DK0937055T3 - Fremgangsmåde til fremstilling af d,I-alfa-tocopherol - Google Patents

Fremgangsmåde til fremstilling af d,I-alfa-tocopherol

Info

Publication number
DK0937055T3
DK0937055T3 DK97950150T DK97950150T DK0937055T3 DK 0937055 T3 DK0937055 T3 DK 0937055T3 DK 97950150 T DK97950150 T DK 97950150T DK 97950150 T DK97950150 T DK 97950150T DK 0937055 T3 DK0937055 T3 DK 0937055T3
Authority
DK
Denmark
Prior art keywords
tocopherol
alpha
preparation
Prior art date
Application number
DK97950150T
Other languages
English (en)
Inventor
Werner Bonrath
Horst Pauling
Marcel Baak
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0937055T3 publication Critical patent/DK0937055T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK97950150T 1996-11-11 1997-11-10 Fremgangsmåde til fremstilling af d,I-alfa-tocopherol DK0937055T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96118037 1996-11-11
PCT/EP1997/006227 WO1998021197A2 (en) 1996-11-11 1997-11-10 PROCESS FOR MANUFACTURING d,l-α-TOCOPHEROL

Publications (1)

Publication Number Publication Date
DK0937055T3 true DK0937055T3 (da) 2002-07-29

Family

ID=8223387

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97950150T DK0937055T3 (da) 1996-11-11 1997-11-10 Fremgangsmåde til fremstilling af d,I-alfa-tocopherol

Country Status (8)

Country Link
US (1) US5908939A (da)
EP (1) EP0937055B1 (da)
JP (1) JP2001504111A (da)
CN (1) CN1105714C (da)
DE (1) DE69711669T2 (da)
DK (1) DK0937055T3 (da)
ES (1) ES2173500T3 (da)
WO (1) WO1998021197A2 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
FR2784104B1 (fr) * 1998-09-18 2002-12-27 Rhone Poulenc Nutrition Animal Procede de preparation de la vitamine e
CA2288851A1 (en) * 1998-11-11 2000-05-11 F. Hoffmann-La Roche Ag Process for manufacturing d,i-alpha-tocopherol
EP1000940A1 (en) * 1998-11-11 2000-05-17 F. Hoffmann-La Roche Ag Process for manufacturing d,l-alpha-tocopherol
RU2163600C2 (ru) * 1998-12-04 2001-02-27 Общество с ограниченной ответственностью конструкторское бюро "Пульс" СПОСОБ ПОЛУЧЕНИЯ α-ТОКОФЕРОЛА (ВИТАМИНА E)
KR100452291B1 (ko) * 1999-12-14 2004-10-08 에스케이 주식회사 고수율 및 고순도로 ＤＬ-α-토코페롤를 제조하는 방법
US6369242B2 (en) * 2000-03-17 2002-04-09 Roche Vitamins Inc. Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
EP1180517B1 (en) * 2000-08-18 2003-07-30 Roche Vitamins AG Process for manufacturing (all-rac)-alpha-tocopherol
EP1370508A2 (en) * 2001-03-12 2003-12-17 The Queen's University of Belfast Process catalysed by fluoroalkysulfonated compounds, preferably bis-triflimide compounds
KR20030092107A (ko) * 2001-04-24 2003-12-03 메사추세츠 인스티튜트 오브 테크놀로지 탄소-헤테로원자 및 탄소-탄소 결합을 형성하는 구리-촉매방법
ATE532764T1 (de) * 2001-12-14 2011-11-15 Dsm Ip Assets Bv Herstellung von trimethylhydrochinondiacylaten
AU2003257062A1 (en) 2002-08-02 2004-02-23 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
CN100344621C (zh) * 2003-01-13 2007-10-24 帝斯曼知识产权资产管理有限公司 α－生育酚乙酸酯的生产方法
CN100355745C (zh) * 2005-03-18 2007-12-19 清华大学 离子液体催化合成D,L－α－生育酚的方法
FR2889519B1 (fr) * 2005-08-04 2008-07-11 Rhodia Chimie Sa Procede de c-alkylation de composes aromatiques hydroxyles avec un catalyseur de type tfsih
EP2050743A1 (en) * 2007-10-19 2009-04-22 Humboldt-Universität zu Berlin Method for the synthesis of dl.(alpha)-tocopherol and means therefore
US8226850B1 (en) * 2009-09-22 2012-07-24 Clemson University Research Foundation Thermally enhanced oxygen scavengers including a transition metal and a free radical scavenger
CN102276572B (zh) * 2011-09-14 2013-03-27 重庆大学 一种制备维生素e乙酸酯的方法
CN102285955B (zh) * 2011-09-14 2012-12-05 重庆大学 一种α-生育酚乙酸酯的制备方法
WO2014094650A1 (en) * 2012-12-21 2014-06-26 Rhodia Operations Process for forming a primary, a secondary or a tertiary amine via a direct amination reaction
CN104936941A (zh) * 2012-12-21 2015-09-23 罗地亚经营管理公司 用于经由直接胺化反应形成伯胺、仲胺或叔胺的方法
CN108017610B (zh) * 2017-12-22 2020-11-06 浙江新和成药业有限公司 一种维生素e的制备方法
CN108409704A (zh) * 2018-01-24 2018-08-17 上海优合生物科技有限公司 一种高纯度生育酚琥珀酸酯盐的制备方法
CN109705082B (zh) * 2018-12-19 2021-04-20 万华化学集团股份有限公司 一种制备维生素e乙酸酯的方法
CN113321669B (zh) * 2020-02-28 2023-03-24 中国科学院上海有机化学研究所 一种磺酰亚胺类金属盐、其制备方法及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723278A (en) * 1954-01-25 1955-11-08 Hoffmann La Roche Preparation of alpha-tocopherol
GB1148652A (en) * 1965-07-20 1969-04-16 Dunlop Co Ltd Polymer compositions comprising polymerized episulphides and a process for the preparation of reaction products of polymerized episulphides
US3459773A (en) * 1966-12-27 1969-08-05 Takasago Perfumery Co Ltd Process for producing alpha-tocopherol and its esters
CH547278A (de) * 1971-01-11 1974-03-29 Hoffmann La Roche Verfahren zur herstellung von chromanderivaten.
US4208334A (en) * 1978-12-22 1980-06-17 Hoffmann-La Roches Inc. Process for preparation of α-tocopherol
US4634781A (en) * 1982-09-30 1987-01-06 Basf Corporation Alpha tocopherol process
FR2637284B1 (fr) * 1988-10-05 1991-07-05 Elf Aquitaine Methode de synthese de sulfonylimidures
DE4243464A1 (de) * 1992-12-22 1994-06-23 Basf Ag Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid
WO1994014794A1 (fr) * 1992-12-28 1994-07-07 Yoshitomi Pharmaceutical Industries, Ltd. Derive d'acide 8-methoxyquinolonecarboxylique
US5526821A (en) * 1993-06-03 1996-06-18 Medical Biopsy, Inc. Biopsy needle with sample retaining means
JP3848380B2 (ja) * 1993-12-14 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 α−トコフェロール誘導体の製造法
JP3166959B2 (ja) * 1994-03-11 2001-05-14 セントラル硝子株式会社 ルイス酸触媒
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
JP3117369B2 (ja) * 1994-09-12 2000-12-11 セントラル硝子株式会社 スルホンイミドの製造方法
DE59610172D1 (de) * 1996-01-05 2003-04-03 Hoffmann La Roche Verfahren zur Herstellung von d,l-alpha-Tocopherol in Gegenwart einer Perfluoralkylensulfonsäure als Katalysator

Also Published As

Publication number Publication date
JP2001504111A (ja) 2001-03-27
DE69711669T2 (de) 2002-10-02
EP0937055B1 (en) 2002-04-03
DE69711669D1 (de) 2002-05-08
WO1998021197A3 (en) 1998-07-23
CN1237163A (zh) 1999-12-01
CN1105714C (zh) 2003-04-16
ES2173500T3 (es) 2002-10-16
WO1998021197A2 (en) 1998-05-22
EP0937055A2 (en) 1999-08-25
US5908939A (en) 1999-06-01

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