
EP2231666B1 (fr)	2007-12-12	2015-07-29	Rigel Pharmaceuticals, Inc.	Composés de carboxamide, de sulfonamide et d'amine servant a traiter les troubles métaboliques
BRPI0911681B8 (pt)	2008-04-23	2021-05-25	Rigel Pharmaceuticals Inc	composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
EP2935274B1 (fr) *	2012-12-18	2018-10-03	Chiesi Farmaceutici S.p.A.	Dérivés de 3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine et leurs utilisation pour le traitement de maladies respiratoire
JP7672641B2 (ja)	2019-09-17	2025-05-08	メレオバイオファーマ４リミテッド	移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL297211B2 (en)	2020-04-16	2025-12-01	Mereo Biopharma 4 Ltd	Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (ko)	2021-10-20	2024-06-21	메레오 바이오파마 4 리미티드	섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2932650A (en) *	1957-11-19	1960-04-12	Arthur C Cope	2-6-diazabicyclo (3. 3. 0) octanes
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
US5610296A (en) *	1994-12-05	1997-03-11	G. D. Searle & Co.	Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs

1997
- 1997-03-26 CA CA002250209A patent/CA2250209A1/fr not_active Abandoned
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 EP EP97915439A patent/EP0891362B1/fr not_active Expired - Lifetime
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/fr not_active Ceased
- 1997-03-26 EE EE9800335A patent/EE9800335A/xx unknown
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Withdrawn
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ331490A (en)	2000-06-23
SK132498A3 (en)	1999-08-06
JP4118337B2 (ja)	2008-07-16
HUP9900567A2 (hu)	1999-06-28
DE69728139T2 (de)	2004-10-21
US5994344A (en)	1999-11-30
WO1997036903A1 (fr)	1997-10-09
PT891362E (pt)	2004-08-31
CN1067075C (zh)	2001-06-13
KR20000005039A (ko)	2000-01-25
CO4790152A1 (es)	1999-05-31
ATE261969T1 (de)	2004-04-15
TR199801935T2 (xx)	1999-03-22
EA199800773A1 (ru)	1999-06-24
BR9708449A (pt)	1999-08-03
NO984470L (no)	1998-11-25
DE69728139D1 (de)	2004-04-22
CZ309798A3 (cs)	1999-02-17
EP0891362A1 (fr)	1999-01-20
JP2000507950A (ja)	2000-06-27
IS4837A (is)	1998-08-28
PE55298A1 (es)	1998-09-19
AU2291797A (en)	1997-10-22
AU726649B2 (en)	2000-11-16
CA2250209A1 (fr)	1997-10-09
NO984470D0 (no)	1998-09-25
US6215002B1 (en)	2001-04-10
YU41198A (sh)	1999-09-27
AR006401A1 (es)	1999-08-25
EA001437B1 (ru)	2001-02-26
ES2217404T3 (es)	2004-11-01
AP823A (en)	2000-04-25
AP9801351A0 (en)	1998-09-30
PL329153A1 (en)	1999-03-15
EP0891362B1 (fr)	2004-03-17
HUP9900567A3 (en)	2001-02-28
CN1219935A (zh)	1999-06-16
IL125859A0 (en)	1999-04-11
US6057457A (en)	2000-05-02
EE9800335A (et)	1999-04-15

Publication	Publication Date	Title
DK0891362T3 (da)	2004-07-12	Pyrrolopyrrolon derivater som inhibitorer for neutrofil elastase
FI944804A7 (fi)	1994-10-12	Pyrimidinyyliasetamideja elastaasin estäjinä
NO992725L (no)	1999-06-04	6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
NO980467L (no)	1998-04-03	4-mercaptopyrrolidin-derivater som farnesyl-transerase-inhibitorer
NO986090D0 (no)	1998-12-23	Fenylalaninderivater som integrininhibitorer
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
NO992821D0 (no)	1999-06-10	Ketobenzamider som calpain-inhibitorer
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
NO985874D0 (no)	1998-12-15	Bestemte fosfinylderivater nyttige som naaladase inhibitorer
NO20002958D0 (no)	2000-06-09	Benzamidinderivater som koagulasjonsfaktor Xa-hemmere
NO973539D0 (no)	1997-08-01	Prolinderivater anvendelige som inhibitorer for human leukocyttelastase
NO20010331D0 (no)	2001-01-19	Ftalazinderivater som fosfodiesterase 4-inhibitorer
EE200000138A (et)	2001-02-15	Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
DE69736109D1 (de)	2006-07-27	Differenzierungsinhibitor
NO991316D0 (no)	1999-03-18	3-mercaptoacetylamino-1,5-substituerte-2-okso-azepanderivater som er anvendbare som inhibitorer av matriksmetalloproteinase
DK0937036T3 (da)	2002-04-02	Substituerede 4-biphenyl-4-hydroxysmørsyrederivater som matrixmetalprotease-inhibitorer
FI964781A7 (fi)	1997-01-29	Uusia elastaasi-inhibiittoreita
EE200000137A (et)	2001-02-15	Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena
NO992858D0 (no)	1999-06-11	Inhibitor for portahypertensjon
ID23866A (id)	2000-05-25	Komposisi untuk menyelamatkan beras terhadap asetoklor
ZA988160B (en)	2000-03-22	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
DE69418656D1 (de)	1999-07-01	2-acyloxycephemderivate als elastaseinhibitoren
SI0891362T1 (en)	2004-08-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
HK1026210A (en)	2000-12-08	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
HK1026420A (en)	2000-12-15	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase