DK0952215T3 - Protease til aktivering af koaguleringsfaktor VII - Google Patents

Protease til aktivering af koaguleringsfaktor VII

Info

Publication number: DK0952215T3
Authority: DK; Denmark
Prior art keywords: protease; kda; factor vii; activating; heparin
Prior art date: 1998-04-24

Application number

DK99106913T

Other languages

Danish (da)

English (en)

Inventor

Juergen Dr Roemisch

Annette Feussner

Hans-Arnold Stoehr

Original Assignee

Zlb Behring Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-24

Filing date

1999-04-08

Publication date

2006-08-07

1999-04-08 Application filed by Zlb Behring Gmbh filed Critical Zlb Behring Gmbh

2006-08-07 Application granted granted Critical

2006-08-07 Publication of DK0952215T3 publication Critical patent/DK0952215T3/da

Links

108091005804 Peptidases Proteins 0.000 title abstract 5
239000004365 Protease Substances 0.000 title abstract 5
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 5
230000003213 activating effect Effects 0.000 title abstract 3
102100023804 Coagulation factor VII Human genes 0.000 title 1
108010023321 Factor VII Proteins 0.000 title 1
229940105772 coagulation factor vii Drugs 0.000 title 1
108010054218 Factor VIII Proteins 0.000 abstract 2
102000001690 Factor VIII Human genes 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
239000003114 blood coagulation factor Substances 0.000 abstract 2
229940012413 factor vii Drugs 0.000 abstract 2
229960000301 factor viii Drugs 0.000 abstract 2
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
108010039627 Aprotinin Proteins 0.000 abstract 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
108010062466 Enzyme Precursors Proteins 0.000 abstract 1
102000010911 Enzyme Precursors Human genes 0.000 abstract 1
108010014172 Factor V Proteins 0.000 abstract 1
208000032843 Hemorrhage Diseases 0.000 abstract 1
229960004405 aprotinin Drugs 0.000 abstract 1
229910001424 calcium ion Inorganic materials 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
230000023597 hemostasis Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000017854 proteolysis Effects 0.000 abstract 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
238000010186 staining Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96447—Factor VII (3.4.21.21)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Pathology (AREA)
Toxicology (AREA)
General Physics & Mathematics (AREA)
Materials Engineering (AREA)

DK99106913T 1998-04-24 1999-04-08 Protease til aktivering af koaguleringsfaktor VII DK0952215T3 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DE19818495		1998-04-24
DE19827734		1998-06-22
DE19851336		1998-11-06
DE19851335		1998-11-06
DE19851332		1998-11-06
DE19903693A DE19903693A1 (de)	1998-04-24	1999-02-01	Protease zur Aktivierung des Gerinnungsfaktors VII

Publications (1)

Publication Number	Publication Date
DK0952215T3 true DK0952215T3 (da)	2006-08-07

Family

ID=27545095

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99106913T DK0952215T3 (da)	1998-04-24	1999-04-08	Protease til aktivering af koaguleringsfaktor VII

Country Status (10)

Country	Link
US (4)	US6528299B1 (fr)
EP (1)	EP0952215B1 (fr)
JP (2)	JP4361986B2 (fr)
KR (2)	KR100776921B1 (fr)
AT (1)	ATE323157T1 (fr)
AU (1)	AU748221B2 (fr)
CA (1)	CA2269109C (fr)
DE (2)	DE19903693A1 (fr)
DK (1)	DK0952215T3 (fr)
ES (1)	ES2262264T3 (fr)

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DE19903693A1 (de) *	1998-04-24	1999-10-28	Centeon Pharma Gmbh	Protease zur Aktivierung des Gerinnungsfaktors VII
DE19937219A1 (de) *	1999-08-06	2001-02-08	Aventis Behring Gmbh	Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie
EP1023902A1 (fr)	1999-01-28	2000-08-02	Aventis Behring Gesellschaft mit beschränkter Haftung	Préparation pharmaceutique pour le traitement des processus inflammatoires
DE10023923A1 (de) *	1999-06-10	2000-12-14	Aventis Behring Gmbh	Verfahren zur Bestimmung der Aktivität der Faktor VII-aktivierenden Protease aus Proteinlösungen
DE19937218A1 (de) *	1999-08-06	2001-02-08	Aventis Behring Gmbh	Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
DE10036641A1 (de) *	2000-07-26	2002-02-14	Aventis Behring Gmbh	Monoklonale Antikörper für die den Blutgerinnungsfaktor VII aktivierende Protease (FSAP)und ihre Verwendung
US7153679B2 (en)	2000-07-26	2006-12-26	Aventis Behring Gmbh	Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
DE10238429A1 (de)	2002-03-19	2003-10-30	Aventis Behring Gmbh Intellect	Marburg I Mutante der Faktor VII aktivierenden Protease (FSAP) als Risikofaktor für Atherosklerose
ES2257361T3 (es)	2000-07-26	2006-08-01	Zlb Behring Gmbh	Mutantes de la proteasa activadora del factor vii y procedimiento de deteccion con anticuerpos especificos.
DE50114021D1 (de)	2001-01-08	2008-07-24	Csl Behring Gmbh	Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms
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DE10148037A1 (de) *	2001-09-28	2003-04-17	Aventis Behring Gmbh	Verwendung der den Blutgerinnungsfaktor VII aktivierenden Protease zur Prophylaxe und Therapie von vaso-proliferativen Erkrankungen
EP1458408B1 (fr)	2001-12-21	2009-04-15	Novo Nordisk Health Care AG	Composition liquide de polypeptides de facteur vii
DE10205520A1 (de) *	2002-02-08	2003-08-14	Aventis Behring Gmbh	Inhibitorischer, monoklonaler Antikörper gegen die den Blutgerinnungsfaktor VII aktivierende Protease
CN1671410B (zh)	2002-06-21	2010-05-12	诺和诺德医疗保健公司	因子ⅶ多肽的稳定化固体组合物
DE10309368A1 (de) *	2002-08-06	2004-02-26	Aventis Behring Gmbh Intellectual Property/Legal	Pharmazeutische Zubereitung mit RNA als Cofaktor der Hämostase
JP3830501B2 (ja) *	2003-01-17	2006-10-04	株式会社ティーティーシー	アフィニティートラップリアクター、及びそれを用いたアンジオスタチン様断片のヒト血漿からの一段階精製プロセス
US7897734B2 (en)	2003-03-26	2011-03-01	Novo Nordisk Healthcare Ag	Method for the production of proteins
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EP1495766A1 (fr) *	2003-07-10	2005-01-12	ZLB Behring GmbH	Polypeptides dérivés de la protéase activatrice du facteur VII (FSAP) pour traiter les troubles liés à l'angiogénèse
JP5653572B2 (ja)	2003-08-14	2015-01-14	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	第ｖｉｉ因子ポリペプチドの液状水性医薬組成物
DE10346751A1 (de) *	2003-10-06	2005-04-21	Transmit Technologietransfer	Clot-Lysis-Assay
CN1917861B (zh)	2003-12-19	2012-03-21	诺和诺德医疗保健公司	因子vii多肽的稳定化固体组合物
DE102005026163A1 (de)	2004-08-24	2006-03-02	Dade Behring Marburg Gmbh	Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
DE502006005169D1 (de)	2005-12-22	2009-12-03	Siemens Healthcare Diagnostics	Diagnostisches Verfahren zur Erkennung von Trägern der Marburg l-Variante der Faktor VII-aktivierenden Protease (FSAP) anhand differenzieller Modulation der FSAP-Aktivität
US20100172830A1 (en) *	2007-03-29	2010-07-08	Cellx Inc.	Extraembryonic Tissue cells and method of use thereof
US9333280B2 (en)	2009-02-25	2016-05-10	Teleflex Medical Incorporated	Stabilized enzyme compositions
US8545459B2 (en) *	2009-02-25	2013-10-01	Teleflex Medical Incorporated	Stabilized enzyme compositions
EP2386652A1 (fr)	2010-05-12	2011-11-16	Siemens Healthcare Diagnostics Products GmbH	Procédé homogène destiné à la détermination de l'activité d'activation de l'activateur de plasminogène de FSAP
CN105188750A (zh)	2013-03-08	2015-12-23	德国杰特贝林生物制品有限公司	治疗和预防远端缺血-再灌注损伤
CA2916399C (fr) *	2013-06-28	2022-08-02	Marc Nolte	Polytherapie utilisant un inhibiteur du facteur xii et un inhibiteur de c1
US10143413B2 (en)	2014-06-13	2018-12-04	Kurin, Inc.	Catheter insertion device with blood analyzer
US9820682B2 (en)	2015-07-24	2017-11-21	Kurin, Inc.	Blood sample optimization system and blood contaminant sequestration device and method
US10827964B2 (en)	2017-02-10	2020-11-10	Kurin, Inc.	Blood contaminant sequestration device with one-way air valve and air-permeable blood barrier with closure mechanism
CN119469908A (zh)	2019-04-01	2025-02-18	酷睿有限公司	非排气机体流体样品优化装置和系统
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DE19937219A1 (de) *	1999-08-06	2001-02-08	Aventis Behring Gmbh	Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie
DE10023923A1 (de) *	1999-06-10	2000-12-14	Aventis Behring Gmbh	Verfahren zur Bestimmung der Aktivität der Faktor VII-aktivierenden Protease aus Proteinlösungen
DE19937218A1 (de) *	1999-08-06	2001-02-08	Aventis Behring Gmbh	Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
US7153679B2 (en) *	2000-07-26	2006-12-26	Aventis Behring Gmbh	Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
ES2257361T3 (es) *	2000-07-26	2006-08-01	Zlb Behring Gmbh	Mutantes de la proteasa activadora del factor vii y procedimiento de deteccion con anticuerpos especificos.
DE50114021D1 (de) *	2001-01-08	2008-07-24	Csl Behring Gmbh	Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms
DE10148037A1 (de) *	2001-09-28	2003-04-17	Aventis Behring Gmbh	Verwendung der den Blutgerinnungsfaktor VII aktivierenden Protease zur Prophylaxe und Therapie von vaso-proliferativen Erkrankungen
DE10205520A1 (de) *	2002-02-08	2003-08-14	Aventis Behring Gmbh	Inhibitorischer, monoklonaler Antikörper gegen die den Blutgerinnungsfaktor VII aktivierende Protease

1999
- 1999-02-01 DE DE19903693A patent/DE19903693A1/de not_active Withdrawn
- 1999-04-08 DE DE69930778T patent/DE69930778T2/de not_active Expired - Lifetime
- 1999-04-08 EP EP99106913A patent/EP0952215B1/fr not_active Expired - Lifetime
- 1999-04-08 AT AT99106913T patent/ATE323157T1/de active
- 1999-04-08 ES ES99106913T patent/ES2262264T3/es not_active Expired - Lifetime
- 1999-04-08 DK DK99106913T patent/DK0952215T3/da active
- 1999-04-21 US US09/295,316 patent/US6528299B1/en not_active Expired - Lifetime
- 1999-04-23 KR KR1019990014636A patent/KR100776921B1/ko not_active Expired - Fee Related
- 1999-04-23 AU AU23935/99A patent/AU748221B2/en not_active Ceased
- 1999-04-23 CA CA2269109A patent/CA2269109C/fr not_active Expired - Lifetime
- 1999-04-23 JP JP11641199A patent/JP4361986B2/ja not_active Expired - Fee Related
2002
- 2002-12-16 US US10/319,592 patent/US6911334B2/en not_active Expired - Lifetime
2005
- 2005-05-02 US US11/118,396 patent/US20050202002A1/en not_active Abandoned
2006
- 2006-09-29 KR KR1020060096156A patent/KR20060107736A/ko not_active Ceased
2007
- 2007-11-13 US US11/984,058 patent/US7879803B2/en not_active Expired - Fee Related
2009
- 2009-03-11 JP JP2009057232A patent/JP4422781B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0952215A2 (fr)	1999-10-27
JP2000023696A (ja)	2000-01-25
US20080175878A1 (en)	2008-07-24
DE69930778D1 (de)	2006-05-24
JP4422781B2 (ja)	2010-02-24
JP4361986B2 (ja)	2009-11-11
EP0952215B1 (fr)	2006-04-12
CA2269109A1 (fr)	1999-10-24
KR20060107736A (ko)	2006-10-16
JP2009131273A (ja)	2009-06-18
KR100776921B1 (ko)	2007-11-20
ATE323157T1 (de)	2006-04-15
ES2262264T3 (es)	2006-11-16
KR19990083444A (ko)	1999-11-25
US7879803B2 (en)	2011-02-01
US6911334B2 (en)	2005-06-28
US6528299B1 (en)	2003-03-04
DE69930778T2 (de)	2007-03-29
EP0952215A3 (fr)	2002-06-26
US20030152567A1 (en)	2003-08-14
US20050202002A1 (en)	2005-09-15
CA2269109C (fr)	2010-06-15
AU748221B2 (en)	2002-05-30
AU2393599A (en)	1999-11-04
DE19903693A1 (de)	1999-10-28

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