DK0920410T3 - Fremgangsmåde til fremstilling af cyclohexencarboxylatderivater - Google Patents
Fremgangsmåde til fremstilling af cyclohexencarboxylatderivaterInfo
- Publication number
- DK0920410T3 DK0920410T3 DK97939508T DK97939508T DK0920410T3 DK 0920410 T3 DK0920410 T3 DK 0920410T3 DK 97939508 T DK97939508 T DK 97939508T DK 97939508 T DK97939508 T DK 97939508T DK 0920410 T3 DK0920410 T3 DK 0920410T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- carboxylate derivatives
- cyclohexene carboxylate
- useful
- formulas
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- NMEZJSDUZQOPFE-UHFFFAOYSA-N Cyclohex-1-enecarboxylic acid Chemical class OC(=O)C1=CCCCC1 NMEZJSDUZQOPFE-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002911 sialidase inhibitor Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2412296P | 1996-08-23 | 1996-08-23 | |
| US08/701,942 US5859284A (en) | 1996-08-23 | 1996-08-23 | Preparation of carbocyclic compounds |
| PCT/US1997/014813 WO1998007685A1 (en) | 1996-08-23 | 1997-08-22 | Preparation of cyclohexene carboxylate derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0920410T3 true DK0920410T3 (da) | 2002-06-10 |
Family
ID=26698076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97939508T DK0920410T3 (da) | 1996-08-23 | 1997-08-22 | Fremgangsmåde til fremstilling af cyclohexencarboxylatderivater |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0920410B1 (da) |
| JP (3) | JP3622983B2 (da) |
| AT (1) | ATE215062T1 (da) |
| AU (1) | AU738577C (da) |
| DE (1) | DE69711395T2 (da) |
| DK (1) | DK0920410T3 (da) |
| ES (1) | ES2173480T3 (da) |
| MX (1) | MXPA99001697A (da) |
| NZ (2) | NZ507106A (da) |
| PT (1) | PT920410E (da) |
| WO (1) | WO1998007685A1 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409844C (zh) | 1995-02-27 | 2008-08-13 | 吉里德科学公司 | 神经氨酸苷酶抑制剂 |
| US5859284A (en) | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
| US5994377A (en) | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
| JP2001516739A (ja) * | 1997-09-17 | 2001-10-02 | ギリアード サイエンシーズ， インコーポレイテッド | ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用 |
| US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
| US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
| ES2167975T3 (es) * | 1998-05-13 | 2002-05-16 | Hoffmann La Roche | Procedimiento para la preparacion de acido shikimico y sus derivados. |
| DE60002949T2 (de) | 1999-06-11 | 2004-05-19 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796 |
| US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
| AU2039301A (en) * | 1999-10-19 | 2001-04-30 | Abbott Laboratories | Neuraminidase inhibitors |
| JP2001131144A (ja) | 1999-11-02 | 2001-05-15 | Sagami Chem Res Center | ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法 |
| US6462226B1 (en) | 1999-12-03 | 2002-10-08 | Hoffmann-La Roche Inc. | Process for the preparation of 4,5-diamino shikimic acid derivatives |
| EP1245569A1 (en) | 1999-12-27 | 2002-10-02 | Sagami Chemical Research Center | Process for the production of 5-oxy-7-oxabicyclo- 4.1.0]hept-3-e ne-3-carboxylic acid esters |
| US6403824B2 (en) * | 2000-02-22 | 2002-06-11 | Hoffmann-La Roche Inc. | Process for the preparation for 4,5-diamino shikimic acid derivatives |
| US6518048B2 (en) * | 2000-04-10 | 2003-02-11 | Hoffmann-La Roche Inc. | Stereo-specific synthesis of shimikic acid derivatives with improved efficiency |
| US7122684B2 (en) * | 2003-03-13 | 2006-10-17 | Roche Colorado Corporation | Process for preparing 1,2-diamino compounds |
| JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| CA2577192C (en) * | 2004-09-02 | 2013-01-15 | F.Hoffmann-La Roche Ag | Process for the preparation of 4,5-diamino shikimic acid |
| US7687658B2 (en) | 2005-11-25 | 2010-03-30 | Hetero Drugs Limited | Process for oseltamivir phosphate |
| EP2178819A2 (en) | 2005-12-28 | 2010-04-28 | F.Hoffmann-La Roche Ag | Epoxide intermediate in the tamiflu synthesis |
| US7732632B2 (en) | 2006-01-02 | 2010-06-08 | Hetero Drugs Limited | Process for obtaining pure oseltamivir |
| EP1987825B1 (en) | 2006-02-20 | 2018-09-05 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising oseltamivir phosphate |
| JP2008050336A (ja) * | 2006-07-28 | 2008-03-06 | Univ Of Tokyo | イソキヌクリジン誘導体およびこれを利用した１−シクロヘキセン−１−カルボン酸誘導体の製法 |
| JP5384504B2 (ja) * | 2007-09-18 | 2014-01-08 | エフ．ホフマン−ラ ロシュ アーゲー | シキミ酸からオセルタミビルリン酸エステルへの方法 |
| US8334319B2 (en) * | 2008-01-04 | 2012-12-18 | Roche Palo Alto Llc | Polymorphic forms of oseltamivir phosphate |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| WO2010143700A1 (ja) | 2009-06-09 | 2010-12-16 | 国立大学法人 岡山大学 | ジヒドロキシヘキセン酸エステル及びその製造方法 |
| JP4496351B1 (ja) * | 2009-09-01 | 2010-07-07 | 国立大学法人 岡山大学 | １，３−ジオキソラン化合物及びその製造方法 |
| SK288218B6 (sk) | 2010-05-05 | 2014-08-05 | Synkola, S.R.O. | Spôsob prípravy 1-nitro-4-oxobutanylamidov a ich opačných enantiomérov |
| JP5039236B1 (ja) | 2011-04-27 | 2012-10-03 | 学校法人東邦大学 | 抗不整脈剤及び心房細動抑制剤 |
| JP6072247B2 (ja) * | 2013-06-28 | 2017-02-01 | 富士フイルム株式会社 | シキミ酸誘導体の製造法および中間体 |
| TWI481600B (zh) * | 2013-07-24 | 2015-04-21 | Nat Applied Res Laboratories | 一種奎尼酸衍生物、其製程及其用途 |
| CN105439884A (zh) * | 2015-10-27 | 2016-03-30 | 沈阳药科大学 | 一种奥司他韦的制备方法 |
| CN110272381A (zh) * | 2019-06-19 | 2019-09-24 | 五邑大学 | 含吡啶片段的奥司他韦类似物及其应用 |
| JP7475578B2 (ja) * | 2020-07-01 | 2024-04-30 | 信越化学工業株式会社 | １，３－ジヒドロキシ－１，１，３，３－テトラ－ｔｅｒｔ－ブトキシジシロキサンの製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409844C (zh) * | 1995-02-27 | 2008-08-13 | 吉里德科学公司 | 神经氨酸苷酶抑制剂 |
-
1997
- 1997-08-22 MX MXPA99001697A patent/MXPA99001697A/es active IP Right Grant
- 1997-08-22 DK DK97939508T patent/DK0920410T3/da active
- 1997-08-22 DE DE69711395T patent/DE69711395T2/de not_active Expired - Lifetime
- 1997-08-22 AU AU41579/97A patent/AU738577C/en not_active Expired
- 1997-08-22 AT AT97939508T patent/ATE215062T1/de active
- 1997-08-22 WO PCT/US1997/014813 patent/WO1998007685A1/en not_active Ceased
- 1997-08-22 PT PT97939508T patent/PT920410E/pt unknown
- 1997-08-22 NZ NZ507106A patent/NZ507106A/xx not_active IP Right Cessation
- 1997-08-22 JP JP51100698A patent/JP3622983B2/ja not_active Expired - Lifetime
- 1997-08-22 ES ES97939508T patent/ES2173480T3/es not_active Expired - Lifetime
- 1997-08-22 EP EP97939508A patent/EP0920410B1/en not_active Expired - Lifetime
- 1997-08-22 NZ NZ522535A patent/NZ522535A/en not_active IP Right Cessation
-
2002
- 2002-06-03 JP JP2002162217A patent/JP2003002888A/ja not_active Withdrawn
-
2009
- 2009-04-21 JP JP2009103480A patent/JP2009167210A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69711395T2 (de) | 2002-11-07 |
| NZ507106A (en) | 2003-01-31 |
| AU738577B2 (en) | 2001-09-20 |
| PT920410E (pt) | 2002-07-31 |
| JP3622983B2 (ja) | 2005-02-23 |
| ES2173480T3 (es) | 2002-10-16 |
| AU738577C (en) | 2002-04-11 |
| EP0920410A1 (en) | 1999-06-09 |
| WO1998007685A1 (en) | 1998-02-26 |
| EP0920410B1 (en) | 2002-03-27 |
| HK1021815A1 (en) | 2000-10-05 |
| JP2000517306A (ja) | 2000-12-26 |
| MXPA99001697A (es) | 2004-04-05 |
| JP2003002888A (ja) | 2003-01-08 |
| ATE215062T1 (de) | 2002-04-15 |
| JP2009167210A (ja) | 2009-07-30 |
| NZ522535A (en) | 2004-07-30 |
| DE69711395D1 (de) | 2002-05-02 |
| AU4157997A (en) | 1998-03-06 |
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