DK0980379T3 - Chimære oligonucleotider og deres anvendelse - Google Patents

Chimære oligonucleotider og deres anvendelse

Info

Publication number: DK0980379T3
Authority: DK; Denmark
Prior art keywords: chimeric oligonucleotides; oligonucleotides; novel; relates; medicaments
Prior art date: 1997-05-02

Application number

DK98933431T

Other languages

English (en)

Inventor

Eckart Matthes

Janta-Lipinski Martin Von

Original Assignee

Max Delbrueck Centrum

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-02

Filing date

1998-05-04

Publication date

2002-12-02

1998-05-04 Application filed by Max Delbrueck Centrum filed Critical Max Delbrueck Centrum

2002-12-02 Application granted granted Critical

2002-12-02 Publication of DK0980379T3 publication Critical patent/DK0980379T3/da

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 3
108010017842 Telomerase Proteins 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK98933431T 1997-05-02 1998-05-04 Chimære oligonucleotider og deres anvendelse DK0980379T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19720151A DE19720151A1 (de)	1997-05-02	1997-05-02	Chimäre Oligonucleotide und ihre Verwendung
PCT/DE1998/001216 WO1998050397A2 (de)	1997-05-02	1998-05-04	Chimäre oligonucleotide und ihre verwendung

Publications (1)

Publication Number	Publication Date
DK0980379T3 true DK0980379T3 (da)	2002-12-02

Family

ID=7829409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98933431T DK0980379T3 (da)	1997-05-02	1998-05-04	Chimære oligonucleotider og deres anvendelse

Country Status (8)

Country	Link
EP (1)	EP0980379B1 (da)
JP (1)	JP2001524972A (da)
AT (1)	ATE221895T1 (da)
DE (2)	DE19720151A1 (da)
DK (1)	DK0980379T3 (da)
ES (1)	ES2182340T3 (da)
PT (1)	PT980379E (da)
WO (1)	WO1998050397A2 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HK1049339B (en) *	1999-09-10	2008-06-27	Geron Corporation	Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use
US7563618B2 (en)	2001-03-23	2009-07-21	Geron Corporation	Oligonucleotide conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD279407A1 (de) *	1986-07-24	1990-06-06	Akad Wissenschaften Ddr	Verfahren zur herstellung eines mittels gegen aids
EP0355031A3 (de) *	1988-08-17	1990-12-27	MATTHES, Eckart, Dr.	Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
US5489508A (en) *	1992-05-13	1996-02-06	University Of Texas System Board Of Regents	Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5643890A (en) *	1995-01-31	1997-07-01	The Board Of Regents Of The University Of Nebraska	Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
US6015710A (en) *	1996-04-09	2000-01-18	The University Of Texas System	Modulation of mammalian telomerase by peptide nucleic acids
WO1997037691A1 (en) *	1996-04-10	1997-10-16	Lynx Therapeutics, Inc.	Telomerase inhibitors
EP0951568A1 (en) *	1996-12-20	1999-10-27	Geron Corporation	Methods for detecting and inhibiting the rna component of telomerase

1997
- 1997-05-02 DE DE19720151A patent/DE19720151A1/de not_active Withdrawn
1998
- 1998-05-04 ES ES98933431T patent/ES2182340T3/es not_active Expired - Lifetime
- 1998-05-04 DK DK98933431T patent/DK0980379T3/da active
- 1998-05-04 PT PT98933431T patent/PT980379E/pt unknown
- 1998-05-04 WO PCT/DE1998/001216 patent/WO1998050397A2/de not_active Ceased
- 1998-05-04 DE DE59805112T patent/DE59805112D1/de not_active Expired - Lifetime
- 1998-05-04 EP EP98933431A patent/EP0980379B1/de not_active Expired - Lifetime
- 1998-05-04 JP JP54761898A patent/JP2001524972A/ja not_active Ceased
- 1998-05-04 AT AT98933431T patent/ATE221895T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE19720151A1 (de)	1998-11-05
WO1998050397A2 (de)	1998-11-12
ES2182340T3 (es)	2003-03-01
PT980379E (pt)	2002-12-31
ATE221895T1 (de)	2002-08-15
WO1998050397A3 (de)	1999-02-11
DE59805112D1 (de)	2002-09-12
JP2001524972A (ja)	2001-12-04
EP0980379A2 (de)	2000-02-23
EP0980379B1 (de)	2002-08-07

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DE69905170D1 (en)	2003-03-06	Thiazolopyrimidinderivate
SE9704546D0 (sv)	1997-12-05	Novel compounds
AP9801392A0 (en)	1998-12-31	Concentrated antibody preparation.
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DK0703786T3 (da)	2002-05-27	Anvendelse af nona- og dekapeptider til fremstilling af et lægemiddel til behandling af AIDS
TW200510375A (en)	2005-03-16	New compounds
MY140539A (en)	2009-12-31	1-amino 1h-imidazoquinolines
FI963070A0 (fi)	1996-08-02	Klooripyrimidiinivälituotteita
AP2000001947A0 (en)	2000-12-31	Novel crystalline forms of an antiviral benzidazole compound.
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
SE9802937D0 (sv)	1998-09-01	Novel compounds
NO20014537D0 (no)	2001-09-18	AKT-nukleinsyrer, -polypeptider og anvendelse av disse
IL121272A0 (en)	1998-01-04	Nucleotide comprising compositions and their use for improving therapeutic index of a therapeutic drug
WO2001029175A3 (en)	2001-10-11	Antisense modulation of fra-1 expression
AU1815899A (en)	1999-06-28	Method and composition to enhance the efficacy of a vaccine using chemokines
NO20012428D0 (no)	2001-05-16	Substituerte kaprolaktamer, farmasöytiske sammensetninger som inneholder dem og deres anvendelse ved behandling av tumorer
MY127675A (en)	2006-12-29	Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods
MXPA03004539A (es)	2004-03-26	Luciferasas aisladas y uso de las mismas.
TR199901385T2 (xx)	1999-11-22	Piperidin t�revleri.
EA200000909A1 (ru)	2001-06-25	ФОРМА VI 5,6-ДИХЛОР-2-(ИЗОПРОПИЛАМИНО)-1-(b-L-РИБОФУРАНОЗИЛ)-1H-БЕНЗИМИДАЗОЛА
PT980379E (pt)	2002-12-31	Oligonucleotidos quimericos e sua utilizacao
WO2001014415A3 (en)	2001-07-26	Egfh2 genes and gene products
TR200000916T2 (tr)	2000-07-21	İkameli piperidin türevleri.