DK0906329T3 - 2'-Substituerede nukleosider og oligonukleotidderivater - Google Patents

2'-Substituerede nukleosider og oligonukleotidderivater

Info

Publication number
DK0906329T3
DK0906329T3 DK97924997T DK97924997T DK0906329T3 DK 0906329 T3 DK0906329 T3 DK 0906329T3 DK 97924997 T DK97924997 T DK 97924997T DK 97924997 T DK97924997 T DK 97924997T DK 0906329 T3 DK0906329 T3 DK 0906329T3
Authority
DK
Denmark
Prior art keywords
oligonucleotide derivatives
substituted nucleosides
nucleoside building
building blocks
oligonucleotide
Prior art date
Application number
DK97924997T
Other languages
Danish (da)
English (en)
Inventor
Bernard Cuenoud
Karl-Heinz Altmann
Pierre Martin
Heinz Ernst Moser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0906329T3 publication Critical patent/DK0906329T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK97924997T 1996-06-06 1997-05-27 2'-Substituerede nukleosider og oligonukleotidderivater DK0906329T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH143296 1996-06-06
PCT/EP1997/002738 WO1997046569A2 (en) 1996-06-06 1997-05-27 2'-substituted nucleosides and oligonucleotide derivatives

Publications (1)

Publication Number Publication Date
DK0906329T3 true DK0906329T3 (da) 2004-02-09

Family

ID=4210329

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97924997T DK0906329T3 (da) 1996-06-06 1997-05-27 2'-Substituerede nukleosider og oligonukleotidderivater

Country Status (11)

Country Link
US (2) US6670468B1 (de)
EP (1) EP0906329B1 (de)
JP (1) JP2000512630A (de)
AT (1) ATE251638T1 (de)
AU (1) AU3029797A (de)
CA (1) CA2256765A1 (de)
CY (1) CY2522B1 (de)
DE (1) DE69725440T2 (de)
DK (1) DK0906329T3 (de)
WO (1) WO1997046569A2 (de)
ZA (1) ZA974952B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2256765A1 (en) * 1996-06-06 1997-12-11 Novartis Ag 2'-substituted nucleosides and oligonucleotide derivatives
US6277967B1 (en) * 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
US6673912B1 (en) 1998-08-07 2004-01-06 Isis Pharmaceuticals, Inc. 2′-O-aminoethyloxyethyl-modified oligonucleotides
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
JP5498392B2 (ja) 2007-11-30 2014-05-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
KR20110063447A (ko) 2008-09-08 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 피라졸로피리미딘 및 ｃｎｓ 장애의 치료를 위한 이들의 용도
AU2010221419B2 (en) * 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
PT2414363E (pt) 2009-03-31 2014-02-26 Boehringer Ingelheim Int Derivados de 1-heterociclil-1,5-di-hidro-pirazolo[3,4- d]pirimidin-4-ona e sua utilização como moduladores de pde9a
EP2603511B1 (de) 2010-08-12 2017-03-15 Boehringer Ingelheim International GmbH 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-on derivate und ihre verwendung als pde9a inhibitoren
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
AU2016301188A1 (en) 2015-08-06 2018-02-15 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
ES3011607T3 (en) 2017-09-21 2025-04-07 Chimerix Inc Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof
WO2025149479A1 (en) * 2024-01-12 2025-07-17 Roche Diagnostics Gmbh Synthesis of modified nucleoside triphosphates

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69034150T2 (de) * 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
WO1995006659A1 (en) 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
WO1992003568A1 (en) 1990-08-13 1992-03-05 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
DE4037363A1 (de) 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
DE4110085A1 (de) 1991-03-27 1992-10-01 Boehringer Ingelheim Int 2'-o-alkyl-oligoribonukleotide, verfahren zu deren herstellung und deren verwendung als antisense-oligonukleotide
DE69233046T2 (de) * 1991-10-24 2004-03-04 Isis Pharmaceuticals, Inc., Carlsfeld Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する２′修飾オリゴヌクレオチド
US5485592A (en) 1992-04-07 1996-01-16 Video Technology Computers, Ltd. Write back cache controller method and apparatus for use in a system having a CPU with internal cache memory
ATE299509T1 (de) * 1992-07-23 2005-07-15 Isis Pharmaceuticals Inc Neue 2'-o-alkyl-nukleoside und -phosphoramidite, verfahren zu ihrer herstellung und ihre verwendungen
ATE177430T1 (de) 1993-05-12 1999-03-15 Novartis Erfind Verwalt Gmbh Nukleoside und oligonukleotide mit 2'- ethergruppen
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
PT679657E (pt) * 1994-04-27 2003-11-28 Novartis Ag Nucleosidos e oligonucleotidos com grupos 2'-eter
US5744362A (en) * 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
CA2256765A1 (en) * 1996-06-06 1997-12-11 Novartis Ag 2'-substituted nucleosides and oligonucleotide derivatives

Also Published As

Publication number Publication date
US20050159374A1 (en) 2005-07-21
ATE251638T1 (de) 2003-10-15
US6670468B1 (en) 2003-12-30
DE69725440T2 (de) 2004-07-22
WO1997046569A3 (en) 1998-02-19
WO1997046569A2 (en) 1997-12-11
CA2256765A1 (en) 1997-12-11
ZA974952B (en) 1997-12-08
CY2522B1 (en) 2006-02-08
AU3029797A (en) 1998-01-05
EP0906329A2 (de) 1999-04-07
DE69725440D1 (de) 2003-11-13
JP2000512630A (ja) 2000-09-26
EP0906329B1 (de) 2003-10-08

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