DK0984938T3 - Cyanoguanidiner som celleproliferationsinhibitorer - Google Patents

Cyanoguanidiner som celleproliferationsinhibitorer

Info

Publication number: DK0984938T3
Authority: DK; Denmark
Prior art keywords: stands; alkoxycarbonyl; trifluoromethyl; carboxy; cyano
Prior art date: 1997-05-29

Application number

DK98924055T

Other languages

English (en)

Inventor

Charlotte Schou

Original Assignee

Leo Pharma As With Secondary N

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-29

Filing date

1998-05-15

Publication date

2004-01-12

1998-05-15 Application filed by Leo Pharma As With Secondary N filed Critical Leo Pharma As With Secondary N

2004-01-12 Application granted granted Critical

2004-01-12 Publication of DK0984938T3 publication Critical patent/DK0984938T3/da

Links

230000004663 cell proliferation Effects 0.000 title 1
QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical class NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
-1 nitro, amino Chemical group 0.000 abstract 7
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK98924055T 1997-05-29 1998-05-15 Cyanoguanidiner som celleproliferationsinhibitorer DK0984938T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9711125.6A GB9711125D0 (en)	1997-05-29	1997-05-29	Novel cyanoguanidines
PCT/DK1998/000196 WO1998054144A1 (en)	1997-05-29	1998-05-15	Cyanoguanidines as cell proliferation inhibitors

Publications (1)

Publication Number	Publication Date
DK0984938T3 true DK0984938T3 (da)	2004-01-12

Family

ID=10813255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98924055T DK0984938T3 (da)	1997-05-29	1998-05-15	Cyanoguanidiner som celleproliferationsinhibitorer

Country Status (20)

Country	Link
US (1)	US6346541B1 (da)
EP (1)	EP0984938B1 (da)
JP (1)	JP4408455B2 (da)
KR (1)	KR100496220B1 (da)
CN (1)	CN1116283C (da)
AT (1)	ATE249438T1 (da)
AU (1)	AU733142B2 (da)
CA (1)	CA2292895C (da)
CZ (1)	CZ294842B6 (da)
DE (1)	DE69818041T2 (da)
DK (1)	DK0984938T3 (da)
ES (1)	ES2206932T3 (da)
GB (1)	GB9711125D0 (da)
HU (1)	HUP0002921A3 (da)
NZ (1)	NZ501071A (da)
PL (1)	PL190314B1 (da)
PT (1)	PT984938E (da)
RO (1)	RO120541B1 (da)
RU (1)	RU2195453C2 (da)
WO (1)	WO1998054144A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9711123D0 (en) *	1997-05-29	1997-07-23	Leo Pharm Prod Ltd	Novel cyanoguanidines
WO2000061561A1 (en)	1999-04-09	2000-10-19	Shionogi Bioresearch Corp.	Cyanoguanidine compounds
AU1494702A (en)	2000-11-21	2002-06-03	Leo Pharma As	Cyanoguanidine prodrugs
US20030045515A1 (en) *	2001-05-24	2003-03-06	Lise Binderup	Combination medicament for treatment of neoplastic diseases
KR20030097897A (ko) *	2001-05-24	2003-12-31	레오 파마 에이/에스	신규한 피리딜 시아노구아니딘 화합물
AU2003229534B2 (en) *	2002-05-17	2009-08-27	Leo Pharma A/S	Cyanoguanidine prodrugs
US7253193B2 (en)	2002-05-17	2007-08-07	Leo Pharma A/S	Cyanoguanidine prodrugs
KR20040111626A (ko) *	2002-05-17	2004-12-31	레오 파마 에이/에스	시아노구아니딘 전구약물
WO2006037468A1 (en) *	2004-09-30	2006-04-13	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Hiv reverse transcriptase inhibitors
WO2006066584A1 (en) *	2004-12-22	2006-06-29	Leo Pharma A/S	Novel cyanoguanidine compounds
US20090137550A1 (en) *	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
US8173677B2 (en)	2007-09-26	2012-05-08	Gemin X Pharmaceuticals Canada Inc.	Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
US8211912B2 (en)	2007-09-26	2012-07-03	Gemin X Pharmaceuticals Canada	Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl tranferase inhibitor
WO2009086835A1 (en) *	2008-01-11	2009-07-16	Topotarget A/S	Novel cyanoguanidines
CN102186822A (zh)	2008-08-29	2011-09-14	顶标公司	新脲和硫脲衍生物
WO2010088842A1 (zh) *	2009-02-06	2010-08-12	天津和美生物技术有限公司	含有吡啶基氰基胍的药物组合物及其制备和应用
US8912184B1 (en)	2010-03-01	2014-12-16	Alzheimer's Institute Of America, Inc.	Therapeutic and diagnostic methods
RU2593759C2 (ru)	2010-09-03	2016-08-10	ФОРМА ТиЭм, ЭлЭлСИ	Гуанидиновые соединения и композиции для ингибирования nampt
US8859594B2 (en)	2010-10-26	2014-10-14	Tianjin Hemay Bio-Tech Co., Ltd.	Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof
CN109843334A (zh)	2016-10-18	2019-06-04	西雅图基因公司	烟酰胺腺嘌呤二核苷酸补救途径抑制剂的靶向递送
WO2018201087A1 (en)	2017-04-27	2018-11-01	Seattle Genetics, Inc.	Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4530693A (en) *	1992-08-13	1994-03-15	Upjohn Company, The	Cyanoguanidines as potassium channel blockers
GB9219472D0 (en) *	1992-09-15	1992-10-28	Leo Pharm Prod Ltd	Chemical compounds
DK0741708T3 (da) *	1994-01-28	1999-01-18	Upjohn Co	Cyanoguanidiner som K-kanal-blokkere

1997
- 1997-05-29 GB GBGB9711125.6A patent/GB9711125D0/en active Pending
1998
- 1998-05-15 CZ CZ19994234A patent/CZ294842B6/cs not_active IP Right Cessation
- 1998-05-15 DE DE69818041T patent/DE69818041T2/de not_active Expired - Lifetime
- 1998-05-15 AT AT98924055T patent/ATE249438T1/de not_active IP Right Cessation
- 1998-05-15 ES ES98924055T patent/ES2206932T3/es not_active Expired - Lifetime
- 1998-05-15 PT PT98924055T patent/PT984938E/pt unknown
- 1998-05-15 WO PCT/DK1998/000196 patent/WO1998054144A1/en not_active Ceased
- 1998-05-15 US US09/424,632 patent/US6346541B1/en not_active Expired - Lifetime
- 1998-05-15 CA CA002292895A patent/CA2292895C/en not_active Expired - Lifetime
- 1998-05-15 AU AU76386/98A patent/AU733142B2/en not_active Expired
- 1998-05-15 KR KR10-1999-7011131A patent/KR100496220B1/ko not_active Expired - Lifetime
- 1998-05-15 EP EP98924055A patent/EP0984938B1/en not_active Expired - Lifetime
- 1998-05-15 DK DK98924055T patent/DK0984938T3/da active
- 1998-05-15 NZ NZ501071A patent/NZ501071A/en not_active IP Right Cessation
- 1998-05-15 HU HU0002921A patent/HUP0002921A3/hu unknown
- 1998-05-15 RU RU99128082/04A patent/RU2195453C2/ru active
- 1998-05-15 CN CN98805595A patent/CN1116283C/zh not_active Expired - Lifetime
- 1998-05-15 JP JP50011499A patent/JP4408455B2/ja not_active Expired - Lifetime
- 1998-05-15 RO RO99-01251A patent/RO120541B1/ro unknown
- 1998-05-15 PL PL98337030A patent/PL190314B1/pl not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL337030A1 (en)	2000-07-31
US6346541B1 (en)	2002-02-12
CA2292895A1 (en)	1998-12-03
EP0984938B1 (en)	2003-09-10
AU733142B2 (en)	2001-05-10
JP4408455B2 (ja)	2010-02-03
CZ9904234A3 (cs)	2001-02-14
CN1116283C (zh)	2003-07-30
PL190314B1 (pl)	2005-11-30
HK1027562A1 (en)	2001-01-19
DE69818041T2 (de)	2004-07-08
DE69818041D1 (de)	2003-10-16
HUP0002921A2 (hu)	2001-01-29
WO1998054144A1 (en)	1998-12-03
ATE249438T1 (de)	2003-09-15
CA2292895C (en)	2007-03-06
EP0984938A1 (en)	2000-03-15
CZ294842B6 (cs)	2005-03-16
JP2001526694A (ja)	2001-12-18
KR100496220B1 (ko)	2005-06-21
ES2206932T3 (es)	2004-05-16
RU2195453C2 (ru)	2002-12-27
RO120541B1 (ro)	2006-03-30
NZ501071A (en)	2001-08-31
GB9711125D0 (en)	1997-07-23
CN1258279A (zh)	2000-06-28
AU7638698A (en)	1998-12-30
KR20010013148A (ko)	2001-02-26
PT984938E (pt)	2004-02-27
HUP0002921A3 (en)	2002-10-28

Publication	Publication Date	Title
ATE249438T1 (de)	2003-09-15	Cyanoguanidine als zellproliferation inhibitoren
DE69928697D1 (de)	2006-01-05	Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
WO2006109075A3 (en)	2006-11-30	Hydroxybenzamide derivatives and their use as inhibitors of hsp90
DK1109785T3 (da)	2003-04-22	Indolderivater og deres anvendelse til behandling af ondartede og andre sygdomme forårsaget af patologisk celleproliferation
DE60335869D1 (de)	2011-03-10	1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
NO20044731L (no)	2004-12-30	Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere
ATE495162T1 (de)	2011-01-15	Azabicyclo-octan und nonan derivate mit ddp-iv hemmender wirkung
NO20065948L (no)	2007-01-23	Quinazolin-4-yl-piperidin- and cinnolin-4-yl-piperidin-derivatives som PDE10-inhibitorer for behandling av CNS forstyrrelser
AR039566A1 (es)	2005-02-23	Inhibidores de la histona deacetilasa, composicion farmaceutica que los contiene y sus procesos de preparacion
NZ508990A (en)	2002-12-20	Pyrazoline derivatives, their preparation and application as medicaments
ATE394383T1 (de)	2008-05-15	Biphenylkarbonsäureamidderivate als p38 kinase- inhibitoren
NO20051051L (no)	2005-03-29	Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme i terapeutiske midler
BG103867A (en)	2001-05-31	Cyanoguanidines as cell proliferation inhibitors
CA2214759A1 (en)	1997-07-24	Intimal hypertrophy inhibitors
NO20063676L (no)	2006-10-13	Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer
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