DK0955310T3 - Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler - Google Patents

Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler

Info

Publication number: DK0955310T3
Authority: DK; Denmark
Prior art keywords: pyridazino; diazepine; dioxo; carboxylic acid; hexahydro
Prior art date: 1998-04-27

Application number

DK99401019T

Other languages

Danish (da)

English (en)

Inventor

Francis Brion

Veronique Crocq

Patrick Roussel

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

1999-04-26

Publication date

2005-02-14

1999-04-26 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2005-02-14 Application granted granted Critical

2005-02-14 Publication of DK0955310T3 publication Critical patent/DK0955310T3/da

Links

QRKPPWPLSQRGSU-UHFFFAOYSA-N diazepine-1-carboxylic acid Chemical class OC(=O)N1C=CC=CC=N1 QRKPPWPLSQRGSU-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
125000003277 amino group Chemical group 0.000 abstract 4
CQEMIEFHWZQKJM-LURJTMIESA-N (7s)-7-amino-6,10-dioxo-2,7,8,9-tetrahydro-1h-pyridazino[1,2-a]diazepine-4-carboxylic acid Chemical class O=C1[C@@H](N)CCC(=O)N2CCC=C(C(O)=O)N21 CQEMIEFHWZQKJM-LURJTMIESA-N 0.000 abstract 2
NWQJXXUYZOCKFS-BQBZGAKWSA-N (4s,7s)-7-amino-6,10-dioxo-2,3,4,7,8,9-hexahydro-1h-pyridazino[1,2-a]diazepine-4-carboxylic acid Chemical class O=C1[C@@H](N)CCC(=O)N2CCC[C@@H](C(O)=O)N21 NWQJXXUYZOCKFS-BQBZGAKWSA-N 0.000 abstract 1
NWQJXXUYZOCKFS-PKPIPKONSA-N (7s)-7-amino-6,10-dioxo-2,3,4,7,8,9-hexahydro-1h-pyridazino[1,2-a]diazepine-4-carboxylic acid Chemical class O=C1[C@@H](N)CCC(=O)N2CCCC(C(O)=O)N21 NWQJXXUYZOCKFS-PKPIPKONSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000005544 phthalimido group Chemical class 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK99401019T 1998-04-27 1999-04-26 Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler DK0955310T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805242A FR2777888B1 (fr)	1998-04-27	1998-04-27	Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
EP99401019A EP0955310B1 (de)	1998-04-27	1999-04-26	Neue (3,4,7,8,9,10) hexahydro-6, 10-dioxo-6H-pyridazino /1, 2-a/ /1, 2/ Diazepin-1-Carbonsäure-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung pharmazeutischer Wirkstoffe

Publications (1)

Publication Number	Publication Date
DK0955310T3 true DK0955310T3 (da)	2005-02-14

Family

ID=9525704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99401019T DK0955310T3 (da)	1998-04-27	1999-04-26	Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler

Country Status (9)

Country	Link
US (2)	US6258947B1 (de)
EP (1)	EP0955310B1 (de)
JP (1)	JP2000001489A (de)
AT (1)	ATE279434T1 (de)
DE (1)	DE69921011T2 (de)
DK (1)	DK0955310T3 (de)
ES (1)	ES2229641T3 (de)
FR (1)	FR2777888B1 (de)
PT (1)	PT955310E (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6177565B1 (en)	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
US6201118B1 (en)	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6451373B1 (en) *	2000-08-04	2002-09-17	Advanced Cardiovascular Systems, Inc.	Method of forming a therapeutic coating onto a surface of an implantable prosthesis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DE59310189D1 (de) *	1992-05-18	2001-08-23	Hoffmann La Roche	Asymmetrische Hydrierung

1998
- 1998-04-27 FR FR9805242A patent/FR2777888B1/fr not_active Expired - Lifetime
1999
- 1999-04-13 JP JP11105457A patent/JP2000001489A/ja active Pending
- 1999-04-22 US US09/296,325 patent/US6258947B1/en not_active Expired - Lifetime
- 1999-04-26 EP EP99401019A patent/EP0955310B1/de not_active Expired - Lifetime
- 1999-04-26 DK DK99401019T patent/DK0955310T3/da active
- 1999-04-26 DE DE69921011T patent/DE69921011T2/de not_active Expired - Lifetime
- 1999-04-26 PT PT99401019T patent/PT955310E/pt unknown
- 1999-04-26 AT AT99401019T patent/ATE279434T1/de active
- 1999-04-26 ES ES99401019T patent/ES2229641T3/es not_active Expired - Lifetime
2001
- 2001-01-19 US US09/765,761 patent/US6433164B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE279434T1 (de)	2004-10-15
DE69921011D1 (de)	2004-11-18
PT955310E (pt)	2005-01-31
ES2229641T3 (es)	2005-04-16
EP0955310B1 (de)	2004-10-13
JP2000001489A (ja)	2000-01-07
US6258947B1 (en)	2001-07-10
DE69921011T2 (de)	2005-10-27
FR2777888B1 (fr)	2004-07-16
US20010002422A1 (en)	2001-05-31
US6433164B2 (en)	2002-08-13
FR2777888A1 (fr)	1999-10-29
EP0955310A1 (de)	1999-11-10

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