DK0928291T3 - 3-Mercaptoacetylamino-1,5-substituerede 2-oxo-azepanderivater, der er nyttige som inhibitorer af matrixmetalloproteinase - Google Patents

3-Mercaptoacetylamino-1,5-substituerede 2-oxo-azepanderivater, der er nyttige som inhibitorer af matrixmetalloproteinase

Info

Publication number: DK0928291T3
Authority: DK; Denmark
Prior art keywords: mercaptoacetylamino; oxo; inhibitors; substituted; matrix metalloproteinase
Prior art date: 1996-09-19

Application number

DK97935308T

Other languages

English (en)

Inventor

Alan M Warshawsky

Gary A Flynn

Meena V Patel

Douglas W Beight

Joseph P Burkhart

Jiu-Tsair Tsay

Michael J Janusz

Jian Shen

Ramalinga M Dharanipragada

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-19

Filing date

1997-08-04

Publication date

2003-03-17

1997-08-04 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-03-17 Application granted granted Critical

2003-03-17 Publication of DK0928291T3 publication Critical patent/DK0928291T3/da

Links

102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical class O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Cardiology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

DK97935308T 1996-09-19 1997-08-04 3-Mercaptoacetylamino-1,5-substituerede 2-oxo-azepanderivater, der er nyttige som inhibitorer af matrixmetalloproteinase DK0928291T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71929196A	1996-09-19	1996-09-19
PCT/US1997/013738 WO1998012211A1 (en)	1996-09-19	1997-08-04	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase

Publications (1)

Publication Number	Publication Date
DK0928291T3 true DK0928291T3 (da)	2003-03-17

Family

ID=24889504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97935308T DK0928291T3 (da)	1996-09-19	1997-08-04	3-Mercaptoacetylamino-1,5-substituerede 2-oxo-azepanderivater, der er nyttige som inhibitorer af matrixmetalloproteinase

Country Status (20)

Country	Link
EP (1)	EP0928291B1 (da)
JP (1)	JP3962091B2 (da)
KR (1)	KR100545460B1 (da)
CN (1)	CN1150205C (da)
AR (1)	AR009363A1 (da)
AT (1)	ATE229034T1 (da)
AU (1)	AU718055B2 (da)
BR (1)	BR9713207A (da)
CA (1)	CA2266759C (da)
DE (1)	DE69717647T2 (da)
DK (1)	DK0928291T3 (da)
ES (1)	ES2184126T3 (da)
HU (1)	HUP9904165A3 (da)
IL (2)	IL129035A0 (da)
NO (1)	NO991316L (da)
NZ (1)	NZ334490A (da)
PT (1)	PT928291E (da)
TW (1)	TW445262B (da)
WO (1)	WO1998012211A1 (da)
ZA (1)	ZA978307B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6486193B2 (en)	1998-12-31	2002-11-26	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
US6770640B1 (en)	1998-12-31	2004-08-03	Aventis Pharmaceuticals Inc.	1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12
WO2000040553A1 (en) *	1998-12-31	2000-07-13	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases
WO2000040577A1 (en) *	1998-12-31	2000-07-13	Aventis Pharmaceuticals Inc.	1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
US6297233B1 (en)	1999-02-09	2001-10-02	Bristol-Myers Squibb Company	Lactam inhibitors of FXa and method
US6344450B1 (en)	1999-02-09	2002-02-05	Bristol-Myers Squibb Company	Lactam compounds and their use as inhibitors of serine proteases and method
US6596715B1 (en)	1999-11-10	2003-07-22	Smithkline Beecham Corporation	Protease inhibitors
EP1229914A4 (en)	1999-11-10	2004-06-23	Smithkline Beecham Corp	PROTEASE INHIBITORS
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
AU4344101A (en)	2000-03-21	2001-10-03	Smithkline Beecham Corp	Protease inhibitors
US6511973B2 (en)	2000-08-02	2003-01-28	Bristol-Myers Squibb Co.	Lactam inhibitors of FXa and method
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US7704521B2 (en)	2007-04-11	2010-04-27	Zinpro Corporation	Rumen protected essential amino acids
US20080255234A1 (en) *	2007-04-11	2008-10-16	Zinpro Corporation	Rumen protected lysine
WO2018220032A1 (en)	2017-05-31	2018-12-06	B.R.A.I.N. Biotechnology Research And Information Network Ag	Optimization of the expression of serine proteases in host cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0358660B1 (en) *	1987-03-17	1994-05-25	Research Corporation Technologies, Inc.	Synthetic inhibitors of mammalian collagenase
JPH07304746A (ja) *	1994-05-11	1995-11-21	Kanebo Ltd	新規ベンゾアゼピンカルボン酸誘導体
ES2133807T3 (es) *	1994-10-05	1999-09-16	Darwin Discovery Ltd	Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids

1997
- 1997-08-04 WO PCT/US1997/013738 patent/WO1998012211A1/en not_active Ceased
- 1997-08-04 DE DE69717647T patent/DE69717647T2/de not_active Expired - Lifetime
- 1997-08-04 EP EP97935308A patent/EP0928291B1/en not_active Expired - Lifetime
- 1997-08-04 NZ NZ334490A patent/NZ334490A/xx not_active IP Right Cessation
- 1997-08-04 PT PT97935308T patent/PT928291E/pt unknown
- 1997-08-04 HU HU9904165A patent/HUP9904165A3/hu unknown
- 1997-08-04 CA CA002266759A patent/CA2266759C/en not_active Expired - Fee Related
- 1997-08-04 AT AT97935308T patent/ATE229034T1/de active
- 1997-08-04 DK DK97935308T patent/DK0928291T3/da active
- 1997-08-04 IL IL12903597A patent/IL129035A0/xx active IP Right Grant
- 1997-08-04 CN CNB971990247A patent/CN1150205C/zh not_active Expired - Fee Related
- 1997-08-04 JP JP51465898A patent/JP3962091B2/ja not_active Expired - Fee Related
- 1997-08-04 ES ES97935308T patent/ES2184126T3/es not_active Expired - Lifetime
- 1997-08-04 BR BR9713207-1A patent/BR9713207A/pt not_active IP Right Cessation
- 1997-08-04 AU AU38278/97A patent/AU718055B2/en not_active Ceased
- 1997-08-04 KR KR1019997002336A patent/KR100545460B1/ko not_active Expired - Fee Related
- 1997-09-13 TW TW086113339A patent/TW445262B/zh not_active IP Right Cessation
- 1997-09-15 ZA ZA9708307A patent/ZA978307B/xx unknown
- 1997-09-17 AR ARP970104242A patent/AR009363A1/es active IP Right Grant
1999
- 1999-03-17 IL IL129035A patent/IL129035A/en not_active IP Right Cessation
- 1999-03-18 NO NO991316A patent/NO991316L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO991316L (no)	1999-05-18
IL129035A0 (en)	2000-02-17
CN1234039A (zh)	1999-11-03
CN1150205C (zh)	2004-05-19
JP3962091B2 (ja)	2007-08-22
ATE229034T1 (de)	2002-12-15
AU718055B2 (en)	2000-04-06
DE69717647D1 (de)	2003-01-16
JP2001501926A (ja)	2001-02-13
ES2184126T3 (es)	2003-04-01
NZ334490A (en)	2000-08-25
AR009363A1 (es)	2000-04-12
CA2266759A1 (en)	1998-03-26
KR20000036246A (ko)	2000-06-26
HUP9904165A2 (hu)	2000-03-28
ZA978307B (en)	1998-03-19
BR9713207A (pt)	2000-04-04
IL129035A (en)	2006-12-10
NO991316D0 (no)	1999-03-18
HK1020741A1 (en)	2000-05-19
AU3827897A (en)	1998-04-14
KR100545460B1 (ko)	2006-01-24
WO1998012211A1 (en)	1998-03-26
DE69717647T2 (de)	2003-09-25
CA2266759C (en)	2004-10-26
EP0928291A1 (en)	1999-07-14
PT928291E (pt)	2003-03-31
HUP9904165A3 (en)	2002-01-28
TW445262B (en)	2001-07-11
EP0928291B1 (en)	2002-12-04

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DK0946512T3 (da)	2004-01-12	6-Phenylpyridyl-2-aminderivater, der er nyttige som NOS-inhibitorer
DK1165516T3 (da)	2005-01-31	Heterocyklisk urinstof og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler
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DK0923585T3 (da)	2002-07-01	Phosphinatbaserede inhibitorer af matrixmetalloproteinaser
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DE69900356D1 (de)	2001-11-22	Nitro-Isoharnstoffderivate
DK0996622T3 (da)	2002-12-30	Hidtil ukendte spiroazabicycliske, heterocykliske forbindelser
DE69906311D1 (de)	2003-04-30	Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren
DK1104420T3 (da)	2003-01-13	Substituerede 1,8-naphthyridin-4(1H)-oner som phosphodiesterase-4-inhibitorer
DK1097127T3 (da)	2003-06-10	Diacylhydrazinderivater som integrininhibitorer
DK0912537T3 (da)	2004-08-30	Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer
NO20013675D0 (no)	2001-07-26	2,3,4,5-Tetrahydro-1H-[1,4)benzodiazepin-3-hydroksamsyre som matriks-metalloproteinaseinhibitorer
NO20021407D0 (no)	2002-03-21	Bifenylderivater anvendt som NHE-3-inhibitorer
NO991316D0 (no)	1999-03-18	3-mercaptoacetylamino-1,5-substituerte-2-okso-azepanderivater som er anvendbare som inhibitorer av matriksmetalloproteinase
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
DK1210326T3 (da)	2004-06-21	Hydroxamsyreforbindelser, der er nyttige som matrixmetalloproteinaseinhibitorer
NO991994D0 (no)	1999-04-27	Substituerte 4-bifenyl-4-hydroksysm°rsyrederivater som matriks-metalloproteaseinhibitorer
NO20023001D0 (no)	2002-06-21	Substituerte piperazinderivater som MTP inhibitorer
NO20001200D0 (no)	2000-03-08	Pyrrolopyrrolonderivater som inhibitorer av neurofil elastase