DK0980526T3 - Inhibitorer af nucleært protein/nucleær receptor interaktion - Google Patents

Inhibitorer af nucleært protein/nucleær receptor interaktion

Info

Publication number
DK0980526T3
DK0980526T3 DK98919329T DK98919329T DK0980526T3 DK 0980526 T3 DK0980526 T3 DK 0980526T3 DK 98919329 T DK98919329 T DK 98919329T DK 98919329 T DK98919329 T DK 98919329T DK 0980526 T3 DK0980526 T3 DK 0980526T3
Authority
DK
Denmark
Prior art keywords
nuclear
protein
nuclear receptor
nuclear protein
signature motif
Prior art date
Application number
DK98919329T
Other languages
English (en)
Inventor
David Michael Heery
Malcolm George Parker
Original Assignee
Imp Cancer Res Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp Cancer Res Tech filed Critical Imp Cancer Res Tech
Application granted granted Critical
Publication of DK0980526T3 publication Critical patent/DK0980526T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK98919329T 1997-04-30 1998-04-28 Inhibitorer af nucleært protein/nucleær receptor interaktion DK0980526T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708676.3A GB9708676D0 (en) 1997-04-30 1997-04-30 Chemical compounds

Publications (1)

Publication Number Publication Date
DK0980526T3 true DK0980526T3 (da) 2006-12-04

Family

ID=10811533

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98919329T DK0980526T3 (da) 1997-04-30 1998-04-28 Inhibitorer af nucleært protein/nucleær receptor interaktion

Country Status (11)

Country Link
EP (1) EP0980526B1 (da)
JP (2) JP2002512690A (da)
AT (1) ATE338276T1 (da)
AU (1) AU7220798A (da)
CY (1) CY1105809T1 (da)
DE (1) DE69835741T2 (da)
DK (1) DK0980526T3 (da)
ES (1) ES2271993T3 (da)
GB (1) GB9708676D0 (da)
PT (1) PT980526E (da)
WO (1) WO1998049561A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101681B1 (en) * 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6303576B1 (en) 1999-04-21 2001-10-16 Adherex Technologies Inc. Compounds and methods for modulating β-catenin mediated gene expression
US20040137441A1 (en) * 2003-01-15 2004-07-15 Isis Pharmaceuticals Inc. Modulation of thyroid hormone receptor interactor 3 expression
GB0215496D0 (en) * 2002-07-04 2002-08-14 Imp College Innovations Ltd Screening for anti-ovulatory compounds
JP6700186B2 (ja) * 2014-01-22 2020-05-27 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 療法の適合性を評価するための改善された患者の層別化

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516085A (ja) * 1996-05-31 2000-12-05 アメリカン シアナミド コンパニー 超気門（Ｕｌｔｒａｓｐｉｒａｃｌｅ）阻害剤のためのスクリーン
US6268173B1 (en) * 1996-07-12 2001-07-31 Institut Natural De La Sante Et La Recherche Medicale Polynucleotide encoding transcriptional intermediary factor-2
US5877282A (en) * 1996-09-20 1999-03-02 Bristol-Myers Squibb Company Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof

Also Published As

Publication number Publication date
JP2007304102A (ja) 2007-11-22
ATE338276T1 (de) 2006-09-15
EP0980526A1 (en) 2000-02-23
JP2002512690A (ja) 2002-04-23
WO1998049561A1 (en) 1998-11-05
CY1105809T1 (el) 2011-02-02
ES2271993T3 (es) 2007-04-16
GB9708676D0 (en) 1997-06-18
EP0980526B1 (en) 2006-08-30
DE69835741T2 (de) 2007-09-13
PT980526E (pt) 2006-12-29
AU7220798A (en) 1998-11-24
DE69835741D1 (de) 2006-10-12
JP4206420B2 (ja) 2009-01-14

Similar Documents

Publication Publication Date Title
DE69637726D1 (de) Gruppen zum einfangen von nukleinsäuren
Hahm et al. Heterogeneous nuclear ribonucleoprotein L interacts with the 3′ border of the internal ribosomal entry site of hepatitis C virus
Palancade et al. Investigating RNA polymerase II carboxyl‐terminal domain (CTD) phosphorylation
Suñé et al. Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat
Bachs et al. Calmodulin-binding proteins in the nuclei of quiescent and proliferatively activated rat liver cells.
Hetzer et al. Decoding Tat: the biology of HIV Tat posttranslational modifications
DE60135912D1 (de) Nachweis der hybridisierung von nukleinsäuren durch fluoreszenzpolarisation
DE69406423D1 (de) Methode zum überbringen von agenzien an zielzellen
ATE348175T1 (de) Method eder intrazellularen bindung von zielgerichteten molekülen
DE69902996D1 (de) Techniken zu detektion von fehlpaarungen
DE60030744D1 (de) Verfahren zum identifizieren von inhibitoren der methioninaminopeptidasen
Straub et al. PSF/p54 nrb stimulates “jumping” of DNA topoisomerase I between separate DNA helices
DK0980526T3 (da) Inhibitorer af nucleært protein/nucleær receptor interaktion
GB2337329A (en) Inhibitors of nuclear protein/nuclear receptor interaction
ATE371732T1 (de) Verfahren zur genexpression
Yan et al. Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin μs poly (A) site processing complex
WO2004042345A3 (en) Bacterial small-molecule three-hybrid system
Schmidlin et al. Presence of argininosuccinate synthetase in glial cells as revealed by peptide-specific antisera
WO1999061613A3 (en) Interference with viral ires-mediated translation by a small yeast rna reveals critical rna-protein interactions
AU2803695A (en) Assay for inhibitors of dp-1 and other dp proteins
WO2003041659A3 (en) Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders
ATE325189T1 (de) Klonierungsverfahren durch multiple verdauung
Smith et al. Role of operator subsites in Arc repression
ATE206157T1 (de) Ein zellfreies system zum start der dna replikation
WO1999064861A3 (en) Method of identifying antidepressant compounds