DK0904272T3 - Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler - Google Patents

Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler

Info

Publication number: DK0904272T3
Authority: DK; Denmark
Prior art keywords: atoms; branched; straight; dihydrobenzofuran; cyclic alkyl
Prior art date: 1996-02-01

Application number

DK97904017T

Other languages

English (en)

Inventor

Zhuliang Chen

John Michael Janusz

Original Assignee

Univ Vanderbilt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-01

Filing date

1997-01-30

Publication date

2003-07-21

1997-01-30 Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt

2003-07-21 Application granted granted Critical

2003-07-21 Publication of DK0904272T3 publication Critical patent/DK0904272T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)

DK97904017T 1996-02-01 1997-01-30 Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler DK0904272T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/595,120 US5686471A (en)	1996-02-01	1996-02-01	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
PCT/US1997/001312 WO1997028155A1 (en)	1996-02-01	1997-01-30	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number	Publication Date
DK0904272T3 true DK0904272T3 (da)	2003-07-21

Family

ID=24381819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97904017T DK0904272T3 (da)	1996-02-01	1997-01-30	Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler

Country Status (15)

Country	Link
US (1)	US5686471A (da)
EP (1)	EP0904272B1 (da)
JP (1)	JP3164157B2 (da)
KR (1)	KR100322943B1 (da)
CN (1)	CN1072668C (da)
AT (1)	ATE236900T1 (da)
AU (1)	AU730292B2 (da)
BR (1)	BR9707342A (da)
CA (1)	CA2244199A1 (da)
DE (1)	DE69720718T2 (da)
DK (1)	DK0904272T3 (da)
ES (1)	ES2196301T3 (da)
MX (1)	MX9806253A (da)
NO (1)	NO983528L (da)
WO (1)	WO1997028155A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
DE102004002235B4 (de) *	2004-01-15	2007-04-26	OCé PRINTING SYSTEMS GMBH	Puffereinrichtung mit einem Vorratspuffer zur Aufnahme einer mit variierender Geschwindigkeit zugeführten Bedruckstoffbahn bei einer elektrografischen Druckeinrichtung
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (en)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Glutathione-based drug delivery system
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6019305B2 (ja) *	1976-07-02	1985-05-15	ウェルファイド株式会社	ジヒドロベンゾフラン誘導体
IT1093805B (it) *	1978-01-31	1985-07-26	Erba Carlo Spa	Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) *	1982-09-30	1984-09-11	Thor Harry A	Impact producing tool
DE3777366D1 (de) *	1986-12-27	1992-04-16	Takeda Chemical Industries Ltd	2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US5234926A (en) *	1987-03-20	1993-08-10	Allergan, Inc.	Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US4833254A (en)	1987-05-11	1989-05-23	The Board Of Regents For The Oklahoma Agricultural And Mechanical Colleges Acting For And On Behalf Of Oklahoma State University	Heteroarotinoids as anticancer agents
US4849428A (en) *	1987-11-23	1989-07-18	The Procter & Gamble Company	Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
JP2855341B2 (ja) *	1988-06-10	1999-02-10	武田薬品工業株式会社	新規２―置換クマラン誘導体
US4966907A (en) *	1988-08-12	1990-10-30	Merck & Co., Inc.	6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
FR2645537B1 (fr) *	1989-04-05	1994-03-04	Fabre Medicament Pierre	Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
US4975457A (en) *	1989-09-25	1990-12-04	Merck & Co., Inc.	Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
EP0458970A4 (en) *	1989-11-17	1992-05-13	Meiji Milk Products Company Limited	Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient
US5091533A (en) *	1990-03-12	1992-02-25	Merck Frosst Canada, Inc.	5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
JPH05505610A (ja) *	1990-03-27	1993-08-19	スミスクライン・ビーチャム・コーポレイション	５―リポキシゲナーゼ阻害剤
ES2301161T3 (es) *	1994-07-27	2008-06-16	Vanderbilt University	Compuestos de dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.
US5684002A (en) *	1994-09-07	1997-11-04	The Procter & Gamble Company	Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

1996
- 1996-02-01 US US08/595,120 patent/US5686471A/en not_active Expired - Fee Related
1997
- 1997-01-30 JP JP52776097A patent/JP3164157B2/ja not_active Expired - Fee Related
- 1997-01-30 AU AU18431/97A patent/AU730292B2/en not_active Ceased
- 1997-01-30 DK DK97904017T patent/DK0904272T3/da active
- 1997-01-30 AT AT97904017T patent/ATE236900T1/de not_active IP Right Cessation
- 1997-01-30 KR KR1019980705953A patent/KR100322943B1/ko not_active Expired - Fee Related
- 1997-01-30 DE DE69720718T patent/DE69720718T2/de not_active Expired - Fee Related
- 1997-01-30 CA CA002244199A patent/CA2244199A1/en not_active Abandoned
- 1997-01-30 WO PCT/US1997/001312 patent/WO1997028155A1/en not_active Ceased
- 1997-01-30 BR BR9707342A patent/BR9707342A/pt not_active Application Discontinuation
- 1997-01-30 CN CN97192017A patent/CN1072668C/zh not_active Expired - Fee Related
- 1997-01-30 ES ES97904017T patent/ES2196301T3/es not_active Expired - Lifetime
- 1997-01-30 EP EP97904017A patent/EP0904272B1/en not_active Expired - Lifetime
1998
- 1998-07-31 NO NO983528A patent/NO983528L/no not_active Application Discontinuation
- 1998-08-03 MX MX9806253A patent/MX9806253A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU1843197A (en)	1997-08-22
US5686471A (en)	1997-11-11
MX9806253A (es)	1998-11-30
DE69720718D1 (de)	2003-05-15
BR9707342A (pt)	1999-07-20
EP0904272B1 (en)	2003-04-09
CN1072668C (zh)	2001-10-10
KR100322943B1 (ko)	2002-05-09
JPH11503468A (ja)	1999-03-26
JP3164157B2 (ja)	2001-05-08
CN1210534A (zh)	1999-03-10
NO983528D0 (no)	1998-07-31
ATE236900T1 (de)	2003-04-15
WO1997028155A1 (en)	1997-08-07
AU730292B2 (en)	2001-03-01
ES2196301T3 (es)	2003-12-16
EP0904272A1 (en)	1999-03-31
CA2244199A1 (en)	1997-08-07
KR19990082225A (ko)	1999-11-25
NO983528L (no)	1998-09-28
DE69720718T2 (de)	2003-12-18

Publication	Publication Date	Title
DK0883616T3 (da)	2004-11-01	Dihydrobenzofuranforbindelser og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler
DK0779886T3 (da)	2002-03-11	Dihydrobenzofuran og beslægtede forbindelser, der er anvendelige som antiinflammatoriske midler
DK0879231T3 (da)	2004-12-20	Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler
NO985679D0 (no)	1998-12-04	Dihydrobenzopyran og beslektede forbindelser nyttige som anti-inflammasjonsmidler
NO983528D0 (no)	1998-07-31	Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler
DK0891346T3 (da)	2004-08-09	Dihydrobenzofuranforbindelser, der er nyttige som antiinflammatoriske midler
DK0904270T3 (da)	2003-12-01	Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midler
MX9806247A (es)	1998-11-30	Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
CA2244245A1 (en)	1997-08-07	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents